Different binding sites for the neuropeptide Y Y1 antagonists 1229U91 and J-104870 on human Y1 receptors

Peptides

Volumn 22, Issue 3, 2001, Pages 405-413

  Kannoa, Tetsuya ^a   Kanatani, Akio ^a   Keen, Sabina L C ^a,b   Arai Otsuki, Sachie ^a   Haga, Yuji ^a   Iwama, Toshiharu ^a   Ishihara, Akane ^a   Sakuraba, Aya ^a   Iwaasa, Hisashi ^a   Hirose, Masaaki ^a   Morishima, Hajime ^a   Fukami, Takehiro ^a   Ihara, Masaki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

1229U91; Binding site; J 104870; Neuropeptide Y; Peptide YY; YI receptor

Indexed keywords

ALANINE; ANOREXIGENIC AGENT; GR 231118; J 104870; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR; PEPTIDE YY; RADIOLIGAND; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR SIZE; MUTAGENESIS; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; APPETITE DEPRESSANTS; BINDING SITES; BINDING, COMPETITIVE; CARBAMATES; HUMANS; LIGANDS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, NEUROPEPTIDE Y; SEQUENCE HOMOLOGY, AMINO ACID; THIAZOLES;

EID: 0035096988     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(01)00350-3     Document Type: Article

References (32)

1. Neuropeptide Y distribution in the rat brain
2. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat
3. The probable arrangement of the helics in G protein-coupled receptors
4. Y-receptor subtypes - How many more?
5. CHARMM: A program for macromolecular energy, minimization, and dynamics calculation
6. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats
7. High-affinity neuropeptide Y receptor antagonists
8. Site-directed mutagenesis of virtually any plasmid by eliminating a unique site
9. Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites
10. Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists
11. SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
12. NPY-induced feeding involves the action of a Y1-like receptor in rodents
13. The novel neuropeptide Y Y1 rerecptor antagonist J-104870: A potent feeding suppressant with oral bioavailability
14. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: Comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice
15. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type
16. Analysis of neuropeptide Y-induced feeding: Dissociation of Y1 and Y2 receptor effects on natural meal patterns
17. Lateral cerebroventricular injection of neuropeptide Y stimulates feeding in sheep
18. Stimulation of feeding in the satiated pig by intracerebroventricular injection of neuropeptide Y
19. ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling
20. The role of cholecystokinin octapeptide in the central control of food intake in the dog
21. Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding
22. Neuropeptide Y and the nonpeptide antagonist BIBP3226 share an overlapping binding site at the human Y1 receptor
23. Structural basis of G protein-coupled receptor function
24. Locating ligand-binding sites in 7 TM receptors by protein engineering
25. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect
26. Neuropeptide Y - A novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
27. Isolation of two novel candidate hormones using a chemical method finding naturally occuring polypeptides
28. 3H]-NPY binding to intact SK-N-MC cells and CHO cells expressing the human Y1 receptor
29. Acidic residues in extracellular loops of the human Y1 neuropeptide Y receptor are essential for ligand binding
30. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents