Activation of the α(1b)-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint

Journal of Biological Chemistry

Volumn 271, Issue 45, 1996, Pages 28318-28323

  Porter, James E ^a   Hwa, John ^a,b   Perez, Dianne M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; ADRENALIN; ADRENERGIC RECEPTOR ALPHA(1B); ALPHA 1 ADRENERGIC RECEPTOR; GLUTAMIC ACID; INOSITOL PHOSPHATE; LYSINE; METHOXAMINE; NORADRENALIN;

ADRENERGIC SYSTEM; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; COVALENT BOND; ENZYME ACTIVATION; GENE DISRUPTION; ISOMERISM; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FAMILY; SITE DIRECTED MUTAGENESIS; ANIMAL; CELL STRAIN COS1; DRUG EFFECT; GENETICS; HAMSTER; METABOLISM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

ANIMALS; COS CELLS; CRICETINAE; EPINEPHRINE; GLUTAMIC ACID; INOSITOL PHOSPHATES; LYSINE; METHOXAMINE; MUTAGENESIS, SITE-DIRECTED; NOREPINEPHRINE; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029661256     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.45.28318     Document Type: Article

References (25)

1. Bylund, D. B. (1992) FASEB J. 6, 832-839
2. Minneman, K. P. (1988) Pharmacol Rev. 40, 87-119
3. Hwa, J., Graham, R. M., and Perez, D. M. (1995) J. Biol Chem. 270, 23189-23195
4. Piascik, M. T., Guarino, R. D., Smith, M. S., Soltis, E. E., Saussy, D. L., Jr., and Perez, D. M. (1995) J. Pharmacol. Exp. Ther. 275, 1583-1589
5. Abel, P. W., Zeng, W., Porter, J. E., Scofield, M. A., Liu, F., Gonzalez-Cabrera, I., Dowd, F. J., and Jeffries, W. B. (1995) Pharmacol. Commun. 6, 29-38
6. Cotecchia, S., Schwinn, D. A., Randall, R. R., Lefkowitz, R. J., Caron, M. G., and Kobilka, B. K. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7159-7163
7. Perez, D. M., Piascik, M. T., and Graham, R. M. (1991) Mol. Pharmacol. 40, 876-883
8. Perez, D. M., Piascik, M. T., Malik, N., Gaivin, R., and Graham, R. M. (1994) Mol. Pharmacol. 46, 823-831
9. Ruffolo, R. R., Jr., Nichols, A. J., Stadel, J. M., and Hieble, J. P. (1991) Pharmacol. Rev. 43, 475-505
10. Hwa, J., DeYoung, M., Perez, D. M., and Graham, R. M. (1996) in The Autonomic Nervous System: The Nervous Control of the Heart (Shepherd, J., and Vatner, S. F., eds) Vol. VIII, pp. 49-77, Harwood Academic Press
11. Robinson, P. R., Cohen, G. B., Zhukovsky, E. A., and Oprian, D. D. (1992) Neuron 9, 719-725
12. Kjelsberg, M. A., Cotecchia, S., Ostrowski, J., Caron, M. G., and Lefkowitz, R. J. (1992) J. Biol. Chem. 267, 1430-1433
13. Samama, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 4625-4636
14. Perez, D. M., Hwa, J., Gaivin, R., Mathur, M., Brown, F., and Graham, R. M. (1996) Mol. Pharmacol. 49, 112-122
15. Strader, C. D., Fong, T. M., Tota, M. R., Underwood, D., and Dixon, R. A. F. (1994) Annu. Rev. Biochem. 63, 101-132
16. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., pp. 15.51-15.71, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
17. Multulsky, H. J., and Ransnas, L. A. (1987) FASEB J. 1, 365-374
18. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
19. Wang, C.-D., Buck, M. A., and Fraser, C. M. (1991) Mol. Pharmacol. 40, 168-179
20. Strader, C. D., Gaffney, T., Sugg, E. E., Candelore, M. R., Keys, R., Patchett, A. A., and Dixon, R. A. F. (1991) J. Biol. Chem. 266, 5-8
21. Ho, B. Y., Karschin, A., Branchek, T., Davidson, N., and Lester, H. A. (1992) FEBS Lett. 312, 259-262
22. Farahbakhsh, Z. T., Ridge, K. D., Khorana, H. G., and Hubbell, W. L. (1995) Biochemistry 34, 8812-8819
23. Hwa, J., and Perez, D. M. (1996) J. Biol. Chem. 271, 6322-6327
24. Kenakin, T. (1995) Trends Pharmacol. Sci. 16, 188-192
25. Hwa, J., Graham, R. M., and Perez, D. M. (1996) J. Biol. Chem. 271, 7956-7964