-
1
-
-
1842334456
-
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
-
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197, 1997
-
(1997)
Diabetes Care
, vol.20
, pp. 1183-1197
-
-
-
2
-
-
0021777067
-
Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited
-
Klöppel G, Löhr M, Habich K, Oberholzer M, Heitz PU: Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 4:110-125, 1985
-
(1985)
Surv Synth Pathol Res
, vol.4
, pp. 110-125
-
-
Klöppel, G.1
Löhr, M.2
Habich, K.3
Oberholzer, M.4
Heitz, P.U.5
-
3
-
-
0020825558
-
Type I diabetes mellitus in monozygotic twins: Chronic progressive β cell dysfunction
-
Srikanta S, Ganda OP, Jackson RA, Gleason RE, Kaldany A, Garovoy MR, Milford EL, Carpenter CB, Soeldner JS, Eisenbarth GS: Type I diabetes mellitus in monozygotic twins: chronic progressive β cell dysfunction. Ann Intern Med 99:320-326, 1983
-
(1983)
Ann Intern Med
, vol.99
, pp. 320-326
-
-
Srikanta, S.1
Ganda, O.P.2
Jackson, R.A.3
Gleason, R.E.4
Kaldany, A.5
Garovoy, M.R.6
Milford, E.L.7
Carpenter, C.B.8
Soeldner, J.S.9
Eisenbarth, G.S.10
-
4
-
-
0035668779
-
A choice of death: The signal-transduction of immune-mediated β-cell apoptosis
-
Eizirik DL, Mandrup-Poulsen T: A choice of death: the signal-transduction of immune-mediated β-cell apoptosis. Diabetologia 44:2115-2133, 2001
-
(2001)
Diabetologia
, vol.44
, pp. 2115-2133
-
-
Eizirik, D.L.1
Mandrup-Poulsen, T.2
-
5
-
-
0024213009
-
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: Quantitative changes in the pancreas in type 2 diabetes
-
Clark A, Wells CA, Buley ID, Cruickshank JK, Vanhegan RI, Matthews DR, Cooper GJ, Holman RR, Turner RC: Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 9:151-159, 1988
-
(1988)
Diabetes Res
, vol.9
, pp. 151-159
-
-
Clark, A.1
Wells, C.A.2
Buley, I.D.3
Cruickshank, J.K.4
Vanhegan, R.I.5
Matthews, D.R.6
Cooper, G.J.7
Holman, R.R.8
Turner, R.C.9
-
6
-
-
0035122212
-
No decrease of the β-cell mass in type 2 diabetic patients
-
Guiot Y, Sempoux C, Moulin P, Rahier J: No decrease of the β-cell mass in type 2 diabetic patients. Diabetes 50 (Suppl. 1):S188, 2001
-
(2001)
Diabetes
, vol.50
, Issue.1 SUPPL.
-
-
Guiot, Y.1
Sempoux, C.2
Moulin, P.3
Rahier, J.4
-
7
-
-
0036163156
-
Reduced β-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients
-
Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S: Reduced β-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia 45:85-96, 2002
-
(2002)
Diabetologia
, vol.45
, pp. 85-96
-
-
Sakuraba, H.1
Mizukami, H.2
Yagihashi, N.3
Wada, R.4
Hanyu, C.5
Yagihashi, S.6
-
8
-
-
0037219411
-
β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC: β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110, 2003
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
9
-
-
0037283601
-
The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes
-
Kahn SE: The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3-19, 2003
-
(2003)
Diabetologia
, vol.46
, pp. 3-19
-
-
Kahn, S.E.1
-
10
-
-
1842844414
-
Decreased β-cell mass in diabetes: Significance, mechanisms and therapeutic implications
-
Donath MY, Halban PA: Decreased β-cell mass in diabetes: significance, mechanisms and therapeutic implications. Diabetologia 47:581-589, 2004
-
(2004)
Diabetologia
, vol.47
, pp. 581-589
-
-
Donath, M.Y.1
Halban, P.A.2
-
11
-
-
0041828484
-
Inflammatory mediators and islet β-cell failure: A link between type 1 and type 2 diabetes
-
Donath MY, Storling J, Maedler K, Mandrup-Poulsen T: Inflammatory mediators and islet β-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 81:455-470, 2003
-
(2003)
J Mol Med
, vol.81
, pp. 455-470
-
-
Donath, M.Y.1
Storling, J.2
Maedler, K.3
Mandrup-Poulsen, T.4
-
12
-
-
0032740992
-
Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release
-
Hostens K, Pavlovic D, Zambre Y, Ling Z, Van Schravendijk C, Eizirik DL, Pipeleers DG: Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release. J Clin Invest 104:67-72, 1999
-
(1999)
J Clin Invest
, vol.104
, pp. 67-72
-
-
Hostens, K.1
Pavlovic, D.2
Zambre, Y.3
Ling, Z.4
Van Schravendijk, C.5
Eizirik, D.L.6
Pipeleers, D.G.7
-
13
-
-
4744375389
-
The cytokine interleukin-1β reduces the docking and fusion of insulin granules in pancreatic β-cells, preferentially decreasing the first phase of exocytosis
-
Ohara-Imaizumi M, Cardozo AK, Kikuta T, Eizirik DL, Nagamatsu S: The cytokine interleukin-1β reduces the docking and fusion of insulin granules in pancreatic β-cells, preferentially decreasing the first phase of exocytosis. J Biol Chem 279:41271-41274, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 41271-41274
-
-
Ohara-Imaizumi, M.1
Cardozo, A.K.2
Kikuta, T.3
Eizirik, D.L.4
Nagamatsu, S.5
-
14
-
-
