Involvement of Asn-293 in stereospecific agonist recognition and in activation of the β2-adrenergic receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 17, 1996, Pages 9276-9281

  Wieland, Kerstin ^a   Zuurmond, Helene M ^b   Krasel, Cornelius ^a   Ijzerman, Ad P ^b   Lohse, Martin J ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

intrinsic activity; isoproterenol; ligand binding; propranolol; stereospecificity

Indexed keywords

ADENYLATE CYCLASE; ADRENALIN; ALPRENOLOL; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLENBUTEROL; COMPLEMENTARY DNA; CYANOIODOPINDOLOL; DOBUTAMINE; DOPAMINE; ISOPRENALINE; METOPROLOL; NORADRENALIN; PROPRANOLOL; RADIOLIGAND; TERBUTALINE;

AMINO ACID SEQUENCE; ARTICLE; CELL LINE; CHIRALITY; COMPUTER MODEL; DNA TRANSFECTION; DRUG BINDING SITE; DRUG RECEPTOR BINDING; EMBRYO; ENZYME ASSAY; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOISOMERISM; STEREOSPECIFICITY;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ALPRENOLOL; ANIMALS; ASPARAGINE; BINDING SITES; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; HUMANS; ISOPROTERENOL; METOPROLOL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA-2; SERINE; SIGNAL TRANSDUCTION; STEREOISOMERISM;

EID: 0029838206     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.17.9276     Document Type: Article

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