Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to Β-cell apoptosis

Cell Death and Differentiation

Volumn 18, Issue 2, 2011, Pages 328-337

  Allagnat, F ^a   Cunha, D ^a   Moore, F ^a   Vanderwinden, J M ^a   Eizirik, D L ^a   Cardozo, A K ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

apoptosis; diabetes; eIF2a; JNK; Mcl 1; pancreatic cells

Indexed keywords

CASPASE 3; CYTOCHROME C; GAMMA INTERFERON; INSULIN; INTERLEUKIN 1BETA; PALMITIC ACID; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; THAPSIGARGIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELF 2ALPHA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FATE; CELL FUNCTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; INSULIN RELEASE; MALE; MITOCHONDRION; MOLECULAR MECHANICS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; TRANSLATION REGULATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 3; CELL LINE, TUMOR; CYTOCHROMES C; CYTOKINES; DOWN-REGULATION; ENDOPLASMIC RETICULUM; INSULIN-SECRETING CELLS; PALMITATES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING; THAPSIGARGIN;

EID: 78651303018     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.105     Document Type: Article

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