메뉴 건너뛰기




Volumn 29, Issue 2, 2015, Pages 274-288

NFAT targets signaling molecules to gene promoters in pancreatic β-cells

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; TACROLIMUS; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; DNA; E1A ASSOCIATED P300 PROTEIN; EP300 PROTEIN, MOUSE; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BINDING; TUMOR NECROSIS FACTOR;

EID: 84922277623     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/me.2014-1066     Document Type: Article
Times cited : (18)

References (42)
  • 1
    • 0019352341 scopus 로고
    • Calcium affects insulin release and membrane potential in islet β-cells
    • Frankel BJ, Atwater I, Grodsky GM. Calcium affects insulin release and membrane potential in islet β-cells. Am J Physiol. 1981;240(1): C64–C72.
    • (1981) Am J Physiol , vol.240 , Issue.1 , pp. C64-C72
    • Frankel, B.J.1    Atwater, I.2    Grodsky, G.M.3
  • 3
    • 33845541249 scopus 로고    scopus 로고
    • Nutrient control of insulin secretion in isolated normal human islets
    • Henquin JC, Dufrane D, Nenquin M. Nutrient control of insulin secretion in isolated normal human islets. Diabetes. 2006;55(12): 3470–3477.
    • (2006) Diabetes , vol.55 , Issue.12 , pp. 3470-3477
    • Henquin, J.C.1    Dufrane, D.2    Nenquin, M.3
  • 4
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes. 2000;49(11):1751–1760.
    • (2000) Diabetes , vol.49 , Issue.11 , pp. 1751-1760
    • Henquin, J.C.1
  • 5
    • 0027393644 scopus 로고
    • The role of the free cytosolic calcium level in β-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7–37)
    • Lu M, Wheeler MB, Leng XH, Boyd AE III. The role of the free cytosolic calcium level in β-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7–37). Endocrinology. 1993;132(1):94–100.
    • (1993) Endocrinology , vol.132 , Issue.1 , pp. 94-100
    • Lu, M.1    Wheeler, M.B.2    Leng, X.H.3    Boyd, A.E.4
  • 6
    • 0028978243 scopus 로고
    • Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic β -cells by the insulinotropic hormone glucagon-like peptide-1
    • Holz GG IV, Leech CA, Habener JF. Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic β -cells by the insulinotropic hormone glucagon-like peptide-1. J Biol Chem. 1995; 270(30):17749–17757.
    • (1995) J Biol Chem , vol.270 , Issue.30 , pp. 17749-17757
    • Holz, G.G.1    Leech, C.A.2    Habener, J.F.3
  • 7
    • 0029149848 scopus 로고
    • Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting β TC3-cells by enhancement of intracellular calcium mobilization
    • Gromada J, Dissing S, Bokvist K, et al. Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting β TC3-cells by enhancement of intracellular calcium mobilization. Diabetes. 1995; 44(7):767–774.
    • (1995) Diabetes , vol.44 , Issue.7 , pp. 767-774
    • Gromada, J.1    Dissing, S.2    Bokvist, K.3
  • 8
    • 33845998516 scopus 로고    scopus 로고
    • The role of gut hormones in glucose homeostasis
    • Drucker DJ. The role of gut hormones in glucose homeostasis. J Clin Invest. 2007;117(1):24–32.
    • (2007) J Clin Invest , vol.117 , Issue.1 , pp. 24-32
    • Drucker, D.J.1
  • 9
    • 0034796114 scopus 로고    scopus 로고
    • Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells
    • Lawrence MC, Bhatt HS, Watterson JM, Easom RA. Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells. Mol Endocrinol. 2001;15(10):1758–1767.
    • (2001) Mol Endocrinol , vol.15 , Issue.10 , pp. 1758-1767
    • Lawrence, M.C.1    Bhatt, H.S.2    Watterson, J.M.3    Easom, R.A.4
  • 10
    • 0036310155 scopus 로고    scopus 로고
    • NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1
    • Lawrence MC, Bhatt HS, Easom RA. NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1. Diabetes. 2002;51(3):691–698.
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 691-698
    • Lawrence, M.C.1    Bhatt, H.S.2    Easom, R.A.3
  • 11
    • 22844446279 scopus 로고    scopus 로고
    • ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter
    • Lawrence MC, McGlynn K, Park BH, Cobb MH. ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter. J Biol Chem. 2005;280(29):26751–26759.
