메뉴 건너뛰기




Volumn 53, Issue 2, 2001, Pages 245-282

Proteinase-activated receptors

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; THROMBIN RECEPTOR;

EID: 0035019636     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1101)

References (430)
  • 2
    • 0032795986 scopus 로고    scopus 로고
    • Modulation of osteoblast-like-cell behavior by activation of protease activated receptor-1
    • Abraham LA and Mackie EJ (1999) Modulation of osteoblast-like-cell behavior by activation of protease activated receptor-1. J Bone Miner Res 14:1320-1329.
    • (1999) J Bone Miner Res , vol.14 , pp. 1320-1329
    • Abraham, L.A.1    Mackie, E.J.2
  • 5
    • 0034670162 scopus 로고    scopus 로고
    • Inhibition of cellular action of thrombin by N3-cyclopropyl-7-([4-(1-methylethyl-)phenyl]methyl)-7H-pyrrolo[3,2-f] quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist
    • Ahn HS, Foster C, Boykow G, Stamford A, Manna M and Graziano M (2000) Inhibition of cellular action of thrombin by N3-cyclopropyl-7-([4-(1-methylethyl-)phenyl]methyl)-7H-pyrrolo[3,2-f] quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem Pharmacol 60:1425-1434.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1425-1434
    • Ahn, H.S.1    Foster, C.2    Boykow, G.3    Stamford, A.4    Manna, M.5    Graziano, M.6
  • 7
    • 0028825940 scopus 로고
    • Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle
    • Al-Ani B, Saifeddine M and Hollenberg MD (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol 73:1203-1207.
    • (1995) Can J Physiol Pharmacol , vol.73 , pp. 1203-1207
    • Al-Ani, B.1    Saifeddine, M.2    Hollenberg, M.D.3
  • 8
    • 0032712580 scopus 로고    scopus 로고
    • Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation
    • Al-Ani B, Saifeddine M, Kawabata A and Hollenberg MD (1999) Proteinase activated receptor 2: role of extracellular loop 2 for ligand-mediated activation. Br J Pharmacol 128:1105-1113.
    • (1999) Br J Pharmacol , vol.128 , pp. 1105-1113
    • Al-Ani, B.1    Saifeddine, M.2    Kawabata, A.3    Hollenberg, M.D.4
  • 10
    • 0031764439 scopus 로고    scopus 로고
    • A comparative SAR study of thrombin receptor derived non peptide mimetics: Importance of phenyl/guanidino proximity for activity
    • Alexopoulos K, Matsoukas J, Tselios T, Roumelioti P, Mavromoustakos T and Holada K (1998) A comparative SAR study of thrombin receptor derived non peptide mimetics: importance of phenyl/guanidino proximity for activity. Amino Acids 15:211-220.
    • (1998) Amino Acids , vol.15 , pp. 211-220
    • Alexopoulos, K.1    Matsoukas, J.2    Tselios, T.3    Roumelioti, P.4    Mavromoustakos, T.5    Holada, K.6
  • 11
  • 13
    • 0033613269 scopus 로고    scopus 로고
    • Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity
    • Andersen H, Greenberg DL, Fujikawa K, Xu WF, Chung DW and Davie EW (1999) Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci USA 96:11189-11193.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11189-11193
    • Andersen, H.1    Greenberg, D.L.2    Fujikawa, K.3    Xu, W.F.4    Chung, D.W.5    Davie, E.W.6
  • 15
    • 0028178065 scopus 로고
    • 2+ in the vascular contraction caused by a thrombin receptor activating peptide
    • 2+ in the vascular contraction caused by a thrombin receptor activating peptide. Eur J Pharmacol 256:37-44.
    • (1994) Eur J Pharmacol , vol.256 , pp. 37-44
    • Antonaccio, M.J.1    Normandin, D.2
  • 16
    • 0027517590 scopus 로고
    • Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth-muscle
    • Antonaccio MJ, Normandin D, Serafino R and Moreland S (1993) Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth-muscle. J Pharmacol Exp Ther 286:125-132.
    • (1993) J Pharmacol Exp Ther , vol.286 , pp. 125-132
    • Antonaccio, M.J.1    Normandin, D.2    Serafino, R.3    Moreland, S.4
  • 17
    • 0030779934 scopus 로고    scopus 로고
    • Divergence in the G-protein-coupled receptor mitogenic signalling pathway at the level of Raf kinase
    • Apostolidis A and Weiss RH (1997) Divergence in the G-protein-coupled receptor mitogenic signalling pathway at the level of Raf kinase. Cell Signalling 9:439-445.
    • (1997) Cell Signalling , vol.9 , pp. 439-445
    • Apostolidis, A.1    Weiss, R.H.2
  • 19
    • 0034142240 scopus 로고    scopus 로고
    • Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor
    • Azim AC, Barkalow K, Chou J and Hartwig JH (2000) Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor. Blood 95:959-964
    • (2000) Blood , vol.95 , pp. 959-964
    • Azim, A.C.1    Barkalow, K.2    Chou, J.3    Hartwig, J.H.4
  • 20
    • 0025091784 scopus 로고
    • Thrombin stimulates inositol phosphate production and intracellular free calcium by a pertussis toxin-insensitive mechanism in osteosarcoma cells
    • Babich M, King KL and Nissenson RA (1990) Thrombin stimulates inositol phosphate production and intracellular free calcium by a pertussis toxin-insensitive mechanism in osteosarcoma cells. Endocrinology 126:948-954.
    • (1990) Endocrinology , vol.126 , pp. 948-954
    • Babich, M.1    King, K.L.2    Nissenson, R.A.3
  • 21
    • 0031044094 scopus 로고    scopus 로고
    • Alpha-thrombin induces transforming growth factor-beta(1) mRNA and protein in cultured vascular smooth muscle cells via a proteolytically activated receptor
    • Bachhuber BG, Sarembock IJ, Gimple LW and Owens GK (1997) Alpha-thrombin induces transforming growth factor-beta(1) mRNA and protein in cultured vascular smooth muscle cells via a proteolytically activated receptor. J Vascular Res 34:41-48.
    • (1997) J Vascular Res , vol.34 , pp. 41-48
    • Bachhuber, B.G.1    Sarembock, I.J.2    Gimple, L.W.3    Owens, G.K.4
  • 22
    • 0028237885 scopus 로고
    • G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts
    • Baffy G, Yang L, Raj S, Manning DR and Williamson JR (1994) G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts. J Biol Chem 269: 8483-8487.
    • (1994) J Biol Chem , vol.269 , pp. 8483-8487
    • Baffy, G.1    Yang, L.2    Raj, S.3    Manning, D.R.4    Williamson, J.R.5
  • 23
    • 0030731075 scopus 로고    scopus 로고
    • The human thrombin receptor gene and the 5q-syndrome
    • Bahou WF and Demetrick DJ (1997) The human thrombin receptor gene and the 5q-syndrome. Leukemia & Lymphoma 27:1-10.
    • (1997) Leukemia & Lymphoma , vol.27 , pp. 1-10
    • Bahou, W.F.1    Demetrick, D.J.2
  • 24
    • 0027983873 scopus 로고
    • Identification of a novel thrombin receptor sequence required for activation-dependent responses
    • Bahou WF, Kutok JL, Wong A, Potter CL and Coller BS (1994) Identification of a novel thrombin receptor sequence required for activation-dependent responses. Blood 84:4195-4202.
    • (1994) Blood , vol.84 , pp. 4195-4202
    • Bahou, W.F.1    Kutok, J.L.2    Wong, A.3    Potter, C.L.4    Coller, B.S.5
  • 25
    • 0023932998 scopus 로고
    • Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Effects on thrombin-mediated responses
    • Banga HS, Walker RK, Winberry LK and Rittenhouse SE (1988) Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Effects on thrombin-mediated responses. Biochem J 252:297-300.
    • (1988) Biochem J , vol.252 , pp. 297-300
    • Banga, H.S.1    Walker, R.K.2    Winberry, L.K.3    Rittenhouse, S.E.4
  • 27
    • 0021091174 scopus 로고
    • Receptor-mediated chemotactic response of a macrophage cell line (J774) to thrombin
    • Bar-Shavit R, Kahn A, Fenton JWD and Wilner GD (1983) Receptor-mediated chemotactic response of a macrophage cell line (J774) to thrombin. Lab Invest 49:702-707.
    • (1983) Lab Invest , vol.49 , pp. 702-707
    • Bar-Shavit, R.1    Kahn, A.2    Fenton, J.W.D.3    Wilner, G.D.4
  • 28
    • 0027533213 scopus 로고
    • Thrombin regulates tissue factor and thrombomodulin messenger-RNA levels and activities in human saphenous-vein endothelial-cells by distinct mechanisms
    • Bartha K, Brisson C, Archipoff G, DeLasalle C, Lanza F, Cazenave JP and Beretz A (1993) Thrombin regulates tissue factor and thrombomodulin messenger-RNA levels and activities in human saphenous-vein endothelial-cells by distinct mechanisms. J Biol Chem 268:421-429.
    • (1993) J Biol Chem , vol.268 , pp. 421-429
    • Bartha, K.1    Brisson, C.2    Archipoff, G.3    DeLasalle, C.4    Lanza, F.5    Cazenave, J.P.6    Beretz, A.7
  • 30
    • 0028085095 scopus 로고
    • Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture
    • Beecher KL, Andersen TT, Fenton JW and Festoff BW (1994) Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture. J Neurosci Res 37:108-115.
    • (1994) J Neurosci Res , vol.37 , pp. 108-115
    • Beecher, K.L.1    Andersen, T.T.2    Fenton, J.W.3    Festoff, B.W.4
  • 31
  • 32
    • 0030894524 scopus 로고    scopus 로고
    • Evidence that thrombin-stimulated DNA synthesis in pulmonary arterial fibroblasts involves phosphatidylinositol 3-kinase-dependent p70 ribosomal S6 kinase activation
    • Belham CM, Scott PH, Twomey DP, Gould GW, Wadsworth RM and Plevin R (1997) Evidence that thrombin-stimulated DNA synthesis in pulmonary arterial fibroblasts involves phosphatidylinositol 3-kinase-dependent p70 ribosomal S6 kinase activation. Cell Signalling 9:109-116.
    • (1997) Cell Signalling , vol.9 , pp. 109-116
    • Belham, C.M.1    Scott, P.H.2    Twomey, D.P.3    Gould, G.W.4    Wadsworth, R.M.5    Plevin, R.6
  • 39
    • 0022470963 scopus 로고
    • Thrombin-induced chemotaxis and aggregation of neutrophils
    • Bizios R, Lai L, Fenton JWD and Malik AB (1986) Thrombin-induced chemotaxis and aggregation of neutrophils. J Cell Physiol 128:485-490.
    • (1986) J Cell Physiol , vol.128 , pp. 485-490
    • Bizios, R.1    Lai, L.2    Fenton, J.W.D.3    Malik, A.B.4
  • 41
    • 0028045033 scopus 로고
    • Clinical features and molecular characteristics of alpha-1-antitrypsin deficiency
    • Blank CA and Brantly M (1994) Clinical features and molecular characteristics of alpha-1-antitrypsin deficiency. Ann Allergy 72:105-121.
    • (1994) Ann Allergy , vol.72 , pp. 105-121
    • Blank, C.A.1    Brantly, M.2
  • 42
    • 0031059468 scopus 로고    scopus 로고
    • Mechanisms attenuating signaling by G-protein coupled receptors
    • Bohm S, Grady E and Bunnett NW (1997) Mechanisms attenuating signaling by G-protein coupled receptors. Biochem J 322:1-18.
    • (1997) Biochem J , vol.322 , pp. 1-18
    • Bohm, S.1    Grady, E.2    Bunnett, N.W.3
  • 43
    • 0029786481 scopus 로고    scopus 로고
    • Mechanisms of desensitization and resensitization of proteinase-activated receptor-2
    • Bohm SK, Khitin LM, Grady EF, Aponte G, Payan DG and Bunnett NW (1996a) Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J Biol Chem 271:22003-22012.
    • (1996) J Biol Chem , vol.271 , pp. 22003-22012
    • Bohm, S.K.1    Khitin, L.M.2    Grady, E.F.3    Aponte, G.4    Payan, D.G.5    Bunnett, N.W.6
  • 45
    • 0031590860 scopus 로고    scopus 로고
    • Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2)
    • Bono F, Lamarche I and Herbert JM (1997) Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2). Biochem Biophys Res Commun 241:762-764.
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 762-764
    • Bono, F.1    Lamarche, I.2    Herbert, J.M.3
  • 46
    • 0028797819 scopus 로고
    • Thrombin interaction with a recombinant N-terminal extracellular domain of the thrombin receptor in an acellular system
    • Bouton MC, Jandrotperrus M, Moog S, Cazenave JP, Guillin MC and Lanza F (1995) Thrombin interaction with a recombinant N-terminal extracellular domain of the thrombin receptor in an acellular system. Biochem J 305:635-641.
    • (1995) Biochem J , vol.305 , pp. 635-641
    • Bouton, M.C.1    Jandrotperrus, M.2    Moog, S.3    Cazenave, J.P.4    Guillin, M.C.5    Lanza, F.6
  • 48
    • 0028111114 scopus 로고
    • Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling
    • Brass LF, Pizarro S, Ahuja M, Belmonte E, Blanchard N, Stadel JM and Hoxie JA (1994) Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling. J Biol Chem 269:2943-2952.
    • (1994) J Biol Chem , vol.269 , pp. 2943-2952
    • Brass, L.F.1    Pizarro, S.2    Ahuja, M.3    Belmonte, E.4    Blanchard, N.5    Stadel, J.M.6    Hoxie, J.A.7
  • 49
    • 0032955959 scopus 로고    scopus 로고
    • Evidence for proteinase-activated receptor-2 (PAR-2)-mediated mitogenesis in coronary artery smooth muscle cells
    • Bretschneider E, Kaufmann R, Braun M, Wittpoth M, Glusa E, Nowak G and Schror K (1999) Evidence for proteinase-activated receptor-2 (PAR-2)-mediated mitogenesis in coronary artery smooth muscle cells. Br J Pharmacol 126:1735-1740.
    • (1999) Br J Pharmacol , vol.126 , pp. 1735-1740
    • Bretschneider, E.1    Kaufmann, R.2    Braun, M.3    Wittpoth, M.4    Glusa, E.5    Nowak, G.6    Schror, K.7
  • 51
    • 0034624973 scopus 로고    scopus 로고
    • Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
    • Camerer E, Huang W and Coughlin SR (2000) Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad USA 97:5255-5260.
