-
1
-
-
0036108526
-
Abnormalities in dendritic cell and macrophage accumulation in the pancreas of nonobese diabetic (NOD) mice during the early neonatal period
-
Charré S, Rosmalen JG, Pelegri C, et al. Abnormalities in dendritic cell and macrophage accumulation in the pancreas of nonobese diabetic (NOD) mice during the early neonatal period. Histol Histopathol 2002;17:393-401 (Pubitemid 34411197)
-
(2002)
Histology and Histopathology
, vol.17
, Issue.2
, pp. 393-401
-
-
Charre, S.1
Rosmalen, J.G.M.2
Pelegri, C.3
Alves, V.4
Leenen, P.J.M.5
Drexhage, H.A.6
Homo-Delarche, F.7
-
2
-
-
38449098081
-
Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes
-
McDuffie M, Maybee NA, Keller SR, et al. Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes 2008;57:199-208
-
(2008)
Diabetes
, vol.57
, pp. 199-208
-
-
McDuffie, M.1
Maybee, N.A.2
Keller, S.R.3
-
4
-
-
79959386535
-
How does type 1 diabetes develop?: The notion of homicide or b-cell suicide revisited
-
Atkinson MA, Bluestone JA, Eisenbarth GS, et al. How does type 1 diabetes develop?: the notion of homicide or b-cell suicide revisited. Diabetes 2011; 60:1370-1379
-
(2011)
Diabetes
, vol.60
, pp. 1370-1379
-
-
Atkinson, M.A.1
Bluestone, J.A.2
Eisenbarth, G.S.3
-
5
-
-
0025363232
-
Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus
-
Strandell E, Eizirik DL, Sandler S. Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus. J Clin Invest 1990;85:1944-1950 (Pubitemid 20192971)
-
(1990)
Journal of Clinical Investigation
, vol.85
, Issue.6
, pp. 1944-1950
-
-
Strandell, E.1
Eizirik, D.L.2
Sandler, S.3
-
7
-
-
0036460571
-
First-phase insulin response in young healthy children at genetic and immunological risk for Type I diabetes
-
DOI 10.1007/s00125-002-0981-8
-
Keskinen P, Korhonen S, Kupila A, et al. First-phase insulin response in young healthy children at genetic and immunological risk for type I diabetes. Diabetologia 2002;45:1639-1648 (Pubitemid 35478133)
-
(2002)
Diabetologia
, vol.45
, Issue.12
, pp. 1639-1648
-
-
Keskinen, P.1
Korhonen, S.2
Kupila, A.3
Veijola, R.4
Erkkila, S.5
Savolainen, H.6
Arvilommi, P.7
Simell, T.8
Ilonen, J.9
Knip, M.10
Simell, O.11
-
8
-
-
77950356610
-
Progression to diabetes in relatives of type 1 diabetic patients: Mechanisms and mode of onset
-
DPT-1 Study Group
-
Ferrannini E, Mari A, Nofrate V, Sosenko JM, Skyler JS; DPT-1 Study Group. Progression to diabetes in relatives of type 1 diabetic patients: mechanisms and mode of onset. Diabetes 2010;59:679-685
-
(2010)
Diabetes
, vol.59
, pp. 679-685
-
-
Ferrannini, E.1
Mari, A.2
Nofrate, V.3
Sosenko, J.M.4
Skyler, J.S.5
-
9
-
-
0032910989
-
Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse
-
DOI 10.2337/diabetes.48.5.989
-
Sreenan S, Pick AJ, Levisetti M, Baldwin AC, Pugh W, Polonsky KS. Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 1999;48:989-996 (Pubitemid 29226344)
-
(1999)
Diabetes
, vol.48
, Issue.5
, pp. 989-996
-
-
Sreenan, S.1
Pick, A.J.2
Levisetti, M.3
Baldwin, A.C.4
Pugh, W.5
Polonsky, K.S.6
-
10
-
-
80052827105
-
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes
-
Ize-Ludlow D, Lightfoot YL, Parker M, et al. Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes. Diabetes 2011;60:2086-2091
-
(2011)
Diabetes
, vol.60
, pp. 2086-2091
-
-
Ize-Ludlow, D.1
Lightfoot, Y.L.2
Parker, M.3
-
11
-
-
38449122843
-
The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death
-
