Agonist-induced Conformational Changes at the Cytoplasmic Side of Transmembrane Segment 6 in the β2 Adrenergic Receptor Mapped by Site-selective Fluorescent Labeling

Journal of Biological Chemistry

Volumn 276, Issue 12, 2001, Pages 9279-9290

  Jensen, Anne Dam ^a,d   Guarnieri, Frank ^b   Rasmussen, Søren G F ^a   Asmar, Fazila ^a   Ballesteros, Juan A ^b,c   Gether, Ulrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Novasite Pharmaceuticals Inc   (United States)

^d Maxygen APS   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; COMPUTATIONAL METHODS; CONFORMATIONS; FLUORESCENCE; HORMONES; HYDROPHOBICITY; MUTAGENESIS; PROTEINS; SPECTROSCOPIC ANALYSIS;

FLUORESCENCE SPECTROSCOPY; POLAR ENVIRONMENT;

BIOCHEMISTRY;

BETA 2 ADRENERGIC RECEPTOR; CYSTEINE; FLUORESCENT DYE; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; LIGAND; N,N' DIMETHYL N (IODOACETYL) N' (7 NITROBENZ 2 OXA 1,3 DIAZOL 4 YL)ETHYLENEDIAMINE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; 4 (N (IODOACETOXY)ETHYL N METHYL)AMINO 7 NITROBENZ 2 OXA 1,3 DIAZOLE; 4-(N-(IODOACETOXY)ETHYL-N-METHYL)AMINO-7-NITROBENZ-2-OXA-1,3-DIAZOLE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; OXADIAZOLE DERIVATIVE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BILAYER MEMBRANE; BINDING AFFINITY; BINDING ASSAY; CALCULATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COVALENT BOND; DOSE RESPONSE; FLUORESCENCE SPECTROSCOPY; GENE INSERTION; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CYTOPLASM; DRUG EFFECT; KINETICS; MOLECULAR GENETICS; PROTEIN CONFORMATION; SPECTROFLUOROMETRY;

ANIMALIA; INSERTION SEQUENCES;

ADRENERGIC BETA-AGONISTS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXADIAZOLES; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; SPECTROMETRY, FLUORESCENCE;

EID: 0035937786     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M004871200     Document Type: Article

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