Structure, function, and control of phosphoinositide-specific phospholipase C

Physiological Reviews

Volumn 80, Issue 4, 2000, Pages 1291-1335

  Rebecchi, Mario J ^a   Pentyala, Srinivas N ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL SURFACE RECEPTOR; CYTOKINE RECEPTOR; DIACYLGLYCEROL; G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE; INOSITOL DERIVATIVE; ISOENZYME; LIPID; PHOSPHATIDYLINOSITOL; PHOSPHODIESTERASE; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; SERINE; THREONINE;

CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CRYSTALLOGRAPHY; CYTOLOGY; DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; ENZYME STRUCTURE; MAMMAL; NONHUMAN; PLANT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TRANSGENIC ANIMAL; YEAST;

EID: 0033779101     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2000.80.4.1291     Document Type: Review

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238. Direct stimulation of Jak/STAT pathway by the angiotensin II AT 1 receptor
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242. A putative modular domain present in diverse signaling proteins
243. Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts
244. A second gene product of the inositol-phospholipid-specific phospholipase C delta subclass
245. Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide
246. Inositol phospholipids and cell surface receptor function
247. Purification of a novel phospholipase C isozyme from bovine cerebellum
248. A G-protein-coupled 130 kDa phospholipase C isozyme, PLC-beta 4, from the particulate fraction of bovine cerebellum
249. Phospholipase C isozymes in neurons and glial cells in culture: An immunocytochemical and immunochemical study
250. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
251. Phosphatidylinositol 4-kinase and phosphatidylinositol-4-phosphate 5-kinase from bovine brain membranes
252. Regulation of effectors by G-protein alpha- and beta gamma-subunits. Recent insights from studies of the phospholipase c-beta isoenzymes
253. Somatostatin receptor-mediated signaling in smooth muscle. Activation of phospholipase C-β3 by Gβγ and inhibition of adenylyl cyclase by Gα(i1) and Gα(o)
254. Functional characterization of phosphoinositide-specific phospholipase C-beta 1 and -beta 3 in intestinal smooth muscle
255. Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by G(i2) and G(o) in smooth muscle
256. Interactions of Gh/transglutaminase with phospholipase Cdelta 1 and with GTP
257. A novel phospholipase C delta 4 splice variant as a negative regulator of PLC
258. 11 alpha), and G(q) alpha expressed in the baculovirus-insect cell system
259. Gh: A GTP-binding protein with transglutaminase activity and receptor signaling function
260. Deletion and site-directed mutagenesis of EF-hand domain of phospholipase C-delta 1: Effects on its activity
261. The C2 domain calcium-binding motif: Structural and functional diversity
262. Potential role for a regulator of G protein signaling (RGS3) in gonadotropin-releasing hormone (GnRH) stimulated desensitization
263. Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-alpha
264. 1 during rat liver regeneration
265. Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains
266. Expression of phospholipase C-gamma 1 and its transcriptional regulators in breast cancer tissues
267. Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues
268. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma
269. Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation
270. Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice kacking G-alpha-q
271. Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane
272. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
273. Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: Analysis of kinetic parameters by a novel biosensor-based approach
274. A cell's sense of direction
275. Cloning, sequencing, expression, and G(q)-independent activation of phospholipase C-beta 2
276. Activation of phospholipase C isozymes by G protein beta gamma subunits
277. Removal of the carboxyl-terminal region of phospholipase C-beta 1 by calpain abolishes activation by G alpha q
278. IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells
279. Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1
280. CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line
281. Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis
282. Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane
283. Binding of phospholipase C delta 1 to phospholipid vesicles
284. Localization of phospholipase C delta 3 in the cell and regulation of its activity by phospholipids and calcium
285. Signaling through scaffold, anchoring, and adaptor proteins
286. A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation
287. A new function for phospholipase C-gamma-1: Coupling to the adaptor protein Grb 2
288. Mutations at residues Tyr(771) and Tyr(783) of phospholipase C-gamma-1 have different effects on cell actin-cytoskeleton organization and cell proliferation in Cc1- 39 cells
289. Epidermal growth factor activates phospholipase C-gamma 1 via G(i)1- 2 proteins in isolated pancreatic acinar membranes
290. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains
291. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover
292. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
293. The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
294. Interactions of Gh/transglutaminase with PLC-delta 1 and with GTP
295. Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling
296. PDZ domain proteins: Scaffolds for signaling complexes
297. Phosphatidyhnositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion
298. The role of the pleckstrin homology domain in membrane targeting and activation of phospholipase C-βI
299. Phosphoinositide-specific phospholipase C-delta 1: Effect of monolayer surface pressure and electrostatic surface potentials on activity