    • (2005) J Biol Chem , vol.280 , Issue.29 , pp. 26751-26759
    • Lawrence, M.C.1    McGlynn, K.2    Park, B.H.3    Cobb, M.H.4
  • 12
    • 33748929299 scopus 로고    scopus 로고
    • Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function
    • Heit JJ, Apelqvist AA, Gu X, et al. Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function. Nature. 2006; 443(7109):345–349.
    • (2006) Nature , vol.443 , Issue.7109 , pp. 345-349
    • Heit, J.J.1    Apelqvist, A.A.2    Gu, X.3
  • 13
    • 78650059541 scopus 로고    scopus 로고
    • Calcineurin signaling regulates human islet β-cell survival
    • Soleimanpour SA, Crutchlow MF, Ferrari AM, et al. Calcineurin signaling regulates human islet β-cell survival. J Biol Chem. 2010; 285(51):40050–40059.
    • (2010) J Biol Chem , vol.285 , Issue.51 , pp. 40050-40059
    • Soleimanpour, S.A.1    Crutchlow, M.F.2    Ferrari, A.M.3
  • 14
    • 80755168889 scopus 로고    scopus 로고
    • Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2 -dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells
    • Demozay D, Tsunekawa S, Briaud I, Shah R, Rhodes CJ. Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2 -dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells. Diabetes. 2011;60(11):2892–2902.
    • (2011) Diabetes , vol.60 , Issue.11 , pp. 2892-2902
    • Demozay, D.1    Tsunekawa, S.2    Briaud, I.3    Shah, R.4    Rhodes, C.J.5
  • 15
    • 84864007651 scopus 로고    scopus 로고
    • Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT
    • Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK. Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. Dev Cell. 2012;23(1):21–34.
    • (2012) Dev Cell , vol.23 , Issue.1 , pp. 21-34
    • Goodyer, W.R.1    Gu, X.2    Liu, Y.3    Bottino, R.4    Crabtree, G.R.5    Kim, S.K.6
  • 16
    • 0035960027 scopus 로고    scopus 로고
    • Posttransplant diabetes mellitus in pediatric renal transplant recipients: A report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)
    • Al-Uzri A, Stablein DM, A Cohn R. Posttransplant diabetes mellitus in pediatric renal transplant recipients: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Transplantation. 2001;72(6):1020–1024.
    • (2001) Transplantation , vol.72 , Issue.6 , pp. 1020-1024
    • Al-Uzri, A.1    Stablein, D.M.2    A Cohn, R.3
  • 17
    • 0035960583 scopus 로고    scopus 로고
    • Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: Analysis of incidence and risk factors
    • Maes BD, Kuypers D, Messiaen T, et al. Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors. Transplantation. 2001;72(10): 1655–1661.
    • (2001) Transplantation , vol.72 , Issue.10 , pp. 1655-1661
    • Maes, B.D.1    Kuypers, D.2    Messiaen, T.3
  • 18
    • 80855128249 scopus 로고    scopus 로고
    • Effects of water-soluble tacrolimus- PEG conjugate on insulin-dependent diabetes mellitus and systemic lupus erythematosus
    • Choi D, Kim BH, Lee MK, Cho H. Effects of water-soluble tacrolimus- PEG conjugate on insulin-dependent diabetes mellitus and systemic lupus erythematosus. Arch Pharm Res. 2011;34(8):1301–1310.
    • (2011) Arch Pharm Res , vol.34 , Issue.8 , pp. 1301-1310
    • Choi, D.1    Kim, B.H.2    Lee, M.K.3    Cho, H.4
  • 19
    • 0036738398 scopus 로고    scopus 로고
    • Glucose-induced β cell production of IL-1 β contributes to glucotoxicity in human pancreatic islets
    • Maedler K, Sergeev P, Ris F, et al. Glucose-induced β cell production of IL-1 β contributes to glucotoxicity in human pancreatic islets. J Clin Invest. 2002;110(6):851–860.
    • (2002) J Clin Invest , vol.110 , Issue.6 , pp. 851-860
    • Maedler, K.1    Sergeev, P.2    Ris, F.3
  • 20
    • 53749100698 scopus 로고    scopus 로고
    • Increased interleukin (IL)-1 β messenger ribonucleic acid expression in β -cells of individuals with type 2 diabetes and regulation of IL-1 β in human islets by glucose and autostimulation
    • Böni-Schnetzler M, Thorne J, Parnaud G, et al. Increased interleukin (IL)-1 β messenger ribonucleic acid expression in β -cells of individuals with type 2 diabetes and regulation of IL-1 β in human islets by glucose and autostimulation. J Clin Endocrinol Metab. 2008;93(10):4065–4074.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.10 , pp. 4065-4074
    • Böni-Schnetzler, M.1    Thorne, J.2    Parnaud, G.3
  • 21
    • 78651383854 scopus 로고    scopus 로고
    • Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF- β gene expression in pancreatic islet endocrine cells
    • Lawrence MC, Naziruddin B, Levy MF, Jackson A, McGlynn K. Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF- β gene expression in pancreatic islet endocrine cells. J Biol Chem. 2011;286(2):1025–1036.