0346846765
-
Global profiling of double stranded RNA- and IFN-γ-induced genes in rat pancreatic β cells
-
Rasschaert J, Liu D, Kutlu B, Cardozo AK, Kruhoffer M, Orntoft TF, Eizirik DL: Global profiling of double stranded RNA- and IFN-γ-induced genes in rat pancreatic β cells. Diabetologia 46:1641-1657, 2003
-
(2003)
Diabetologia
, vol.46
, pp. 1641-1657
-
-
Rasschaert, J.1
Liu, D.2
Kutlu, B.3
Cardozo, A.K.4
Kruhoffer, M.5
Orntoft, T.F.6
Eizirik, D.L.7
-
15
-
-
0242363618
-
Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells
-
Kutlu B, Cardozo AK, Darville MI, Kruhoffer M, Magnusson N, Orntoft T, Eizirik DL: Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes 52:2701-2719, 2003
-
(2003)
Diabetes
, vol.52
, pp. 2701-2719
-
-
Kutlu, B.1
Cardozo, A.K.2
Darville, M.I.3
Kruhoffer, M.4
Magnusson, N.5
Orntoft, T.6
Eizirik, D.L.7
-
16
-
-
0035966006
-
A comprehensive analysis of cytokine-induced and nuclear factor-κB-dependent genes in primary rat pancreatic β-cells
-
Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhoffer M, Orntoft T, Eizirik DL: A comprehensive analysis of cytokine-induced and nuclear factor-κB-dependent genes in primary rat pancreatic β-cells. J Biol Chem 276:48879-48886, 2001
-
(2001)
J Biol Chem
, vol.276
, pp. 48879-48886
-
-
Cardozo, A.K.1
Heimberg, H.2
Heremans, Y.3
Leeman, R.4
Kutlu, B.5
Kruhoffer, M.6
Orntoft, T.7
Eizirik, D.L.8
-
17
-
-
0035029867
-
Identification of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays
-
Cardozo AK, Kruhoffer M, Leeman R, Orntoft T, Eizirik DL: Identification of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays. Diabetes 50:909-920, 2001
-
(2001)
Diabetes
, vol.50
, pp. 909-920
-
-
Cardozo, A.K.1
Kruhoffer, M.2
Leeman, R.3
Orntoft, T.4
Eizirik, D.L.5
-
18
-
-
1942507406
-
Use of microarray analysis to unveil transcription factor and gene networks contributing to β cell dysfunction and apoptosis
-
Eizirik DL, Kutlu B, Rasschaert J, Darville M, Cardozo AK: Use of microarray analysis to unveil transcription factor and gene networks contributing to β cell dysfunction and apoptosis. Ann N Y Acad Sci 1005:55-74, 2003
-
(2003)
Ann N Y Acad Sci
, vol.1005
, pp. 55-74
-
-
Eizirik, D.L.1
Kutlu, B.2
Rasschaert, J.3
Darville, M.4
Cardozo, A.K.5
-
19
-
-
13444254250
-
T1DBase, a community web-based resource for type 1 diabetes research
-
Smink LJ, Helton EM, Healy BC, Cavnor CC, Lam AC, Flamez D, Burren OS, Wang Y, Dolman GE, Burdick DB, Everett VH, Glusman G, Laneri D, Rowen L, Schuilenburg H, Walker NM, Mychaleckyj J, Wicker LS, Eizirik DL, Todd JA, Goodman N: T1DBase, a community web-based resource for type 1 diabetes research. Nucleic Acid Res 33:D544-D549, 2005
-
(2005)
Nucleic Acid Res
, vol.33
-
-
Smink, L.J.1
Helton, E.M.2
Healy, B.C.3
Cavnor, C.C.4
Lam, A.C.5
Flamez, D.6
Burren, O.S.7
Wang, Y.8
Dolman, G.E.9
Burdick, D.B.10
Everett, V.H.11
Glusman, G.12
Laneri, D.13
Rowen, L.14
Schuilenburg, H.15
Walker, N.M.16
Mychaleckyj, J.17
Wicker, L.S.18
Eizirik, D.L.19
Todd, J.A.20
Goodman, N.21
more..
-
20
-
-
0034711250
-
Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor
-
Giannoukakis N, Rudert WA, Trucco M, Robbins PD: Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor. J Biol Chem 275:36509-36513, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 36509-36513
-
-
Giannoukakis, N.1
Rudert, W.A.2
Trucco, M.3
Robbins, P.D.4
-
21
-
-
0035488777
-
Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents β-cell apoptosis
-
Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL: Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents β-cell apoptosis. Diabetes 50:2219-2224, 2001
-
(2001)
Diabetes
, vol.50
, pp. 2219-2224
-
-
Heimberg, H.1
Heremans, Y.2
Jobin, C.3
Leemans, R.4
Cardozo, A.K.5
Darville, M.6
Eizirik, D.L.7
-
22
-
-
0031827241
-
Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells
-
Darville MI, Eizirik DL: Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 41:1101-1108, 1998
-
(1998)
Diabetologia
, vol.41
, pp. 1101-1108
-
-
Darville, M.I.1
Eizirik, D.L.2
-
23
-
-
12144279068
-
Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion
-
Norlin S, Ahlgren U, Edlund H: Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion. Diabetes 54:125-132, 2005
-
(2005)
Diabetes
, vol.54
, pp. 125-132
-
-
Norlin, S.1
Ahlgren, U.2
Edlund, H.3
-
24
-
-
0035834171
-
Suppressor of cytokine signaling 3 (SOCS-3) protects β-cells against interleukin-1β- and interferon-γ-mediated toxicity
-
Karlsen AE, Ronn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N: Suppressor of cytokine signaling 3 (SOCS-3) protects β-cells against interleukin-1β- and interferon-γ-mediated toxicity. Proc Natl Acad Sci U S A 98:12191-12196, 2001
