Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine(2A) and 5- hydroxytryptamine(2C) receptors: Direct and indirect effects on ligand affinity mediated by the same locus

Molecular Pharmacology

Volumn 50, Issue 1, 1996, Pages 34-42

  Almaula, Niva ^a   Ebersole, Barbara J ^a   Ballesteros, Juan A ^a   Weinstein, Harel ^a   Sealfon, Stuart C ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; BUFOTENINE; ERGOMETRINE; KETANSERIN; LISURIDE; LYSERGIDE; MESULERGINE; PHOSPHATIDYLINOSITOL; PSILOCIN; PSYCHEDELIC AGENT; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 1C RECEPTOR; SEROTONIN 2A RECEPTOR; TRYPTAMINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CERCOPITHECUS AETHIOPS; ERGOLINES; HALLUCINOGENS; HUMANS; KETANSERIN; KINETICS; LIGANDS; LYSERGIC ACID DIETHYLAMIDE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHATIDYLINOSITOLS; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0030014571     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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