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301. Pleckstrin homology domain: A common fold with diverse functions
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304. Regulation of phosphoinositide-specific phospholipase C isozymes
305. Multiple forms of phospholipase C isozymes and their activation mechanisms
306. Multiple forms of phosphoinositide-specific phospholipase C and different modes of activation
307. Assays of phosphoinositide-specific phospholipase C and purification of isozymes from bovine brains
308. 2+-binding domain
309. 2 for fibroblast cell division
310. Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: Evidence for the existence of Ras-dependent and Ras-independent pathways
311. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
312. Brain phospholipase C isozymes: Differential mRNA localizations by in situ hybridization
313. The rat phospholipase C beta 4 gene is expressed at high abundance in cerebellar Purkinje cells
314. Membrane binding of phospholipases C-beta 1 and C-beta 2 is independent of phosphatidylinositol 4,5-bisphosphate and the alpha and beta gamma subunits of G proteins
315. Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-beta effectors
316. Phosphorylation of phospholipase C gamma 1 and its association with the FGF receptor is developmentally regulated and occurs during mesoderm induction in Xenopus laevis
317. Feedback regulation of phospholipase C-beta by protein kinase C
318. Identification of a structural element in phospholipase C beta 2 that interacts with G protein betagamma subunits
319. Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences
320. 3: A regulatory nexus between tyrosine kinases and sustained calcium signals
321. Angiotensin II activates the beta- 1 isoform of phospholipase C in vascular smooth muscle cells
322. Regulation of phospholipase C and D activities by small molecular weight G proteins and muscarinic receptors
323. Activation of a phospholipase C-beta- 2 deletion mutant by limited proteolysis
324. CDC25-dependent induction of inositol 1,4,5-trisphosphate and diacylglycerol in Saccharomyces cerevisiae by nitrogen
325. Integrins: Emerging paradigms of signal transduction
326. Lights out: Deactivation of the phototransduction cascade
327. Dynamin binds to SH3 domains of phospholipase C gamma and GRB- 2
328. Rapid and long-term effects of protein kinase C on receptor tyrosine kinase phosphorylation and degradation
329. 2+-channel current in vascular smooth muscle cells is inhibited by lavendustin-A and LY- 294002
330. 2+-binding motif in C 2 domains of synaptotagmin and protein kinase C
331. The pleckstrin homology domain: An intriguing multifunctional protein module
332. Ion channel targeting in neurons
333. Characterization of a plasma membrane-associated phosphoinositide-specific phospholipase C from soybean
334. Association of Inad with norpa is essential for controlled activation and deactivation of Drosophila phototransduction in vivo
335. A Drosophila phospholipase C gene that is expressed in the central nervous system
336. Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/ 56Lyn and a 120-kDa phosphoprotein
337. The unfolded protein response: An intracellular signalling pathway with many surprising features
338. CD38 signal transduction in human B cell precursors. Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and phosphatidylinositol 3-kinase
339. Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity
340. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D
341. Identification and biochemical characterization of an 80 kilodalton GTP-binding/transglutaminase from rabbit liver nuclei
342. Characterisation of a phospholipase C-delta from Schizosaccharomyces pombe
343. Overexpression of phosphoinositide-specific phospholipase C-gamma in NIH 3t3 Cells promotes transformation and tumorigenicity
344. Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C
345. PLC gamma 1 Src homology domain induces mitogenesis in quiescent NIH 3T3 fibroblasts
346. Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity
347. S-phase induction and transformation of quiescent NIH 3T3 cells by micro-injection of phospholipase C
348. Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits
349. Localization of a binding site for phosphatidylinositol 4,5-bisphosphate on human profilin
350. Individual epidermal growth factor receptor autophosphorylation sites do not stringently define association motifs for several SH2-containing proteins
351. 2 concentration monitored in living cells
352. Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues
353. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
354. Hormone signalling via G-protein: Regulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by G(q)
355. G protein diversity: A distinct class of alpha subunits is present in vertebrates and invertebrates
356. 2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
357. Monoclonal antibodies to three phospholipase C isozymes from bovine brain
358. Inositol phospholipid-specific phospholipase C: Complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products
359. Effects of CapG overexpression on agonist-induced motility and second messenger generation
360. Gelsolin modulates phospholipase C activity in vivo through phospholipid binding
361. Complexity and diversity of mammalian adenylyl cyclases
362. 2+/ phospholipid-binding fold
363. Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis
364. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2
365. 2+ mobilization through distinct pathways
366. Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs
367. Dynamics of phosphatidylinositol 4,5-bisphosphate in actin-rich structures
368. Localization of mRNAs for three novel members (beta 3, beta 4 and gamma 2) of phospholipase C family in mature rat brain
