Cell-permeable peptide inhibitors of JNK. Novel blockers of β-cell death

Diabetes

Volumn 50, Issue 1, 2001, Pages 77-82

  Bonny, C ^a   Oberson, A ^a   Negri, S ^a   Sauser, C ^a   Schorderet, D F ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; INSULIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PEPTIDE; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ARTICLE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG MECHANISM; ENANTIOMER; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE C FOS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 0035152487     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.1.77     Document Type: Article

References (42)

1. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
2. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
3. Transcription factor ATF2 regulation by the JNK signal transduction pathway
4. Integration of MAP kinase signal transduction pathways at the serum response element
5. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
6. BCL-2 family members and the mitochondria in apoptosis
7. Requirement of JNK for stress-induced activation of the cytochrome C-mediated death pathway
8. The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic β-cells
9. cDNA cloning and mapping of a novel islet-brain/JNK interacting protein
10. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1
11. IB1, a JIP-1-related nuclear protein present in insulin-secreting cells
12. A cytoplasmic inhibitor of the JNK signal transduction pathway
13. IB1 reduces cytokine-induced apoptosis of insulin-secreting cells
14. The gene encoding MAPK8IP1, encoding islet-brain 1, is a candidate for type 2 diabetes
15. The JIP group of mitogen-activated protein kinase scaffold proteins
16. In vivo protein transduction: Delivery of a biologically active protein into the mouse
17. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
18. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene
19. Glucose promotes survival of rat pancreatic β-cells by activating synthesis of proteins which suppress a constitutive apoptotic program
20. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
21. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p 27Kip1 induces cell migration
22. Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein
23. On the immunogenic properties of retro-inverso peptides: Total retro-inversion of T-cell epitopes causes a loss of binding to MHC II molecules
24. The retro-inverso form of a homeobox-derived short peptide is rapidly internalised by cultured neurones: A new basis for an efficient intracellular delivery system
25. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
26. Induction of c-fos expression through JNK-mediated TCF/EIk-1 phosphorylation
27. Interleukin 1-induced Fos and Jun do not regulate inducible nitric oxide synthase in rat islets of Langerhans and RINm5F cells
28. Apoptosis and the pathogenesis of IDDM: A question of life and death
29. Protection of NIT-1 pancreatic β-cells from immune attack by inhibition of NF-κB
30. Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects β-cells from cytokine-induced destruction
31. Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice
32. Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells
33. Selection of insulinoma cell lines with resistance to interleukin-1β- and γ-interferon-induced cytotoxicity
34. SOCS: Suppressors of cytokine signalling
35. MyD88, an adapter protein involved in interleukin-1 signaling
36. Tumor necrosis factor-α-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic β-cells
37. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
38. Noninvasive intracellular delivery of functional peptides and proteins
39. Transduced p16INK4a peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1
40. Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
41. Regulation of NF-kappa B, AP-1 NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50
42. Peptide-directed suppression of a pro-inflammatory cytokine response