    • (2000) Proc Natl Acad USA , vol.97 , pp. 5255-5260
    • Camerer, E.1    Huang, W.2    Coughlin, S.R.3
  • 53
    • 0018235874 scopus 로고
    • Conditions which affect initiation of animal cell division by trypsin and thrombin
    • Carney DH, Glenn KC and Cunningham DD (1978) Conditions which affect initiation of animal cell division by trypsin and thrombin. J Cell Physiol 95:13-22.
    • (1978) J Cell Physiol , vol.95 , pp. 13-22
    • Carney, D.H.1    Glenn, K.C.2    Cunningham, D.D.3
  • 55
    • 0033694764 scopus 로고    scopus 로고
    • Trypsin-induced, neurokinin- Mediated contraction of guinea pig bronchus
    • Carr MJ, Schechter NM and Undem BJ (2000) Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus. Am J Respir Crit Care Med 162: 1662-1667.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 1662-1667
    • Carr, M.J.1    Schechter, N.M.2    Undem, B.J.3
  • 56
    • 0025255579 scopus 로고
    • Reciprocal modulation of astrocyte stellation by thrombin and protease nNexin-1
    • Cavanaugh KP, Gurwitz D, Cunningham DD and Bradshaw RA (1990) Reciprocal modulation of astrocyte stellation by thrombin and protease nNexin-1. J Neurochem 54:1735-1743.
    • (1990) J Neurochem , vol.54 , pp. 1735-1743
    • Cavanaugh, K.P.1    Gurwitz, D.2    Cunningham, D.D.3    Bradshaw, R.A.4
  • 57
    • 0033490425 scopus 로고    scopus 로고
    • Thrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies
    • Ceruso MA, McComsey DF, Leo GC, Andrade-Gordon P, Addo MF, Scarborough RM, Oksenberg D and Maryanoff BE (1999) Thrombin receptor-activating peptides (TRAPs): investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies. Bioorg Med Chem 7:2353-2371.
    • (1999) Bioorg Med Chem , vol.7 , pp. 2353-2371
    • Ceruso, M.A.1    McComsey, D.F.2    Leo, G.C.3    Andrade-Gordon, P.4    Addo, M.F.5    Scarborough, R.M.6    Oksenberg, D.7    Maryanoff, B.E.8
  • 58
    • 0032126368 scopus 로고    scopus 로고
    • Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1
    • Chambers RC, Dabbagh K, McAnulty RJ, Gray AJ, Blanc-Brude OP and Laurent GJ (1998) Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. Biochem J 333:121-127.
    • (1998) Biochem J , vol.333 , pp. 121-127
    • Chambers, R.C.1    Dabbagh, K.2    McAnulty, R.J.3    Gray, A.J.4    Blanc-Brude, O.P.5    Laurent, G.J.6
  • 59
    • 0026734601 scopus 로고
    • Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor
    • Chao BH, Kalkunte S, Maraganore JM and Stone SR (1992) Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor. Biochemistry 31:6175-6178.
    • (1992) Biochemistry , vol.31 , pp. 6175-6178
    • Chao, B.H.1    Kalkunte, S.2    Maraganore, J.M.3    Stone, S.R.4
  • 60
    • 0028364862 scopus 로고
    • Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode
    • Chen J, Ishii M, Wang L, Ishii K and Coughlin SR (1994a) Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. J Biol Chem 269: 16041-16045.
    • (1994) J Biol Chem , vol.269 , pp. 16041-16045
    • Chen, J.1    Ishii, M.2    Wang, L.3    Ishii, K.4    Coughlin, S.R.5
  • 61
    • 0016432831 scopus 로고
    • Mitogenic activity of blood components. I. Thrombin and prothrombin
    • Chen LB and Buchanan JM (1975) Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci USA 72:131-135.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 131-135
    • Chen, L.B.1    Buchanan, J.M.2
  • 62
    • 0017152878 scopus 로고
    • Mitogenicity of thrombin and surface alterations on mouse splenocytes
    • Chen LB, Teng NNH and Buchanan JM (1976) Mitogenicity of thrombin and surface alterations on mouse splenocytes. Exp Cell Res 101:41-46.
    • (1976) Exp Cell Res , vol.101 , pp. 41-46
    • Chen, L.B.1    Teng, N.N.H.2    Buchanan, J.M.3
  • 63
    • 0029915662 scopus 로고    scopus 로고
    • Functional expression of a human thrombin receptor in Sf9 insect cells: Evidence for an active tethered ligand
    • Chen X, Earley K, Luo W, Lin SH and Schilling WP (1996a) Functional expression of a human thrombin receptor in Sf9 insect cells: evidence for an active tethered ligand. Biochem J 314:603-611.
    • (1996) Biochem J , vol.314 , pp. 603-611
    • Chen, X.1    Earley, K.2    Luo, W.3    Lin, S.H.4    Schilling, W.P.5
  • 64
    • 0029964035 scopus 로고    scopus 로고
    • She adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor
    • Chen Y, Grall D, Salcini AE, Pelicci PG, Pouyssegur J and Van Obberghen-Schilling E (1996b) She adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. EMBO J 15:1037-1044.
    • (1996) EMBO J , vol.15 , pp. 1037-1044
    • Chen, Y.1    Grall, D.2    Salcini, A.E.3    Pelicci, P.G.4    Pouyssegur, J.5    Van Obberghen-Schilling, E.6
  • 65
    • 0027999621 scopus 로고
    • Activation of Sre family kinase-activity by the G-protein-coupled thrombin receptor in growth responsive fibroblasts
    • Chen YH, Pouyssegur J, Courtneidge SA and Van Obberghen-Schilling E (1994b) Activation of Sre family kinase-activity by the G-protein-coupled thrombin receptor in growth responsive fibroblasts. J Biol Chem 269:27372-27377.
    • (1994) J Biol Chem , vol.269 , pp. 27372-27377
    • Chen, Y.H.1    Pouyssegur, J.2    Courtneidge, S.A.3    Van Obberghen-Schilling, E.4
  • 66
    • 0032952353 scopus 로고    scopus 로고
    • Dual coupling of the alpha-thrombin receptor to signal-transduction pathways involving phosphatidylinositol and phosphatidylcholine metabolism
    • Cheng J, Baldassare JJ and Raben DM (1999) Dual coupling of the alpha-thrombin receptor to signal-transduction pathways involving phosphatidylinositol and phosphatidylcholine metabolism. Biochem J 337:97-104.
    • (1999) Biochem J , vol.337 , pp. 97-104
    • Cheng, J.1    Baldassare, J.J.2    Raben, D.M.3
  • 67
    • 0031919771 scopus 로고    scopus 로고
    • Receptor- Activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo
    • Cheung WM, Andrade-Gordon P, Derian CK and Damiano BP (1998) Receptor-activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo. Can J Physiol Pharmacol 76:16-25.
    • (1998) Can J Physiol Pharmacol , vol.76 , pp. 16-25
    • Cheung, W.M.1    Andrade-Gordon, P.2    Derian, C.K.3    Damiano, B.P.4
  • 69
    • 0025500410 scopus 로고
    • Protease nexin-1-localization in the human brain suggests a potective role against extravasated serine protreases
    • Choi BH, Suzuki M, Kim TS, Wagner SL and Cunningham DD (1990) Protease nexin-1-localization in the human brain suggests a potective role against extravasated serine protreases. Am J Pathol 137:741-747.
    • (1990) Am J Pathol , vol.137 , pp. 741-747
    • Choi, B.H.1    Suzuki, M.2    Kim, T.S.3    Wagner, S.L.4    Cunningham, D.D.5
  • 70
    • 0025506964 scopus 로고
    • TGF-beta and retinoic acid - Regulators of growth and modifiers of differentiation in human epidermal cells
    • Choi Y and Fuchs E (1990) TGF-beta and retinoic acid - regulators of growth and modifiers of differentiation in human epidermal cells. Cell Regul 1:791-809.
    • (1990) Cell Regul , vol.1 , pp. 791-809
    • Choi, Y.1    Fuchs, E.2
  • 71
    • 0029925581 scopus 로고    scopus 로고
    • Thrombin stimulates association of src homology domain containing adaptor protein Nck with pp125 (FAK)
    • Choudhury GG, Marra F and Abboud HE (1996) Thrombin stimulates association of src homology domain containing adaptor protein Nck with pp125 (FAK). Am J Physiol-Renal Fluid Electrolyte Physiol 39:F295-F300.
    • (1996) Am J Physiol-Renal Fluid Electrolyte Physiol , vol.39
    • Choudhury, G.G.1    Marra, F.2    Abboud, H.E.3
  • 72
    • 0034528452 scopus 로고    scopus 로고
    • Effect of protease-activated receptor (PAR)-1, -2 and -4- Activating peptides, thrombin and trypsin in rat isolated airways
    • Chow JM, Moffatt JD and Cocks TM (2000) Effect of protease-activated receptor (PAR)-1, -2 and -4-activating peptides, thrombin and trypsin in rat isolated airways. Br J Pharmacol 131:1584-1591.
    • (2000) Br J Pharmacol , vol.131 , pp. 1584-1591
    • Chow, J.M.1    Moffatt, J.D.2    Cocks, T.M.3
  • 74
    • 0026612304 scopus 로고
    • p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets
    • Cichowski K, McCormick F and Brugge JS (1992) p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. J Biol Chem 267:5025-5028.
    • (1992) J Biol Chem , vol.267 , pp. 5025-5028
    • Cichowski, K.1    McCormick, F.2    Brugge, J.S.3
  • 75
    • 0034746994 scopus 로고    scopus 로고
    • Alpha 1-antitrypsin deficiency biological answers to clinical questions
    • Coakley RJ, Taggart C, O'Neill S and McElvaney NG (2001) Alpha 1-antitrypsin deficiency biological answers to clinical questions. Am J Med Sci 321:33-41.
    • (2001) Am J Med Sci , vol.321 , pp. 33-41
    • Coakley, R.J.1    Taggart, C.2    O'Neill, S.3    McElvaney, N.G.4
  • 77
    • 0034161592 scopus 로고    scopus 로고
    • Protease-activated receptors: Sentries for inflammation?
    • Cocks TM and Moffatt JD (2000) Protease-activated receptors: sentries for inflammation? Trends Pharmacol Sci 21:103-108.
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 103-108
    • Cocks, T.M.1    Moffatt, J.D.2
  • 78
    • 4243952532 scopus 로고    scopus 로고
    • Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo
    • Cocks TM and Sobey CG (1998) Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo. FASEB J 12:5519.
    • (1998) FASEB J , vol.12 , pp. 5519
    • Cocks, T.M.1    Sobey, C.G.2
  • 79
    • 0032971765 scopus 로고    scopus 로고
    • Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle
    • Cocks TM, Sozzi V, Moffatt JD and Selemidis S (1999b) Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle. Gastroenterology 116:586-592.
    • (1999) Gastroenterology , vol.116 , pp. 586-592
    • Cocks, T.M.1    Sozzi, V.2    Moffatt, J.D.3    Selemidis, S.4
  • 80
    • 0027527732 scopus 로고
    • Substituting isoserine for serine in the thrombin receptor activation peptide SFLLRN confers resistance to aminopeptidase M-induced cleavage and inactivation
    • Coller BS, Springer KT, Scudder LE, Kutok JL, Ceruso M and Prestwich GD (1993) Substituting isoserine for serine in the thrombin receptor activation peptide SFLLRN confers resistance to aminopeptidase M-induced cleavage and inactivation. J Biol Chem 268:20741-20743.
    • (1993) J Biol Chem , vol.268 , pp. 20741-20743
    • Coller, B.S.1    Springer, K.T.2    Scudder, L.E.3    Kutok, J.L.4    Ceruso, M.5    Prestwich, G.D.6
  • 81
    • 0026459474 scopus 로고
    • Thrombin receptor activating peptides: Importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M
    • Coller BS, Ward P, Ceruso M, Scudder LE, Springer K, Kutok J and Prestwich GD (1992) Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M. Biochemistry 31:11713-11720.
    • (1992) Biochemistry , vol.31 , pp. 11713-11720
    • Coller, B.S.1    Ward, P.2    Ceruso, M.3    Scudder, L.E.4    Springer, K.5    Kutok, J.6    Prestwich, G.D.7
  • 82
    • 0029666415 scopus 로고    scopus 로고
    • G alpha (12) stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac
    • Collins LR, Minden A, Karin M and Brown JH (1996) G alpha (12) stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac. J Biol Chem 271:17349-17353.
    • (1996) J Biol Chem , vol.271 , pp. 17349-17353
    • Collins, L.R.1    Minden, A.2    Karin, M.3    Brown, J.H.4
  • 83
    • 0030612752 scopus 로고    scopus 로고
    • The G12 coupled thrombin receptor stimulates mitogenesis through the She SH2 domain
    • Collins LR, Ricketts WA, Olefsky JM and Brown JH (1997) The G12 coupled thrombin receptor stimulates mitogenesis through the She SH2 domain. Oncogene 15: 595-600.
    • (1997) Oncogene , vol.15 , pp. 595-600
    • Collins, L.R.1    Ricketts, W.A.2    Olefsky, J.M.3    Brown, J.H.4
  • 84
    • 0032529228 scopus 로고    scopus 로고
    • The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: Tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells
    • Compton SJ, Cairns JA, Holgate ST and Walls AF (1998) The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: Tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells. J Immunol 161:1939-1946.
    • (1998) J Immunol , vol.161 , pp. 1939-1946
    • Compton, S.J.1    Cairns, J.A.2    Holgate, S.T.3    Walls, A.F.4
  • 85
    • 0034671716 scopus 로고    scopus 로고
    • A polymorphic protease activated receptor-2 (PAR-2) displaying reduced sensitivity to trypsin and differential responses to par agonists
    • Compton SJ, Cairns JA, Palmer KJ, Al-Ani B, Hollenberg MD and Walls AF (2000) A polymorphic protease activated receptor-2 (PAR-2) displaying reduced sensitivity to trypsin and differential responses to par agonists. J Biol Chem 275:39207-39212.
