Selective inhibition of eukaryotic translation initiation factor 2α dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis

Journal of Biological Chemistry

Volumn 282, Issue 6, 2007, Pages 3989-3997

  Cnop, Miriam ^a,b   Ladriere, Laurence ^a   Hekerman, Paul ^a   Ortis, Fernanda ^a   Cardozo, Alessandra K ^a   Dogusan, Zeynep ^a   Flamez, Daisy ^a   Boyce, Michael ^c   Yuan, Junying ^c   Eizirik, Decio L ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DYSFUNCTION; ENDOPLASMIC RETICULUM; EUKARYOTIC TRANSLATION INITIATION; FATTY ACID-INDUCED APOPTOSIS; SELECTIVE INHIBITION;

CELL DEATH; DISEASE CONTROL; FATTY ACIDS; HORMONES; MEDICAL PROBLEMS; PHOSPHORYLATION; TRANSCRIPTION FACTORS;

ENZYME INHIBITION;

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; FATTY ACID; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INSULIN; OLEIC ACID; PALMITIC ACID; PROTEIN; PROTEIN IRE1; PROTEIN KINASE R; CINNAMIC ACID DERIVATIVE; DRUG DERIVATIVE; INITIATION FACTOR 2; SALUBRINAL; THIOUREA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; INHIBITION KINETICS; INSULIN RELEASE; MALE; MOLECULAR BIOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; RAT; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENDOPLASMIC RETICULUM; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; WISTAR RAT;

EUKARYOTA;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CINNAMATES; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; FATTY ACIDS, NONESTERIFIED; INSULIN-SECRETING CELLS; MALE; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; RATS, WISTAR; THIOUREA;

EID: 33947510911     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607627200     Document Type: Article

References (58)

