A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice

Biochemistry

Volumn 37, Issue 4, 1998, Pages 998-1006

  Javitch, Jonathan A ^a   Ballesteros, Juan A ^b   Weinstein, Harel ^b   Chen, Jiayun ^a  

^a Columbia University ^*  (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR; SULPIRIDE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; EXTRACELLULAR MATRIX; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE MUTATION; LIPID BILAYER; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RESIDUE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACIDS, CYCLIC; BINDING SITES; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; ETHYL METHANESULFONATE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, DOPAMINE D2; SPIPERONE; SULPIRIDE;

EID: 0032570306     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972241y     Document Type: Article

References (42)

1. Civelli, O., Bunzow, J. R., Grandy, D. K., Zhou, Q. Y., and Van Tol, H. H. (1991) Eur. J. Pharmacol. 207, 277-286.
2. Strader, C. D., Fong, T. M., Tota, M. R., Underwood, D., and Dixon, R. A. (1994) Annu. Rev. Biochem. 63, 101-132.
3. Oprian, D. D. (1992) J. Bioenerg. Biomembr. 24, 211-217.
4. Akabas, M. H., Kaufmann, C., Archdeacon, P., and Karlin, A. (1994) Neuron 13, 919-927.
5. Akabas, M. H., Stauffer, D. A., Xu, M., and Karlin, A. (1992) Science 258, 307-310.
6. Javitch, J. A., Li, X., Kaback, J., and Karlin, A. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 10355-10359.
7. Javitch, J. A., Fu, D., Chen, J., and Karlin, A. (1995) Neuron 14, 825-831.
8. Javitch, J. A., Fu, D., and Chen, J. (1995) Biochemistry 34, 16433-16439.
9. Fu, D., Ballesteros, J. A., Weinstein, H., Chen, J., and Javitch, J. A. (1996) Biochemistry 35, 11278-11285.
10. Stauffer, D. A., and Karlin, A. (1994) Biochemistry 33, 6840-6849.
11. van Rhee, A. M., and Jacobson, K. A. (1996) Drug Dev. Res. 37, 1-38.
12. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W. L., and Khorana, H. G. (1996) Science 274, 768-770.
13. Javitch, J. A., Fu, D., Liapakis, G., and Chen, J. (1997) J. Biol. Chem. 272, 18546-18549.
14. Gether, U., Lin, S., Ghanouni, P., Ballesteros, J. A., Weinstein, H., and Kobilka, B. K. (1997) EMBO J. 16, 6737-6747.
15. Zhang, D., and Weinstein, H. (1993) J. Med. Chem. 36, 934-938.
16. Luo, X., Zhang, D., and Weinstein, H. (1994) Protein Eng. 7, 1441-1448.
17. Ballesteros, J. A., and Weinstein, H. (1995) Methods Neurosci. 25, 366-428.
18. Kobilka, B. K. (1995) Anal. Biochem. 231, 269-271.
19. Rees, S., Coote, J., Stables, J., Goodson, S., Harris, S., and Lee, M. G. (1996) BioTechniques 20, 102-110.
20. Javitch, J. A., Fu, D., and Chen, J. (1996) Mol. Pharmacol. 49, 692-698.
21. Roberts, D. D., Lewis, S. D., Ballou, D. P., Olson, S. T., and Shafer, J. A. (1986) Biochemistry 25, 5595-5601.
22. Woodward, R., Daniell, S. J., Strange, P. G., and Naylor, L. H. (1994) J. Neurochem. 62, 1664-1669.
23. Freedman, S. B., Poat, J. A., and Woodruff, G. N. (1982) J. Neurochem. 38, 1459-1465.
24. Niznik, H. B., Grigoriadis, D. E., Pri-Bar, I., Buchman O., and Seeman, P. (1985) Naunyn-Schmiedebergs Arch. Pharmacol. 329, 333-343.
25. Barlow, D. J., and Thornton, J. M. (1988) J. Mol. Biol. 201, 601-619.
26. Ballesteros, J. A., and Weinstein, H. (1992) Biophys. J. 62, 107-109.
27. Sansom, M. S. (1992) Protein Eng. 5, 53-60.
28. Williams, K. A., and Deber, C. M. (1991) Biochemistry 30, 8919-8923.
29. Woolfson, D. N., Mortishire, S. R. J., and Williams D. H. (1991) Biochem. Biophys. Res. Commun. 175, 733 737.
30. Sheikh, S. P., Zvyaga, T. A., Lichtarge, O., Sakmar, T. P., and Bourne, H. R. (1996) Nature 383, 347-350.
31. Dougherty, D. A. (1996) Science 271, 163-168.
32. Cho, W., Taylor, L. P., Mansour, A., and Akil, H. (1995) J. Neurochem. 65, 2105-2115.
33. Roth, B. L., Shomam, M., Choudhary, M. S., and Khan, N. (1997) Mol. Pharmacol. 52, 259-266.
34. Seeman, P. (1980) Pharmacol. Rev. 32, 229-313.
35. Strader, C. D., Sigal, I. S., Candelore, M. R., Rands, E., Hill, W. S., and Dixon, R. A. (1988) J. Biol. Chem. 263, 10267-10271.
36. Mansour, A., Meng, F., Meador, W. J. H., Taylor, L. P., Civelli, O., and Akil, H. (1992) Eur. J. Pharmacol. 227, 205-214.
37. Strader, C. D., Sigal, I. S., and Dixon, R. A. (1989) Trends Pharmacol. Sci. 10 (Suppl.), 26-30.
38. Cox, B. A., Henningsen, R. A., Spanoyannis, A., Neve, R. L., and Neve, K. A. (1992) J. Neurochem. 59, 627-635.
39. Reid, K. S. C., Lindley, P. F., and Thornton, J. M. (1985) FEBS Lett. 190, 209-213.
40. Viguera, A. R., and Serrano, L. (1995) Biochemistry 34, 8771-8779.
41. Cheng, Y., and Prusoff, W. H. (1973) Biochem. Pharmacol 22, 3099-3108.
42. Schertler, G. F. X., and Hargrave, P. A. (1995) Proc. Natl Acad. Sci. U.S.A. 92, 11578-11582.