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Volumn 22, Issue 7, 2001, Pages 368-376

G-protein-coupled receptors and signaling networks: Emerging paradigms

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM SENSING RECEPTOR; CHOLECYSTOKININ RECEPTOR; FOLLITROPIN RECEPTOR; G PROTEIN COUPLED RECEPTOR; GASTRIN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LUTEINIZING HORMONE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEUROMEDIN B RECEPTOR; NEUROPEPTIDE RECEPTOR; NEUROTENSIN RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; THYROTROPIN RECEPTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR; VIRUS RECEPTOR;

EID: 0035398487     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01678-3     Document Type: Review
Times cited : (875)

References (76)
  • 6
    • 17344362824 scopus 로고    scopus 로고
    • Cell growth control by G protein-coupled receptors: From signal transduction to signal integration
    • (1998) Oncogene , vol.17 , pp. 1331-1342
    • Gutkind, J.S.1
  • 7
    • 0022536710 scopus 로고
    • Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains
    • (1986) Cell , vol.45 , pp. 711-719
    • Young, D.1
  • 8
    • 0024385411 scopus 로고
    • Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation
    • (1989) Science , vol.244 , pp. 1057-1062
    • Julius, D.1
  • 10
    • 0026318020 scopus 로고
    • G-protein-coupled receptor genes as protooncogenes: Constitutively activating mutation of the α1B-adrenergic receptor enhances mitogenesis and tumorigenicity
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 11354-11358
    • Allen, L.F.1
  • 11
    • 0027369421 scopus 로고
    • Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
    • (1993) Nature , vol.365 , pp. 649-651
    • Parma, J.1
  • 12
    • 0027372340 scopus 로고
    • A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty
    • (1993) Nature , vol.365 , pp. 652-654
    • Shenker, A.1
  • 14
    • 0033287568 scopus 로고    scopus 로고
    • Calcium-induced activation of a mutant G-protein-coupled receptor causes in vitro transformation of NIH/3T3 cells
    • (1999) Neoplasia , vol.1 , pp. 485-491
    • Hoff, A.O.1
  • 15
    • 0035952679 scopus 로고    scopus 로고
    • Autocrine and paracrine signaling through neuropeptide receptors in human cancer
    • (2001) Oncogene , vol.20 , pp. 1563-1569
    • Heasley, L.E.1
  • 16
    • 0026541641 scopus 로고
    • Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins
    • (1992) Nature , vol.355 , pp. 362-365
    • Nicholas, J.1
  • 17
    • 0031032769 scopus 로고    scopus 로고
    • Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation
    • (1997) Nature , vol.385 , pp. 347-350
    • Arvanitakis, L.1
  • 19
    • 0034282553 scopus 로고    scopus 로고
    • The Kaposi's sarcoma-associated herpes virus G protein-coupled receptors up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inucible factor 1α
    • (2000) Cancer Res. , vol.60 , pp. 4873-4880
    • Sodhi, A.1
  • 20
    • 0032038939 scopus 로고    scopus 로고
    • CXC chemokine modulation of angiogenesis: The importance of balance between angiogenic and angiostatic members of the family
    • (1998) J. Invest. Med. , vol.46 , pp. 113-120
    • Moore, B.B.1
  • 23
    • 0028296444 scopus 로고
    • Suppression of Ras-induced transformation of NIH 3T3 cells by activated Gαs
    • (1994) Science , vol.263 , pp. 1278-1281
    • Chen, J.1    Iyengar, R.2
  • 24
    • 0029083694 scopus 로고
    • Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5524-5530
    • Erhardt, P.1
  • 25
    • 0025127424 scopus 로고
    • Two G protein oncogenes in human endocrine tumors
    • (1990) Science , vol.249 , pp. 655-659
    • Lyons, J.1
  • 28
    • 0031037296 scopus 로고    scopus 로고
    • Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ
    • (1997) Science , vol.275 , pp. 394-397
    • Lopez-Ilasaca, M.1
  • 29
    • 0034614695 scopus 로고    scopus 로고
    • Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Gαo protein
    • (2000) Science , vol.287 , pp. 142-144
    • Ram, P.T.1
  • 31
    • 0027497516 scopus 로고
    • Expression cDNA cloning of a transforming gene encoding the wild-type Gα 12 gene product
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 762-768
    • Chan, A.M.1
  • 33
    • 0028973505 scopus 로고
    • Gα12 and Gα13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly
    • (1995) J. Biol. Chem. , vol.270 , pp. 24631-24634
    • Buhl, A.M.1
  • 34
    • 0030886445 scopus 로고    scopus 로고
    • The small GTP-binding protein Rho links G protein-coupled receptors and Gα12 to the serum response element and to cellular transformation
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 10098-10103
    • Fromm, C.1
  • 35
    • 0032569051 scopus 로고    scopus 로고
    • p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13
    • (1998) Science , vol.280 , pp. 2109-2111
    • Kozasa, T.1
  • 36
    • 0033605294 scopus 로고    scopus 로고
    • A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
    • (1999) J. Biol. Chem. , vol.274 , pp. 5868-5879
    • Fukuhara, S.1
  • 37
    • 0034711449 scopus 로고    scopus 로고
    • Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho
    • (2000) FEBS Lett. , vol.485 , pp. 183-188
    • Fukuhara, S.1
  • 40
    • 0031893949 scopus 로고    scopus 로고
    • The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades
    • (1998) J. Biol. Chem. , vol.273 , pp. 1839-1842
    • Gutkind, J.S.1
  • 41
    • 0028240869 scopus 로고
    • Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
    • (1994) Nature , vol.369 , pp. 418-420
    • Crespo, P.1
  • 43
    • 0028091046 scopus 로고
    • Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway
    • (1994) J. Biol. Chem. , vol.269 , pp. 645-651
    • Hordijk, P.L.1
  • 44
    • 0028977847 scopus 로고
    • Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
    • (1995) Nature , vol.376 , pp. 781-784
    • Van Biesen, T.1
  • 45
    • 0029778177 scopus 로고    scopus 로고
    • Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gβγ subunit-mediated activation of mitogen-activated protein kinases
    • (1996) J. Biol. Chem. , vol.271 , pp. 19443-19450
    • Luttrell, L.M.1
  • 46
    • 0033613938 scopus 로고    scopus 로고
    • β-Arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes
    • (1999) Science , vol.283 , pp. 655-661
    • Luttrell, L.M.1
  • 47
    • 0033574525 scopus 로고    scopus 로고
    • Role of arrestins in endocytosis and signaling of α2-adrenergic receptor subtypes
    • (1999) J. Biol. Chem. , vol.274 , pp. 11253-11259
    • DeGraff, J.L.1
  • 48
    • 0034268796 scopus 로고    scopus 로고
    • Src tyrosine kinase is a novel direct effector of G proteins
    • (2000) Cell , vol.102 , pp. 635-646
    • Ma, Y.C.1
  • 49
    • 0034624055 scopus 로고    scopus 로고
    • 3-adrenergic receptor is required for MAP kinase activation
    • (2000) J. Biol. Chem. , vol.275 , pp. 38131-38134
    • Cao, W.1
  • 50
    • 0030683639 scopus 로고    scopus 로고
    • Signal characteristics of G protein-transactivated EGF receptor
    • (1997) EMBO J. , vol.16 , pp. 7032-7044
    • Daub, H.1
  • 51
    • 0030614911 scopus 로고    scopus 로고
    • Gβγ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation
    • (1997) J. Biol. Chem. , vol.272 , pp. 4637-4644
    • Luttrell, L.M.1
  • 52
    • 0034737483 scopus 로고    scopus 로고
    • The β2-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor
    • (2000) J. Biol. Chem. , vol.275 , pp. 9572-9580
    • Maudsley, S.1
  • 53
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1
