Cross-Talk between the unfolded protein response and nuclear factor-?B signalling pathways regulates cytokine-Mediated beta cell death in MIN6 cells and isolated mouse islets

Diabetologia

Volumn 55, Issue 11, 2012, Pages 2999-3009

  Chan, J Y ^a   Biden, T J ^a   Laybutt, D R ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

Apoptosis; Cytokines; Endoplasmic reticulum stress; Islets; Nuclear factor kappa B; Pancreatic beta cell; Type 1 diabetes; Unfolded protein response

Indexed keywords

4 PHENYLBUTYRIC ACID; GAMMA INTERFERON; GLUCOSE TRANSPORTER 2; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; THAPSIGARGIN; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; TUMOR NECROSIS FACTOR ALPHA; TUNICAMYCIN; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CCL2 GENE; CELL DEATH; CELL DESTRUCTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FAS GENE; GENE; GENE EXPRESSION; I KAPPA B ALPHA GENE; INCUBATION TIME; INOS GENE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERCA2B GENE; SIGNAL TRANSDUCTION; SOD2 GENE; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CYTOKINES; DIABETES MELLITUS, TYPE 1; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITORS; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; NF-KAPPA B; PANCREATIC NEOPLASMS; PHENYLBUTYRATES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THAPSIGARGIN; TRANSCRIPTION FACTOR CHOP; TUMOR NECROSIS FACTOR-ALPHA; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE;

EID: 84867571170     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2657-3     Document Type: Article

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