    • (2000) J Biol Chem , vol.275 , pp. 39207-39212
    • Compton, S.J.1    Cairns, J.A.2    Palmer, K.J.3    Al-Ani, B.4    Hollenberg, M.D.5    Walls, A.F.6
  • 91
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin SR (2000) Thrombin signalling and protease-activated receptors. Nature (Lond) 407:258-264.
    • (2000) Nature (Lond) , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 92
    • 0031557653 scopus 로고    scopus 로고
    • Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase
    • Crouch MF (1997) Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase. Biochem Biophys Res Commun 233:193-199.
    • (1997) Biochem Biophys Res Commun , vol.233 , pp. 193-199
    • Crouch, M.F.1
  • 93
    • 0034614895 scopus 로고    scopus 로고
    • Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis
    • Cunningham MA, Rondeau E, Chen X, Coughlin SR, Holdsworth SR and Tipping PG (2000) Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med 191:455-461.
    • (2000) J Exp Med , vol.191 , pp. 455-461
    • Cunningham, M.A.1    Rondeau, E.2    Chen, X.3    Coughlin, S.R.4    Holdsworth, S.R.5    Tipping, P.G.6
  • 94
    • 0031935469 scopus 로고    scopus 로고
    • Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism
    • Dabbagh K, Laurent GJ, McAnulty RJ and Chambers RC (1998) Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism. Thromb Haemostasis 79:405-409.
    • (1998) Thromb Haemostasis , vol.79 , pp. 405-409
    • Dabbagh, K.1    Laurent, G.J.2    McAnulty, R.J.3    Chambers, R.C.4
  • 98
    • 0029890169 scopus 로고    scopus 로고
    • Activation of vascular thrombin receptors mediates cardiac response to alpha-thrombin in isolated, perfused guinea pig heart
    • Damiano BP, Mitchell JA, Cheung WM and Falotico R (1996b) Activation of vascular thrombin receptors mediates cardiac response to alpha-thrombin in isolated, perfused guinea pig heart. Am J Physiol-Heart Circ Physiol 39:H1585-H1596.
    • (1996) Am J Physiol-Heart Circ Physiol , vol.39
    • Damiano, B.P.1    Mitchell, J.A.2    Cheung, W.M.3    Falotico, R.4
  • 100
    • 0023001143 scopus 로고
    • Thrombin stimulates C-sis gene-expression in microvascular endothelial-cells
    • Daniel TO, Gibbs VC, Milfay DF, Garovoy MR and Williams LT (1986) Thrombin stimulates C-sis gene-expression in microvascular endothelial-cells. J Biol Chem 261:9579-9582.
    • (1986) J Biol Chem , vol.261 , pp. 9579-9582
    • Daniel, T.O.1    Gibbs, V.C.2    Milfay, D.F.3    Garovoy, M.R.4    Williams, L.T.5
  • 101
    • 0031777293 scopus 로고    scopus 로고
    • Thrombin promotes platelet- Mediated melanoma cell adhesion to endothelial cells under flow conditions: Role of platelet glycoproteins P-selectin and GPIIb-IIIA
    • Dardik R, Savion N, Kaufmann Y and Varon D (1998) Thrombin promotes platelet-mediated melanoma cell adhesion to endothelial cells under flow conditions: role of platelet glycoproteins P-selectin and GPIIb-IIIA. Br J Cancer 77:2069-2075.
    • (1998) Br J Cancer , vol.77 , pp. 2069-2075
    • Dardik, R.1    Savion, N.2    Kaufmann, Y.3    Varon, D.4
  • 103
    • 0014191175 scopus 로고
    • Actions of thrombin and other coagulant and proteolytic enzymes on blood platelets
    • Davey MG and Luscher EF (1967) Actions of thrombin and other coagulant and proteolytic enzymes on blood platelets. Nature (Lond) 216:857-858.
    • (1967) Nature (Lond) , vol.216 , pp. 857-858
    • Davey, M.G.1    Luscher, E.F.2
  • 104
    • 0026337077 scopus 로고
    • The coagulation cascade - Initiation, maintenance, and regulation
    • Davie EW, Fujikawa K and Kisiel W (1991) The coagulation cascade - initiation, maintenance, and regulation. Biochemistry 80:10363-10370.
    • (1991) Biochemistry , vol.80 , pp. 10363-10370
    • Davie, E.W.1    Fujikawa, K.2    Kisiel, W.3
  • 105
    • 0026499863 scopus 로고
    • The pathological spectrum of the nephropathy associated with alpha-1-antitrypsin deficiency
    • Davis ID, Burke B, Freese D, Sharp HL and Kim YK (1992) The pathological spectrum of the nephropathy associated with alpha-1-antitrypsin deficiency. Hum Pathol 23:07-62.
    • (1992) Hum Pathol , vol.23 , pp. 7-62
    • Davis, I.D.1    Burke, B.2    Freese, D.3    Sharp, H.L.4    Kim, Y.K.5
  • 106
    • 0031004161 scopus 로고    scopus 로고
    • Pharmacological characterization of protease-activated receptor (PAR-1) in rat astrocytes
    • Debeir T, Vige X and Benavides J (1997) Pharmacological characterization of protease-activated receptor (PAR-1) in rat astrocytes. Eur J Pharmacol 323:111-117.
    • (1997) Eur J Pharmacol , vol.323 , pp. 111-117
    • Debeir, T.1    Vige, X.2    Benavides, J.3
  • 107
    • 0026582531 scopus 로고
    • Synergism between the contractile effect of epidermal growth factor and that of Des-Arg9-bradykinin or of alpha-thrombin in rabbit aortic rings
    • Deblois D, Drapeau G, Petitclerc E and Marceau F (1992) Synergism between the contractile effect of epidermal growth factor and that of Des-Arg9-bradykinin or of alpha-thrombin in rabbit aortic rings. Br J Pharmacol 105:959-967.
    • (1992) Br J Pharmacol , vol.105 , pp. 959-967
    • Deblois, D.1    Drapeau, G.2    Petitclerc, E.3    Marceau, F.4
  • 108
    • 0033850541 scopus 로고    scopus 로고
    • Mechanisms of initiation and termination of signalling by neuropeptide receptors: A comparison with the proteinase-activated receptors
    • DeFea K, Schmidlin F, Dery O, Grady EF and Bunnett NW (2000a) Mechanisms of initiation and termination of signalling by neuropeptide receptors: a comparison with the proteinase-activated receptors. Biochem Soc Trans 28:419-426.
    • (2000) Biochem Soc Trans , vol.28 , pp. 419-426
    • DeFea, K.1    Schmidlin, F.2    Dery, O.3    Grady, E.F.4    Bunnett, N.W.5
  • 109
    • 0034689003 scopus 로고    scopus 로고
    • Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
    • DeFea KA, Zalevsky J, Thoma MS, Dery O, Mullins RD and Bunnett NW (2000b) Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 148:1267-1281.
    • (2000) J Cell Biol , vol.148 , pp. 1267-1281
    • DeFea, K.A.1    Zalevsky, J.2    Thoma, M.S.3    Dery, O.4    Mullins, R.D.5    Bunnett, N.W.6
  • 110
    • 0030034469 scopus 로고    scopus 로고
    • G-protein coupled and tyrosine kinase receptors: Evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells
    • Delafontaine P, Anwar A, Lou H and Ku L (1996) G-protein coupled and tyrosine kinase receptors: evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells. J Clin Invest 97:139-145.
    • (1996) J Clin Invest , vol.97 , pp. 139-145
    • Delafontaine, P.1    Anwar, A.2    Lou, H.3    Ku, L.4
  • 111
    • 0026317444 scopus 로고
    • Function of glycoprotein Ib-alpha in platelet activation induced by alpha-thrombin
    • Demarco L, Mazzucato M, Masotti A, Fenton JW and Ruggeri ZM (1991) Function of glycoprotein Ib-alpha in platelet activation induced by alpha-thrombin. J Biol Chem 266:23776-23783.
    • (1991) J Biol Chem , vol.266 , pp. 23776-23783
    • Demarco, L.1    Mazzucato, M.2    Masotti, A.3    Fenton, J.W.4    Ruggeri, Z.M.5
  • 112
    • 0028181751 scopus 로고
    • Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib- Alpha
    • Demarco L, Mazzucato M, Masotti A and Ruggeri ZM (1994) Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib-alpha. J Biol Chem 269:6478-6484.
    • (1994) J Biol Chem , vol.269 , pp. 6478-6484
    • Demarco, L.1    Mazzucato, M.2    Masotti, A.3    Ruggeri, Z.M.4
  • 113
    • 0030059710 scopus 로고    scopus 로고
    • The thrombin receptor gene is centromeric to the common proximal breakpoint in patients with the 5q-syndrome: Identification of a previously unrecognized chromosome 5 inversion
    • Demetrick DJ, Dewald GW, Lanman J and Bahou WF (1996) The thrombin receptor gene is centromeric to the common proximal breakpoint in patients with the 5q-syndrome: identification of a previously unrecognized chromosome 5 inversion. Br J Haematol 92:339-343.
    • (1996) Br J Haematol , vol.92 , pp. 339-343
    • Demetrick, D.J.1    Dewald, G.W.2    Lanman, J.3    Bahou, W.F.4
  • 114
    • 0030741952 scopus 로고    scopus 로고
    • Differential regulation of human keratinocyte growth and differentiation by a novel family of protease- Activated receptors
    • Derian CK, Eckardt AJ and Andrade-Gordon P (1997) Differential regulation of human keratinocyte growth and differentiation by a novel family of protease-activated receptors. Cell Growth Differen 8:743-749.
    • (1997) Cell Growth Differen , vol.8 , pp. 743-749
    • Derian, C.K.1    Eckardt, A.J.2    Andrade-Gordon, P.3
  • 115
    • 0031744875 scopus 로고    scopus 로고
    • Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
    • Dery O, Corvera CU, Steinhoff M and Bunnett NW (1998) Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol-Cell Physiol 43:C1429-C1452.
    • (1998) Am J Physiol-Cell Physiol , vol.43
    • Dery, O.1    Corvera, C.U.2    Steinhoff, M.3    Bunnett, N.W.4
  • 116
    • 0039843091 scopus 로고    scopus 로고
    • Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein-beta-arrestin-dependent endocytosis of a proteinase receptor
    • Dery O, Thoma MS, Wong H, Grady EF and Bunnett NW (1999) Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein-beta-arrestin-dependent endocytosis of a proteinase receptor. J Biol Chem 274:18524-18535.
    • (1999) J Biol Chem , vol.274 , pp. 18524-18535
    • Dery, O.1    Thoma, M.S.2    Wong, H.3    Grady, E.F.4    Bunnett, N.W.5
  • 117
    • 0015879483 scopus 로고
    • Kinetics of the thrombin-induced release of adenosine triphosphate by platelets. Comparison with release of calcium
    • Detwiler TC and Feinman RD (1973) Kinetics of the thrombin-induced release of adenosine triphosphate by platelets. Comparison with release of calcium. Biochemistry 12:2462-2468.
    • (1973) Biochemistry , vol.12 , pp. 2462-2468
    • Detwiler, T.C.1    Feinman, R.D.2
  • 118
    • 0030960071 scopus 로고    scopus 로고
    • Role of glycoprotein V in the formation of the platelet high-affinity thrombin-binding site
    • Dong JF, SaeTung G and Lopez JA (1997) Role of glycoprotein V in the formation of the platelet high-affinity thrombin-binding site. Blood 89:4355-4363.
    • (1997) Blood , vol.89 , pp. 4355-4363
    • Dong, J.F.1    SaeTung, G.2    Lopez, J.A.3
  • 119
    • 16944366731 scopus 로고    scopus 로고
    • Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and Rhoa activities
    • Donovan FM, Pike CJ, Cotman CW and Cunningham DD (1997) Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci 17:5316-5326.
    • (1997) J Neurosci , vol.17 , pp. 5316-5326
    • Donovan, F.M.1    Pike, C.J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 122
    • 0034128648 scopus 로고    scopus 로고
    • Stratum corneum tryptic enzyme in normal epidermis: A missing link in the desquamation process?
    • Ekholm IE, Brattsand M and Egelrud T (2000) Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process? J Invest Dermatol 114:56-63.
    • (2000) J Invest Dermatol , vol.114 , pp. 56-63
    • Ekholm, I.E.1    Brattsand, M.2    Egelrud, T.3
  • 123
    • 0033579967 scopus 로고    scopus 로고
    • Photoactivatable peptides based on BMS-197525: A potent antagonist of the human thrombin receptor (PAR-1)
    • Elliott JT, Hoekstra WJ, Maryanoff BE and Prestwich GD (1999) Photoactivatable peptides based on BMS-197525: a potent antagonist of the human thrombin receptor (PAR-1). Bioorg Med Chem Lett 9:279-284.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 279-284
    • Elliott, J.T.1    Hoekstra, W.J.2    Maryanoff, B.E.3    Prestwich, G.D.4
  • 124
    • 0032953866 scopus 로고    scopus 로고
    • Time course of recovery of endothelial cell surface thrombin receptor (PAR-1) expression
    • Ellis CA, Tiruppathi C, Sandoval R, Niles WD and Malik AB (1999) Time course of recovery of endothelial cell surface thrombin receptor (PAR-1) expression. Am J Physiol 276:C38-45.
    • (1999) Am J Physiol , vol.276
    • Ellis, C.A.1    Tiruppathi, C.2    Sandoval, R.3    Niles, W.D.4    Malik, A.B.5
  • 126
    • 0032555506 scopus 로고    scopus 로고
    • Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells
    • Essler M, Amano M, Kruse HJ, Kaibuchi K, Weber PC and Aepfelbacher M (1998) Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells. J Biol Chem 273:21867-21874.
    • (1998) J Biol Chem , vol.273 , pp. 21867-21874
    • Essler, M.1    Amano, M.2    Kruse, H.J.3    Kaibuchi, K.4    Weber, P.C.5    Aepfelbacher, M.6
  • 128
    • 0034733558 scopus 로고    scopus 로고
    • Structure- Function analysis of protease-activated receptor 4 tethered ligand peptides - determinants of specificity and utility in assays of receptor function
    • Faruqi TR, Weiss EJ, Shapiro MJ, Huang W and Coughlin SR (2000) Structure-function analysis of protease-activated receptor 4 tethered ligand peptides - determinants of specificity and utility in assays of receptor function. J Biol Chem 275:19728-19734.