Chambers KT, Unverferth JA, Weber SM, Wek RC, Urano F, Corbett JA. The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes 2008;57:124-132
-
(2008)
Diabetes
, vol.57
, pp. 124-132
-
-
Chambers, K.T.1
Unverferth, J.A.2
Weber, S.M.3
Wek, R.C.4
Urano, F.5
Corbett, J.A.6
-
12
-
-
0035845568
-
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
-
DOI 10.1073/pnas.191207498
-
Oyadomari S, Takeda K, Takiguchi M, et al. Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci USA 2001;98:10845-10850 (Pubitemid 32878707)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.19
, pp. 10845-10850
-
-
Oyadomari, S.1
Takeda, K.2
Takiguchi, M.3
Gotoh, T.4
Matsumoto, M.5
Wada, I.6
Akira, S.7
Araki, E.8
Mori, M.9
-
13
-
-
19944432792
-
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
-
Cardozo AK, Ortis F, Storling J, et al. Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 2005;54:452-461
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
-
14
-
-
79955782921
-
CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse
-
Satoh T, Abiru N, Kobayashi M, et al. CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse. Apoptosis 2011;16:438-448
-
(2011)
Apoptosis
, vol.16
, pp. 438-448
-
-
Satoh, T.1
Abiru, N.2
Kobayashi, M.3
-
15
-
-
77953186469
-
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice
-
Maier B, Ogihara T, Trace AP, et al. The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest 2010;120:2156-2170
-
(2010)
J Clin Invest
, vol.120
, pp. 2156-2170
-
-
Maier, B.1
Ogihara, T.2
Trace, A.P.3
-
16
-
-
64649092274
-
Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of ER stress and maintenance of euchromatin structure
-
Evans-Molina C, Robbins RD, Kono T, et al. Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of ER stress and maintenance of euchromatin structure. Mol Cell Biol 2009;29:2053-2067
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2053-2067
-
-
Evans-Molina, C.1
Robbins, R.D.2
Kono, T.3
-
17
-
-
20444482821
-
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: Application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes
-
DOI 10.1074/jbc.M414381200
-
Iype T, Francis J, Garmey JC, et al. Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem 2005;280:16798-16807 (Pubitemid 41389138)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.17
, pp. 16798-16807
-
-
Iype, T.1
Francis, J.2
Garmey, J.C.3
Schisler, J.C.4
Nesher, R.5
Weir, G.C.6
Becker, T.C.7
Newgard, C.B.8
Griffen, S.C.9
Mirmira, R.G.10
-
18
-
-
33747849846
-
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
-
DOI 10.1016/j.cmet.2006.07.007, PII S1550413106002701
-
Lipson KL, Fonseca SG, Ishigaki S, et al. Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab 2006;4:245-254 (Pubitemid 44283955)
-
(2006)
Cell Metabolism
, vol.4
, Issue.3
, pp. 245-254
-
-
Lipson, K.L.1
Fonseca, S.G.2
Ishigaki, S.3
Nguyen, L.X.4
Foss, E.5
Bortell, R.6
Rossini, A.A.7
Urano, F.8
-
19
-
-
2542535432
-
2+-ATPase (SERCA)-2b and -3
-
DOI 10.2337/diabetes.53.6.1517
-
Kulkarni RN, Roper MG, Dahlgren G, et al. Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Diabetes 2004;53:1517-1525 (Pubitemid 38697664)
-
(2004)
Diabetes
, vol.53
, Issue.6
, pp. 1517-1525
-
-
Kulkarni, R.N.1
Roper, M.G.2
Dahlgren, G.3
Shih, D.Q.4
Kauri, L.M.5
Peters, J.L.6
Stoffel, M.7
Kennedy, R.T.8
-
20
-
-
73149099638
-
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress
-
