Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations

Journal of Biological Chemistry

Volumn 277, Issue 39, 2002, Pages 36577-36584

  Ebersole, Barbara J ^a,b,c   Weinstein, Harel ^a,b,c   Sealfon, Stuart C ^a,b,c  

^a Cassandra Prioleau   (United States)

^b Department of Neurology ^*  (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; PROTEINS; SIGNALING;

MUTATIONS;

BIOCHEMISTRY;

G PROTEIN COUPLED RECEPTOR; RHODOPSIN; SEROTONIN 2C RECEPTOR; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVERTANT; SIGNAL TRANSDUCTION; WILD TYPE;

AMINO ACID MOTIFS; ANIMALS; COS CELLS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INDOLES; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTATION; PHENOTYPE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SOFTWARE; TIME FACTORS; TRANSFECTION; TYROSINE;

EID: 0037184031     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206223200     Document Type: Article

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