    • (2000) J Biol Chem , vol.275 , pp. 19728-19734
    • Faruqi, T.R.1    Weiss, E.J.2    Shapiro, M.J.3    Huang, W.4    Coughlin, S.R.5
  • 129
    • 0028068960 scopus 로고
    • A Chinese hamster fibroblast mutant defective in thrombin-induced signaling has a low level of phospholipase C-beta 1
    • Fee JA, Monsey JD, Handler RJ, Leonis MA, Mullaney SR, Hope HM and Silbert DF (1984) A Chinese hamster fibroblast mutant defective in thrombin-induced signaling has a low level of phospholipase C-beta 1. J Biol Chem 269:21699-21708.
    • (1984) J Biol Chem , vol.269 , pp. 21699-21708
    • Fee, J.A.1    Monsey, J.D.2    Handler, R.J.3    Leonis, M.A.4    Mullaney, S.R.5    Hope, H.M.6    Silbert, D.F.7
  • 133
    • 0032828541 scopus 로고    scopus 로고
    • Rapid release of matrix metalloproteinaae (MMP)-2 by thrombin in the rat aorta: Modulation by protein tyrosine kinase/phosphatase
    • Fernandez-Patron C, Zhang YL, Radomski MN, Hollenberg MD and Davidge ST (1999) Rapid release of matrix metalloproteinaae (MMP)-2 by thrombin in the rat aorta: modulation by protein tyrosine kinase/phosphatase. Thromb Haemostasis 82:1353-1357.
    • (1999) Thromb Haemostasis , vol.82 , pp. 1353-1357
    • Fernandez-Patron, C.1    Zhang, Y.L.2    Radomski, M.N.3    Hollenberg, M.D.4    Davidge, S.T.5
  • 134
    • 0026333506 scopus 로고
    • Alpha-1 antitrypsin deficiency and systemic necrotizing vasculitis
    • Fortin PR, Fraser RS, Watts CS and Esdaile JM (1991) Alpha-1 antitrypsin deficiency and systemic necrotizing vasculitis. J Rheumatol 18:1613-1616.
    • (1991) J Rheumatol , vol.18 , pp. 1613-1616
    • Fortin, P.R.1    Fraser, R.S.2    Watts, C.S.3    Esdaile, J.M.4
  • 135
    • 0030727854 scopus 로고    scopus 로고
    • Identification of potential activators of proteinase-activated receptor-2
    • Fox MT, Harriott P, Walker B and Stone SR (1997) Identification of potential activators of proteinase-activated receptor-2. FEBS Lett 417:267-269.
    • (1997) FEBS Lett , vol.417 , pp. 267-269
    • Fox, M.T.1    Harriott, P.2    Walker, B.3    Stone, S.R.4
  • 136
    • 0032855356 scopus 로고    scopus 로고
    • Design and synthesis of para-fluorophenylalanine amide derivatives as thrombin receptor antagonists
    • Fujita T, Nose T, Nakajima M, Inoue Y, Costa T and Shimohigashi Y (1999) Design and synthesis of para-fluorophenylalanine amide derivatives as thrombin receptor antagonists. J Biochem 126:174-179.
    • (1999) J Biochem , vol.126 , pp. 174-179
    • Fujita, T.1    Nose, T.2    Nakajima, M.3    Inoue, Y.4    Costa, T.5    Shimohigashi, Y.6
  • 137
    • 0034647517 scopus 로고    scopus 로고
    • Signaling from G protein-coupled receptors to ERK5/big MAPK 1 involves G alpha(q) and G alpha(12/13) families of heterotrimeric G proteins - Evidence for the existence of a novel Ras and Rho-independent pathway
    • Fukuhara S, Marinissen MJ, Chiariello M and Gutkind JS (2000) Signaling from G protein-coupled receptors to ERK5/big MAPK 1 involves G alpha(q) and G alpha(12/13) families of heterotrimeric G proteins - evidence for the existence of a novel Ras and Rho-independent pathway. J Biol Chem 275:21730-21736.
    • (2000) J Biol Chem , vol.275 , pp. 21730-21736
    • Fukuhara, S.1    Marinissen, M.J.2    Chiariello, M.3    Gutkind, J.S.4
  • 138
    • 0033605294 scopus 로고    scopus 로고
    • A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
    • Fukuhara S, Murga C, Zohar M, Igishi T and Gutkind JS (1999) A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem 274:5868-5879.
    • (1999) J Biol Chem , vol.274 , pp. 5868-5879
    • Fukuhara, S.1    Murga, C.2    Zohar, M.3    Igishi, T.4    Gutkind, J.S.5
  • 139
    • 0016258274 scopus 로고
    • Binding of thrombin to human platelets
    • Ganguly P (1974) Binding of thrombin to human platelets. Nature (Lond) 274:306-307.
    • (1974) Nature (Lond) , vol.274 , pp. 306-307
    • Ganguly, P.1
  • 140
    • 0027275314 scopus 로고
    • 2+ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth-factor messenger-RNA expression in cultured endothelium
    • 2+ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth-factor messenger-RNA expression in cultured endothelium. J Cell Physiol 156:541-549.
    • (1993) J Cell Physiol , vol.156 , pp. 541-549
    • Garcia, J.G.N.1    Patterson, C.2    Bahler, C.3    Aschner, J.4    Hart, C.M.5    English, D.6
  • 143
    • 0034660448 scopus 로고    scopus 로고
    • Potentiation of NMDA receptor function by the serine protease thrombin
    • Gingrich MB, Junge CE, Lyuboslavsky P and Traynelis SF (2000) Potentiation of NMDA receptor function by the serine protease thrombin. J Neurosci 20:4582-4595.
    • (2000) J Neurosci , vol.20 , pp. 4582-4595
    • Gingrich, M.B.1    Junge, C.E.2    Lyuboslavsky, P.3    Traynelis, S.F.4
  • 144
    • 0034284153 scopus 로고    scopus 로고
    • Serine proteases and brain damage - Is there a link?
    • Gingrich MB and Traynelis SF (2000) Serine proteases and brain damage - is there a link? Trends Neurosci 23:399-407.
    • (2000) Trends Neurosci , vol.23 , pp. 399-407
    • Gingrich, M.B.1    Traynelis, S.F.2
  • 145
  • 146
    • 0031807552 scopus 로고    scopus 로고
    • Thrombin regulation of endothelin-1 gene in isolated human pulmonary endothelial cells
    • Golden CL, Nick HS and Visner GA (1998) Thrombin regulation of endothelin-1 gene in isolated human pulmonary endothelial cells. Am J Physiol-Lung Cell Mol Physiol 18:L854-L863.
    • (1998) Am J Physiol-Lung Cell Mol Physiol , vol.18
    • Golden, C.L.1    Nick, H.S.2    Visner, G.A.3
  • 148
    • 0028873060 scopus 로고
    • Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways - Involvement of tyrosine phosphorylation
    • Grabham P and Cunningham DD (1995) Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways - involvement of tyrosine phosphorylation. J Neurochem 64:583-591.
    • (1995) J Neurochem , vol.64 , pp. 583-591
    • Grabham, P.1    Cunningham, D.D.2
  • 149
    • 0024465346 scopus 로고
    • Modulation of morphological differentiation of human neuroepithelial cells by serine proteases: Independence from blood coagulation
    • Grand RJ, Grabham PW, Gallimore MJ and Gallimore PH (1989) Modulation of morphological differentiation of human neuroepithelial cells by serine proteases: independence from blood coagulation. EMBO J 8:2209-2215.
    • (1989) EMBO J , vol.8 , pp. 2209-2215
    • Grand, R.J.1    Grabham, P.W.2    Gallimore, M.J.3    Gallimore, P.H.4
  • 150
    • 0030032791 scopus 로고    scopus 로고
    • Cellular consequences of thrombin- Receptor activation
    • Grand RJ, Turnell AS and Grabham PW (1996) Cellular consequences of thrombin-receptor activation. Biochem J 313:353-368.
    • (1996) Biochem J , vol.313 , pp. 353-368
    • Grand, R.J.1    Turnell, A.S.2    Grabham, P.W.3
  • 151
    • 0026091505 scopus 로고
    • High and moderate affinity pathways for alpha- Thrombin-induced platelet activation
    • Greco NJ and Jamieson GA (1991) High and moderate affinity pathways for alpha-thrombin-induced platelet activation. Proc Soc Exp Biol Med 198:792-799.
    • (1991) Proc Soc Exp Biol Med , vol.198 , pp. 792-799
    • Greco, N.J.1    Jamieson, G.A.2
  • 154
    • 0033798625 scopus 로고    scopus 로고
    • Intestinal type 2 proteinase-activated receptors expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport
    • Green BT, Bunnett NW, Kulkarni-Narla A, Steinhoff M and Brown DR (2000) Intestinal type 2 proteinase-activated receptors expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport. J Pharmacol Exp Ther 295:410-416.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 410-416
    • Green, B.T.1    Bunnett, N.W.2    Kulkarni-Narla, A.3    Steinhoff, M.4    Brown, D.R.5
  • 155
    • 0018966025 scopus 로고
    • Importance of bile in regulation of intraluminal proteolytic enzyme activities in the rat
    • Green GM and Nasset ES (1980) Importance of bile in regulation of intraluminal proteolytic enzyme activities in the rat. Gastroenterology 79:695-702.
    • (1980) Gastroenterology , vol.79 , pp. 695-702
    • Green, G.M.1    Nasset, E.S.2
  • 156
    • 0023278236 scopus 로고
    • Thrombin interaction with platelets- Influence of a platelet protease nexin
    • Gronke RS, Bergman BL and Baker JB (1987) Thrombin interaction with platelets-influence of a platelet protease nexin. J Biol Chem 262:3030-3036.
    • (1987) J Biol Chem , vol.262 , pp. 3030-3036
    • Gronke, R.S.1    Bergman, B.L.2    Baker, J.B.3
  • 157
    • 0011811083 scopus 로고
    • Thrombin modulates and reverses neuroblastoma neurite outgrowth
    • Gurwitz D and Cunningham DD (1988) Thrombin modulates and reverses neuroblastoma neurite outgrowth. Proc Natl Acad Sci USA 85:3440-3444.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3440-3444
    • Gurwitz, D.1    Cunningham, D.D.2
  • 158
    • 0032993174 scopus 로고    scopus 로고
    • Protease-activated receptor-2 turnover stimulated independently of receptor activation in porcine coronary endothelial cells
    • Hamilton JR, Chow JM and Cocks TM (1999) Protease-activated receptor-2 turnover stimulated independently of receptor activation in porcine coronary endothelial cells. Br J Pharmacol 127:617-622.
    • (1999) Br J Pharmacol , vol.127 , pp. 617-622
    • Hamilton, J.R.1    Chow, J.M.2    Cocks, T.M.3
  • 159
    • 0032577955 scopus 로고    scopus 로고
    • Atypical protease-activated receptor mediates endothelium-dependent relaxation of human coronary arteries
    • Hamilton JR, Nguyen PB and Cocks TM (1998) Atypical protease-activated receptor mediates endothelium-dependent relaxation of human coronary arteries. Circ Res 82:1306-1311.
    • (1998) Circ Res , vol.82 , pp. 1306-1311
    • Hamilton, J.R.1    Nguyen, P.B.2    Cocks, T.M.3
  • 160
    • 0033587603 scopus 로고    scopus 로고
    • Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail
    • Hammes S, Shapiro M and Coughlin S (1999) Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail. Biochemistry 38:9308-9316.
    • (1999) Biochemistry , vol.38 , pp. 9308-9316
    • Hammes, S.1    Shapiro, M.2    Coughlin, S.3
  • 161
    • 0033596749 scopus 로고    scopus 로고
    • Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: Evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand
    • Hammes SR and Coughlin SR (1999) Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand. Biochemistry 38:2486-2493.
    • (1999) Biochemistry , vol.38 , pp. 2486-2493
    • Hammes, S.R.1    Coughlin, S.R.2
  • 163
    • 0022870417 scopus 로고
    • The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor-sites for thrombin - A soluble radioreceptor assay for the interaction of thrombin with platelets
    • Harmon JT and Jamieson GA (1986a) The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor-sites for thrombin - a soluble radioreceptor assay for the interaction of thrombin with platelets. J Biol Chem 261:3224-3229.
    • (1986) J Biol Chem , vol.261 , pp. 3224-3229
    • Harmon, J.T.1    Jamieson, G.A.2
  • 164
    • 0022924104 scopus 로고
    • Platelet activation by alpha-thrombin is a receptor-mediated event
    • Harmon JT and Jamieson GA (1986b) Platelet activation by alpha-thrombin is a receptor-mediated event. Ann N Y Acad Sci 485:387-395.
    • (1986) Ann N Y Acad Sci , vol.485 , pp. 387-395
    • Harmon, J.T.1    Jamieson, G.A.2
  • 166
    • 0031452755 scopus 로고    scopus 로고
    • Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized in primary neurons - Implications for the regulation of motor learning and neuronal survival
    • Hastings GA, Coleman TA, Haudenschild CC, Stefansson S, Smith KP, Barlow R, Cherry S, Sandkvist M and Lawrence DA (1997) Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized in primary neurons - implications for the regulation of motor learning and neuronal survival. J Biol Chem 272:33062-33067.
    • (1997) J Biol Chem , vol.272 , pp. 33062-33067
    • Hastings, G.A.1    Coleman, T.A.2    Haudenschild, C.C.3    Stefansson, S.4    Smith, K.P.5    Barlow, R.6    Cherry, S.7    Sandkvist, M.8    Lawrence, D.A.9
  • 167
    • 0024391784 scopus 로고
    • Stimulated secretion of endothelial Von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein Gmp-140
    • Hattori R, Hamilton KK, Fugate RD, McEver RP and Sims PJ (1989) Stimulated secretion of endothelial Von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein Gmp-140. J Biol Chem 264:7768-7771.
    • (1989) J Biol Chem , vol.264 , pp. 7768-7771
    • Hattori, R.1    Hamilton, K.K.2    Fugate, R.D.3    McEver, R.P.4    Sims, P.J.5
  • 169
    • 0026763390 scopus 로고
    • Pharmacological aspects of the development of selective synthetic thrombin inhibitors as anticoagulants
    • Hauptmann J and Markwardt F (1992) Pharmacological aspects of the development of selective synthetic thrombin inhibitors as anticoagulants. Semin Thromb Hemostasis 18:200-217.