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12191-12196
-
-
Karlsen, A.E.1
Ronn, S.G.2
Lindberg, K.3
Johannesen, J.4
Galsgaard, E.D.5
Pociot, F.6
Nielsen, J.H.7
Mandrup-Poulsen, T.8
Nerup, J.9
Billestrup, N.10
-
25
-
-
0042266289
-
Diabetogenic potential of human pathogens uncovered in experimentally permissive β-cells
-
Flodström M, Tsai D, Fine C, Maday A, Sarvetnick N: Diabetogenic potential of human pathogens uncovered in experimentally permissive β-cells. Diabetes 52:2025-2034, 2003
-
(2003)
Diabetes
, vol.52
, pp. 2025-2034
-
-
Flodström, M.1
Tsai, D.2
Fine, C.3
Maday, A.4
Sarvetnick, N.5
-
26
-
-
19944429062
-
Suppressor of cytokine signalling (SOCS)-3 protects β cells against IL-1β-mediated toxicity through inhibition of multiple nuclear factor-κB-regulated proapoptotic pathways
-
Karlsen AE, Heding PE, Frobose H, Ronn SG, Kruhoffer M, Orntoft TF, Darville M, Eizirik DL, Pociot F, Nerup J, Mandrup-Poulsen T, Billestrup N: Suppressor of cytokine signalling (SOCS)-3 protects β cells against IL-1β-mediated toxicity through inhibition of multiple nuclear factor-κB-regulated proapoptotic pathways. Diabetologia 47:1998-2011, 2004
-
(2004)
Diabetologia
, vol.47
, pp. 1998-2011
-
-
Karlsen, A.E.1
Heding, P.E.2
Frobose, H.3
Ronn, S.G.4
Kruhoffer, M.5
Orntoft, T.F.6
Darville, M.7
Eizirik, D.L.8
Pociot, F.9
Nerup, J.10
Mandrup-Poulsen, T.11
Billestrup, N.12
-
27
-
-
0035152487
-
Cell-permeable peptide inhibitors of JNK: Novel blockers of β-cell death
-
Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF: Cell-permeable peptide inhibitors of JNK: novel blockers of β-cell death. Diabetes 50:77-82, 2001
-
(2001)
Diabetes
, vol.50
, pp. 77-82
-
-
Bonny, C.1
Oberson, A.2
Negri, S.3
Sauser, C.4
Schorderet, D.F.5
-
28
-
-
0032510838
-
Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases
-
Larsen CM, Wadt KA, Juhl LF, Andersen HU, Karlsen AE, Su MS, Seedorf K, Shapiro L, Dinarello CA, Mandrup-Poulsen T: Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J Biol Chem 273:15294-15300, 1998
-
(1998)
J Biol Chem
, vol.273
, pp. 15294-15300
-
-
Larsen, C.M.1
Wadt, K.A.2
Juhl, L.F.3
Andersen, H.U.4
Karlsen, A.E.5
Su, M.S.6
Seedorf, K.7
Shapiro, L.8
Dinarello, C.A.9
Mandrup-Poulsen, T.10
-
29
-
-
0035877087
-
Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis
-
Saldeen J, Lee JC, Welsh N: Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis. Biochem Pharmacol 61:1561-1569, 2001
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 1561-1569
-
-
Saldeen, J.1
Lee, J.C.2
Welsh, N.3
-
30
-
-
0033778471
-
Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic β-cells
-
Pavlovic D, Andersen NA, Mandrup-Poulsen T, Eizirik DL: Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic β-cells. Eur Cytokine Netw 11:267-274, 2000
-
(2000)
Eur Cytokine Netw
, vol.11
, pp. 267-274
-
-
Pavlovic, D.1
Andersen, N.A.2
Mandrup-Poulsen, T.3
Eizirik, D.L.4
-
31
-
-
0037281153
-
Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis
-
Saldeen J, Tillmar L, Karlsson E, Welsh N: Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis. Mol Cell Biochem 243:113-122, 2003
-
(2003)
Mol Cell Biochem
, vol.243
, pp. 113-122
-
-
Saldeen, J.1
Tillmar, L.2
Karlsson, E.3
Welsh, N.4
-
32
-
-
10444226462
-
ER stress and the unfolded protein response
-
Schroder M, Kaufman RJ: ER stress and the unfolded protein response. Mutat Res 569:29-63, 2005
-
(2005)
Mutat Res
, vol.569
, pp. 29-63
-
-
Schroder, M.1
Kaufman, R.J.2
-
33
-
-
0034968330
-
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
-
Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D: Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 7:1153-1163, 2001
-
(2001)
Mol Cell
, vol.7
, pp. 1153-1163
-
-
Harding, H.P.1
Zeng, H.2
Zhang, Y.3
Jungries, R.4
Chung, P.5
Plesken, H.6
Sabatini, D.D.7
Ron, D.8
-
34
-
-
0035845568
-
Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway
-
Oyadomari S, Takeda K, Takiguchi M, Gotoh T, Matsumoto M, Wada I, Akira S, Araki E, Mori M: Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A 98:10845-10850, 2001
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10845-10850
-
-
Oyadomari, S.1
Takeda, K.2
Takiguchi, M.3
Gotoh, T.4
Matsumoto, M.5
Wada, I.6
Akira, S.7
Araki, E.8
Mori, M.9
-
35
-
-
19944432792
-
2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells
-
2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells. Diabetes 54:452-461, 2005
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
Feng, Y.M.4
Rasschaert, J.5
Tonnesen, M.6
Van Eylen, F.7
Mandrup-Poulsen, T.8
Herchuelz, A.9
Eizirik, D.L.10
-
36
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: Role of nuclear factor-κB and endoplasmic reticulum stress
-
Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL: Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: role of nuclear factor-κB and endoplasmic reticulum stress. Endocrinology 145:5087-5096, 2004
-
(2004)
Endocrinology
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
Eizirik, D.L.6
-
37
-
-
0035856942
-
Mitochondrial function in normal and diabetic β-cells
-
Maechler P, Wollheim CB: Mitochondrial function in normal and diabetic β-cells. Nature 414:807-812, 2001
-
(2001)
Nature
, vol.414
, pp. 807-812
-
-
Maechler, P.1
Wollheim, C.B.2
-
38
-
-
0037459081
-
Mitochondria: Releasing power for life and unleashing the machineries of death
-
Newmeyer DD, Ferguson-Miller S: Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112:481-490, 2003
-
(2003)
Cell
, vol.112
, pp. 481-490
-
-
Newmeyer, D.D.1
Ferguson-Miller, S.2
-
39
-
-
0037417220
-
Apoptosis and caspases in neurodegenerative diseases
-
Friedlander RM: Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 348:1365-1375, 2003
-
(2003)
N Engl J Med
, vol.348
, pp. 1365-1375
-
-
Friedlander, R.M.1
-
40
-
-
0037171446
-
Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential in pancreatic RINm5F cells: Prevention by Bcl-2
-
Barbu A, Welsh N, Saldeen J: Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential in pancreatic RINm5F cells: prevention by Bcl-2. Mol Cell Endocrinol 190:75-82, 2002
-
(2002)
Mol Cell Endocrinol
, vol.190
, pp. 75-82
-
-
Barbu, A.1
Welsh, N.2
Saldeen, J.3
-
41
-
-
9244232272
-
Cytokine-induced apoptotic cell death in a mouse pancreatic β-cell line: Inhibition by Bcl-2
-
Iwahashi H, Hanafusa T, Eguchi Y, Nakajima H, Miyagawa J, Itoh N, Tomita K, Namba M, Kuwajima M, Noguchi T, Tsujimoto Y, Matsuzawa Y: Cytokine-induced apoptotic cell death in a mouse pancreatic β-cell line: inhibition by Bcl-2. Diabetologia 39:530-536, 1996
-
(1996)
Diabetologia
, vol.39
, pp. 530-536
-
-
Iwahashi, H.1
Hanafusa, T.2
Eguchi, Y.3
Nakajima, H.4
Miyagawa, J.5
Itoh, N.6
Tomita, K.7
Namba, M.8
Kuwajima, M.9
Noguchi, T.10
Tsujimoto, Y.11
Matsuzawa, Y.12
-
42
-
-
0345161818
-
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects β-cells from cytokine-induced destruction
-
Rabinovitch A, Suarez-Pinzon W, Strynadka K, Ju Q, Edelstein D, Brownlee M, Korbutt GS, Rajotte RV: Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects β-cells from cytokine-induced destruction. Diabetes 48:1223-1229, 1999
-
(1999)
Diabetes
, vol.48
, pp. 1223-1229
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.2
Strynadka, K.3
Ju, Q.4
Edelstein, D.5
Brownlee, M.6
Korbutt, G.S.7
Rajotte, R.V.8
-
43
-
-
0344837711
-
Adenoviral-induced islet cell cytotoxicity is not counteracted by Bcl-2 overexpression
-
Barbu AR, Akusjarvi G, Welsh N: Adenoviral-induced islet cell cytotoxicity is not counteracted by Bcl-2 overexpression. Mol Med 8:733-741, 2002
-
(2002)
Mol Med
, vol.8
, pp. 733-741
-
-
Barbu, A.R.1
Akusjarvi, G.2
Welsh, N.3
-
44
-
-
0033957476
-
Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction
-
Allison J, Thomas H, Beck D, Brady JL, Lew AM, Elefanty A, Kosaka H, Kay TW, Huang DC, Strasser A: Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction. Int Immunol 12:9-17, 2000
-
(2000)
Int Immunol
, vol.12
, pp. 9-17
-
-
Allison, J.1
Thomas, H.2
Beck, D.3
Brady, J.L.4
Lew, A.M.5
Elefanty, A.6
Kosaka, H.7
Kay, T.W.8
Huang, D.C.9
Strasser, A.10
-
45
-
-
0034453105
-
Interferon-γ induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism
-
Karlsen AE, Pavlovic D, Nielsen K, Jensen J, Andersen HU, Pociot F, Mandrup-Poulsen T, Eizirik DL, Nerup J: Interferon-γ induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism. J Clin Endocrinol Metab 85:830-836, 2000
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 830-836
-
-
Karlsen, A.E.1
Pavlovic, D.2
Nielsen, K.3
Jensen, J.4
Andersen, H.U.5
Pociot, F.6
Mandrup-Poulsen, T.7
Eizirik, D.L.8
Nerup, J.9
-
46
-
-
0037219109
-
Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-κB activation in insulin-producing cells
-
Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M: Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-κB activation in insulin-producing cells. Diabetes 52:93-101, 2003
-
(2003)
Diabetes
, vol.52
, pp. 93-101
-
-
Azevedo-Martins, A.K.1
Lortz, S.2
Lenzen, S.3
Curi, R.4
Eizirik, D.L.5
Tiedge, M.6
-
47
-
-
0028817815
-
U.K. Prospective Diabetes Study 16. Overview of 6 years' therapy of type II diabetes: A progressive disease
-
U.K. Prospective Diabetes Study Group: U.K. Prospective Diabetes Study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 44:1249-1258, 1995
-
(1995)
Diabetes
, vol.44
, pp. 1249-1258
-
-
-
49
-
-
12344323484
-
Type 2 diabetes: A matter of β-cell life and death?