1. Porte, D., Jr., and Kahn, S. E. (2001) Diabetes 50, (Suppl. 1) S160-S163
2. Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., and Butler, P. C. (2003) Diabetes 52, 102-110
3. Mann, J. I. (2002) Lancet 360, 783-789
4. Cnop, M., Welsh, N., Jonas, J. C., Jörns, A., Lenzen, S., and Eizirik, D. L. (2005) Diabetes 54, (Suppl. 2) S97-S107
5. Kharroubi, I., Ladriere, L., Cardozo, A. K., Dogusan, Z., Cnop, M., and Eizirik, D. L. (2004) Endocrinology 145, 5087-5096
6. Karaskov, E., Scott, C., Zhang, L., Teodoro, T., Ravazzola, M., and Volchuk, A. (2006) Endocrinology 147, 3398 -3407
7. Wang, H., Kouri, G., and Wollheim, C. B. (2005) J. Cell Sci. 118, 3905-3915
8. Ozcan, U., Cao, Q., Yilmaz, E., Lee, A. H., Iwakoshi, N. N., Ozdelen, E., Tuncman, G., Gorgun, C., Glimcher, L. H., and Hotamisligil, G. S. (2004) Science 306, 457-461
9. Rutkowski, D. T., and Kaufman, R. J. (2004) Trends Cell Biol. 14, 20-28
10. Schroder, M., and Kaufman, R. J. (2006) Curr. Mol. Med. 6, 5-36
11. Boyce, M., and Yuan, J. (2006) Cell Death Differ. 13, 363-373
12. Oakes, S. A., Lin, S. S., and Bassik, M. C. (2006) Curr Mol. Med. 6, 99-109
13. Xu, C., Bailly-Maitre, B., and Reed, J. C. (2005) J. Clin. Investig. 115, 2656-2664
14. Harding, H. P., Zeng, H., Zhang, Y., Jungries, R., Chung, P., Plesken, H., Sabatini, D. D., and Ron, D. (2001) Mol. Cell 7, 1153-1163
15. Scheuner, D., Mierde, D. V., Song, B., Flamez, D., Creemers, J. W., Tsukamoto, K., Ribick, M., Schuit, F. C., and Kaufman, R. J. (2005) Nat. Med. 11, 757-764
16. Delepine, M., Nicolino, M., Barrett, T., Golamaully, M., Lathrop, G. M., and Julier, C. (2000) Nat. Genet. 25, 406-409
17. Senee, V., Vattem, K. M., Delepine, M., Rainbow, L. A., Haton, C., Lecoq, A., Shaw, N. J., Robert, J. J., Rooman, R., Diatloff-Zito, C., Michaud, J. L., Bin-Abbas, B., Taha, D., Zabel, B., Franceschini, P., Topaloglu, A. K., Lathrop, G. M., Barrett, T. G., Nicolino, M., Wek, R. C., and Julier, C. (2004) Diabetes 53, 1876-1883
18. Boyce, M., Bryant, K. F., Jousse, C., Long, K., Harding, H. P., Scheuner, D., Kaufman, R. J., Ma, D., Coen, D. M., Ron, D., and Yuan, J. (2005) Science 307, 935-939
19. Harding, H. P., Zhang, Y., Bertolotti, A., Zeng, H., and Ron, D. (2000) Mol. Cell 5, 897-904
20. Jousse, C., Oyadomari, S., Novoa, I., Lu, P., Zhang, Y., Harding, H. P., and Ron, D. (2003) J. Cell Biol. 163, 767-775
21. Lu, P. D., Jousse, C., Marciniak, S. J., Zhang, Y., Novoa, I., Scheuner, D., Kaufman, R. J., Ron, D., and Harding, H. P. (2004) EMBO J. 23, 169-179
22. Scheuner, D., Song, B., McEwen, E., Liu, C., Laybutt, R., Gillespie, P., Saunders, T., Bonner-Weir, S., and Kaufman, R. J. (2001) Mol. Cell 7, 1165-1176
23. Cardozo, A. K., Ortis, F., Storling, J., Feng, Y. M., Rasschaert, J., Tonnesen, M., Van Eylen, F., Mandrup-Poulsen, T., Herchuelz, A., and Eizirik, D. L. (2005) Diabetes 54, 452-461
24. Pirot, P., Eizirik, D. L., and Cardozo, A. K. (2006) Diabetologia 49, 1229-1236
25. Pipeleers, D. G., in't Veld, P. A., Van de Winkel, M., Maes, E., Schuit, F. C., and Gepts, W. (1985) Endocrinology 117, 806-816
26. Rasschaert, J., Ladriere, L., Urbain, M., Dogusan, Z., Katabua, B., Sato, S., Akira, S., Gysemans, C., Mathieu, C., and Eizirik, D. L. (2005) J. Biol. Chem. 280, 33984-33991
27. Ling, Z., Hannaert, J. C., and Pipeleers, D. (1994) Diabetologia 37, 15-21
28. Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A., and Wollheim, C. B. (1992) Endocrinology 130, 167-178