    • (2011) J Biol Chem , vol.286 , Issue.2 , pp. 1025-1036
    • Lawrence, M.C.1    Naziruddin, B.2    Levy, M.F.3    Jackson, A.4    McGlynn, K.5
  • 22
    • 0031871335 scopus 로고    scopus 로고
    • An update on cytokines in the pathogenesis of insulin- dependent diabetes mellitus
    • Rabinovitch A. An update on cytokines in the pathogenesis of insulin- dependent diabetes mellitus. Diabetes Metab Rev. 1998; 14(2):129–151.
    • (1998) Diabetes Metab Rev , vol.14 , Issue.2 , pp. 129-151
    • Rabinovitch, A.1
  • 23
    • 0036094994 scopus 로고    scopus 로고
    • Human pancreatic islets produce and secrete MCP-1/CCL2: Relevance in human islet transplantation
    • Piemonti L, Leone BE, Nano R, et al. Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation. Diabetes. 2002;51(1):55–65.
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 55-65
    • Piemonti, L.1    Leone, B.E.2    Nano, R.3
  • 24
    • 0037603320 scopus 로고    scopus 로고
    • IL-1 β, IFN- β and TNF- β increase vulnerability of pancreatic β cells to autoimmune destruction
    • Wachlin G, Augstein P, Schröder D, et al. IL-1 β, IFN- β and TNF- β increase vulnerability of pancreatic β cells to autoimmune destruction. J Autoimmun. 2003;20(4):303–312.
    • (2003) J Autoimmun , vol.20 , Issue.4 , pp. 303-312
    • Wachlin, G.1    Augstein, P.2    Schröder, D.3
  • 26
    • 67649373025 scopus 로고    scopus 로고
    • IL-1 β receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis
    • Schwarznau A, Hanson MS, Sperger JM, et al. IL-1 β receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis. J Cell Physiol. 2009;220(2):341–347.
    • (2009) J Cell Physiol , vol.220 , Issue.2 , pp. 341-347
    • Schwarznau, A.1    Hanson, M.S.2    Sperger, J.M.3
  • 27
    • 64749093078 scopus 로고    scopus 로고
    • Serum monocyte chemoattractant protein-1 concentrations associate with diabetes status but not arterial stiffness in children with type 1 diabetes
    • Zineh I, Beitelshees AL, Silverstein JH, Haller MJ. Serum monocyte chemoattractant protein-1 concentrations associate with diabetes status but not arterial stiffness in children with type 1 diabetes. Diabetes Care. 2009;32(3):465–467.
    • (2009) Diabetes Care , vol.32 , Issue.3 , pp. 465-467
    • Zineh, I.1    Beitelshees, A.L.2    Silverstein, J.H.3    Haller, M.J.4
  • 28
    • 84856473153 scopus 로고    scopus 로고
    • Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient mice
    • McCall M, Pawlick R, Kin T, Shapiro AM. Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient mice. Am J Transplant. 2012;12(2):322–329.
    • (2012) Am J Transplant , vol.12 , Issue.2 , pp. 322-329
    • McCall, M.1    Pawlick, R.2    Kin, T.3    Shapiro, A.M.4
  • 29
    • 84865410857 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 (MCP-1) in obesity and diabetes
    • Panee J. Monocyte chemoattractant protein 1 (MCP-1) in obesity and diabetes. Cytokine. 2012;60(1):1–12.
    • (2012) Cytokine , vol.60 , Issue.1 , pp. 1-12
    • Panee, J.1
  • 30
    • 0035128919 scopus 로고    scopus 로고
    • Imidazoline compounds protect against interleukin 1 β -induced β -cell apoptosis
    • Zaitsev SV, Appelskog IB, Kapelioukh IL, et al. Imidazoline compounds protect against interleukin 1 β -induced β -cell apoptosis. Diabetes. 2001;50(suppl 1):S70–S76.
    • (2001) Diabetes , vol.50 , Issue.1 , pp. S70-S76
    • Zaitsev, S.V.1    Appelskog, I.B.2    Kapelioukh, I.L.3
  • 31
    • 0041375468 scopus 로고    scopus 로고
    • Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic β cells
    • Arnette D, Gibson TB, Lawrence MC, et al. Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic β cells. J Biol Chem. 2003;278(35):32517–32525.