Sachdeva MM, Claiborn KC, Khoo C, et al. Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proc Natl Acad Sci USA 2009;106:19090-19095
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 19090-19095
-
-
Sachdeva, M.M.1
Claiborn, K.C.2
Khoo, C.3
-
21
-
-
78650053328
-
Inhibition of deoxyhypusine synthase enhances islet beta cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes
-
Robbins RD, Tersey SA, Ogihara T, et al. Inhibition of deoxyhypusine synthase enhances islet beta cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes. J Biol Chem 2010;285:39943-39952
-
(2010)
J Biol Chem
, vol.285
, pp. 39943-39952
-
-
Robbins, R.D.1
Tersey, S.A.2
Ogihara, T.3
-
22
-
-
79953224498
-
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation
-
Palam LR, Baird TD, Wek RC. Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem 2011;286:10939-10949
-
(2011)
J Biol Chem
, vol.286
, pp. 10939-10949
-
-
Palam, L.R.1
Baird, T.D.2
Wek, R.C.3
-
23
-
-
33847393267
-
Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets
-
DOI 10.2337/db06-1440
-
Evans-Molina C, Garmey JC, Ketchum RJ, Brayman KL, Deng S, Mirmira RG. Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets. Diabetes 2007;56:827-835 (Pubitemid 46348457)
-
(2007)
Diabetes
, vol.56
, Issue.3
, pp. 827-835
-
-
Evans-Molina, C.1
Garmey, J.C.2
Ketchum, R.3
Brayman, K.L.4
Deng, S.5
Mirmira, R.G.6
-
24
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
DOI 10.1016/S0092-8674(01)00611-0
-
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001;107:881-891 (Pubitemid 34084979)
-
(2001)
Cell
, vol.107
, Issue.7
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
25
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
DOI 10.1038/415092a
-
Calfon M, Zeng H, Urano F, et al. IRE1 couples endoplasmic reticulumload to secretory capacity by processing the XBP-1 mRNA. Nature 2002;415:92-96 (Pubitemid 34062456)
-
(2002)
Nature
, vol.415
, Issue.6867
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
26
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
DOI 10.1038/nrm2199, PII NRM2199
-
Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007;8:519-529 (Pubitemid 46985379)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.7
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
27
-
-
77949751415
-
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
-
Fonseca SG, Ishigaki S, Oslowski CM, et al. Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest 2010;120:744-755
-
(2010)
J Clin Invest
, vol.120
, pp. 744-755
-
-
Fonseca, S.G.1
Ishigaki, S.2
Oslowski, C.M.3
-
28
-
-
27744523525
-
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
-
DOI 10.1007/s00125-005-1947-4
-
Riggs AC, Bernal-Mizrachi E, Ohsugi M, et al. Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Diabetologia 2005;48:2313-2321 (Pubitemid 41618923)
-
(2005)
Diabetologia
, vol.48
, Issue.11
, pp. 2313-2321
-
-
Riggs, A.C.1
Bernal-Mizrachi, E.2
Ohsugi, M.3
Wasson, J.4
Fatrai, S.5
Welling, C.6
Murray, J.7
Schmidt, R.E.8
Herrera, P.L.9
Permutt, M.A.10
-
29
-
-
79952586301
-
Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells
-
Hatanaka M, Tanabe K, Yanai A, et al. Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells. Hum Mol Genet 2011;20:1274-1284
-
(2011)
Hum Mol Genet
, vol.20
, pp. 1274-1284
-
-
Hatanaka, M.1
Tanabe, K.2
Yanai, A.3
-
30
-
-
17144389838
-
Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition
-
DOI 10.1074/jbc.M413660200
-
