Electrostatic and aromatic microdomains within the binding-site crevice of the D2 receptor: Contributions of the second membrane-spanning segment

Biochemistry

Volumn 38, Issue 25, 1999, Pages 7961-7968

  Javitch, Jonathan A ^a,c   Ballesteros, Juan A ^b   Chen, Jiayun ^a   Chiappa, Victor ^a   Simpson, Merrill M ^a  

^a Columbia University ^*  (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; DOPAMINE 2 RECEPTOR; SULPIRIDE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; HYDROPHILICITY; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ASPARTIC ACID; BINDING, COMPETITIVE; CELL LINE; CELL MEMBRANE; CYSTEINE; DOPAMINE ANTAGONISTS; ELECTROSTATICS; ETHYL METHANESULFONATE; HUMANS; MESYLATES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, DOPAMINE D2; SULPIRIDE;

EID: 0033594927     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9905314     Document Type: Article

References (40)

1. Civelli, O., Bunzow, J. R., Grandy, D. K., Zhou, Q. Y., and Van Tol, H. H. (1991) Eur. J. Pharmacol. 207 (4), 277-86.
2. Strader, C. D., Fong, T. M., Tota, M. R., Underwood, D., and Dixon, R. A. (1994) Annu. Rev. Biochem. 63, 101-32.
3. Oprian, D. D. (1992) J. Bioenerg. Biomembr. 24 (2), 211-7.
4. Akabas, M. H., Kaufmann, C., Archdeacon, P., and Karlin, A. (1994) Neuron 13, 919-927.
5. Akabas, M. H., Stauffer, D. A., Xu, M., and Karlin, A. (1992) Science 258 (5080), 307-10.
6. Javitch, J. A., Li, X., Kaback, J., and Karlin, A. (1994) Proc. Natl. Acad. Sci. U.S.A. 91 (22), 10355-9.
7. Javitch, J. A., Fu, D., Chen, J., and Karlin, A. (1995) Neuron 14 (4), 825-31.
8. Javitch, J. A., Fu, D., and Chen, J. (1995) Biochemistry 34 (50), 16433-9.
9. Fu, D., Ballesteros, J. A., Weinstein, H., Chen, J., and Javitch, J. A. (1996) Biochemistry 35 (35), 11278-85.
10. Javitch, J. A., Ballesteros, J. A., Weinstein, H., and Chen, J. (1998) Biochemistry 37 (4), 998-1006.
11. Stauffer, D. A., and Karlin, A. (1994) Biochemistry 33 (22), 6840-9.
12. van Rhee, A. M., and Jacobson, K. A. (1996) Drug Dev. Res. 37, 1-38.
13. Hamaguchi, N., True, T. A., Saussy, D. L., Jr., and Jeffs, P. W. (1996) Biochemistry 35 (45), 14312-7.
14. Dohlman, H. G., Caron, M. G., Strader, C. D., Amlaiky, N., and Lefkowitz, R. J. (1988) Biochemistry 27 (6), 1813-7.
15. Horstman, D. A., Brandon, S., Wilson, A. L., Guyer, C. A., Cragoe, E. J. J., and Limbird, L. E. (1990) J. Biol. Chem. 265 (35), 21590-5.
16. Neve, K. A., Cox, B. A., Henningsen, R. A., Spanoyannis, A., and Neve, R. L. (1991) Mol. Pharmacol. 39 (6), 733-9.
17. Zhou, W., Flanagan, C., Ballesteros, J. A., Konvicka, K., Davidson, J. S., Weinstein, H., Millar, R. P., and Sealfon, S. C. (1994) Mol. Pharmacol. 45, 165-170.
18. Sealfon, S. C., Chi, L., Ebersole, B. J., Rodic, V., Zhang, D., Ballesteros, J. A., and Weinstein, H. (1995) J. Biol. Chem. 270 (28), 16683-8 (issn, 0021-9258).
19. Ballesteros, J. A., and Weinstein, H. (1995) Methods Neurosci. 25, 366-428.
20. Rees, S., Coote, J., Stables, J., Goodson, S., Harris, S., and Lee, M. G. (1996) BioTechniques 20, 102-110.
21. Roberts, D. D., Lewis, S. D., Ballou, D. P., Olson, S. T., and Shafer, J. A. (1986) Biochemistry 25 (19), 5595-601.
22. Dohlman, H. G., Caron, M. G., Strader, C. D., Amlaiky, N., and Lefkowitz, R. J. (1988) Biochemistry 27 (6), 1813-7.
23. Barlow, D. J., and Thornton, J. M. (1988) J. Mol. Biol. 201 (3), 601-19.
24. Ballesteros, J. A., and Weinstein, H. (1992) Biophys. J. 62 (1), 107-9.
25. Sansom, M. S. (1992) Protein Eng. 5 (1), 53-60.
26. Williams, K. A., and Deber, C. M. (1991) Biochemistry 30 (37), 8919-23.
27. Woolfson, D. N., Mortishire, S. R. J., and Williams, D. H. (1991) Biochem. Biophys. Res. Commun. 175 (3), 733-7.
28. Javitch, J. A., Fu, D., and Chen, J. (1996) Mol. Pharmacol. 49 (4), 692-8.
29. Unger, V. M., Margrave, P. A., Baldwin, J. M., and Schertler, G. F. (1997) Nature 389 (6647), 203-6.
30. Schertler, G. F. X., and Hargrave, P. A. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 11578-11582.
31. Baldwin, J. M. (1993) EMBO J. 12 (4), 1693-703.
32. Elling, C. E., and Schwartz, T. W. (1996) EMBO J. 15 (22), 6213-9.
33. Dougherty, D. A. (1996) Science 271 (5246), 163-168.
34. Ballesteros, J., Kitanovic, S., Guarnieri, F., Davies, P., Fromme, B. J., Konvicka, K., Chi, L., Millar, R. P., Davidson, J. S., Weinstein, H., and Sealfon, S. C. (1998) J. Biol. Chem. 273 (17), 10445-53.
35. Strader, C. D., Sigal, I. S., Register, R. B., Candelore, M. R., Rands, E., and Dixon, R. A. (1987) Proc. Natl. Acad. Sci. U.S.A. 84 (13), 4384-8.
36. Strader, C. D., Sigal, I. S., Candelore, M. R., Rands, E., Hill, W. S., and Dixon, R. A. (1988) J. Biol. Chem. 263 (21), 10267-71.
37. Strader, C. D., Gaffney, T., Sugg, E. E., Candelore, M. R., Keys, R., Patchett, A. A., and Dixon, R. A. (1991) J. Biol. Chem. 266 (1), 5-8.
38. Hall, D. A., and Strange, P. G. (1997) Br. J. Pharmacol. 121 (4), 731-6.
39. Kozell, L. B., and Neve, K. A. (1997) Mol. Pharmacol. 52 (6), 1137-49.
40. Cheng, Y., and Prusoff, W. H. (1973) Biochem. Pharmacol. 22 (23), 3099-108.