β2 adrenergic receptor activation: Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

Journal of Biological Chemistry

Volumn 277, Issue 43, 2002, Pages 40989-40996

  Shi, Lei ^a,b   Liapakis, George ^a   Xu, Rui ^a,b   Guarnieri, Frank ^d,e   Ballesteros, Juan A ^c   Javitch, Jonathan A ^a,e  

^a Center for Molecular Recognition   (United States)

^b College of Physicians and Surgeons ^*  (United States)

^c SARNOFF CORPORATION   (United States)

^d Novasite Pharmaceuticals Inc   (United States)

^e UNIVERSITY OF CRETE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; MONTE CARLO METHODS;

RECEPTOR ACTIVATION;

PROTEINS;

BETA 2 ADRENERGIC RECEPTOR; PROLINE; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYSTEINE; PROPANOLAMINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MODULATION; MONTE CARLO METHOD; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; KINETICS; METABOLISM; PROTEIN CONFORMATION;

ADRENERGIC BETA-ANTAGONISTS; CELL LINE; CYSTEINE; HUMANS; KINETICS; MODELS, MOLECULAR; PROLINE; PROPANOLAMINES; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2;

EID: 0037174606     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206801200     Document Type: Article

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