369. Mammalian membrane-bound adenylyl cyclases
370. Small wing encodes a phospholipase C-(gamma) that acts as a negative regulator of R 7 development in Drosophila
371. TOR signalling and control of cell growth
372. Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor
373. A multivalent Pdz-domain protein assembles signalling complexes in a G-protein-coupled cascade
374. G protein beta gamma subunits. Simplified purification and properties of novel isoforms
375. Temporal dispersion of activation of phospholipase C-beta 1 and -gamma isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, alpha 12, and beta gamma G protein subunits
376. Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively
377. 2+ influx
378. A novel, phospholipase C-independent pathway of inositol 1,4,5-trisphosphate formation in Dictyostelium and rat liver
379. Transduction of the chemotactic cAMP signal across the plasma membrane of Dictyostelium cells
380. 3H]inositol-labeled phosphoinositide pools
381. Association of a receptor and G-protein-regulated phospholipase C with the cytoskeleton
382. Angiotensin II-induced association of phospholipase Cgamma1 with the G-protein-coupled AT 1 receptor
383. Reduction in Gh protein expression is associated with cytodifferentiation of vascular smooth muscle cells
384. 31P NMR study
385. Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes
386. Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC- 1 cells
387. Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium
388. Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes
389. Positive charge at position 549 is essential for phosphatidylinositol 4,5-bisphosphate-hydrolyzing but not phosphatidylinositol-hydrolyzing activities of human phospholipase C delta 1
390. Targeted disruption of the mouse phospholipase C beta 3 gene results in early embryonic lethality
391. Plekstrin homology domain of PLC-beta 2 confers G-bg activation to the catalytic core
392. Selective interaction of the C2 domains of phospholipase C-beta 1 and beta 2 with activated G(q)
393. Differential association of the pleckstrin homology domains of phospholipases C-beta1, C-beta2, and C-delta1 with lipid bilayers and the beta-gamma subunits of heterotrimeric G proteins
394. Requirement for phospholipase C-gamma-1 enzymatic activity in growth factor-induced mitogenesis
395. A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C
396. Characterization of G-protein alpha subunits in the G(q) class: Expression in murine tissues and in stromal and hematopoietic cell lines
397. Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells
398. Structural views of phosphoinositide-specific phospholipase C: Signalling the way ahead
399. Identification of critical regions on phospholipase C-beta 1 required for activation by G-proteins
400. Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of G(q) family
401. Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein
402. G protein-coupled signal transduction pathways for interleukin-8
403. 11 proteins in transfected Cos-7 cells
404. Phosphoinositide-specific phospholipase C delta-1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: A sequential mechanism and allosteric activation
405. Promiscuous coupling of receptors to G(q) class alpha subunits and effector proteins in pancreatic and submandibular gland cells
406. RGS proteins determine signaling specificity of G(q)-coupled receptors
407. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell
408. Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1
409. Replacements of single basic smino scids in the pleckstrin homology domain of phospholipase C-delta-1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane
410. Developmental changes of three phosphoinositide-specific phospholipase C isozymes in the rat nervous system
411. Phospholipase C-delta 1 contains a functional nuclear export signal sequence
412. Structural determinants for interaction with three different effectors on the G protein beta subunit
413. Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase C gamma 2 in human platelets and phospholipase C gamma 1 in NIH-3T3 fibroblasts
414. Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes
415. Epidermal growth factor-induced activation and translocation of phospholipase C-gamma 1 to the cytoskeleton in rat hepatocytes
416. Isolation and characterization of temperature-sensitive plc 1 mutants of the yeast Saccharomyces cerevisiae
417. The putative phosphoinositide-specific phospholipase C gene, PLC 1, of the yeast Saccharomyces cerevisiae is important for cell growth
418. A phospholipase C-dependent inositol polyphosphate kinase pathway required for effecient messenger RNA export
419. D-Myo-inositol 1,4,5-trisphosphate-binding proteins in rat brain membranes
420. Phosphorylation of phospholipase Cgamma1 on tyrosine residue 783 by platelet-derived growth factor regulates reorganization of the cytoskeleton
421. Differential requirement of a motif within the carboxyl-terminal domain of alpha-platelet-derived growth factor (alpha PDGF) receptor for PDGF focus forming activity chemotaxis, or growth
422. Phosphorylation of serine 1105 by protein kinase A inhibits phospholipase Cbeta3 stimulation by Galphaq
423. Inhibition by toxin B of inositol phosphate formation induced by G protein-coupled and tyrosine kinase receptors in NIE-115 neuroblastoma cells: Involvement of Rho proteins
424. Novel bimodal effects of G-protein tissue transglutaminase on adrenoceptor signalling
425. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
426. Action of phosphatidylinositol-specific phospholipase Cgamma 1 on soluble and micellar substrates. Separating effects on catalysis from modulation of the surface
427. Tissue-specific expression of phospholipase C encoded by the norpA gene of Drosophila melanogaster
428. Determination of neuronal cell fate: Lessons from the R 7 neuron of Drosophila