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Volumn 275, Issue 43, 2000, Pages 33750-33758

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan [b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors

(15) Pagano, Adriana a,b Rüegg, Doris a Litschig, Stephane a,d Stoehr, Natacha a Stierlin, Christine a Heinrich, Micheline a Floersheim, Philipp a Prezèau, Laurent c Carroll, Fiona c Pin, Jean Philippe c Cambria, Antonio b Vranesic, Ivo a Flor, Peter Josef a Gasparini, Fabrizio a Kuhn, Rainer a

a NOVARTIS PHARMA AG (Switzerland)

b UNIVERSITY OF CATANIA (Italy)

c INSERM (France)

d Hesperion Ltd (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 6 (3 METHOXYPHENYL)ETHYNYLPYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 7 HYDROXYIMINOCYCLOPROPAN[B]CHROMEN 1A CARBOXYLIC ACID ETHYL ESTER; ALANINE; MEMBRANE RECEPTOR; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; PROLINE; RECEPTOR SUBTYPE; SERINE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; BINDING SITE; CHO CELL; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FIBROBLAST; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHO CELLS; CHROMONES; COS CELLS; CRICETINAE; EXCITATORY AMINO ACID ANTAGONISTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PYRIDINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0034721795 PISSN: 00219258 EISSN: None Source Type: Journal
DOI: 10.1074/jbc.M006230200 Document Type: Article

Times cited : (250)

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