    • (1992) Semin Thromb Hemostasis , vol.18 , pp. 200-217
    • Hauptmann, J.1    Markwardt, F.2
  • 170
    • 0033534612 scopus 로고    scopus 로고
    • The platelet high affinity binding site for thrombin mimics hirudin, modulates thrombin-induced platelet activation, and is distinct from the glycoprotein Ib-IX-V complex
    • Hayes KL and Tracy PB (1999) The platelet high affinity binding site for thrombin mimics hirudin, modulates thrombin-induced platelet activation, and is distinct from the glycoprotein Ib-IX-V complex. J Biol Chem 274:972-980.
    • (1999) J Biol Chem , vol.274 , pp. 972-980
    • Hayes, K.L.1    Tracy, P.B.2
  • 171
    • 0028053488 scopus 로고
    • Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor
    • Hein L, Ishii K, Coughlin SR and Kobilka BK (1994) Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. J Biol Chem 269:27719-27726.
    • (1994) J Biol Chem , vol.269 , pp. 27719-27726
    • Hein, L.1    Ishii, K.2    Coughlin, S.R.3    Kobilka, B.K.4
  • 174
    • 0028027007 scopus 로고
    • Thrombin induces endothelial cell growth via both a proteolytic and a non- Proteolytic pathway
    • Herbert JM, Dupuy E, Laplace MC, Zini JM, Bar Shavit R and Tobelem G (1994) Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway. Biochem J 303:227-231.
    • (1994) Biochem J , vol.303 , pp. 227-231
    • Herbert, J.M.1    Dupuy, E.2    Laplace, M.C.3    Zini, J.M.4    Bar Shavit, R.5    Tobelem, G.6
  • 175
    • 0033764692 scopus 로고    scopus 로고
    • Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: Effect of depigmenting agents
    • Hermanns JF, Petit L, Martalo O, Pierard-Franchimont C, Cauwenbergh C and Pierard GE (2000) Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: effect of depigmenting agents. Dermatology 201:118-122.
    • (2000) Dermatology , vol.201 , pp. 118-122
    • Hermanns, J.F.1    Petit, L.2    Martalo, O.3    Pierard-Franchimont, C.4    Cauwenbergh, C.5    Pierard, G.E.6
  • 178
    • 0024990439 scopus 로고
    • Effect of recombinant hirudin, a specific inhibitor of thrombin, on endotoxin-induced intravascular coagulation and acute lung injury in pigs
    • Hoffmann H, Siebeck M, Spannagl M, Weis M, Geiger R, Jochum M and Fritz H (1990) Effect of recombinant hirudin, a specific inhibitor of thrombin, on endotoxin-induced intravascular coagulation and acute lung injury in pigs. Am Rev Respir Dis 142:782-788.
    • (1990) Am Rev Respir Dis , vol.142 , pp. 782-788
    • Hoffmann, H.1    Siebeck, M.2    Spannagl, M.3    Weis, M.4    Geiger, R.5    Jochum, M.6    Fritz, H.7
  • 179
    • 0030030210 scopus 로고    scopus 로고
    • Protease-mediated signalling: New paradigms for cell regulation and drug development
    • Hollenberg MD (1996) Protease-mediated signalling: new paradigms for cell regulation and drug development. Trends Pharmacol Sci 17:3-6.
    • (1996) Trends Pharmacol Sci , vol.17 , pp. 3-6
    • Hollenberg, M.D.1
  • 180
    • 0030044693 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 in rat aorta: Structural requirements for agonist activity of receptor-activating peptides
    • Hollenberg MD, Saifeddine M and Al-Ani B (1996) Proteinase-activated receptor-2 in rat aorta: structural requirements for agonist activity of receptor-activating peptides. Mol Pharmacol 49:229-233.
    • (1996) Mol Pharmacol , vol.49 , pp. 229-233
    • Hollenberg, M.D.1    Saifeddine, M.2    Al-Ani, B.3
  • 181
    • 0033506048 scopus 로고    scopus 로고
    • Proteinase-activated receptor 4 (PAR(4)): Action of PAR(4)-activating peptides in vascular and gastric tissue and lack of cross-reactivity with PAR(1) and PAR(2)
    • Hollenberg MD, Saifeddine M, Al-Ani B and Gui Y (1999) Proteinase-activated receptor 4 (PAR(4)): action of PAR(4)-activating peptides in vascular and gastric tissue and lack of cross-reactivity with PAR(1) and PAR(2). Can J Physiol Pharmacol 77:458-464.
    • (1999) Can J Physiol Pharmacol , vol.77 , pp. 458-464
    • Hollenberg, M.D.1    Saifeddine, M.2    Al-Ani, B.3    Gui, Y.4
  • 182
    • 0030823980 scopus 로고    scopus 로고
    • Proteinase-activated receptors: Structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides
    • Hollenberg MD, Saifeddine M, Al-Ani B and Kawabata A (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can J Physiol Pharmacol 75:832-841.
    • (1997) Can J Physiol Pharmacol , vol.75 , pp. 832-841
    • Hollenberg, M.D.1    Saifeddine, M.2    Al-Ani, B.3    Kawabata, A.4
  • 183
    • 0033982381 scopus 로고    scopus 로고
    • Proteinase-activated receptors (PARs) activation of PAR(1) and PAR(2) by a proteolytic fragment of the neuronal growth associated protein B-50/GAP-43
    • Hollenberg MD, Saifeddine M and Zwiers H (2000) Proteinase-activated receptors (PARs) activation of PAR(1) and PAR(2) by a proteolytic fragment of the neuronal growth associated protein B-50/GAP-43. Can J Physiol Pharmacol 78:81-85.
    • (2000) Can J Physiol Pharmacol , vol.78 , pp. 81-85
    • Hollenberg, M.D.1    Saifeddine, M.2    Zwiers, H.3
  • 184
    • 0027074984 scopus 로고
    • Action of thrombin receptor polypeptide in gastric smooth muscle - Identification of a core pentapeptide retaining full thrombin-mimetic intrinsic activity
    • Hollenberg MD, Yang SG, Laniyonu AA, Moore GJ and Saifeddine M (1992) Action of thrombin receptor polypeptide in gastric smooth muscle - Identification of a core pentapeptide retaining full thrombin-mimetic intrinsic activity. Mol Pharmacol 42:186-191.
    • (1992) Mol Pharmacol , vol.42 , pp. 186-191
    • Hollenberg, M.D.1    Yang, S.G.2    Laniyonu, A.A.3    Moore, G.J.4    Saifeddine, M.5
  • 187
    • 0034057086 scopus 로고    scopus 로고
    • Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway
    • Huang YQ, Li JJ and Karpatkin S (2000) Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway. J Biol Chem 278:6462-6468.
    • (2000) J Biol Chem , vol.278 , pp. 6462-6468
    • Huang, Y.Q.1    Li, J.J.2    Karpatkin, S.3
  • 188
    • 0026782001 scopus 로고
    • The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
    • Hung DT, Wong YH, Vu TK and Coughlin SR (1992) The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem 267:20831-20834.
    • (1992) J Biol Chem , vol.267 , pp. 20831-20834
    • Hung, D.T.1    Wong, Y.H.2    Vu, T.K.3    Coughlin, S.R.4
  • 189
    • 0029979497 scopus 로고    scopus 로고
    • Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells
    • Hwa JJ, Ghibaudi L, Williams P, Chintala M, Zhang RM, Chatterjee M and Sybertz E (1996) Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells. Circ Res 78:581-588.
    • (1996) Circ Res , vol.78 , pp. 581-588
    • Hwa, J.J.1    Ghibaudi, L.2    Williams, P.3    Chintala, M.4    Zhang, R.M.5    Chatterjee, M.6    Sybertz, E.7
  • 190
    • 33750866137 scopus 로고    scopus 로고
    • Myocardial overexpression of GRK3 in transgenic mice: Evidence for in vivo selectivity of GRKs
    • Iaccarino G, Rockman HA, Shotwell KF, Tomhave ED and Koch WJ (1998) Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. Am J Physiol 275:H1298-H1306.
    • (1998) Am J Physiol , vol.275
    • Iaccarino, G.1    Rockman, H.A.2    Shotwell, K.F.3    Tomhave, E.D.4    Koch, W.J.5
  • 191
    • 0034116656 scopus 로고    scopus 로고
    • Identification of a novel 33 kDa ser/thr kinase that phosphorylates the cytoplasmic tail of protease-activated receptor 1 (thrombin receptor) in human platelets
    • Ido M, Hayashi T, Gabazza E and Suzuki K (2000) Identification of a novel 33 kDa ser/thr kinase that phosphorylates the cytoplasmic tail of protease-activated receptor 1 (thrombin receptor) in human platelets. Thromb Haemostasia 83:617-621.
    • (2000) Thromb Haemostasia , vol.83 , pp. 617-621
    • Ido, M.1    Hayashi, T.2    Gabazza, E.3    Suzuki, K.4
  • 194
    • 0032101592 scopus 로고    scopus 로고
    • Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin
    • Ishihara H, Zeng D, Connolly AJ, Tam C and Coughlin SR (1998) Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood 91, 4152-4157.
    • (1998) Blood , vol.91 , pp. 4152-4157
    • Ishihara, H.1    Zeng, D.2    Connolly, A.J.3    Tam, C.4    Coughlin, S.R.5
  • 195
    • 0028009801 scopus 로고
    • Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases
    • Ishii K, Chen J, Ishii M, Koch WJ, Freedman NJ, Lefkowitz RJ and Coughlin SR (1994) Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. J Biol Chem 269:1125-1130.
    • (1994) J Biol Chem , vol.269 , pp. 1125-1130
    • Ishii, K.1    Chen, J.2    Ishii, M.3    Koch, W.J.4    Freedman, N.J.5    Lefkowitz, R.J.6    Coughlin, S.R.7
  • 196
    • 0029026320 scopus 로고
    • Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate
    • Ishii K, Gerszten R, Zheng YW, Welsh JB, Turck CW and Coughlin SR (1995) Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate. J Biol Chem 270:16435-16440.
    • (1995) J Biol Chem , vol.270 , pp. 16435-16440
    • Ishii, K.1    Gerszten, R.2    Zheng, Y.W.3    Welsh, J.B.4    Turck, C.W.5    Coughlin, S.R.6
  • 197
    • 0027309290 scopus 로고
    • Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling
    • Ishii K, Hein L, Kobilka B and Coughlin SR (1993) Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. J Biol Chem 268:9780-9786.
    • (1993) J Biol Chem , vol.268 , pp. 9780-9786
    • Ishii, K.1    Hein, L.2    Kobilka, B.3    Coughlin, S.R.4
  • 199
    • 0034666151 scopus 로고    scopus 로고
    • Alpha(2A)/alpha(2C)-adrenergic receptor third loop chimera show that agonist interaction with receptor subtype backbone establishes G protein-coupled receptor kinase phosphorylation
    • Jewell-Motz EA, Small KM, Theiss CT and Liggett SB (2000) alpha(2A)/alpha(2C)-adrenergic receptor third loop chimera show that agonist interaction with receptor subtype backbone establishes G protein-coupled receptor kinase phosphorylation. J Biol Chem 275:28989-28993.
    • (2000) J Biol Chem , vol.275 , pp. 28989-28993
    • Jewell-Motz, E.A.1    Small, K.M.2    Theiss, C.T.3    Liggett, S.B.4
  • 200
    • 0033541441 scopus 로고    scopus 로고
    • A p85 subunit-independent p110 alpha PI 3-kinase colocalizes with p70 S6 kinase on actin stress fibers and regulates thrombin-stimulated stress fiber formation in Swiss 3T3 cells
    • Johanson SO, Naccache PA and Crouch MF (1999) A p85 subunit-independent p110 alpha PI 3-kinase colocalizes with p70 S6 kinase on actin stress fibers and regulates thrombin-stimulated stress fiber formation in Swiss 3T3 cells. Exp Cell Res 248:223-233.
    • (1999) Exp Cell Res , vol.248 , pp. 223-233
    • Johanson, S.O.1    Naccache, P.A.2    Crouch, M.F.3
  • 201
    • 0026772506 scopus 로고
    • Coordinate, biphasic activation of P44 mitogen-activated protein-kinase and S6 kinase by growth-factors in hamster fibroblasts - Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition
    • Kahan C, Seuwen K, Meloche S and Pouyssegur J (1992) Coordinate, biphasic activation of P44 mitogen-activated protein-kinase and S6 kinase by growth-factors in hamster fibroblasts - evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition. J Biol Chem 267: 13369-13375.
    • (1992) J Biol Chem , vol.267 , pp. 13369-13375
    • Kahan, C.1    Seuwen, K.2    Meloche, S.3    Pouyssegur, J.4
  • 204
    • 4243681432 scopus 로고    scopus 로고
    • Regulation of c-Jun-N-terminal kinase and p38 MAP kinase by proteinase activated receptor-2 in human skin epithelial cell line NCT2544
    • Kanke T, Macfarlane S, Seatter M and Plevin R (2000) Regulation of c-Jun-N-terminal kinase and p38 MAP kinase by proteinase activated receptor-2 in human skin epithelial cell line NCT2544. Br J Pharmacol 129:23P.
    • (2000) Br J Pharmacol , vol.129
    • Kanke, T.1    Macfarlane, S.2    Seatter, M.3    Plevin, R.4
  • 205
    • 0030025078 scopus 로고    scopus 로고
    • Involvement of pertussis toxin-sensitive and -insensitive G proteins in alpha-thrombin signalling on cultured human vascular smooth muscle cells
    • Kanthou C, Kanse SM, Kakkar W and Benzakour O (1996) Involvement of pertussis toxin-sensitive and -insensitive G proteins in alpha-thrombin signalling on cultured human vascular smooth muscle cells. Cell Signalling 8:59-66.
    • (1996) Cell Signalling , vol.8 , pp. 59-66
    • Kanthou, C.1    Kanse, S.M.2    Kakkar, W.3    Benzakour, O.4
  • 207
    • 0032899143 scopus 로고    scopus 로고
    • Presence of the proteinase-activated receptor-2 (PAR-2) in human brain tumor cells - Trypsin- and SLIGRL-induced calcium response in primary cultured meningiomas
    • Kaufmann R, Patt S, Zieger M, Kraft R and Nowak G (1999) Presence of the proteinase-activated receptor-2 (PAR-2) in human brain tumor cells - trypsin- and SLIGRL-induced calcium response in primary cultured meningiomas. Cancer Lett 139:109-113.
