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Volumn 44, Issue 12, 2001, Pages 2115-2133

A choice of death - The signal-transduction of immune-mediated beta-cell apoptosis

Author keywords

Apoptosis; Beta cell; Diabetes mellitus; Interferon ; Interleukin 1; Nitric oxide

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

EID: 0035668779     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100021     Document Type: Review
Times cited : (765)

References (181)
  • 3
    • 0034641932 scopus 로고    scopus 로고
    • From bench to clinic with apoptosis-based therapeutic agents
    • (2000) Nature , vol.407 , pp. 810-816
    • Nicholson, D.W.1
  • 15
    • 0032586826 scopus 로고    scopus 로고
    • Apoptosis of pancreatic β-cells detected in accelerated diabetes of NOD mice: No role of Fas-Fas ligand interaction in autoimmune diabetes
    • (1999) Eur J Immunol , vol.29 , pp. 455-465
    • Kim, Y.H.1    Kim, S.2    Kim, K.A.3
  • 27
    • 0034176744 scopus 로고    scopus 로고
    • Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
    • (2000) J Immunol , vol.164 , pp. 3913-3918
    • Graser, R.T.1    DiLorenzo, T.P.2    Wang, F.3
  • 31
    • 0032514701 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 12538-12543
    • DiLorenzo, T.P.1    Graser, R.T.2    Ono, T.3
  • 40
  • 43
    • 0033755202 scopus 로고    scopus 로고
    • Virus-induced autoimmune diabetes: Most β-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes
    • (2000) Diabetes , vol.49 , pp. 1801-1809
    • Seewaldt, S.1    Thomas, H.E.2    Ejrnaes, M.3
  • 56
    • 0030842535 scopus 로고    scopus 로고
    • Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction
    • (1997) Nat Med , vol.3 , pp. 738-743
    • Kang, S.M.1    Schneider, D.B.2    Lin, Z.3
  • 68
    • 0026474808 scopus 로고
    • Expression of a tumor necrosis factor α transgene in murine pancreatic βcells results in severe and permanent insulitis without evolution towards diabetes
    • (1992) J Exp Med , vol.176 , pp. 1719-1731
    • Higuchi, Y.1    Herrera, P.2    Muniesa, P.3
  • 90
    • 0030905895 scopus 로고    scopus 로고
    • Some misconceptions about understanding autoimmunity through experiments with knock-outs
    • (1997) J Exp Med , vol.185 , pp. 2039-2041
    • Steinman, L.1
  • 93
    • 0032964810 scopus 로고    scopus 로고
    • Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis
    • (1999) Diabetologia , vol.42 , pp. 55-59
    • Hoorens, A.1    Pipeleers, D.2
  • 99
    • 0034456628 scopus 로고    scopus 로고
    • Cytokines induce both necrosis and apoptosis via a common bcl-2-inhibitable pathway in rat insulin-producing cells
    • (2000) Endocrinology , vol.141 , pp. 2003-2010
    • Saldeen, J.1
  • 100
    • 0027934873 scopus 로고
    • TNF-α and IFN-γ potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide
    • (1994) Cytokine , vol.6 , pp. 399-406
    • Cetkovic-Cvrlje, M.1    Eizirik, D.L.2
  • 105
    • 0029401861 scopus 로고
    • Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus
    • (1995) Mol Med , vol.1 , pp. 806-820
    • Welsh, N.1    Margulis, B.2    Borg, L.A.3
  • 107
    • 0032768772 scopus 로고    scopus 로고
    • Heat shock proteins as cellular life-guards
    • (1999) Ann Med , vol.31 , pp. 261-271
    • Jaattela, M.1
  • 108
    • 0035076588 scopus 로고    scopus 로고
    • The role of viruses in Type I diabetes: Two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals
    • (2001) Diabetologia , vol.44 , pp. 271-285
    • Jun, H.S.1    Yoon, J.W.2
  • 110
    • 0030585155 scopus 로고    scopus 로고
    • When two strands are better than one: The mediators and modulators of the cellular responses to double-stranded RNA
    • (1996) Virology , vol.219 , pp. 339-349
    • Jacobs, B.L.1    Langland, J.O.2
  • 111
  • 115
    • 0035408430 scopus 로고    scopus 로고
    • Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis
    • (2001) Am J Pathol , vol.159 , pp. 273-283
    • Scarim, A.L.1    Arnush, M.2    Blair, L.A.3
  • 116
  • 120
    • 0033595892 scopus 로고    scopus 로고
    • The Rel/NF-ℜB signal transduction pathway: Introduction
    • (1999) Oncogene , vol.18 , pp. 6842-6844
    • Gilmore, T.D.1
  • 121
    • 0030695187 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFℜB and AP-1 activation
    • (1997) J Biol Chem , vol.272 , pp. 29167-29173
    • Reddy, S.A.1    Huang, J.H.2    Liao, W.S.3
  • 128
    • 0029808748 scopus 로고    scopus 로고
    • Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
    • (1996) J Mol Med , vol.74 , pp. 589-607
    • Whitmarsh, A.J.1    Davis, R.J.2
  • 129
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 131
    • 0032510838 scopus 로고    scopus 로고
    • Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases
    • (1998) J Biol Chem , vol.273 , pp. 15294-15300
    • Larsen, C.M.1    Wadt, K.A.2    Juhl, L.F.3
  • 134
    • 0029932759 scopus 로고    scopus 로고
    • Interleukin-1β-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF-2 in the insulin-producing cell line RINm5F
    • (1996) J Biol Chem , vol.271 , pp. 8307-8312
    • Welsh, N.1
  • 135
    • 0033850451 scopus 로고    scopus 로고
    • The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells
    • (2000) Diabetes , vol.49 , pp. 1468-1476
    • Ammendrup, A.1    Maillard, A.2    Nielsen, K.3
  • 148
    • 0033755391 scopus 로고    scopus 로고
    • Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans
    • (2000) Diabetes , vol.49 , pp. 1819-1829
    • John, N.E.1    Andersen, H.U.2    Fey, S.J.3
  • 150
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-ℜB transcription factors
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 156
    • 0035432603 scopus 로고    scopus 로고
    • Cytokine-induction of Fas gene expression in insulin-producing cells requires the transcription factors NK-ℜB and C/EBP
    • (2001) Diabetes , vol.50 , pp. 1741-1748
    • Darville, M.I.1    Eizirik, D.L.2
  • 157
    • 0035488777 scopus 로고    scopus 로고
    • Inhibition of cytokine-induced NF-ℜB activation by adenovirus-mediated expression of a nuclear factor ℜB super-repressor prevents β-cell apoptosis
    • (2001) Diabetes , vol.50 , pp. 2219-2224
    • Heimberg, H.1    Heremans, Y.2    Jobin, C.3
  • 164
    • 0035313059 scopus 로고    scopus 로고
    • IFN-γ/TNF-α synergism as the final effector in autoimmune diabetes: A key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death
    • (2001) J Immunol , vol.166 , pp. 4481-4489
    • Suk, K.1    Kim, S.2    Kim, Y.H.3
  • 167
    • 0023768414 scopus 로고
    • Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor
    • (1988) Acta Endocrinol (Copenh) , vol.119 , pp. 321-325
    • Eizirik, D.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.