Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 40, 2015, Pages E5496-E5502

  Vomund, Anthony N ^a   Zinselmeyer, Bernd H ^a   Hughes, Jing ^a   Calderon, Boris ^a   Valderrama, Carolina ^a   Ferris, Stephen T ^a   Wan, Xiaoxiao ^a   Kanekura, Kohsuke ^a   Carrero, Javier A ^a   Urano, Fumihiko ^a   Unanue, Emil R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmune diabetes; Autoimmunity; Insulin reactivity; Insulin reactive T cells

Indexed keywords

CALCIUM; INSULIN; 1,2-BIS(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID ACETOXYMETHYL ESTER; EGTAZIC ACID; GLUCOSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78;

ADULT; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CALCIUM CELL LEVEL; CASE REPORT; CD4+ T LYMPHOCYTE; CELL CONTACT; CELL FRACTIONATION; CONTROLLED STUDY; ENDOCRINE CELL; ENDOPLASMIC RETICULUM; EXTRACELLULAR SPACE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHAGOCYTE; PRIORITY JOURNAL; SECRETORY GRANULE; SECRETORY VESICLE; T LYMPHOCYTE; UNFOLDED PROTEIN RESPONSE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL COMMUNICATION; CELL CULTURE; DENDRITIC CELL; DRUG EFFECTS; EXOSOME; GENE EXPRESSION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MULTIPHOTON MICROSCOPY; NONOBESE DIABETIC MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRASTRUCTURE;

ADULT; ANIMALS; ANTIGEN PRESENTATION; CALCIUM; CELL COMMUNICATION; CELLS, CULTURED; DENDRITIC CELLS; EGTAZIC ACID; EXTRACELLULAR VESICLES; FEMALE; GENE EXPRESSION; GLUCOSE; HEAT-SHOCK PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; PHAGOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TRANSCRIPTION FACTOR CHOP;

EID: 84943429713     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1515954112     Document Type: Article

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