  • 54
    • 0034697121 scopus 로고    scopus 로고
    • A novel role for phosphatidylinositol 3-kinase β in signaling from G protein-coupled receptors to Akt
    • (2000) J. Biol. Chem. , vol.275 , pp. 12069-12073
    • Murga, C.1
  • 55
    • 0034624783 scopus 로고    scopus 로고
    • Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak
    • (2000) Curr. Biol. , vol.10 , pp. 281-284
    • Sun, H.1
  • 57
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1
  • 58
    • 0033591228 scopus 로고    scopus 로고
    • Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades
    • (1999) J. Biol. Chem. , vol.274 , pp. 14893-14901
    • Blaukat, A.1
  • 59
    • 0032725309 scopus 로고    scopus 로고
    • Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-jun NH(2)-terminal kinase activation
    • (1999) J. Biol. Chem. , vol.274 , pp. 30738-30746
    • Igishi, T.1
  • 60
    • 0032561309 scopus 로고    scopus 로고
    • Regulation of apoptosis by alpha-subunits of G12 and G13 proteins via apoptosis signal-regulating kinase-1
    • (1998) J. Biol. Chem. , vol.273 , pp. 27816-27823
    • Berestetskaya, Y.V.1
  • 61
    • 0034711397 scopus 로고    scopus 로고
    • β-Arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3
    • (2000) Science , vol.290 , pp. 1574-1577
    • McDonald, P.H.1
  • 62
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 64
    • 0030784775 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase by signaling through G protein-coupled receptors. Involvement of Gβγ and Gαq/11 subunits
    • (1997) J. Biol Chem. , vol.272 , pp. 27771-27777
    • Yamauchi, J.1
  • 65
    • 1842299315 scopus 로고    scopus 로고
    • Direct stimulation of Bruton's tyrosine kinase by G(q)-protein α-subunit
    • (1997) Nature , vol.389 , pp. 296-299
    • Bence, K.1
  • 66
    • 0032483381 scopus 로고    scopus 로고
    • Involvement of protein kinase C and Src family tyrosine kinase in Gαq/11-induced activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
    • (1998) J. Biol. Chem. , vol.273 , pp. 22892-22898
    • Nagao, M.1
  • 67
    • 0031963773 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase p38-2 is necessary for the inhibition of N-type calcium current by bradykinin
    • (1998) J. Neurosci. , vol.18 , pp. 112-118
    • Wilk-Blaszczak, M.A.1
  • 68
    • 0032977187 scopus 로고    scopus 로고
    • A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: A role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4289-4301
    • Marinissen, M.J.1
  • 69
    • 0032531881 scopus 로고    scopus 로고
    • Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
    • (1998) Nature , vol.395 , pp. 713-716
    • Kato, Y.1
  • 70
    • 0034647517 scopus 로고    scopus 로고
    • Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Gαq and Gα 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras and Rho-independent pathway
    • (2000) J. Biol. Chem. , vol.275 , pp. 21730-21736
    • Fukuhara, S.1
  • 71
    • 0033595764 scopus 로고    scopus 로고
    • Neuronal activity-dependent cell survival mediated by transcription factor MEF2
    • (1999) Science , vol.286 , pp. 785-790
    • Mao, Z.1
  • 72
    • 0033635242 scopus 로고    scopus 로고
    • Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases
    • (2000) Mol. Cell , vol.6 , pp. 233-244
    • Lu, J.1
  • 74
    • 0033118334 scopus 로고    scopus 로고
    • Molecular tinkering of G protein-coupled receptors: An evolutionary success
    • (1999) EMBO J. , vol.18 , pp. 1723-1729
    • Bockaert, J.1    Pin, J.P.2
  • 76
    • 0033620487 scopus 로고    scopus 로고
    • Heptahelical receptor signaling: Beyond the G protein paradigm
    • (1999) J. Cell Biol. , vol.145 , pp. 927-932
    • Hall, R.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.