Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

Science

Volumn 287, Issue 5453, 2000, Pages 664-666

  Urano, Fumihiko ^a   Wang, XiaoZhong ^a   Bertolotti, Anne ^a   Zhang, Yuhong ^a   Chung, Peter ^a   Harding, Heather P ^a   Ron, David ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CHAPERONE; MEMBRANE RECEPTOR; PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; FIBROBLAST; GENE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; SIGNAL TRANSDUCTION; STRESS;

ANIMALS; CELL LINE; CELLS, CULTURED; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; ENZYME ACTIVATION; GENE TARGETING; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; THAPSIGARGIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA; MAMMALIA;

EID: 0034723235     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5453.664     Document Type: Article

References (43)

1. R. J. Davis, Biochem. Soc. Symp. 64, 1 (1999); A. Minden and M. Karin, Biochim. Biophys. Acta 1333, F85 (1997).
2. R. J. Davis, Biochem. Soc. Symp. 64, 1 (1999); A. Minden and M. Karin, Biochim. Biophys. Acta 1333, F85 (1997).
3. M. Hibi, A, Lin, T. Smeal, A. Minden, M. Karin, Genes Dev. 7, 2135 (1993); I. Sanchez et al., Nature 372, 794 (1994); S. Gupta, D. Campbell, B. Derijard, R. J. Davis, Science 267, 389 (1995).
4. M. Hibi, A, Lin, T. Smeal, A. Minden, M. Karin, Genes Dev. 7, 2135 (1993); I. Sanchez et al., Nature 372, 794 (1994); S. Gupta, D. Campbell, B. Derijard, R. J. Davis, Science 267, 389 (1995).
5. M. Hibi, A, Lin, T. Smeal, A. Minden, M. Karin, Genes Dev. 7, 2135 (1993); I. Sanchez et al., Nature 372, 794 (1994); S. Gupta, D. Campbell, B. Derijard, R. J. Davis, Science 267, 389 (1995).
6. C. Y. Chen, F. Del Gatto-Konczak, Z. Wu, M. Karin, Science 280, 1945 (1998).
7. D. C. Goberdhan and C. Wilson, Bioessays 20, 1009 (1998); S. Noselli, Trends Genet. 14, 33 (1998).
8. D. C. Goberdhan and C. Wilson, Bioessays 20, 1009 (1998); S. Noselli, Trends Genet. 14, 33 (1998).
9. I. Herskowitz, Cell 80, 187 (1995).
10. Z. G. Liu, H. Hsu, D. V. Goeddel, M. Karin, Cell 87, 565 (1996); C. Reinhard, B. Shamoon, V. Shyamala, L. T. Williams, EMBO J. 16, 1080 (1997).
11. Z. G. Liu, H. Hsu, D. V. Goeddel, M. Karin, Cell 87, 565 (1996); C. Reinhard, B. Shamoon, V. Shyamala, L. T. Williams, EMBO J. 16, 1080 (1997).
12. S. Y. Lee et al., Immunity 7, 703 (1997); W. C. Yeh et al., Immunity 7, 715 (1997).
13. S. Y. Lee et al., Immunity 7, 703 (1997); W. C. Yeh et al., Immunity 7, 715 (1997).
14. C. S. Shi and J. H. Kehrl, J. Biol. Chem. 272, 32102 (1997); T. Yuasa, S. Ohno, J. H. Kehrl, J. M. Kyriakis, J. Biol. Chem. 273, 22681 (1998); H. Nishitoh et al., Mol. Cell 2, 389 (1998); H. Liu, Y. C. Su, E. Becker, J. Treisman, E. Y. Skolnik, Curr. Biol. 9, 101 (1999); V. Baud et al., Genes Dev. 13, 1297 (1999).
15. C. S. Shi and J. H. Kehrl, J. Biol. Chem. 272, 32102 (1997); T. Yuasa, S. Ohno, J. H. Kehrl, J. M. Kyriakis, J. Biol. Chem. 273, 22681 (1998); H. Nishitoh et al., Mol. Cell 2, 389 (1998); H. Liu, Y. C. Su, E. Becker, J. Treisman, E. Y. Skolnik, Curr. Biol. 9, 101 (1999); V. Baud et al., Genes Dev. 13, 1297 (1999).
16. C. S. Shi and J. H. Kehrl, J. Biol. Chem. 272, 32102 (1997); T. Yuasa, S. Ohno, J. H. Kehrl, J. M. Kyriakis, J. Biol. Chem. 273, 22681 (1998); H. Nishitoh et al., Mol. Cell 2, 389 (1998); H. Liu, Y. C. Su, E. Becker, J. Treisman, E. Y. Skolnik, Curr. Biol. 9, 101 (1999); V. Baud et al., Genes Dev. 13, 1297 (1999).