-
Rhodes CJ: Type 2 diabetes: a matter of β-cell life and death? Science 307:380-384, 2005
-
(2005)
Science
, vol.307
, pp. 380-384
-
-
Rhodes, C.J.1
-
50
-
-
0018899699
-
Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment
-
Kosaka K, Kuzuya T, Akanuma Y, Hagura R: Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment. Diabetologia 18:23-28, 1980
-
(1980)
Diabetologia
, vol.18
, pp. 23-28
-
-
Kosaka, K.1
Kuzuya, T.2
Akanuma, Y.3
Hagura, R.4
-
51
-
-
0037341238
-
Glucose toxicity in β-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
-
Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H: Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52:581-587, 2003
-
(2003)
Diabetes
, vol.52
, pp. 581-587
-
-
Robertson, R.P.1
Harmon, J.2
Tran, P.O.3
Tanaka, Y.4
Takahashi, H.5
-
52
-
-
0027509353
-
Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats
-
Malaisse WJ, Maggetto C, Leclercq-Meyer V, Sener A: Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats. J Clin Invest 91:432-436, 1993
-
(1993)
J Clin Invest
, vol.91
, pp. 432-436
-
-
Malaisse, W.J.1
Maggetto, C.2
Leclercq-Meyer, V.3
Sener, A.4
-
53
-
-
0035130272
-
β-Cell adaptation and decompensation during the progression of diabetes
-
Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A: β-Cell adaptation and decompensation during the progression of diabetes. Diabetes 50 (Suppl. 1):S154-S159, 2001
-
(2001)
Diabetes
, vol.50
, Issue.1 SUPPL.
-
-
Weir, G.C.1
Laybutt, D.R.2
Kaneto, H.3
Bonner-Weir, S.4
Sharma, A.5
-
54
-
-
0347064086
-
Overexpression of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets: A common mechanism for glucose toxicity and lipotoxicity?
-
Zhou YP, Marlen K, Palma JF, Schweitzer A, Reilly L, Gregoire FM, Xu GG, Blume JE, Johnson JD: Overexpression of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets: a common mechanism for glucose toxicity and lipotoxicity? J Biol Chem 278:51316-51323, 2003
-
(2003)
J Biol Chem
, vol.278
, pp. 51316-51323
-
-
Zhou, Y.P.1
Marlen, K.2
Palma, J.F.3
Schweitzer, A.4
Reilly, L.5
Gregoire, F.M.6
Xu, G.G.7
Blume, J.E.8
Johnson, J.D.9
-
55
-
-
2442595206
-
Interleukin-1β swiftly downregulates UCP-2 mRNA in β-cells by mechanisms not directly coupled to toxicity
-
Li LX, Yoshikawa H, Egeberg KW, Grill V: Interleukin-1β swiftly downregulates UCP-2 mRNA in β-cells by mechanisms not directly coupled to toxicity. Cytokine 23:101-107, 2003
-
(2003)
Cytokine
, vol.23
, pp. 101-107
-
-
Li, L.X.1
Yoshikawa, H.2
Egeberg, K.W.3
Grill, V.4
-
56
-
-
16844377896
-
High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NF-κB
-
Elouil H, Cardozo AK, Eizirik DL, Henquin JC, Jonas JC: High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NF-κB. Diabetologia 48:496-505, 2005
-
(2005)
Diabetologia
, vol.48
, pp. 496-505
-
-
Elouil, H.1
Cardozo, A.K.2
Eizirik, D.L.3
Henquin, J.C.4
Jonas, J.C.5
-
57
-
-
0030005411
-
The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic beta cells
-
Eizirik DL, Flodström M, Karlsen AE, Welsh N: The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39:875-890, 1996
-
(1996)
Diabetologia
, vol.39
, pp. 875-890
-
-
Eizirik, D.L.1
Flodström, M.2
Karlsen, A.E.3
Welsh, N.4
-
58
-
-
4344716628
-
Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines
-
Gurgul E, Lortz S, Tiedge M, Jörns A, Lenzen S: Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines. Diabetes 53:2271-2280, 2004
-
(2004)
Diabetes
, vol.53
, pp. 2271-2280
-
-
Gurgul, E.1
Lortz, S.2
Tiedge, M.3
Jörns, A.4
Lenzen, S.5
-
59
-
-
3242789423
-
Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic β-cells?
-
Fridlyand LE, Philipson LH: Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic β-cells? Diabetes 53:1942-1948, 2004
-
(2004)
Diabetes
, vol.53
, pp. 1942-1948
-
-
Fridlyand, L.E.1
Philipson, L.H.2
-
60
-
-
0035122490
-
Overstimulation and β-cell function
-
Grill V, Bjorklund A: Overstimulation and β-cell function. Diabetes 50 (Suppl. 1):S122-S124, 2001
-
(2001)
Diabetes
, vol.50
, Issue.1 SUPPL.
-
-
Grill, V.1
Bjorklund, A.2
-
61
-
-
0346093889
-
A radical explanation for glucose-induced β cell dysfunction
-
Brownlee M: A radical explanation for glucose-induced β cell dysfunction. J Clin Invest 112:1788-1790, 2003
-
(2003)
J Clin Invest
, vol.112
, pp. 1788-1790
-
-
Brownlee, M.1
-
62
-
-
0036324151
-
Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes
-
Pertusa JA, Nesher R, Kaiser N, Cerasi E, Henquin JC, Jonas JC: Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes. Diabetes 51:2552-2560, 2002
-
(2002)
Diabetes
, vol.51
, pp. 2552-2560
-
-
Pertusa, J.A.1
Nesher, R.2
Kaiser, N.3
Cerasi, E.4
Henquin, J.C.5
Jonas, J.C.6
-
63
-
-
0030467497
-
Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation
-
Ling Z, Pipeleers DG: Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest 98:2805-2812, 1996
-
(1996)
J Clin Invest
, vol.98
, pp. 2805-2812
-
-
Ling, Z.1
Pipeleers, D.G.2
-
64
-
-
3242718780
-
Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose
-
Khaldi MZ, Guiot Y, Gilon P, Henquin JC, Jonas JC: Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose. Am J Physiol Endocrinol Metab 287:E207-E217, 2004
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Khaldi, M.Z.1
Guiot, Y.2
Gilon, P.3
Henquin, J.C.4
Jonas, J.C.5
-
65
-
-
0035125490
-
Human type 2 diabetes: Morphological evidence for abnormal β-cell function
-
Sempoux C, Guiot Y, Dubois D, Moulin P, Rahier J: Human type 2 diabetes: morphological evidence for abnormal β-cell function. Diabetes 50 (Suppl. 1):S172-S177, 2001
-
(2001)
Diabetes
, vol.50
, Issue.1 SUPPL.
