JNK signaling in apoptosis

Oncogene

Volumn 27, Issue 48, 2008, Pages 6245-6251

  Dhanasekaran, D N ^a   Reddy, E P ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cell death; JNK; MAP3K; MKK4; MKK7

Indexed keywords

CYTOCHROME C; DEATH RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 3; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

APOPTOSIS; CELL ACTIVATION; CELL NUCLEUS INCLUSION BODY; CELL STRESS; COUPLING FACTOR; GENETIC REGULATION; HUMAN; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; TRANSACTIVATION; UPREGULATION;

APOPTOSIS; CELL NUCLEUS; HUMANS; MAP KINASE KINASE 4; MITOCHONDRIA; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 54249119561     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.301     Document Type: Review

References (73)

1. Aoki H, Kang PM, Hampe J, Yoshimura K, Noma T, Matsuzaki M et al. (2002). Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J Biol Chem 277: 10244-10250.
2. Barone MC, Desouza LA, Freeman RS. (2008). Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity. J Neurochem 106: 734-745.
3. Behrens A, Sibilia M, Wagner EF. (1999). Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 21: 326-329.
4. Björkblom B, Vainio JC, Hongisto V, Herdegen T, Courtney MJ, Coffey ET. (2008). All JNKs can kill, but nuclear localization is critical for neuronal death. J Biol Chem 283: 19704-19713.
5. Bossy-Wetzel E, Green DR. (1999). Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J Biol Chem 274: 17484-17490.
6. Cano E, Hazzalin CA, Mahadevan LC. (1994). Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol Cell Biol 14: 7352-7362.
7. Cano E, Mahadevan LC. (1995). Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20: 117-122.
8. Chang L, Karin M. (2001). Mammalian MAP kinase signalling cascades. Nature 410: 37-40.
9. Chauhan D, Li G, Hideshima T, Podar K, Mitsiades C, Mitsiades N et al. (2003). JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells. J Biol Chem 278: 17593-17596.
10. Chen YR, Meyer CF, Tan TH. (1996). Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J Biol Chem 271: 631-634.
11. Chen YR, Tan TH. (2000). The c-Jun N-terminal kinase pathway and apoptotic signaling. Int J Oncol 16: 651-662.
12. Chen Z, Seimiya H, Naito M, Mashima T, Kizaki A, Dan S et al. (1999). ASK1 mediates apoptotic cell death induced by genotoxic stress. Oncogene 18: 173-180.
13. Chinnaiyan AM. (1999). The apoptosome: heart and soul of the cell death machine. Neoplasia 1: 5-15.
14. Dai T, Rubie E, Franklin CC, Kraft A, Gillespie DA, Avruch J et al. (1995). Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function. Oncogene 10: 849-855.
15. Davis RJ. (1994). MAPKs: new JNK expands the group. Trends Biochem Sci 19: 470-473.
16. Davis RJ. (2000). Signal transduction by the JNK group of MAP kinases. Cell 103: 239-252.
17. Deng Y, Ren X, Yang L, Lin Y, Wu X. (2003). A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell 115: 61-70.
18. Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T et al. (1994). JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037.
19. Dhanasekaran DN, Johnson GL. (2007). MAPKs: function, regulation, role in cancer and therapeutic targeting. Oncogene 26: 3097-3099. Review.
20. Dhanasekaran DN, Kashef K, Lee CM, Xu H, Reddy EP. (2007). Scaffold proteins of MAP-kinase modules. Oncogene 26: 3185-3202. Review.
21. Dhanasekaran N, Reddy EP. (1998). Signaling by dual specificity kinases. Oncogene 17: 1447-1755.
22. Donovan N, Becker EB, Konishi Y, Bonni A. (2002). JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem 277: 40944-40949.
23. Elmore S. (2007). Apoptosis: a review of programmed cell death. Toxicol Pathol 35: 495-516.
24. Fan M, Chambers TC. (2001). Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist Updat 4: 253-267.
25. Fanger GR, Gerwins P, Widmann C, Jarpe MB, Johnson GL. (1997). MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases? Curr Opin Genet Dev 7: 67-74.
26. Ferrandi C, Ballerio R, Gaillard P, Giachetti C, Carboni S, Vitte PA et al. (2004). Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats. Br J Pharmacol 142: 953-960.
27. Fuchs SY, Adler V, Pincus MR, Ronai Z. (1998). MEKK1/JNK signaling stabilizes and activates p53. Proc Natl Acad Sci USA 95: 10541-10546.
28. Fujino G, Noguchi T, Matsuzawa A, Yamauchi S, Saitoh M, Takeda K et al. (2007). Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. Mol Cell Biol 27: 8152-8163.
29. Gross A, McDonnell JM, Korsmeyer SJ. (1999). BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911.
30. Hibi M, Lin A, Smeal T, Minden A, Karin M. (1993). Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 7: 2135-2148.
31. Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ. (2004). Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes. EMBO J 23: 2134-2145.
32. Johnson GL, Nakamura K. (2007). The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta 1773: 1341-1348.
33. Jones EV, Dickman MJ, Whitmarsh AJ. (2007). Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase. Biochem J 405: 617-623.
34. Kharbanda S, Saxena S, Yoshida K, Pandey P, Kaneki M, Wang Q et al. (2000). Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem 275: 322-327.
35. Kolomeichuk SN, Terrano DT, Lyle CS, Sabapathy K, Chambers TC. (2008). Distinct signaling pathways of microtubule inhibitors-vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively. FEBS J 275: 1889-1899.
36. Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R et al. (2002). Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111: 331-342.
37. Lei K, Davis RJ. (2003). NK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci USA 100: 2432-2437.
38. Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB et al. (2002). The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol 22: 4929-4942.
39. Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ. (2002). Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2: 183-192.
40. Lin A, Dibling B. (2002). The true face of JNK activation in apoptosis. Aging Cell 1: 112-116.
41. Liu H, Nishitoh H, Ichijo H, Kyriakis JM. (2000b). Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol 20: 2198-2208.
42. Liu J, Lin A. (2005). Role of JNK activation in apoptosis: a double-edged sword. Cell Res 15: 36-42.
43. Liu TC, Huang CJ, Chu YC, Wei CC, Chou CC, Chou MY et al. (2000a). Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. Biochem Biophys Res Commun 274: 811-816.
44. Madesh M, Antonsson B, Srinivasula SM, Alnemri ES, Hajnóczky G. (2002). Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J Biol Chem 277: 5651-5659.
45. Marani M, Tenev T, Hancock D, Downward J, Lemoine NR. (2002). Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol Cell Biol 22: 3577-3589.
46. Matsuzawa A, Ichijo H. (2001). Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1. J Biochem 130: 1-8.
47. Mei Y, Yuan Z, Song B, Li D, Ma C, Hu C et al. (2008). Activating transcription factor 3 up-regulated by c-Jun NH(2)-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons. Neuroscience 151: 771-779.
48. Nagai H, Noguchi T, Takeda K, Ichijo H. (2007). Pathophysiological roles of ASK1-MAP kinase signaling pathways. J Biochem Mol Biol 40: 1-6.
49. Oleinik NV, Krupenko NI, Krupenko SA. (2007). Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway. Oncogene 26: 7222-7230.
50. Prasad MV, Dermott JM, Heasley LE, Johnson GL, Dhanasekaran N. (1995). Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of Gα12 and Gα13. J Biol Chem 270: 18655-18659.
51. Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A. (1999). The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 3: 287-296.
52. Puthalakath H, Strasser A. (2002). Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptoticac tivity of BH3-only proteins. Cell Death Differ 9: 505-512.
53. Raman M, Chen W, Cobb MH. (2007). Differential regulation and properties of MAPKs. Oncogene 26: 3100-3112.
54. Robitaille K, Daviau A, Lachance G, Couture JP, Blouin R. (2008). Calphostin C induced apoptosis is mediated by a tissue transglutaminase- dependent mechanism involving the DLK/JNK signaling pathway. Cell Death Differ. (e-pub ahead of print).
55. Sánchez-Perez I, Murguía JR, Perona R. (1998). Cisplatin induces a persistent activation of JNK that is related to cell death. Oncogene 16: 533-540.
56. Schroeter H, Boyd CS, Ahmed R, Spencer JP, Duncan RF, Rice-Evans C et al. (2003). c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem J 372: 359-369.
57. Sluss HK, Barrett T, Dérijard B, Davis RJ. (1994). Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol Cell Biol 14: 8376-8384.
58. Srivastava RK, Mi QS, Hardwick JM, Longo DL. (1999). Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis. Proc Natl Acad Sci USA 96: 3775-3780.
59. Sunayama J, Tsuruta F, Masuyama N, Gotoh Y. (2005). JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J Cell Biol 170: 295-304.
60. Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K et al. (2001). ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2: 222-228.
61. Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A et al. (2000). Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288: 870-874.
62. Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y et al. (2004). JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J 23: 1889-1899.
63. Turjanski AG, Vaqué JP, Gutkind JS. (2007). MAP kinases and the control of nuclear events. Oncogene 26: 3240-3253.
64. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK et al. (2005). JNK mediates hepaticisc hemia reperfusion injury. J Hepatol 242: 850-859.
65. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S et al. (1996). Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380: 75-79.
66. Wang XT, Pei DS, Xu J, Guan QH, Sun YF, Liu XM et al. (2007). Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury. Cell Signal 19: 1844-1856.
67. Westwick JK, Weitzel C, Minden A, Karin M, Brenner DA. (1994). Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. J Biol Chem 269: 26396-26401.
68. Widmann C, Gerwins P, Johnson NL, Jarpe MB, Johnson GL. (1998). MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol Cell Biol 18: 2416-2429.
69. Wilson DJ, Fortner KA, Lynch DH, Mattingly RR, Macara IG, Posada JA et al. (1996). JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells. Eur J Immunol 26: 989-994.
70. Xu Z, Maroney AC, Dobrzanski P, Kukekov NV, Greene LA. (2001). The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol 21: 4713-4724.
71. Yamamoto K, Ichijo H, Korsmeyer SJ. (1999). BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19: 8469-8478.
72. Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ et al. (1997). Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389: 865-870.
73. Zanke BW, Boudreau K, Rubie E, Winnett E, Tibbles LA, Zon L et al. (1996). The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr Biol 6: 606-613.