Modeling the 3D structure of GPCRs: Advances and application to drug discovery

Current Opinion in Drug Discovery and Development

Volumn 6, Issue 3, 2003, Pages 353-361

  Becker, Oren M ^a   Shacham, Sharon ^a   Marantz, Yael ^a   Noiman, Silvia ^a  

^a Predix Pharmaceuticals Ltd   (Israel)

Author keywords

3D models; Docking; Drug discovery; G protein coupled receptors; In silico screening

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; BUSPIRONE; DIHYDROPYRIDINE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; J 104870; LOSARTAN; MEMBRANE PROTEIN; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; NEW DRUG; PIPERIDINE DERIVATIVE; PRX 92026; RHODOPSIN; ROFECOXIB; RS 102895; SEROTONIN; UNCLASSIFIED DRUG;

ALGORITHM; COMPUTER MODEL; CONCENTRATION (PARAMETERS); DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG MANUFACTURE; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; NONHUMAN; PHARMACOPHORE; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; VALIDATION PROCESS; X RAY ANALYSIS;

ANIMALS; DRUG DESIGN; GTP-BINDING PROTEINS; HUMANS; MODELS, MOLECULAR; RECEPTORS, CELL SURFACE; SOFTWARE; TECHNOLOGY, PHARMACEUTICAL;

EID: 0038458865     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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