Jiang HY, Wek RC. Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition. J Biol Chem 2005;280:14189-14202 (Pubitemid 40517321)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 14189-14202
-
-
Jiang, H.-Y.1
Wek, R.C.2
-
31
-
-
67649450485
-
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells
-
Back SH, Scheuner D, Han J, et al. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab 2009;10:13-26
-
(2009)
Cell Metab
, vol.10
, pp. 13-26
-
-
Back, S.H.1
Scheuner, D.2
Han, J.3
-
32
-
-
79251517391
-
Methods for analyzing eIF2 kinases and translational control in the unfolded protein response
-
Teske BF, Baird TD, Wek RC. Methods for analyzing eIF2 kinases and translational control in the unfolded protein response. Methods Enzymol 2011;490:333-356
-
(2011)
Methods Enzymol
, vol.490
, pp. 333-356
-
-
Teske, B.F.1
Baird, T.D.2
Wek, R.C.3
-
33
-
-
0041666293
-
Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial
-
DOI 10.2337/diacare.26.3.832
-
Steffes MW, Sibley S, Jackson M, Thomas W. Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 2003;26:832-836 (Pubitemid 36929351)
-
(2003)
Diabetes Care
, vol.26
, Issue.3
, pp. 832-836
-
-
Steffes, M.W.1
Sibley, S.2
Jackson, M.3
Thomas, W.4
-
34
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010;140:900-917
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
36
-
-
34047235220
-
Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells
-
DOI 10.2337/db06-1253
-
Pirot P, Ortis F, Cnop M, et al. Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells. Diabetes 2007;56:1069-1077 (Pubitemid 46540305)
-
(2007)
Diabetes
, vol.56
, Issue.4
, pp. 1069-1077
-
-
Pirot, P.1
Ortis, F.2
Cnop, M.3
Ma, Y.4
Hendershot, L.M.5
Eizirik, D.L.6
Cardozo, A.K.7
-
37
-
-
58149337392
-
Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling
-
Akerfeldt MC, Howes J, Chan JY, et al. Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes 2008;57: 3034-3044
-
(2008)
Diabetes
, vol.57
, pp. 3034-3044
-
-
Akerfeldt, M.C.1
Howes, J.2
Chan, J.Y.3
-
38
-
-
0031594742
-
2+ store: A view from the lumen
-
DOI 10.1016/S0968-0004(97)01143-2, PII S0968000497011432
-
Meldolesi J, Pozzan T. The endoplasmic reticulum Ca2+ store: a view from the lumen. Trends Biochem Sci 1998;23:10-14 (Pubitemid 28093986)
-
(1998)
Trends in Biochemical Sciences
, vol.23
, Issue.1
, pp. 10-14
-
-
Meldolesi, J.1
Pozzan, T.2
-
39
-
-
0029887393
-
What is the concentration of calcium ions in the endoplasmic reticulum?
-
DOI 10.1016/S0143-4160(96)90064-0
-
Bygrave FL, Benedetti A. What is the concentration of calcium ions in the endoplasmic reticulum? Cell Calcium 1996;19:547-551 (Pubitemid 26248770)
-
(1996)
Cell Calcium
, vol.19
, Issue.6
, pp. 547-551
-
-
Bygrave, F.L.1
Benedetti, A.2
-
40
-
-
78650665214
-
Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: Evidence for regulation by Rac1
-
Subasinghe W, Syed I, Kowluru A. Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1. Am J Physiol Regul Integr Comp Physiol 2011;300: R12-R20
-
(2011)
Am J Physiol Regul Integr Comp Physiol
, vol.300
-
-
Subasinghe, W.1
Syed, I.2
Kowluru, A.3
-
41
-
-
0032055842
-
Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse
-
Dahlén E, Dawe K, Ohlsson L, Hedlund G. Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse. J Immunol 1998;160:3585-3593 (Pubitemid 28164755)
-
(1998)
Journal of Immunology
, vol.160
, Issue.7
, pp. 3585-3593
-
-
Dahlen, E.1
Dawe, K.2
Ohlsson, L.3
Hedlund, G.4
|