Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: Molecular modeling and mutagenesis approaches to receptor structure and function

Pharmacology and Therapeutics

Volumn 103, Issue 1, 2004, Pages 21-80

  Kristiansen, Kurt ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

5 hydroxytryptamine; 5HT; 7 transmembrane helix domain; 7TM; ABP280; AC; actin binding protein 280; adenylyl cyclase; AKAP; G protein coupled receptors; Molecular modeling; Pharmaceuticals; Scaffolding; Signaling; Site directed mutagenesis

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 4 AMINOBUTYRIC ACID B RECEPTOR; AMINE; CADHERIN; CALCIUM ION; CELL ADHESION MOLECULE; CLATHRIN; EPIDERMAL GROWTH FACTOR; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE; LAMININ; LEUCINE; LIGAND; LIPID; MUCIN; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; OPSIN; PEPTIDE; PHENTOLAMINE; PHOSPHOLIPASE D; PROLINE; SIGNAL PEPTIDE; THROMBOSPONDIN 1; TYROSINE; UNINDEXED DRUG; WNT PROTEIN;

AGONIST; ALPHA HELIX; AMINO TERMINAL SEQUENCE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHEMISTRY; CHROMATOPHORE; CLASSIFICATION; COMPARATIVE STUDY; COMPETITIVE INHIBITION; COMPLEX FORMATION; CYTOSKELETON; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; GLYCOSYLATION; HUMAN; HYDROPHOBICITY; LIGAND BINDING; MAMMAL; MOLECULAR BIOLOGY; MOLECULAR CLONING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR MODEL; MUTAGENESIS; MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; PHOTON; PREDICTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SIMULATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; SULFATION;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3042798261     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2004.05.002     Document Type: Review

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