    • (1999) Cancer Lett , vol.139 , pp. 109-113
    • Kaufmann, R.1    Patt, S.2    Zieger, M.3    Kraft, R.4    Nowak, G.5
  • 209
    • 0031794504 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2-mediated signaling and inhibition of DNA synthesis in human pancreatic cancer cells
    • Kaufmann R, Schafberg H and Nowak G (1998) Proteinase-activated receptor-2-mediated signaling and inhibition of DNA synthesis in human pancreatic cancer cells. Int J Pancreatol 24:97-102.
    • (1998) Int J Pancreatol , vol.24 , pp. 97-102
    • Kaufmann, R.1    Schafberg, H.2    Nowak, G.3
  • 210
    • 0033771536 scopus 로고    scopus 로고
    • Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): A novel role for PAR-4 as opposed to PAR-1
    • Kawabata A, Kuroda R, Kuroki N, Nishikawa H and Kawai K (2000a) Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): a novel role for PAR-4 as opposed to PAR-1. Br J Pharmacol 131:578-584.
    • (2000) Br J Pharmacol , vol.131 , pp. 578-584
    • Kawabata, A.1    Kuroda, R.2    Kuroki, N.3    Nishikawa, H.4    Kawai, K.5
  • 211
    • 0034613016 scopus 로고    scopus 로고
    • Characerization of the protease-activated receptor-1 mediated contraction and relaxation in the rat duodenal smooth muscle
    • Kawabata A, Kuroda R, Kuroki N, Nishikawa H, Kawai K and Araki H (2000d) Characerization of the protease-activated receptor-1 mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci 67:2521-2530.
    • (2000) Life Sci , vol.67 , pp. 2521-2530
    • Kawabata, A.1    Kuroda, R.2    Kuroki, N.3    Nishikawa, H.4    Kawai, K.5    Araki, H.6
  • 212
    • 0032695476 scopus 로고    scopus 로고
    • Modulation by protease-activated receptors of the rat duodenal motility in vitro: Possible mechanisms underlying the evoked contraction and relaxation
    • Kawabata A, Kuroda R, Nishikawa H and Kawai K (1999a) Modulation by protease-activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation. Br J Pharmacol 128:865-872.
    • (1999) Br J Pharmacol , vol.128 , pp. 865-872
    • Kawabata, A.1    Kuroda, R.2    Nishikawa, H.3    Kawai, K.4
  • 213
    • 0034595060 scopus 로고    scopus 로고
    • Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland
    • Kawabata A, Morimoto N, Nishikawa H, Kuroda R, Oda Y and Kakehi K (2000b) Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland. Biochem Biophys Res Commun 270:298-302.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 298-302
    • Kawabata, A.1    Morimoto, N.2    Nishikawa, H.3    Kuroda, R.4    Oda, Y.5    Kakehi, K.6
  • 214
    • 0033997882 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 (PAR-2) regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice
    • Kawabata A, Nishikawa H, Kuroda R, Kawai K and Hollenberg MD (2000c) Proteinase-activated receptor-2 (PAR-2) regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice. Br J Pharmacol 129:1808-1814.
    • (2000) Br J Pharmacol , vol.129 , pp. 1808-1814
    • Kawabata, A.1    Nishikawa, H.2    Kuroda, R.3    Kawai, K.4    Hollenberg, M.D.5
  • 215
    • 0032911415 scopus 로고    scopus 로고
    • Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: Activation of PAR2 by PAR1-targeted ligands
    • Kawabata A, Saifeddine M, Al-Ani B, Leblond L and Hollenberg MD (1999b) Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands. J Pharmacol Exp Ther 288:358-370.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 358-370
    • Kawabata, A.1    Saifeddine, M.2    Al-Ani, B.3    Leblond, L.4    Hollenberg, M.D.5
  • 216
    • 0027733860 scopus 로고
    • Degranulation of human platelets by the thrombin receptor peptide SFLLRN: Comparison with degranulation by thrombin
    • Kinlough-Rathbone RL, Perry DW, Guccione MA, Rand ML and Packham MA (1993) Degranulation of human platelets by the thrombin receptor peptide SFLLRN: comparison with degranulation by thrombin. Thromb Haemostasis 70:1019-1023.
    • (1993) Thromb Haemostasis , vol.70 , pp. 1019-1023
    • Kinlough-Rathbone, R.L.1    Perry, D.W.2    Guccione, M.A.3    Rand, M.L.4    Packham, M.A.5
  • 217
    • 0027481431 scopus 로고
    • Thrombin stimulates melanoma tumor-cell binding to endothelial cells and subendothelial matrix
    • Klepfish A, Greco MA and Karpatkin S (1993) Thrombin stimulates melanoma tumor-cell binding to endothelial cells and subendothelial matrix. Int J Cancer 53:978-982.
    • (1993) Int J Cancer , vol.53 , pp. 978-982
    • Klepfish, A.1    Greco, M.A.2    Karpatkin, S.3
  • 218
    • 0026572461 scopus 로고
    • Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured porcine endothelial cells
    • Kohno M, Yokokawa K, Horio T, Yasunari K, Murakawa K, Ikeda M and Takeda T (1992) Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured porcine endothelial cells. J Vasc Res 29:56-63.
    • (1992) J Vasc Res , vol.29 , pp. 56-63
    • Kohno, M.1    Yokokawa, K.2    Horio, T.3    Yasunari, K.4    Murakawa, K.5    Ikeda, M.6    Takeda, T.7
  • 224
    • 0030731808 scopus 로고    scopus 로고
    • Expression of thrombin receptors in human atherosclerotic coronary arteries leads to an exaggerated vasoconstrictory response in vitro
    • Ku DD and Dai J (1997) Expression of thrombin receptors in human atherosclerotic coronary arteries leads to an exaggerated vasoconstrictory response in vitro. J Cardiovasc Pharmacol 30:649-657.
    • (1997) J Cardiovasc Pharmacol , vol.30 , pp. 649-657
    • Ku, D.D.1    Dai, J.2
  • 225
    • 0033528761 scopus 로고    scopus 로고
    • Plasmin desensitization of the PARI thrombin receptor: Kinetics, sites of truncation, and implications for thrombolytic therapy
    • Kuliopulos A, Covic L, Seeley SK, Sheridan PJ, Helin J and Costello CE (1999) Plasmin desensitization of the PARI thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy. Biochemistry 38:4572-4585.
    • (1999) Biochemistry , vol.38 , pp. 4572-4585
    • Kuliopulos, A.1    Covic, L.2    Seeley, S.K.3    Sheridan, P.J.4    Helin, J.5    Costello, C.E.6
  • 227
    • 0006296520 scopus 로고    scopus 로고
    • Modulation of airway smooth muscle tone by protease activated receptor-1, -2, -3 and-4 in trachea isolated from influenza A virus-infected mice
    • Lan RS, Stewart GA and Henry PJ (2000) Modulation of airway smooth muscle tone by protease activated receptor-1, -2, -3 and-4 in trachea isolated from influenza A virus-infected mice. Br J Pharmacol 129:63-70.
    • (2000) Br J Pharmacol , vol.129 , pp. 63-70
    • Lan, R.S.1    Stewart, G.A.2    Henry, P.J.3
  • 228
    • 0032943041 scopus 로고    scopus 로고
    • Endothelial protease-activated receptor-2 induces tissue factor expression and von Willebrand factor release
    • Langer F, Morys Wortmann C, Kusters B and Storck J (1999) Endothelial protease-activated receptor-2 induces tissue factor expression and von Willebrand factor release. Br J Haematol 105:542-550.
    • (1999) Br J Haematol , vol.105 , pp. 542-550
    • Langer, F.1    Morys Wortmann, C.2    Kusters, B.3    Storck, J.4
  • 229
    • 0028929078 scopus 로고
    • Vascular actions of thrombin receptor-derived polypeptides - Structure-activity profiles for contractile and relaxant effects in rat aorta
    • Laniyonu AA and Hollenberg MD (1995) Vascular actions of thrombin receptor-derived polypeptides - structure-activity profiles for contractile and relaxant effects in rat aorta. Br J Pharmacol 114:1680-1686.
    • (1995) Br J Pharmacol , vol.114 , pp. 1680-1686
    • Laniyonu, A.A.1    Hollenberg, M.D.2
  • 230
    • 0026534991 scopus 로고
    • The thrombin high-affinity binding site on platelets is a negative regulator of thrombin-induced platelet activation. Structure-function studies using two mutant thrombins, Quick I and Quick II
    • Leong L, Henriksen RA, Kermode JC, Rittenhouse SE and Tracy PB (1992) The thrombin high-affinity binding site on platelets is a negative regulator of thrombin-induced platelet activation. Structure-function studies using two mutant thrombins, Quick I and Quick II. Biochemistry 31:2567-2576.
    • (1992) Biochemistry , vol.31 , pp. 2567-2576
    • Leong, L.1    Henriksen, R.A.2    Kermode, J.C.3    Rittenhouse, S.E.4    Tracy, P.B.5
  • 231
    • 0029943079 scopus 로고    scopus 로고
    • Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function
    • Lerner DJ, Chen M, Tram T and Coughlin SR (1996) Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. J Biol Chem 271:13943-13947.
    • (1996) J Biol Chem , vol.271 , pp. 13943-13947
    • Lerner, D.J.1    Chen, M.2    Tram, T.3    Coughlin, S.R.4
  • 233
    • 0032508557 scopus 로고    scopus 로고
    • Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis
    • Lourbakos A, Chinni C, Thompson P, Potempa J, Travis J, Mackie EJ and Pike RN (1998) Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis. FEBS Lett 435:45-48.
    • (1998) FEBS Lett , vol.435 , pp. 45-48
    • Lourbakos, A.1    Chinni, C.2    Thompson, P.3    Potempa, J.4    Travis, J.5    Mackie, E.J.6    Pike, R.N.7
  • 234
    • 0028226881 scopus 로고
    • Thrombin receptor activation peptide induces pulmonary vasoconstriction
    • Lum H, Andersen TT, Fenton JW and Malik AB (1994) Thrombin receptor activation peptide induces pulmonary vasoconstriction. Am J Physiol 266:C448-C454.
    • (1994) Am J Physiol , vol.266
    • Lum, H.1    Andersen, T.T.2    Fenton, J.W.3    Malik, A.B.4
  • 235
    • 0030477840 scopus 로고    scopus 로고
    • Mechanisms of increased endothelial permeability
    • Lum H and Malik AB (1996) Mechanisms of increased endothelial permeability. Can J Physiol Pharmacol 74:787-800.
    • (1996) Can J Physiol Pharmacol , vol.74 , pp. 787-800
    • Lum, H.1    Malik, A.B.2
  • 237
    • 4244175282 scopus 로고    scopus 로고
    • Trypsin stimulates the NF kappa B signalling pathway in NCTC 2544 transfected with human protease-activated receptor-2
    • Macfarlane SR, Kanke T, Scatter M, Davenport E, Paul A and Plevin R (2000) Trypsin stimulates the NF kappa B signalling pathway in NCTC 2544 transfected with human protease-activated receptor-2. Br J Pharmacol 129:21P.
    • (2000) Br J Pharmacol , vol.129
    • Macfarlane, S.R.1    Kanke, T.2    Scatter, M.3    Davenport, E.4    Paul, A.5    Plevin, R.6
  • 238
    • 0029942335 scopus 로고    scopus 로고
    • Protease activated receptors modulate aortic vascular tone
    • Magazine HI, King JM and Srivastava KD (1996) Protease activated receptors modulate aortic vascular tone. Int J Cardiol 53:875-880.
    • (1996) Int J Cardiol , vol.53 , pp. 875-880
    • Magazine, H.I.1    King, J.M.2    Srivastava, K.D.3
  • 239
    • 0023741142 scopus 로고
    • Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C
    • Magnaldo I, Pouyssegur J and Paris S (1988) Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C. Biochem J 253:711-719.
    • (1988) Biochem J , vol.253 , pp. 711-719
    • Magnaldo, I.1    Pouyssegur, J.2    Paris, S.3
  • 240
    • 0032562675 scopus 로고    scopus 로고
    • Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis
    • Majumdar M, Seasholtz TM, Goldstein D, de Lanerolle P and Brown JH (1998) Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis. J Biol Chem 273:10099-10106.
    • (1998) J Biol Chem , vol.273 , pp. 10099-10106
    • Majumdar, M.1    Seasholtz, T.M.2    Goldstein, D.3    De Lanerolle, P.4    Brown, J.H.5
  • 241
    • 0029025036 scopus 로고
    • The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors
    • Malarkey K, Belham CM, Paul A, Graham A, McLees A, Scott PH and Plevin R (1995) The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors. Biochem J 309:361-375.
    • (1995) Biochem J , vol.309 , pp. 361-375
    • Malarkey, K.1    Belham, C.M.2    Paul, A.3    Graham, A.4    McLees, A.5    Scott, P.H.6    Plevin, R.7
  • 242
    • 0033795542 scopus 로고    scopus 로고
    • Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts
    • Malcolm KC, Chambard JC, Grall D, Pouyssegur J and Van Obberghen-Schilling E (2000) Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts. J Cell Physiol 185:235-243.
    • (2000) J Cell Physiol , vol.185 , pp. 235-243
    • Malcolm, K.C.1    Chambard, J.C.2    Grall, D.3    Pouyssegur, J.4    Van Obberghen-Schilling, E.5
  • 243
    • 25944460542 scopus 로고
    • Thrombin induced adherence of neutrophils (PMN) to endothelial monolayers (ECM)
    • Malik AB, Bizios R, Lai LC and Delvecchio PJ (1986) Thrombin induced adherence of neutrophils (PMN) to endothelial monolayers (ECM). J Cell Biol 103:A195.
    • (1986) J Cell Biol , vol.103
    • Malik, A.B.1    Bizios, R.2    Lai, L.C.3    Delvecchio, P.J.4
  • 244
    • 0025346345 scopus 로고
    • Design and characterization of hirulogs - A novel class of bivalent peptide inhibitors of thrombin
    • Maraganore JM, Bourdon P, Jablonski J, Ramachandran KL and Fenton JW (1990) Design and characterization of hirulogs - a novel class of bivalent peptide inhibitors of thrombin. Biochemistry 29:7095-7101.
