Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif

FEBS Letters

Volumn 547, Issue 1-3, 2003, Pages 145-150

  Chang, Gin Wen ^a   Stacey, Martin ^a   Kwakkenbos, Mark J ^b   Hamann, Jörg ^b   Gordon, Siamon ^a   Lin, Hsi Hsien ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Post translational modification; Proteolytic cleavage

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; LEUCINE; MEMBRANE PROTEIN; PROTEIN EMR2; PROTEIN SUBUNIT; RECEPTOR PROTEIN; SERINE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ALTERNATIVE RNA SPLICING; ARTICLE; BETA CHAIN; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN MOTIF; PROTEIN PROCESSING; TRANSLATION REGULATION;

EID: 0038642821     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(03)00695-1     Document Type: Article

References (26)

1. Stacey M., Lin H.H., Gordon S., McKnight A.J. Trends Biochem. Sci. 25:2000;284-289.
2. Hayflick J.S. J. Receptor Signal Transduct. Res. 20:2000;119-131.
3. Harmar A.J. Genome Biol. 2:2001;1-10.
4. Krasnoperov V.G., et al. Neuron. 18:1997;925-937.
5. Krasnoperov V., Bittner M.A., Holz R.W., Chepurny O., Petrenko A.G. J. Biol. Chem. 274:1999;3590-3596.
6. Ponting C.P., Hofmann K., Bork P. Curr. Biol. 9:1999;R585-8.
7. The European Polycystic Kidney Disease Consortium (1994) Cell 77, 881-94.
8. The International Polycystic Kidney Disease Consortium (1995) Cell 81, 289-98.
9. Mengerink K.J., Moy G.W., Vacquier V.D. J. Biol. Chem. 277:2002;943-948.
10. Hughes J., Ward C.J., Aspinwall R., Butler R., Harris P.C. Hum. Mol. Genet. 8:1999;543-549.
11. McKnight A.J., Gordon S. Immunol. Today. 17:1996;283-287.
12. McKnight A.J., Gordon S. J. Leukoc. Biol. 63:1998;271-280.
13. Hamann J., Vogel B., van Schijndel G.M., van Lier R.A. J. Exp. Med. 184:1996;1185-1189.
14. Qian Y.M., Haino M., Kelly K., Song W. Immunology. 98:1999;303-311.
15. Stacey M., Lin H.H., Hilyard K.L., Gordon S., McKnight A.J. J. Biol. Chem. 276:2001;18863-18870.
16. Stacey M., Chang G.W., Sanos S.L., Chittenden L.R., Stubbs L., Gordon S., Lin H.H. J. Biol. Chem. 277:2002;29283-29293.
17. Hamann J., van Zeventer C., Bijl A., Molenaar C., Tesselaar K., van Lier R.A. Int. Immunol. 12:2000;439-448.
18. Lin H.H., Stacey M., Hamann J., Gordon S., McKnight A.J. Genomics. 67:2000;188-200.
19. Kwakkenbos M.J., Chang G.W., Lin H.H., Pouwels W., de Jong E.C., van Lier R.A., Gordon S., Hamann J. J. Leukoc. Biol. 71:2002;854-862.
20. Gray J.X., et al. J. Immunol. 157:1996;5438-5447.
21. Nechiporuk T., Urness L.D., Keating M.T. J. Biol. Chem. 276:2001;4150-4157.
22. Lin H.H., et al. J. Biol. Chem. 276:2001;24160-24169.
23. Abe J., Fukuzawa T., Hirose S. J. Biol. Chem. 277:2002;23391-23398.
24. Krasnoperov V., Lu Y., Buryanovsky L., Neubert T.A., Ichtchenko K., Petrenko A.G. J. Biol. Chem. 277:2002;46518-46526.
25. Qian F., et al. Proc. Natl. Acad. Sci. USA. 99:2002;16981-16986.
26. Moy G.W., Mendoza L.M., Schulz J.R., Swanson W.J., Glabe C.G., Vacquier V.D. J. Cell Biol. 133:1996;809-817.