-
-
Sempoux, C.1
Guiot, Y.2
Dubois, D.3
Moulin, P.4
Rahier, J.5
-
66
-
-
33644763113
-
Distinct effects of the antioxidant N-acetyl-L-cystein on β-cell dysfunction induced by high glucose and hydrogen peroxide in cultured rat islets
-
Khaldi MZ, Elouil H, Henquin JC, Jonas JC: Distinct effects of the antioxidant N-acetyl-L-cystein on β-cell dysfunction induced by high glucose and hydrogen peroxide in cultured rat islets. Diabetologia 47 (Suppl. 1):A173, 2004
-
(2004)
Diabetologia
, vol.47
, Issue.1 SUPPL.
-
-
Khaldi, M.Z.1
Elouil, H.2
Henquin, J.C.3
Jonas, J.C.4
-
67
-
-
0036169137
-
Gradual loss of pancreatic β-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2 diabetes in Psammomys obesus (sand rat)
-
Jörns A, Tiedge M, Ziv E, Shafrir E, Lenzen S: Gradual loss of pancreatic β-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2 diabetes in Psammomys obesus (sand rat). Virchows Arch 440:63-69, 2002
-
(2002)
Virchows Arch
, vol.440
, pp. 63-69
-
-
Jörns, A.1
Tiedge, M.2
Ziv, E.3
Shafrir, E.4
Lenzen, S.5
-
68
-
-
0029146542
-
Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice
-
Jansson L, Eizirik DL, Pipeleers DG, Borg LA, Hellerström C, Andersson A: Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice. J Clin Invest 96:721-726, 1995
-
(1995)
J Clin Invest
, vol.96
, pp. 721-726
-
-
Jansson, L.1
Eizirik, D.L.2
Pipeleers, D.G.3
Borg, L.A.4
Hellerström, C.5
Andersson, A.6
-
69
-
-
0030752865
-
Mechanisms of defective glucose-induced insulin release in human pancreatic islets transplanted to diabetic nude mice
-
Eizirik DL, Jansson L, Flodström M, Hellerström C, Andersson A: Mechanisms of defective glucose-induced insulin release in human pancreatic islets transplanted to diabetic nude mice. J Clin Endocrinol Metab 82:2660-2663, 1997
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 2660-2663
-
-
Eizirik, D.L.1
Jansson, L.2
Flodström, M.3
Hellerström, C.4
Andersson, A.5
-
70
-
-
0141755326
-
Insulin sensitivity, insulin secretion, and abdominal fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
-
Wagenknecht LE, Langefeld CD, Scherzinger AL, Norris JM, Haffner SM, Saad MF, Bergman RN: Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes 52:2490-2496, 2003
-
(2003)
Diabetes
, vol.52
, pp. 2490-2496
-
-
Wagenknecht, L.E.1
Langefeld, C.D.2
Scherzinger, A.L.3
Norris, J.M.4
Haffner, S.M.5
Saad, M.F.6
Bergman, R.N.7
-
71
-
-
0029049346
-
A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM
-
Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, Ravussin E: A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 38:1213-1217, 1995
-
(1995)
Diabetologia
, vol.38
, pp. 1213-1217
-
-
Paolisso, G.1
Tataranni, P.A.2
Foley, J.E.3
Bogardus, C.4
Howard, B.V.5
Ravussin, E.6
-
72
-
-
0028268936
-
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
-
Zhou YP, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
-
(1994)
J Clin Invest
, vol.93
, pp. 870-876
-
-
Zhou, Y.P.1
Grill, V.E.2
-
73
-
-
0141755328
-
A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
-
Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K: A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes 52:2461-2474, 2003
-
(2003)
Diabetes
, vol.52
, pp. 2461-2474
-
-
Kashyap, S.1
Belfort, R.2
Gastaldelli, A.3
Pratipanawatr, T.4
Berria, R.5
Pratipanawatr, W.6
Bajaj, M.7
Mandarino, L.8
Defronzo, R.9
Cusi, K.10
-
74
-
-
0027947379
-
β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationships
-
Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH: β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci U S A 91:10878-10882, 1994
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 10878-10882
-
-
Lee, Y.1
Hirose, H.2
Ohneda, M.3
Johnson, J.H.4
McGarry, J.D.5
Unger, R.H.6
-
75
-
-
0030852877
-
Role of nitric oxide in obesity-induced β cell disease
-
Shimabukuro M, Ohneda M, Lee Y, Unger RH: Role of nitric oxide in obesity-induced β cell disease. J Clin Invest 100:290-295, 1997
-
(1997)
J Clin Invest
, vol.100
, pp. 290-295
-
-
Shimabukuro, M.1
Ohneda, M.2
Lee, Y.3
Unger, R.H.4
-
76
-
-
0035430782
-
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation
-
Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG: Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 50:1771-1777, 2001
-
(2001)
Diabetes
, vol.50
, pp. 1771-1777
-
-
Cnop, M.1
Hannaert, J.C.2
Hoorens, A.3
Eizirik, D.L.4
Pipeleers, D.G.5
-
77
-
-
0036535976
-
Troglitazone does not protect rat pancreatic β cells against free fatty acid-induced cytotoxicity
-
Cnop M, Hannaert JC, Pipeleers DG: Troglitazone does not protect rat pancreatic β cells against free fatty acid-induced cytotoxicity. Biochem Pharmacol 63:1281-1285, 2002
