Activation of the ERK/MAPK pathway by an isoform of rap1 GAP associated with Gα(i)

Nature

Volumn 400, Issue 6747, 1999, Pages 891-894

  Mochizuki, Naoki ^a   Ohba, Yusuke ^a   Kiyokawa, Etsuko ^b   Kurata, Takeshi ^b   Murakami, Takeshi ^c   Ozaki, Takefumi ^c   Kitabatake, Akira ^c   Nagashima, Kazuo ^c   Matsuda, Michiyuki ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; RAT;

3T3 CELLS; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; CELL MEMBRANE; CYTOSOL; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ETS-DOMAIN PROTEIN ELK-1; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; GUANOSINE TRIPHOSPHATE; HELA CELLS; HUMANS; JURKAT CELLS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; PROTEINS; PROTO-ONCOGENE PROTEINS; RAP GTP-BINDING PROTEINS; RAS GTPASE-ACTIVATING PROTEINS; RATS; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0033606980     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/23738     Document Type: Article

References (25)

1. raf-1. J. Biol. Chem. 268, 20717-20720 (1993).
2. Alblas, J. et al. Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts. J. Biol. Chem. 268, 22235-22238 (1993).
3. Winitz, S. et al. Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-accivated protein (MAP) kinase kinase and MAP kinase. J. Biol. Chem. 268, 19196-19199 (1993).
4. Crespo, P., Xu, N. Z., Simonds, W. F. & Gutkind, I. S. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature 369, 418-420 (1994).
5. Koch, W. J., Hawes, B. E., Allen, L. F. & Lefkowitz, R. J. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G-βγ activation of p21ras. Proc. Natl Acad. Sci. USA 91, 12706-12710 (1994).
6. van Biesen, T. et al. Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway. Nature 376, 781-784 (1995).
7. Lyons, J. et al. Two G protein oncogenes in human endocrine tumors. Science 249, 655-659 (1990).
8. Wong, Y. H. et al. Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. Nature 351, 63-65 (1991).
9. Pace, A. M., Wong, Y. H. & Bourne, H. R. A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells. Proc. Natl Acad. Sci. USA 88, 7031-7035 (1991).
10. Gupta, S. K., Gallego, C., Johnson, G. L. & Heasley, L. E. MAP kinase is constitutively activated in gip2 and src transformed rat1a fibroblasts. J. Biol Chem. 267, 7987-7990 (1992).
11. Cook, S. J., Rubinfeld, B., Albert, I. & McCormick, F. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 12, 3475-3485 (1993).
12. rap1. Cell 65, 1033-1042 (1991).
13. McCormick, F. Ras-related proteins in signal transduction and growth control. Mol. Reprod. Dev. 42, 500-506 (1995).
14. Zwartkruis, F. J. et al. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling. EMBO J. 17, 5905-5912 (1998).
15. Kawasaki, H. et al. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc. Natl Acad. Sci. USA 95, 13278-13283 (1998).
16. Della Rocca, G. J. et al. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. J. Biol. Chem. 272, 19125-19132 (1997).
17. Kitayama, H. et al. A ras-related gene with transformation suppressor activity. Cell 56, 77-84 (1989).
18. Okada, S. et al. Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes. EMBO J. 17, 2554-2565 (1998).
19. Bos, J. L. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral. EMBO J. 17, 6776-6782 (1998).
20. Boussiotis, V. A. et al. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rapl. Science 278, 124-128 (1997).
21. Vossler, M. R. et al. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89, 73-82 (1997).
22. York, R. D. et al. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392, 622-626 (1998).
23. Ishimaru, S. et al. Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1. EMBO J. 18, 145-155 (1999).
24. Pizon, V. et al. Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex. J. Cell Sci. 107, 1661-1670 (1994).
25. 2+-meduted activation of Rap1 in human platelets. EMBO J. 15, 252-259 (1997).