29. Cnop, M., Hannaert, J. C., Hoorens, A., Eizirik, D. L., and Pipeleers, D. G. (2001) Diabetes 50, 1771-1777
30. Cnop, M., Hannaert, J. C., and Pipeleers, D. G. (2002) Biochem. Pharmacol. 63, 1281-1285
31. Hoorens, A., Van de Casteele, M., Kloppel, G., and Pipeleers, D. (1996) J. Clin. Investig. 98, 1568-1574
32. Eizirik, D. L. (1991) Autoimmunity 10, 107-113
33. Leclercq-Meyer, V., Marchand, J., Woussen-Colle, M. C., Giroix, M. H., and Malaisse, W. J. (1985) Endocrinology 116, 1168-1174
34. Valverde, I., Barreto, M., and Malaisse, W. J. (1988) Endocrinology 122, 1443-1448
35. Chen, M. C., Proost, P., Gysemans, C., Mathieu, C., and Eizirik, D. L. (2001) Diabetologia 44, 325-332
36. Overbergh, L., Valckx, D., Waer, M., and Mathieu, C. (1999) Cytokine 11, 305-312
37. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., and Mori, K. (2001) Cell 107, 881-891
38. Wang, Y., Shen, J., Arenzana, N., Tirasophon, W., Kaufman, R. J., and Prywes, R. (2000) J. Biol. Chem. 275, 27013-27020
39. Darville, M. I., and Eizirik, D. L. (1998) Diabetologia 41, 1101-1108
40. Kutlu, B., Darville, M. I., Cardozo, A. K., and Eizirik, D. L. (2003) Diabetes 52, 348-355
41. Maedler, K., Oberholzer, J., Bucher, P., Spinas, G. A., and Donath, M. Y. (2003) Diabetes 52, 726-733
42. Deng, J., Lu, P. D., Zhang, Y., Scheuner, D., Kaufman, R. J., Sonenberg, N., Harding, H. P., and Ron, D. (2004) Mol. Cell. Biol. 24, 10161-10168
43. Eldor, R., Yeffet, A., Baum, K., Doviner, V., Amar, D., Ben-Neriah, Y., Christofori, G., Peled, A., Carel, J. C., Boitard, C., Klein, T., Serup, P., Eizirik, D. L., and Melloul, D. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 5072-5077
44. Heimberg, H., Heremans, Y., Jobin, C., Leemans, R., Cardozo, A. K., Darville, M., and Eizirik, D. L. (2001) Diabetes 50, 2219-2224
45. Kharroubi, I., Lee, C. H., Hekerman, P., Darville, M., Evans, R. M., Eizirik, D. L., and Cnop, M. (2006) Diabetologia 49, 2350-2358
46. Ortis, F., Cardozo, A. K., Crispim, D., Storling, J., Mandrup-Poulsen, T., and Eizirik, D. L. (2006) Mol. Endocrinol. 20, 1867-1879
47. Zinszner, H., Kuroda, M., Wang, X., Batchvarova, N., Lightfoot, R. T., Remotti, H., Stevens, J. L., and Ron, D. (1998) Genes Dev. 12, 982-995
48. Ma, Y., Brewer, J. W., Diehl, J. A., and Hendershot, L. M. (2002) J. Mol. Biol. 318, 1351-1365
49. Novoa, I., Zeng, H., Harding, H. P., and Ron, D. (2001) J. Cell Biol. 153, 1011-1022
50. Smith, W. W., Jiang, H., Pei, Z., Tanaka, Y., Morita, H., Sawa, A., Dawson, V. L., Dawson, T. M., and Ross, C. A. (2005) Hum. Mol. Genet. 14, 3801-3811
51. Kessel, D. (2006) Biochem. Biophys. Res. Commun. 346, 1320-1323
52. Scheuner, D., Patel, R., Wang, F., Lee, K., Kumar, K., Wu, J., Nilsson, A., Karin, M., and Kaufman, R. J. (2006) J. Biol. Chem. 281, 21458-21468
53. McCullough, K. D., Martindale, J. L., Klotz, L. O., Aw, T. Y., and Holbrook, N. J. (2001) Mol. Cell. Biol. 21, 1249-1259
54. Oyadomari, S., Araki, E., and Mori, M. (2002) Apoptosis 7, 335-345
55. Korth, M. J., Lyons, C. N., Wambach, M., and Katze, M. G. (1996) Gene (Amst.) 170, 181-188
56. Yan, W., Frank, C. L., Korth, M. J., Sopher, B. L., Novoa, I., Ron, D., and Katze, M. G. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 15920-15925
57. Lee, T. G., Tomita, J., Hovanessian, A. G., and Katze, M. G. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 6208-6212
58. Ladiges, W. C., Knoblaugh, S. E., Morton, J. F., Korth, M. J., Sopher, B. L., Baskin, C. R., MacAuley, A., Goodman, A. G., LeBoeuf, R. C., and Katze, M. G. (2005) Diabetes 54, 1074-1081