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 1281-1285
-
-
Cnop, M.1
Hannaert, J.C.2
Pipeleers, D.G.3
-
78
-
-
0036318123
-
Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic versus normoglycemic rats
-
Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V: Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic versus normoglycemic rats. Diabetes 51:662-668, 2002
-
(2002)
Diabetes
, vol.51
, pp. 662-668
-
-
Briaud, I.1
Kelpe, C.L.2
Johnson, L.M.3
Tran, P.O.4
Poitout, V.5
-
79
-
-
0037230114
-
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1
-
Maestre I, Jordan J, Calvo S, Reig JA, Cena V, Soria B, Prentki M, Roche E: Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1. Endocrinology 144:335-345, 2003
-
(2003)
Endocrinology
, vol.144
, pp. 335-345
-
-
Maestre, I.1
Jordan, J.2
Calvo, S.3
Reig, J.A.4
Cena, V.5
Soria, B.6
Prentki, M.7
Roche, E.8
-
80
-
-
0032488968
-
Troglitazone lowers islet fat and restores β cell function of Zucker diabetic fatty rats
-
Shimabukuro M, Zhou YT, Lee Y, Unger RH: Troglitazone lowers islet fat and restores β cell function of Zucker diabetic fatty rats. J Biol Chem 273:3547-3550, 1998
-
(1998)
J Biol Chem
, vol.273
, pp. 3547-3550
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Lee, Y.3
Unger, R.H.4
-
81
-
-
0032484214
-
Fatty acid-mediated calcium sequestration within intracellular calcium pools
-
Rys-Sikora KE, Gill DL: Fatty acid-mediated calcium sequestration within intracellular calcium pools. J Biol Chem 273:32627-32635, 1998
-
(1998)
J Biol Chem
, vol.273
, pp. 32627-32635
-
-
Rys-Sikora, K.E.1
Gill, D.L.2
-
82
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS: Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461, 2004
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
83
-
-
19944430402
-
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
-
Nakatani Y, Kaneto H, Kawamori D, Yoshiuchi K, Hatazaki M, Matsuoka TA, Ozawa K, Ogawa S, Hori M, Yamasaki Y, Matsuhisa M: Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem 280:847-851, 2005
-
(2005)
J Biol Chem
, vol.280
, pp. 847-851
-
-
Nakatani, Y.1
Kaneto, H.2
Kawamori, D.3
Yoshiuchi, K.4
Hatazaki, M.5
Matsuoka, T.A.6
Ozawa, K.7
Ogawa, S.8
Hori, M.9
Yamasaki, Y.10
Matsuhisa, M.11
-
85
-
-
17944372927
-
The LEW. 1AR1/Ztm-iddm rat: A new model of spontaneous insulin-dependent diabetes mellitus
-
Lenzen S, Tiedge M, Elsner M, Lortz S, Weiss H, Jörns A, Klöppel G, Wedekind D, Prokop CM, Hedrich HJ: The LEW. 1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus. Diabetologia 44:1189-1196, 2001
-
(2001)
Diabetologia
, vol.44
, pp. 1189-1196
-
-
Lenzen, S.1
Tiedge, M.2
Elsner, M.3
Lortz, S.4
Weiss, H.5
Jörns, A.6
Klöppel, G.7
Wedekind, D.8
Prokop, C.M.9
Hedrich, H.J.10
-
86
-
-
1542375195
-
Pathology of the pancreas and other organs in the diabetic LEW. 1AR1/Ztm-iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus
-
Jörns A, Kubat B, Tiedge M, Wedekind D, Hedrich HJ, Klöppel G, Lenzen S: Pathology of the pancreas and other organs in the diabetic LEW. 1AR1/Ztm-iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus. Virchows Arch 444:183-189, 2004
-
(2004)
Virchows Arch
, vol.444
, pp. 183-189
-
-
Jörns, A.1
Kubat, B.2
Tiedge, M.3
Wedekind, D.4
Hedrich, H.J.5
Klöppel, G.6
Lenzen, S.7
-
87
-
-
0035856952
-
β-Cell death during progression to diabetes
-
Mathis D, Vence L, Benoist C: β-Cell death during progression to diabetes. Nature 414:792-798, 2001
-
(2001)
Nature
, vol.414
, pp. 792-798
-
-
Mathis, D.1
Vence, L.2
Benoist, C.3
-
88
-
-
0029955383
-
Cytokine gene expression in the BB rat pancreas: Natural course and impact of bacterial vaccines
-
Kolb H, Worz-Pagenstert U, Kleemann R, Rothe H, Rowsell P, Scott FW: Cytokine gene expression in the BB rat pancreas: natural course and impact of bacterial vaccines. Diabetologia 39:1448-1454, 1996
-
(1996)
Diabetologia
, vol.39
, pp. 1448-1454
-
-
Kolb, H.1
Worz-Pagenstert, U.2
Kleemann, R.3
Rothe, H.4
Rowsell, P.5
Scott, F.W.6
-
89
-
-
0029922661
-
Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: Expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM
-
Rabinovitch A, Suarez-Pinzon W, El-Sheikh A, Sorensen O, Power RF: Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM. Diabetes 45:749-754, 1996
-
(1996)
Diabetes
, vol.45
, pp. 749-754
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.2
El-Sheikh, A.3
Sorensen, O.4
Power, R.F.5
-
90
-
-
0034746991
-
Immunoexpression of interleukin-1β in pancreatic islets of NOD mice during cyclophosphamide-accelerated diabetes: Co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide
