The role of IRE1α in the degradation of insulin mRNA in pancreatic β-cells

PLoS ONE

Volumn 3, Issue 2, 2008, Pages

  Lipson, Kathryn L ^a   Ghosh, Rajarshi ^a   Urano, Fumihiko ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INOSITOL REQUIRING 1 ALPHA; INSULIN; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN IRE1ALPHA; PROTEIN KINASE; ERN1 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HETEROZYGOSITY; HOMEOSTASIS; INSULIN DEGRADATION; INSULIN RELEASE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN FOLDING; PROTEIN FUNCTION; RAT; RNA DEGRADATION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; CELL CULTURE; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; PHYSIOLOGY;

MUS;

ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; ENDORIBONUCLEASES; INSULIN; INSULIN-SECRETING CELLS; MICE; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 45749114525     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001648     Document Type: Article

References (26)

1. Kaufman RJ (2002) Orchestrating the unfolded protein response in health and disease. J Clin Invest 110: 1389-1398.
2. Harding HP, Calfon M, Urano F, Novoa I, Ron D (2002) Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol 18: 575-599.
3. Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529.
4. Rutkowski DT, Kaufman RJ (2007) That which does not kill me makes me stronger: adapting to chronic ER stress. Trends Biochem Sci.
5. Aridor M, Balch WE (1999) Integration of endoplasmic reticulum signaling in health and disease. Nat Med 5: 745-751.
6. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, et al. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-461.
7. Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, et al. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes & Development 16: 1345-1355.
8. Leahy JL (2004) Detrimental effects of chronic hyperglycemia on the pancreatic beta-cells. In: LeRoith D, Taylor SI, Olefsky JM, eds. Diabetes Mellitus. Philadelphia, PA: Lippincott Williams & Wilkins. pp 115-127.
9. Robertson RP, Harmon J, Tanaka Y, Tran PO, Poitout V (2004) Glucose toxicity of the beta-cell. In: LeRoith D, Taylor SI, Olefsky JM, eds. Diabetes Mellitus. Philadelphia, PA: Lippincott Williams & Wilkins. pp 129-139.
10. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881-891.
11. Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, et al. (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415: 92-96.
12. Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C, et al. (2001) Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat Cell Biol 3: 158-164.
13. Tirasophon W, Lee K, Callaghan B, Welihinda. A, Kaufman RJ (2000) The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev 14: 2725-2736.
14. Hollien J, Weissman JS (2006) Decay of endoplasmic, reticulum-localized mRNAs during the unfolded protein response. Science 313: 104-107.
15. Rhodes CJ, Shoelson S, Halban PA (2005) Insulin Biosynthesis, Processing, and Chemistry. In: Kahn CR, Weir GC, King GL, Jacobson AM, Moses AC, eds. Joslin's Diabetes Mellitus. Boston: Joslin Diabetes Center. pp 65-82.
16. Pirot P, Naamane N, Libert F, Magnusson NE, Orntoft TF, et al. (2007) Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs. Diabetologia 50: 1006-1014.
17. Kataoka K, Han SI, Shioda S, Hirai M, Nishizawa M, et al. (2002) MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem 277: 49903-49910.
18. Matsuoka TA, Kaneto H, Stein R, Miyatsuka T, Kawamori D, et al. (2007) MafA regulates expression of genes important to islet {beta} cell function. Mol Endocrinol.
19. Olbrot M, Rud J, Moss LG, Sharma A (2002) Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A 99: 6737-6742.
20. Poitout V, Olson LK, Robertson RP (1996) Chronic exposure of beta TC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. j Clin Invest 97: 1041-1046.
21. Sharma A, Olson LK, Robertson RP, Stein R (1995) The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression. Mol Endocrinol 9: 1127-1134.
22. Olson LK, Redmon JB, Towle HC, Robertson RP (1993) Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein. J Clin Invest 92: 514-519.
23. Olson LK, Sharma A, Peshavaria M, Wright CV, Towle HC, et al. (1995) Reductign of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc Natl Acad Sci U S A 92: 9127-9131.
24. Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, et al. (2002) Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem 277: 30010-30018.
25. Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664-666.
26. Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, et al. (2006) Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab 4: 245-254.