Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins bim and puma and multi-BH domain protein bax

Diabetes

Volumn 59, Issue 3, 2010, Pages 644-652

  McKenzie, Mark D ^a,b   Jamieson, Emma ^a   Jansen, Elisa S ^c   Scott, Clare L ^c   Huang, David C S ^c   Bouillet, Philippe ^c   Allison, Janette ^a   Kay, Thomas W H ^a,b   Strasser, Andreas ^c   Thomas, Helen E ^a,b  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; CYTOCHROME C; FAS ANTIGEN; GLUCOSE; INTERLEUKIN 1 RECEPTOR; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN NOXA; PUMA PROTEIN; RIBOSE; APOPTOSIS REGULATORY PROTEIN; BAK1 PROTEIN, MOUSE; BAX PROTEIN, MOUSE; BCL 2 LIKE PROTEIN 11; BCL-2-LIKE PROTEIN 11; MEMBRANE PROTEIN; MESSENGER RNA; ONCOPROTEIN; PUMA PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME RELEASE; METABOLIC STRESS; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; MITOCHONDRION; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELLS, CULTURED; CYTOCHROMES C; DIABETES MELLITUS, TYPE 2; DNA FRAGMENTATION; GLUCOSE; INSULIN-SECRETING CELLS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MITOCHONDRIA; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, INTERLEUKIN-1; RIBOSE; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 77950352322     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-1151     Document Type: Article

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