A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 10, 2000, Pages 5639-5644

  Dragic, Tatjana ^a,c   Trkola, Alexandra ^a   Thompson, Daniah A D ^a,c   Cormier, Emmanuel G ^a,c   Kajumo, Francis A ^a,c   Maxwell, Elizabeth ^a   Lin, Steven W ^a   Ying, Weiwen ^b   Smith, Steven O ^b   Sakmar, Thomas P ^a   Moore, John P ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(N,N DIMETHYL N (4 [[[2 (4 METHYLPHENYL) 6,7 DIHYDRO 5H BENZOCYCLOHEPTEN 8 YL]CARBON YL]AMINO]BENZYL) TETRAHYDRO 2H PYRAN 4 AMINIUM CHLORIDE; ANTIVIRUS AGENT; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS INHIBITION; VIRUS REPLICATION;

AMIDES; AMINO ACID SEQUENCE; ANIMALS; ANTI-HIV AGENTS; BINDING SITES; CD4-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; CHO CELLS; CRICETINAE; GENE PRODUCTS, ENV; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; KINETICS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MEMBRANE FUSION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, CCR5; RECOMBINANT PROTEINS; TRANSFECTION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034625144     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.090576697     Document Type: Article

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