IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress

Cell Metabolism

Volumn 16, Issue 2, 2012, Pages 250-264

  Lerner, Alana G ^a,b,c   Upton, John Paul ^a   Praveen, P V K ^a,b,c   Ghosh, Rajarshi ^a,b,c   Nakagawa, Yoshimi ^a,b,c   Igbaria, Aeid ^a,b,c   Shen, Sarah ^a,b,c   Nguyen, Vinh ^a   Backes, Bradley J ^a,b   Heiman, Myriam ^f,g   Heintz, Nathaniel ^g   Greengard, Paul ^g   Hui, Simon ^d   Tang, Qizhi ^a   Trusina, Ala ^e   Oakes, Scott A ^a   Papa, Feroz R ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CRYOPYRIN; ENHANCED GREEN FLUORESCENT PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; MESSENGER RNA; MICRORNA; PROCASPASE 1; PROINSULIN; PROTEIN IRE1; RIBONUCLEASE; RIBONUCLEASE INHIBITOR; THIOREDOXIN INTERACTING PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEGENERATION; CELL LOSS; CYTOKINE RELEASE; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE DELETION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RNA ISOLATION; RNA STABILITY; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; DNA PRIMERS; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; FLOW CYTOMETRY; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; THIOREDOXINS; UNFOLDED PROTEIN RESPONSE;

EID: 84864682160     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2012.07.007     Document Type: Article

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