INS-gene mutations: From genetics and beta cell biology to clinical disease

Molecular Aspects of Medicine

Volumn 42, Issue , 2015, Pages 3-18

  Liu, Ming ^a,b   Sun, Jinhong ^b   Cui, Jinqiu ^a   Chen, Wei ^b   Guo, Huan ^b   Barbetti, Fabrizio ^c   Arvan, Peter ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Diabetes; Endoplasmic reticulum stress; Insulin biosynthesis; Insulin gene mutation; Pancreatic beta cell; Proinsulin misfolding

Indexed keywords

INSULIN; INSULIN RECEPTOR; PREPROINSULIN; PROINSULIN; PROTEIN PRECURSOR;

DIABETES MELLITUS; ENDOPLASMIC RETICULUM; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MUTATION; PANCREAS ISLET BETA CELL; PATHOLOGY; PROTEIN FOLDING; PROTEIN TRANSPORT;

DIABETES MELLITUS; ENDOPLASMIC RETICULUM; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MUTATION; PROINSULIN; PROTEIN FOLDING; PROTEIN PRECURSORS; PROTEIN TRANSPORT; RECEPTOR, INSULIN; TRANSCRIPTION, GENETIC;

EID: 84940009221     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2014.12.001     Document Type: Review

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