Mutational and computational analysis of the α 1b-adrenergic receptor: Involvement of basic and hydrophobic residues in receptor activation and G protein coupling

Journal of Biological Chemistry

Volumn 276, Issue 49, 2001, Pages 46485-46494

  Greasley, Peter J ^a   Fanelli, Francesca ^b   Scheer, Alexander ^c   Abuin, Liliane ^a   Nenniger Tosato, Monique ^a   DeBenedetti, Pier G ^b   Cotecchia, Susanna ^d  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

^d University of Lausanne Departement de Pharmacologie et de Toxicologie   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CRYSTAL STRUCTURE; MOLECULAR BIOLOGY; NUMERICAL ANALYSIS; PROTEINS;

RECEPTOR COUPLINGS;

BIOCHEMISTRY;

ADRENALIN; ALPHA 1B ADRENERGIC RECEPTOR; AMINO ACID DERIVATIVE; ARGININE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; LEUCINE; LIGAND; LYSINE; RHODOPSIN; VALINE; ADRENERGIC RECEPTOR ALPHA(1B); ALPHA 1 ADRENERGIC RECEPTOR; GTP BINDING PROTEINS; RECEPTORS, ADRENERGIC, ALPHA 1;

AB INITIO CALCULATION; ADRENERGIC SYSTEM; AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CRYSTAL STRUCTURE; CYTOSOL; GENE MUTATION; GENETIC CONSERVATION; HYDROPHOBICITY; HYPOTHESIS; INTRACELLULAR TRANSPORT; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROCESS MONITORING; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING; RECEPTOR UPREGULATION; RESIDUE ANALYSIS; SEQUENCE HOMOLOGY; SURFACE PROPERTY; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; CELL STRAIN COS1; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HAMSTER; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMAL; COS CELLS; GTP-BINDING PROTEINS; HAMSTERS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, ALPHA-1; SUPPORT, NON-U.S. GOV'T;

EID: 0035824582     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105791200     Document Type: Article

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