Minireview: Insights into G protein-coupled receptor function using molecular models

Endocrinology

Volumn 142, Issue 1, 2001, Pages 2-10

  Gershengorn, Marvin C ^a,c   Osman, Roman ^b  

^a Weill Cornell Medical Center   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; RHODOPSIN;

CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; LIGAND BINDING; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; RECEPTOR BINDING; RECEPTOR UPREGULATION; SHORT SURVEY; SIGNAL TRANSDUCTION; TARGET CELL;

EID: 0035117505     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.1.7919     Document Type: Short Survey

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4. The probable arrangement of the helices in G protein-coupled receptors
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6. Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state
7. Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin
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12. 2 bradykinin receptor reveal a different pattern of contacts for peptidic agonists and peptidic antagonists
13. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function
14. Molecular modeling and site-directed mutagenesis of CCR5 reveal residues critical for chemokine binding and signal transduction
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23. 1 receptor
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