Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human α(2A)-adrenergic receptor

Journal of Biological Chemistry

Volumn 274, Issue 31, 1999, Pages 21867-21872

  Marjamäkit, Anne ^a   Frang, Heini ^a   Pihlavisto, Marjo ^a   Hoffrén, Anna Marja ^b   Salminen, Tiina ^c   Johnson, Mark S ^c   Kallio, Jaana ^a   Javitch, Jonathan A ^d   Scheinin, Mika ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b Oy Juvantia Pharma Ltd   (Finland)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

^d New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CHLOROETHYLCLONIDINE; THIOMESYLIC ACID METHYL ESTER;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; GENETIC TRANSFECTION; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

ADRENERGIC ALPHA-ANTAGONISTS; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CHO CELLS; CLONIDINE; CRICETINAE; CYSTEINE; ETHYL METHANESULFONATE; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ADRENERGIC, ALPHA-2; RECOMBINANT PROTEINS; THERMODYNAMICS; TRANSFECTION;

EID: 0039772517     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.31.21867     Document Type: Article

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