High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress-mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

Diabetes

Volumn 56, Issue 8, 2007, Pages 2016-2027

  Huang, Chang Jiang ^a   Lin, Chia Yu ^a   Haataja, Leena ^a   Gurlo, Tatyana ^a   Butler, Alexandra E ^a   Rizza, Robert A ^b   Butler, Peter C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; CASPASE 12; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153;

ADULT; AGED; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET CELL TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AGED, 80 AND OVER; AMYLOID; ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; BIOLOGICAL MARKERS; CASPASE 12; CELL LINE; CELL NUCLEUS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; RATS; TRANSCRIPTION FACTOR CHOP;

EID: 34547638958     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db07-0197     Document Type: Article

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