    • (2003) J Biol Chem , vol.278 , Issue.35 , pp. 32517-32525
    • Arnette, D.1    Gibson, T.B.2    Lawrence, M.C.3
  • 32
    • 51649088697 scopus 로고    scopus 로고
    • Chromatin-bound mitogen- activated protein kinases transmit dynamic signals in transcription complexes in β -cells
    • Lawrence MC, McGlynn K, Shao C, et al. Chromatin-bound mitogen- activated protein kinases transmit dynamic signals in transcription complexes in β -cells. Proc Natl Acad Sci USA. 2008;105(36): 13315–13320.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.36 , pp. 13315-13320
    • Lawrence, M.C.1    McGlynn, K.2    Shao, C.3
  • 33
    • 0028990801 scopus 로고
    • Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody
    • Ruff VA, Leach KL. Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. J Biol Chem. 1995;270(38): 22602–22607.
    • (1995) J Biol Chem , vol.270 , Issue.38 , pp. 22602-22607
    • Ruff, V.A.1    Leach, K.L.2
  • 34
    • 0031943003 scopus 로고    scopus 로고
    • P300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene
    • Qiu Y, Sharma A, Stein R. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol Cell Biol. 1998;18(5):2957–2964.
    • (1998) Mol Cell Biol , vol.18 , Issue.5 , pp. 2957-2964
    • Qiu, Y.1    Sharma, A.2    Stein, R.3
  • 35
    • 0036134978 scopus 로고    scopus 로고
    • Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E 47
    • Qiu Y, Guo M, Huang S, Stein R. Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E 47. Mol Cell Biol. 2002;22(2):412–420.
    • (2002) Mol Cell Biol , vol.22 , Issue.2 , pp. 412-420
    • Qiu, Y.1    Guo, M.2    Huang, S.3    Stein, R.4
  • 36
    • 4544233448 scopus 로고    scopus 로고
    • Glucose regulation of insulin gene expression requires the recruitment of p300 by the β -cell-specific transcription factor Pdx-1
    • Mosley AL, Corbett JA, Ozcan S. Glucose regulation of insulin gene expression requires the recruitment of p300 by the β -cell-specific transcription factor Pdx-1. Mol Endocrinol. 2004;18(9):2279–2290.
    • (2004) Mol Endocrinol , vol.18 , Issue.9 , pp. 2279-2290
    • Mosley, A.L.1    Corbett, J.A.2    Ozcan, S.3
  • 37
    • 76049126005 scopus 로고    scopus 로고
    • Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription
    • Lawrence MC, Shao C, McGlynn K, Naziruddin B, Levy MF, Cobb MH. Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription. Proc Natl Acad Sci USA. 2009;106(52):22181–22186.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.52 , pp. 22181-22186
    • Lawrence, M.C.1    Shao, C.2    McGlynn, K.3    Naziruddin, B.4    Levy, M.F.5    Cobb, M.H.6
  • 38
    • 69549098032 scopus 로고    scopus 로고
    • IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    • Ehses JA, Lacraz G, Giroix MH, et al. IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat. Proc Natl Acad Sci USA. 2009;106(33):13998–14003.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.33 , pp. 13998-14003
    • Ehses, J.A.1    Lacraz, G.2    Giroix, M.H.3
  • 39
    • 84894580064 scopus 로고    scopus 로고
    • Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes
    • Butcher MJ, Hallinger D, Garcia E, et al. Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes. Diabetologia. 2014;57(3):491–501.
    • (2014) Diabetologia , vol.57 , Issue.3 , pp. 491-501
    • Butcher, M.J.1    Hallinger, D.2    Garcia, E.3
  • 41
    • 12844271214 scopus 로고    scopus 로고
    • Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth
    • Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Mol Cell Biol. 2005; 25(3):865–878.
    • (2005) Mol Cell Biol , vol.25 , Issue.3 , pp. 865-878
    • Sanna, B.1    Bueno, O.F.2    Dai, Y.S.3    Wilkins, B.J.4    Molkentin, J.D.5
  • 42
    • 67449164361 scopus 로고    scopus 로고
    • KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals
    • Dougherty MK, Ritt DA, Zhou M, et al. KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. Mol Cell. 2009;34(6):652–662.
    • (2009) Mol Cell , vol.34 , Issue.6 , pp. 652-662
    • Dougherty, M.K.1    Ritt, D.A.2    Zhou, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.