17. C. S. Shi and J. H. Kehrl, J. Biol. Chem. 272, 32102 (1997); T. Yuasa, S. Ohno, J. H. Kehrl, J. M. Kyriakis, J. Biol. Chem. 273, 22681 (1998); H. Nishitoh et al., Mol. Cell 2, 389 (1998); H. Liu, Y. C. Su, E. Becker, J. Treisman, E. Y. Skolnik, Curr. Biol. 9, 101 (1999); V. Baud et al., Genes Dev. 13, 1297 (1999).
18. C. S. Shi and J. H. Kehrl, J. Biol. Chem. 272, 32102 (1997); T. Yuasa, S. Ohno, J. H. Kehrl, J. M. Kyriakis, J. Biol. Chem. 273, 22681 (1998); H. Nishitoh et al., Mol. Cell 2, 389 (1998); H. Liu, Y. C. Su, E. Becker, J. Treisman, E. Y. Skolnik, Curr. Biol. 9, 101 (1999); V. Baud et al., Genes Dev. 13, 1297 (1999).
19. M. Takeuchi, M. Rothe, D. V. Goeddel, J. Biol. Chem. 271, 19935 (1996); H. Y. Song, C. H. Regnier, C. J. Kirschning, D. V. Goeddel, M. Rothe, Proc. Natl. Acad. Sci. U.S.A. 94, 9792 (1997).
20. M. Takeuchi, M. Rothe, D. V. Goeddel, J. Biol. Chem. 271, 19935 (1996); H. Y. Song, C. H. Regnier, C. J. Kirschning, D. V. Goeddel, M. Rothe, Proc. Natl. Acad. Sci. U.S.A. 94, 9792 (1997).
21. J. M. Kyriakis et al., Nature 369, 156 (1994); R. K. Srivastava et al., Mol. Cell Biol. 19, 5659 (1999).
22. J. M. Kyriakis et al., Nature 369, 156 (1994); R. K. Srivastava et al., Mol. Cell Biol. 19, 5659 (1999).
23. C. E. Shamu and P. Walter, EMBO J. 15, 3028 (1996).
24. R. J. Kaufman, Genes Dev. 13, 1211 (1999).
25. W. Tirasophon, A. A. Welihinda, R. J. Kaufman, Genes Dev. 12, 1812 (1998).
26. X. Z. Wang et al., EMBO J. 17, 5708 (1998).
27. H. Harding, Y. Zhang, D. Ron, Nature 397, 271 (1999).
28. K. Mori, W. Ma, M. J. Gething, J. Sambrook, Cell 74, 743 (1993).
29. J. S. Cox, C. E. Shamu, P. Walter, Cell 73, 1197 (1993).
30. M. Yan et al., Nature 372, 798 (1994).
31. A. Minden et al., Science 266, 1719 (1994).
32. -/- genotypes were evaluated.
33. Antiserum to IRE1α was raised in rabbits against a bacterially expressed fusion protein consisting of the COOH-terminal 542 residues of mouse IRE1α that encode for the entire kinase-endonuclease domain of the protein fused to a polyhistidine tag.
34. The COOH-terminal IRE1β bait consisted of a fusion between the GAL4 DNA-binding domain and the 460 COOH-terminal residues encompassing the entire kinase and endonuclease domain of IRE1β in the pAS2-1 vector (Clontech). The larger of the two in-frame TRAF2 clones obtained by screening the library made in the pACT2 vector were modified to delete the COOH-terminal region (233 to 501) of TRAF2 (ΔTRAF domain) or to create an in-frame deletion of the first 199 residues (ΔN-term). Interactions were studied in the Matchmaker two-hybrid system 2 (Clontech) according to the manufacturer's instructions.
35. J. S. Oghalai, H.-B. Zhao, T. W. Kutz, W. E. Brownell, data not shown.
36. M. Rothe, S. C. Wong, W. J. Henzel, D. V. Goeddel, Cell 78, 681 (1994).
37. H. Hsu, H. B. Shu, M. G. Pan, D. V. Goeddel, Cell 84, 299 (1996).
38. C. Reinhard, B. Shamoon, V. Shyamala, L. T. Williams, EMBO J. 16, 1080 (1997).
39. Y. C. Park, V. Burkitt, A. R. Villa, L. Tong, H. Wu, Nature 398, 533 (1999).
40. V. Baud et al., Genes Dev. 13, 1297 (1999).
41. M. Hibi, A. Lin, T. Smeal, A. Minden, M. Karin, Genes Dev. 7, 2135 (1993).
42. M. Rothe, V. Sarma, V. M. Dixit, D. V. Goeddel, Science 269, 1424 (1995).
43. Supported by NIH grants ES08681 and DK47119. F.U., H.P.M., and A.B. were supported by fellowships from the Japan Society for the Promotion of Science, NIH, and the European Molecular Biology Organisation, respectively. We thank E. Skolnik and E. Becker (New York University) for advice, R. Kaufman (University of Michigan) for the IRE1α expression plasmids, D. Goeddel (Tularik Corp., San Francisco) for the anti-TRAF2 antiserum, and T. Fujino (Keio University, Tokyo) for the fibroblast cDNA library in pACT2 plasmid.