-
Reddy S, Young M, Ginn S: Immunoexpression of interleukin-1β in pancreatic islets of NOD mice during cyclophosphamide-accelerated diabetes: co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide. Histochem J 33:317-327, 2001
-
(2001)
Histochem J
, vol.33
, pp. 317-327
-
-
Reddy, S.1
Young, M.2
Ginn, S.3
-
91
-
-
0037300827
-
IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice
-
Cardozo AK, Proost P, Gysemans C, Chen MC, Mathieu C, Eizirik DL: IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. Diabetologia 46:255-266, 2003
-
(2003)
Diabetologia
, vol.46
, pp. 255-266
-
-
Cardozo, A.K.1
Proost, P.2
Gysemans, C.3
Chen, M.C.4
Mathieu, C.5
Eizirik, D.L.6
-
92
-
-
0035097990
-
Treatment of diabetes with vanadium salts: General overview and amelioration of nutritionally induced diabetes in the Psammomys obesus gerbil
-
Shafrir E, Spielman S, Nachliel I, Khamaisi M, Bar-On H, Ziv E: Treatment of diabetes with vanadium salts: general overview and amelioration of nutritionally induced diabetes in the Psammomys obesus gerbil. Diabete Metab Res Rev 17:55-66, 2001
-
(2001)
Diabete Metab Res Rev
, vol.17
, pp. 55-66
-
-
Shafrir, E.1
Spielman, S.2
Nachliel, I.3
Khamaisi, M.4
Bar-On, H.5
Ziv, E.6
-
93
-
-
0029583378
-
β-Cell mass depletion precedes the onset of hyperglycaemia in the GK rat, a genetic model of non-insulin-dependent diabetes mellitus
-
Movassat J, Saulnier C, Portha B: β-Cell mass depletion precedes the onset of hyperglycaemia in the GK rat, a genetic model of non-insulin-dependent diabetes mellitus. Diabete Metab 21:365-370, 1995
-
(1995)
Diabete Metab
, vol.21
, pp. 365-370
-
-
Movassat, J.1
Saulnier, C.2
Portha, B.3
-
94
-
-
0033770540
-
Life and death of the pancreatic β cells
-
Bonner-Weir S: Life and death of the pancreatic β cells. Trends Endocrinol Metab 11:375-378, 2000
-
(2000)
Trends Endocrinol Metab
, vol.11
, pp. 375-378
-
-
Bonner-Weir, S.1
-
95
-
-
0036594045
-
Thyroxine induces pancreatic β cell apoptosis in rats
-
Jörns A, Tiedge M, Lenzen S: Thyroxine induces pancreatic β cell apoptosis in rats. Diabetologia 45:851-855, 2002
-
(2002)
Diabetologia
, vol.45
, pp. 851-855
-
-
Jörns, A.1
Tiedge, M.2
Lenzen, S.3
-
96
-
-
1542284737
-
Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic β-cell line INS-1
-
Rakatzi I, Mueller H, Ritzeler O, Tennagels N, Eckel J: Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic β-cell line INS-1. Diabetologia 47:249-258, 2004
-
(2004)
Diabetologia
, vol.47
, pp. 249-258
-
-
Rakatzi, I.1
Mueller, H.2
Ritzeler, O.3
Tennagels, N.4
Eckel, J.5
-
97
-
-
2942568445
-
Glucagon-like peptide-1 prevents β cell glucolipotoxicity
-
Buteau J, El-Assaad W, Rhodes CJ, Rosenberg L, Joly E, Prentki M: Glucagon-like peptide-1 prevents β cell glucolipotoxicity. Diabetologia 47:806-815, 2004
-
(2004)
Diabetologia
, vol.47
, pp. 806-815
-
-
Buteau, J.1
El-Assaad, W.2
Rhodes, C.J.3
Rosenberg, L.4
Joly, E.5
Prentki, M.6
-
98
-
-
0033305516
-
Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro
-
Carlsson C, Borg LA, Welsh N: Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140:3422-3428, 1999
-
(1999)
Endocrinology
, vol.140
, pp. 3422-3428
-
-
Carlsson, C.1
Borg, L.A.2
Welsh, N.3
-
99
-
-
33644669584
-
Is there a role for locally produced interkeukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
-
Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL: Is there a role for locally produced interkeukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets? Diabetes S4:3238-3244, 2005
-
(2005)
Diabetes
, vol.S4
, pp. 3238-3244
-
-
Welsh, N.1
Cnop, M.2
Kharroubi, I.3
Bugliani, M.4
Lupi, R.5
Marchetti, P.6
Eizirik, D.L.7
-
100
-
-
33644701286
-
Glucose toxicity in β-cells is independent of IL-1 and Fas
-
28-31 March 2004, Cambridge, U.K. Program and Abstracts
-
Jamieson E, Thomas H, Kay TW: Glucose toxicity in β-cells is independent of IL-1 and Fas. Presented at the Immunology of Diabetes Society 7th Conference, 28-31 March 2004, Cambridge, U.K. Program and Abstracts: 135, 2004
-
(2004)
Immunology of Diabetes Society 7th Conference
, pp. 135
-
-
Jamieson, E.1
Thomas, H.2
Kay, T.W.3
-
101
-
-
23744439083
-
Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
-
Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR: Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122:337-349, 2005
-
(2005)
Cell
, vol.122
, pp. 337-349
-
-
Gunton, J.E.1
Kulkarni, R.N.2
Yim, S.3
Okada, T.4
Hawthorne, W.J.5
Tseng, Y.H.6
Roberson, R.S.7
Ricordi, C.8
O'Connell, P.J.9
Gonzalez, F.J.10
Kahn, C.R.11
|