Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice

Diabetologia

Volumn 52, Issue 4, 2009, Pages 653-663

  Akiyama, M ^a   Hatanaka, M ^a   Ohta, Y ^a   Ueda, K ^b   Yanai, A ^a   Uehara, Y ^a   Tanabe, K ^a,c   Tsuru, M ^a   Miyazaki, M ^a   Saeki, S ^a   Saito, T ^a   Shinoda, K ^a   Oka, Y ^d   Tanizawa, Y ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b YAMAGUCHI UNIVERSITY   (Japan)

^c Japan Health Sciences Foundation   (Japan)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Diabetes mellitus; Endoplasmic reticulum; Endoplasmic reticulum stress; Insulin; Pancreatic beta cell; Pioglitazone; Wolfram syndrome

Indexed keywords

BINDING PROTEIN; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; IMMUNOGLOBULIN; INITIATION FACTOR 2; INITIATION FACTOR 2ALPHA; INSULIN; PIOGLITAZONE;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREEDING; C57BL 6 MOUSE; CELL DEATH; CELL LOSS; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; GENETIC VARIABILITY; IN VIVO STUDY; INSULIN RESISTANCE; KNOCKOUT MOUSE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

AGING; ANIMALS; APOPTOSIS; BODY WEIGHT; ENDOPLASMIC RETICULUM; GENETIC VARIATION; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; THIAZOLIDINEDIONES;

EID: 61449254259     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1270-6     Document Type: Article

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