Endothelial-specific X-box binding protein 1 deficiency limits tumor necrosis factor-induced leukocyte recruitment and vasculitis

Arthritis and Rheumatology

Volumn 67, Issue 12, 2015, Pages 3279-3285

  Ziogas, Athanasios ^a   Muders, Michael H ^a   Economopoulou, Matina ^a   Sprott, David ^a   Grossklaus, Sylvia ^a   Siegert, Gabriele ^a   Baretton, Gustavo B ^a   Mitroulis, Ioannis ^a   Chavakis, Triantafyllos ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1; X BOX BINDING PROTEIN 1; DNA BINDING PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; CELL ADHESION; CELL STRESS; CONTROLLED STUDY; DERMAL MICROVASCULAR ENDOTHELIAL CELL; ENDOTHELIUM CELL; EXPERIMENTAL INFLAMMATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LEUKOCYTE; MALE; MOLECULAR PATHOLOGY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SHWARTZMAN PHENOMENON; SIGNAL TRANSDUCTION; SMALL VESSEL VASCULITIS; TRANSCRIPTION INITIATION; VASCULAR ENDOTHELIUM; WILD TYPE; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; VASCULITIS;

ANIMALS; CELL ADHESION; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; LEUKOCYTES; MICE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NF-KAPPA B; SHWARTZMAN PHENOMENON; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA; VASCULITIS;

EID: 84948419955     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39309     Document Type: Article

References (18)

1. Hu N, Westra J, Kallenberg CG., Dysregulated neutrophil-endothelial interaction in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides: implications for pathogenesis and disease intervention. Autoimmun Rev 2011; 10: 536-43.
2. Madge LA, Pober JS., TNF signaling in vascular endothelial cells. Exp Mol Pathol 2001; 70: 317-25.
3. Mitroulis I, Alexaki VI, Kourtzelis I, Ziogas A, Hajishengallis G, Chavakis T., Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease. Pharmacol Ther 2015; 147: 123-35.
4. Halbwachs L, Lesavre P., Endothelium-neutrophil interactions in ANCA-associated diseases. J Am Soc Nephrol 2012; 23: 1449-61.
5. Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, et al., XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol Cell 2007; 27: 53-66.
6. Glimcher LH., XBP1: the last two decades. Ann Rheum Dis 2010; 69 Suppl 1: i67-71.
7. Hetz C, Lee AH, Gonzalez-Romero D, Thielen P, Castilla J, Soto C, et al., Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci U S A 2008; 105: 757-62.
8. Langer HF, Orlova VV, Xie C, Kaul S, Schneider D, Lonsdorf AS, et al., A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis. Cancer Res 2011; 71: 4096-105.
9. Choi EY, Orlova VV, Fagerholm SC, Nurmi SM, Zhang L, Ballantyne CM, et al., Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins. Blood 2008; 111: 3607-14.
10. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, et al., Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity 2006; 25: 271-83.
11. Todd DJ, Lee AH, Glimcher LH., The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008; 8: 663-74.
12. Booth AD, Jayne DR, Kharbanda RK, McEniery CM, Mackenzie IS, Brown J, et al., Infliximab improves endothelial dysfunction in systemic vasculitis: a model of vascular inflammation. Circulation 2004; 109: 1718-23.
13. Xue X, Piao JH, Nakajima A, Sakon-Komazawa S, Kojima Y, Mori K, et al., Tumor necrosis factor α (TNFα) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFα. J Biol Chem 2005; 280: 33917-25.
14. Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH., Autocrine tumor necrosis factor α links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression. Mol Cell Biol 2006; 26: 3071-84.
15. Tam AB, Mercado EL, Hoffmann A, Niwa M., ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK. PloS One 2012; 7: e45078.
16. Martinon F, Chen X, Lee AH, Glimcher LH., TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 2010; 11: 411-8.
17. Li J, Wang JJ, Zhang SX., Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1. J Biol Chem 2011; 286: 4912-21.
18. Argenbright LW, Barton RW., Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo: the Shwartzman reaction revisited. J Clin Invest 1992; 89: 259-72.