Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

Nature Medicine

Volumn 11, Issue 7, 2005, Pages 757-764

  Scheuner, Donalyn ^a   Mierde, Dirk Vander ^b   Song, Benbo ^a   Flamez, Daisy ^c,f   Creemers, John W M ^b,d   Tsukamoto, Katsura ^b   Ribick, Mark ^e   Schuit, Frans C ^b   Kaufman, Randal J ^a,e  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c DIABETES RESEARCH CENTER   (Belgium)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 2ALPHA; INSULIN; MESSENGER RNA; PROINSULIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE MUTATION; GENETIC SUSCEPTIBILITY; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HETEROZYGOSITY; INSULIN RELEASE; INSULIN SYNTHESIS; LIPID DIET; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION;

AMINO ACID SUBSTITUTION; ANIMALS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DIET FADS; DIET, FAT-RESTRICTED; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; GLUCOSE; GLUCOSE INTOLERANCE; HEAT-SHOCK PROTEINS; HOMEOSTASIS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, MUTANT STRAINS; MOLECULAR CHAPERONES; OBESITY; PHOSPHORYLATION; PROINSULIN; PROTEIN BIOSYNTHESIS;

ANIMALIA; EUKARYOTA;

EID: 22544444513     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1259     Document Type: Article

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