Alanine exchanges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants

Journal of Biological Chemistry

Volumn 272, Issue 12, 1997, Pages 7846-7854

  Ishii, Isao ^a,b   Izumi, Takashi ^a   Tsukamoto, Hiroaki ^c   Umeyama, Hideaki ^c   Ui, Michio ^b   Shimizuf, Takao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 O ALKYLGLYCERO 3 PHOSPHORYLCHOLINE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ALANINE; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CHO CELLS; COS CELLS; CRICETINAE; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLATELET ACTIVATING FACTOR; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; ZINC;

EID: 0030956418     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.12.7846     Document Type: Article

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