The binding-site crevice of the D4 dopamine receptor is coupled to three distinct sites of allosteric modulation

Journal of Pharmacology and Experimental Therapeutics

Volumn 296, Issue 2, 2001, Pages 359-363

  Schetz, John A ^a   Sibley, David R ^b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (N ISOBUTYL N METHYL)AMILORIDE; AMILORIDE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; G PROTEIN COUPLED RECEPTOR; METHYLSPIPERONE; SODIUM CHLORIDE; SODIUM ION; UNCLASSIFIED DRUG; ZINC;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG RECEPTOR BINDING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMILORIDE; BINDING SITES; DNA; GTP-BINDING PROTEINS; INDICATORS AND REAGENTS; MEMBRANES; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; SODIUM; TRANSFECTION; ZINC;

EID: 0035144450     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Allosteric regulation of G-protein linked receptors
2. 50) of an enzymatic reaction
3. The evolution and structure of aminergic G protein-coupled receptors
4. Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods
5. Regulation of human D(1), d(2(long)), d(2(short)), D(3) and D(4) dopamine receptors by amiloride and amiloride analogues
6. 2 dopamine receptors by amiloride and amiloride analogues
7. 2-adrenergic receptors by sodium
8. Spanning binding sites on allosteric proteins with polymer-linked ligand dimers
9. Detection, quantification, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: Interactions of strychnine and acetylcholine at muscarinic receptors
10. 2-adrenergic receptor system of the human platelets
11. Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase
12. Regulation of dopamine D2 receptors by sodium and pH
13. Zinc modulates antagonist interactions with D2-lie dopamine receptors through distinct molecular mechanisms
14. 2L dopamine receptors
15. Biochemical characterization of dopamine receptors
16. +, and 5-amino-substituted amiloride analogs