    • (1990) Biochemistry , vol.29 , pp. 7095-7101
    • Maraganore, J.M.1    Bourdon, P.2    Jablonski, J.3    Ramachandran, K.L.4    Fenton, J.W.5
  • 246
    • 0016835728 scopus 로고
    • Platelet stimulation by thrombin and other proteases
    • Martin BM, Feinman RD and Detwiler TC (1975) Platelet stimulation by thrombin and other proteases. Biochemistry 14:1308-1314.
    • (1975) Biochemistry , vol.14 , pp. 1308-1314
    • Martin, B.M.1    Feinman, R.D.2    Detwiler, T.C.3
  • 248
    • 0029816605 scopus 로고    scopus 로고
    • Synthesis and contractile activities of cyclic thrombin receptor-derived peptide analogues with a Phe-Leu-Leu-Arg motif: Importance of the Phe/Arg relative conformation and the primary amino group for activity
    • Matsoukas JM, Panagiotopoulos D, Keramida M, Mavromoustakos T, Yamdagni R, Wu Q, Moore GJ, Saifeddine M and Hollenberg MD (1996) Synthesis and contractile activities of cyclic thrombin receptor-derived peptide analogues with a Phe-Leu-Leu-Arg motif: importance of the Phe/Arg relative conformation and the primary amino group for activity, J Med Chem 39:3585-3591.
    • (1996) J Med Chem , vol.39 , pp. 3585-3591
    • Matsoukas, J.M.1    Panagiotopoulos, D.2    Keramida, M.3    Mavromoustakos, T.4    Yamdagni, R.5    Wu, Q.6    Moore, G.J.7    Saifeddine, M.8    Hollenberg, M.D.9
  • 252
    • 0027492461 scopus 로고
    • Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor
    • McNamara CA, Sarembock IJ, Gimple LW, Fenton JWD, Coughlin SR and Owens GK (1993) Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 91:94-98.
    • (1993) J Clin Invest , vol.91 , pp. 94-98
    • McNamara, C.A.1    Sarembock, I.J.2    Gimple, L.W.3    Fenton, J.W.D.4    Coughlin, S.R.5    Owens, G.K.6
  • 253
    • 0030912537 scopus 로고    scopus 로고
    • Thrombin receptor-activating peptide releases arachidonic acid from human platelets: A comparison with thrombin and trypsin
    • McNicol A and Robson CA (1997) Thrombin receptor-activating peptide releases arachidonic acid from human platelets: A comparison with thrombin and trypsin. J Pharmacol Exp Ther 281:861-867.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 861-867
    • McNicol, A.1    Robson, C.A.2
  • 254
    • 0029790022 scopus 로고    scopus 로고
    • Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5
    • Miller S, Sehati N, Romano C and Cotman CW (1996) Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5. J Neurochem 67:1435-1447.
    • (1996) J Neurochem , vol.67 , pp. 1435-1447
    • Miller, S.1    Sehati, N.2    Romano, C.3    Cotman, C.W.4
  • 255
    • 0030783689 scopus 로고    scopus 로고
    • Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases
    • Mirza H, Schmidt VA, Derian CK, Jesty J and Bahou WF (1997) Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha-or beta-tryptases. Blood 90:3914-3922.
    • (1997) Blood , vol.90 , pp. 3914-3922
    • Mirza, H.1    Schmidt, V.A.2    Derian, C.K.3    Jesty, J.4    Bahou, W.F.5
  • 256
    • 0030003829 scopus 로고    scopus 로고
    • The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells -molecular characterization and evidence for functional coupling to the thrombin receptor
    • Mirza H, Yatsula V and Bahou WF (1996) The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells -molecular characterization and evidence for functional coupling to the thrombin receptor. J Clin Invest 97:1705-1714.
    • (1996) J Clin Invest , vol.97 , pp. 1705-1714
    • Mirza, H.1    Yatsula, V.2    Bahou, W.F.3
  • 258
    • 0343036955 scopus 로고    scopus 로고
    • Thrombin-specific activation of c-jun N-terminal kinase and P38 mitogen-activated protein kinase in human liver cells
    • Mitsui H, Maruyama T, Kimura S and Takuwa Y (1997) Thrombin-specific activation of c-jun N-terminal kinase and P38 mitogen-activated protein kinase in human liver cells. Hepatology 26:546.
    • (1997) Hepatology , vol.26 , pp. 546
    • Mitsui, H.1    Maruyama, T.2    Kimura, S.3    Takuwa, Y.4
  • 259
    • 0031960208 scopus 로고    scopus 로고
    • Thrombin activates two stress-activated protein kinases, c-Jun N-terminal kinase and p38, in HepG2 cells
    • Mitsui H, Maruyama T, Kimura S and Takuwa Y (1998) Thrombin activates two stress-activated protein kinases, c-Jun N-terminal kinase and p38, in HepG2 cells. Hepatology 27:1362-1367.
    • (1998) Hepatology , vol.27 , pp. 1362-1367
    • Mitsui, H.1    Maruyama, T.2    Kimura, S.3    Takuwa, Y.4
  • 260
    • 0032806642 scopus 로고    scopus 로고
    • Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture
    • Miyata S, Koshikawa N, Higashi S, Miyagi Y, Nagashima Y, Yanoma S, Kato Y, Yasumitsu H and Miyazaki K (1999) Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture. J Biochem 125:1067-1076.
    • (1999) J Biochem , vol.125 , pp. 1067-1076
    • Miyata, S.1    Koshikawa, N.2    Higashi, S.3    Miyagi, Y.4    Nagashima, Y.5    Yanoma, S.6    Kato, Y.7    Yasumitsu, H.8    Miyazaki, K.9
  • 261
    • 0034681427 scopus 로고    scopus 로고
    • Trypsin stimulates integrin alpha(5)beta(1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2
    • Miyata S, Koshikawa N, Yasumitsu H and Miyazaki K (2000) Trypsin stimulates integrin alpha(5)beta(1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2. J Biol Chem 275:4592-4598.
    • (2000) J Biol Chem , vol.275 , pp. 4592-4598
    • Miyata, S.1    Koshikawa, N.2    Yasumitsu, H.3    Miyazaki, K.4
  • 262
    • 0034635376 scopus 로고    scopus 로고
    • Proteolysis and phosphorylation-media ted regulation of thrombin receptor activity in in situ endothelial cells
    • Mizuno O, Hirano K, Nishimura J, Kubo C and Kanaide H (2000) Proteolysis and phosphorylation-media ted regulation of thrombin receptor activity in in situ endothelial cells. Eur J Pharmacol 389:13-23.
    • (2000) Eur J Pharmacol , vol.389 , pp. 13-23
    • Mizuno, O.1    Hirano, K.2    Nishimura, J.3    Kubo, C.4    Kanaide, H.5
  • 263
    • 0032749501 scopus 로고    scopus 로고
    • The role of protease-activated receptor-2 (PAR2) in the modulation of beating of the mouse isolated ureter: Lack of involvement of mast cells or sensory nerves
    • Moffatt JD and Cocks TM (1999) The role of protease-activated receptor-2 (PAR2) in the modulation of beating of the mouse isolated ureter: lack of involvement of mast cells or sensory nerves. Br J Pharmacol 128:860-864.
    • (1999) Br J Pharmacol , vol.128 , pp. 860-864
    • Moffatt, J.D.1    Cocks, T.M.2
  • 264
    • 0031029290 scopus 로고    scopus 로고
    • Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
    • Mohle R, Green D, Moore MAS, Nachman RL and Rafii S (1997) Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc Natl Acad Sci USA 94:663-668.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 663-668
    • Mohle, R.1    Green, D.2    Moore, M.A.S.3    Nachman, R.L.4    Rafii, S.5
  • 265
    • 0031041906 scopus 로고    scopus 로고
    • Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation
    • Molino M, Bainton DF, Hoxie JA, Coughlin SR and Brass LF (1997a) Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation. J Biol Chem 272:6011-6017.
    • (1997) J Biol Chem , vol.272 , pp. 6011-6017
    • Molino, M.1    Bainton, D.F.2    Hoxie, J.A.3    Coughlin, S.R.4    Brass, L.F.5
  • 269
    • 0032483381 scopus 로고    scopus 로고
    • Involvement of protein kinase C and Src family tyrosine kinase in G alpha(q/11)-induced activation of c-jun N-terminal kinase and p38 mitogen-activated protein kinase
    • Nagao M, Yamauchi J, Kaziro Y and Itoh H (1998) Involvement of protein kinase C and Src family tyrosine kinase in G alpha(q/11)-induced activation of c-jun N-terminal kinase and p38 mitogen-activated protein kinase. J Biol Chem 273: 22892-22898.
    • (1998) J Biol Chem , vol.273 , pp. 22892-22898
    • Nagao, M.1    Yamauchi, J.2    Kaziro, Y.3    Itoh, H.4
  • 271
    • 0031681419 scopus 로고    scopus 로고
    • Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation
    • Naldini A, Sower L, Bocci V, Meyers B and Carney DH (1998) Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation. J Cell Physiol 177:76-84.
    • (1998) J Cell Physiol , vol.177 , pp. 76-84
    • Naldini, A.1    Sower, L.2    Bocci, V.3    Meyers, B.4    Carney, D.H.5
  • 272
    • 0029143923 scopus 로고
    • Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site
    • Nanevicz T, Ishii M, Wang L, Chen M, Chen J, Turck CW, Cohen FE and Coughlin SR (1995) Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site. J Biol Chem 270:21619-21625.
    • (1995) J Biol Chem , vol.270 , pp. 21619-21625
    • Nanevicz, T.1    Ishii, M.2    Wang, L.3    Chen, M.4    Chen, J.5    Turck, C.W.6    Cohen, F.E.7    Coughlin, S.R.8
  • 273
    • 0030066317 scopus 로고    scopus 로고
    • Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling
    • Nanevicz T, Wang L, Chen M, Ishii M and Coughlin SR (1996) Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling. J Biol Chem 271:702-706.
    • (1996) J Biol Chem , vol.271 , pp. 702-706
    • Nanevicz, T.1    Wang, L.2    Chen, M.3    Ishii, M.4    Coughlin, S.R.5
  • 275
    • 0028919211 scopus 로고
    • Tethered ligand derived pentapeptide agonists of thrombin receptor - A study of side-chain requirements for human platelet activation and GTPase Stimulation
    • Natarajan S, Riexinger D, Peluso M and Seiler SM (1995) Tethered ligand derived pentapeptide agonists of thrombin receptor - a study of side-chain requirements for human platelet activation and GTPase Stimulation. Int J Peptide Protein Res 45:145-151.
    • (1995) Int J Peptide Protein Res , vol.45 , pp. 145-151
    • Natarajan, S.1    Riexinger, D.2    Peluso, M.3    Seiler, S.M.4
  • 276
    • 0028799617 scopus 로고
    • Platelet shape change induced by thrombin receptor activation. Rapid stimulation of tyrosine phosphorylation of novel protein substrates through an integrin- and Ca(2+)-independent mechanism
    • Negrescu EV, de Quintana KL and Siess W (1995) Platelet shape change induced by thrombin receptor activation. Rapid stimulation of tyrosine phosphorylation of novel protein substrates through an integrin- and Ca(2+)-independent mechanism. J Biol Chem 270:1057-1061.
    • (1995) J Biol Chem , vol.270 , pp. 1057-1061
    • Negrescu, E.V.1    De Quintana, K.L.2    Siess, W.3
  • 278
    • 0027510492 scopus 로고
    • Enhancement of the synthesis and secretion of nerve growth factor in primary cultures of glial cells by proteases - A possible involvement of thrombin
    • Neveu I, Jehan F, Jandrotperrus M, Wion D and Brachet P (1993) Enhancement of the synthesis and secretion of nerve growth factor in primary cultures of glial cells by proteases - a possible involvement of thrombin. J Neurochem 60:858-867.
    • (1993) J Neurochem , vol.60 , pp. 858-867
    • Neveu, I.1    Jehan, F.2    Jandrotperrus, M.3    Wion, D.4    Brachet, P.5
  • 279
    • 0032902109 scopus 로고    scopus 로고
    • Thrombin rapidly and efficiently activates gelatinase A in human microvascular endothelial cells via a mechanism independent of active MT1 matrix metalloproteinase
    • Nguyen M, Arkell J and Jackson CJ (1999a) Thrombin rapidly and efficiently activates gelatinase A in human microvascular endothelial cells via a mechanism independent of active MT1 matrix metalloproteinase. Lab Invest 79:467-475.
    • (1999) Lab Invest , vol.79 , pp. 467-475
    • Nguyen, M.1    Arkell, J.2    Jackson, C.J.3
  • 280
    • 0032896792 scopus 로고    scopus 로고
    • Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2
    • Nguyen TD, Moody MW, Steinhoff M, Okolo C, Koh DS and Bunnett NW (1999b) Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest 103:261-269.
    • (1999) J Clin Invest , vol.103 , pp. 261-269
    • Nguyen, T.D.1    Moody, M.W.2    Steinhoff, M.3    Okolo, C.4    Koh, D.S.5    Bunnett, N.W.6
  • 282
    • 0029153853 scopus 로고
    • Role of platelets, thrombin, integrin IIb-IIIa, fibronectin and von Willebrand factor on tumor adhesion in vitro and metastasis in vivo
    • Nierodzik ML, Klepfish A and Karpatkin S (1995) Role of platelets, thrombin, integrin IIb-IIIa, fibronectin and von Willebrand factor on tumor adhesion in vitro and metastasis in vivo. Thromb Haemostasis 74:282-290.
    • (1995) Thromb Haemostasis , vol.74 , pp. 282-290
    • Nierodzik, M.L.1    Klepfish, A.2    Karpatkin, S.3
  • 284
    • 0031661719 scopus 로고    scopus 로고
    • Interaction mode of the phe-phenyl group of thrombin receptor-tethered ligand SFLLRNP in receptor activation
    • Nose T, Fujita T, Nakajima M, Inoue Y, Costa T and Shimohigashi Y (1998a) Interaction mode of the phe-phenyl group of thrombin receptor-tethered ligand SFLLRNP in receptor activation. J Biochem 124:354-358.
    • (1998) J Biochem , vol.124 , pp. 354-358
    • Nose, T.1    Fujita, T.2    Nakajima, M.3    Inoue, Y.4    Costa, T.5    Shimohigashi, Y.6
  • 285
    • 0000917381 scopus 로고    scopus 로고
    • The role of arginine in thrombin receptor tethered-ligand peptide in intramolecular receptor binding and self-activation
    • Nose T, Satoh Y, Fujita T, Ohno M, Nakajima M, Inoue Y, Ogino Y, Costa T and Shimohigashi Y (1998b) The role of arginine in thrombin receptor tethered-ligand peptide in intramolecular receptor binding and self-activation. Bull Chem Soc Jpn 71:1661-1665.
    • (1998) Bull Chem Soc Jpn , vol.71 , pp. 1661-1665
    • Nose, T.1    Satoh, Y.2    Fujita, T.3    Ohno, M.4    Nakajima, M.5    Inoue, Y.6    Ogino, Y.7    Costa, T.8    Shimohigashi, Y.9
  • 286
    • 0027325620 scopus 로고
    • Enhancement of thrombin receptor activation by thrombin receptor-derived heptapeptide with para-fluorophenylalanine in place of phenylalanine
    • Nose T, Shimohigashi Y, Ohno M, Costa T, Shimizu N and Ogino Y (1993) Enhancement of thrombin receptor activation by thrombin receptor-derived heptapeptide with para-fluorophenylalanine in place of phenylalanine. Biochem Biophys Res Commun 193:694-699.
    • (1993) Biochem Biophys Res Commun , vol.193 , pp. 694-699
    • Nose, T.1    Shimohigashi, Y.2    Ohno, M.3    Costa, T.4    Shimizu, N.5    Ogino, Y.6
  • 287
    • 0029113121 scopus 로고
    • Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2
    • Nystedt S, Emilsson K, Larsson AK, Strombeck B and Sundelin J (1995a) Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur J Biochem 232:84-89.
    • (1995) Eur J Biochem , vol.232 , pp. 84-89
    • Nystedt, S.1    Emilsson, K.2    Larsson, A.K.3    Strombeck, B.4    Sundelin, J.5
  • 289
    • 0028934047 scopus 로고
    • The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression
    • Nystedt S, Larsson AK, Aberg H and Sundelin J (1995b) The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression. J Biol Chem 270:5950-5955.
    • (1995) J Biol Chem , vol.270 , pp. 5950-5955
    • Nystedt, S.1    Larsson, A.K.2    Aberg, H.3    Sundelin, J.4
  • 290
    • 15844401726 scopus 로고    scopus 로고
    • The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells -comparison with the thrombin receptor
    • Nystedt S, Ramakrishnan V and Sundelin J (1996) The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells -comparison with the thrombin receptor. J Biol Chem 271:14910-14915.
    • (1996) J Biol Chem , vol.271 , pp. 14910-14915
    • Nystedt, S.1    Ramakrishnan, V.2    Sundelin, J.3
  • 291
    • 0034608013 scopus 로고    scopus 로고
    • Thrombin responses in human endothelial cells - Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1
    • O'Brien PJ, Prevost N, Molino M, Hollinger MK, Woolkalis MJ, Woulfe DS and Brass LF (2000) Thrombin responses in human endothelial cells - contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. J Biol Chem 275:13502-13509.
    • (2000) J Biol Chem , vol.275 , pp. 13502-13509
    • O'Brien, P.J.1    Prevost, N.2    Molino, M.3    Hollinger, M.K.4    Woolkalis, M.J.5    Woulfe, D.S.6    Brass, L.F.7
  • 292
    • 0028179510 scopus 로고
    • G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
    • Offermanns S, Laugwitz KL, Spicher K and Schultz G (1994) G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc Natl Acad Sci USA 91:504-508.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 504-508
    • Offermanns, S.1    Laugwitz, K.L.2    Spicher, K.3    Schultz, G.4
  • 293
    • 0030756508 scopus 로고    scopus 로고
    • Defective platelet activation in G alpha(q)-deficient mice
    • Offermanns S, Toombs CF, Hu YH and Simon MI (1997) Defective platelet activation in G alpha(q)-deficient mice. Nature (Lond) 389:183-186.
    • (1997) Nature (Lond) , vol.389 , pp. 183-186
    • Offermanns, S.1    Toombs, C.F.2    Hu, Y.H.3    Simon, M.I.4
  • 294
    • 0030605209 scopus 로고    scopus 로고
    • Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells
    • Ogino Y, Tanaka K and Shimizu N (1996) Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells. Eur J Pharmacol 316:105-109.
    • (1996) Eur J Pharmacol , vol.316 , pp. 105-109
    • Ogino, Y.1    Tanaka, K.2    Shimizu, N.3
  • 295
    • 0034656081 scopus 로고    scopus 로고
    • Involvement of proline-rich tyrosine kinase 2 in platelet activation: Tyrosine phosphorylation mostly dependent on alpha lib beta 3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2
    • Ohmori T, Yatomi Y, Asazuma N, Satoh K and Ozaki Y (2000) Involvement of proline-rich tyrosine kinase 2 in platelet activation: tyrosine phosphorylation mostly dependent on alpha lib beta 3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2. Biochem J 347:561-569.
    • (2000) Biochem J , vol.347 , pp. 561-569
    • Ohmori, T.1    Yatomi, Y.2    Asazuma, N.3    Satoh, K.4    Ozaki, Y.5
  • 296
    • 0018190052 scopus 로고
    • Platelet glycocalicin: Interaction with thrombin and role as thrombin receptor on the platelet surface
    • Okamura T, Hasitz M and Jamieson GA (1978) Platelet glycocalicin: interaction with thrombin and role as thrombin receptor on the platelet surface. J Biol Chem 253:3435-3443.
    • (1978) J Biol Chem , vol.253 , pp. 3435-3443
    • Okamura, T.1    Hasitz, M.2    Jamieson, G.A.3
  • 297
    • 0034704906 scopus 로고    scopus 로고
    • G-protein-coupled receptors function as oligomers in vivo
    • Overton MC and Blumer KJ (2000) G-protein-coupled receptors function as oligomers in vivo. Curr Biol 10:341-344.
    • (2000) Curr Biol , vol.10 , pp. 341-344
    • Overton, M.C.1    Blumer, K.J.2
  • 299
    • 0034640499 scopus 로고    scopus 로고
    • Factor Viia and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa center dot tissue factor-induced signal transduction
    • Pendurthi UR, Allen KE, Ezban M and Rao LVM (2000) Factor Viia and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa center dot tissue factor-induced signal transduction. J Biol Chem 275:14632-14641.
    • (2000) J Biol Chem , vol.275 , pp. 14632-14641
    • Pendurthi, U.R.1    Allen, K.E.2    Ezban, M.3    Rao, L.V.M.4
  • 301
    • 0029914487 scopus 로고    scopus 로고
    • Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro
    • Pike CJ, Vaughan PJ, Cunningham DD and Cotman CW (1996) Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro. J Neurochem 66:1374-1382.
    • (1996) J Neurochem , vol.66 , pp. 1374-1382
    • Pike, C.J.1    Vaughan, P.J.2    Cunningham, D.D.3    Cotman, C.W.4
  • 302
    • 0027365121 scopus 로고
    • Receptor mechanism of thrombin-mediated pulmonary vasodilation in neonates
    • Pinheiro JMB, Andersen TT and Malik AB (1993) Receptor mechanism of thrombin-mediated pulmonary vasodilation in neonates. Am J Physiol 265:L355-L359.
    • (1993) Am J Physiol , vol.265
    • Pinheiro, J.M.B.1    Andersen, T.T.2    Malik, A.B.3
  • 303
    • 0027956391 scopus 로고
    • Evidence for a selective inhibitory effect of thrombin on megakaryocyte progenitor growth mediated by the thrombin receptor
    • Plantier JL, Berthier R, Rival Y, Schweitzer A and Rabiet MJ (1994) Evidence for a selective inhibitory effect of thrombin on megakaryocyte progenitor growth mediated by the thrombin receptor. Br J Haematol 87:755-762.
    • (1994) Br J Haematol , vol.87 , pp. 755-762
    • Plantier, J.L.1    Berthier, R.2    Rival, Y.3    Schweitzer, A.4    Rabiet, M.J.5
  • 304
    • 0029990852 scopus 로고    scopus 로고
    • Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells
    • Post GR, Collins LR, Kennedy ED, Moskowitz SA, Aragay AM, Goldstein D and Brown JH (1996) Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells. Mol Biol Cell 7:1679-1690.
    • (1996) Mol Biol Cell , vol.7 , pp. 1679-1690
    • Post, G.R.1    Collins, L.R.2    Kennedy, E.D.3    Moskowitz, S.A.4    Aragay, A.M.5    Goldstein, D.6    Brown, J.H.7
  • 305
  • 307
    • 0028805435 scopus 로고
    • Thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-gamma 1 in rat aortic smooth muscle cells
    • Rao GN, Delafontaine P and Runge MS (1995) Thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-gamma 1 in rat aortic smooth muscle cells. J Biol Chem 270:27871-27875.
    • (1995) J Biol Chem , vol.270 , pp. 27871-27875
    • Rao, G.N.1    Delafontaine, P.2    Runge, M.S.3
  • 310
    • 0028933979 scopus 로고
    • The phosphotyrosine phosphatase Ptp1d, but not Ptp1c, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G-protein-coupled receptors
    • Rivard N, McKenzie FR, Brondello JM and Pouyssegur J (1995) The phosphotyrosine phosphatase Ptp1d, but not Ptp1c, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G-protein-coupled receptors. J Biol Chem 270:11017-11024.
    • (1995) J Biol Chem , vol.270 , pp. 11017-11024
    • Rivard, N.1    McKenzie, F.R.2    Brondello, J.M.3    Pouyssegur, J.4
  • 311
    • 0028026923 scopus 로고
    • Phosphorylation of JAK2 in thrombin-stimulated human platelets
    • Rodriguez-Linares B and Watson SP (1994) Phosphorylation of JAK2 in thrombin-stimulated human platelets. FEBS Lett 352:335-338.
    • (1994) FEBS Lett , vol.352 , pp. 335-338
    • Rodriguez-Linares, B.1    Watson, S.P.2
  • 312
    • 0031890089 scopus 로고    scopus 로고
    • Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: Evidence for receptor heterogeneity
    • Roy SS, Saifeddine M, Loutzenhiser R, Triggle CR and Hollenberg MD (1998) Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity. Br J Pharmacol 123: 1434-1440.
    • (1998) Br J Pharmacol , vol.123 , pp. 1434-1440
    • Roy, S.S.1    Saifeddine, M.2    Loutzenhiser, R.3    Triggle, C.R.4    Hollenberg, M.D.5
  • 314
    • 0034717192 scopus 로고    scopus 로고
    • Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors
    • Sabri A, Muske G, Zhang HL, Pak E, Darrow A, Andrade-Gordon P and Steinberg SF (2000) Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors. Circ Res 86:1054-1061.
    • (2000) Circ Res , vol.86 , pp. 1054-1061
    • Sabri, A.1    Muske, G.2    Zhang, H.L.3    Pak, E.4    Darrow, A.5    Andrade-Gordon, P.6    Steinberg, S.F.7
  • 315
    • 0030008482 scopus 로고    scopus 로고
    • Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
    • Saifeddine M, Al-Ani B, Cheng CH, Wang L and Hollenberg MD (1996) Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol 118:521-530.
    • (1996) Br J Pharmacol , vol.118 , pp. 521-530
    • Saifeddine, M.1    Al-Ani, B.2    Cheng, C.H.3    Wang, L.4    Hollenberg, M.D.5
  • 316
    • 0035125329 scopus 로고    scopus 로고
    • Contractile actions of proteinase-activated receptor-derived polypeptides in guinea-pig gastric and lung parenchymal strips: Evidence for distinct receptor systems
    • Saifeddine M, Al-Ani B, Sandhu S, Wijesuriya SJ and Hollenberg MD (2001) Contractile actions of proteinase-activated receptor-derived polypeptides in guinea-pig gastric and lung parenchymal strips: evidence for distinct receptor systems. Br J Pharmacol 132:556-566.
    • (2001) Br J Pharmacol , vol.132 , pp. 556-566
    • Saifeddine, M.1    Al-Ani, B.2    Sandhu, S.3    Wijesuriya, S.J.4    Hollenberg, M.D.5
  • 317
    • 0031792955 scopus 로고    scopus 로고
    • Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: Release of a contracting factor via a novel receptor
    • Saifeddine M, Roy SS, Al-Ani B, Triggle CR and Hollenberg MD (1998) Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: release of a contracting factor via a novel receptor. Br J Pharmacol 125:1445-1454.
    • (1998) Br J Pharmacol , vol.125 , pp. 1445-1454
    • Saifeddine, M.1    Roy, S.S.2    Al-Ani, B.3    Triggle, C.R.4    Hollenberg, M.D.5
  • 318
    • 0028070998 scopus 로고
    • Structural essentials of Ser-1 in tethered peptide ligand of human thrombin receptor for phosphoinositide hydrolysis
    • Sakaguchi K, Kodama H, Ogino Y, Costa T, Nose T and Shimohigashi Y (1994) Structural essentials of Ser-1 in tethered peptide ligand of human thrombin receptor for phosphoinositide hydrolysis. Bull Chem Soc Jpn 67:1659-1663.
    • (1994) Bull Chem Soc Jpn , vol.67 , pp. 1659-1663
    • Sakaguchi, K.1    Kodama, H.2    Ogino, Y.3    Costa, T.4    Nose, T.5    Shimohigashi, Y.6
  • 319
    • 0033947541 scopus 로고    scopus 로고
    • Functional significance of oligomerization of G-protein-coupled receptors
    • Salahpour A, Angers S and Bouvier M (2000) Functional significance of oligomerization of G-protein-coupled receptors. Trends Endocrinol Metab 11:163-168.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 163-168
    • Salahpour, A.1    Angers, S.2    Bouvier, M.3
  • 323
    • 0030598870 scopus 로고    scopus 로고
    • Differential mobilization of tyrosine kinases in human platelets stimulated with thrombin or thrombin receptor agonist peptide
    • Satoh K, Ozaki Y, Asazuma N, Yatomi Y, Qi RM, Kuroda K, Yang LB and Kume S (1996) Differential mobilization of tyrosine kinases in human platelets stimulated with thrombin or thrombin receptor agonist peptide. Biochem Biophys Res Commun 225:1084-1089.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 1084-1089
    • Satoh, K.1    Ozaki, Y.2    Asazuma, N.3    Yatomi, Y.4    Qi, R.M.5    Kuroda, K.6    Yang, L.B.7    Kume, S.8
  • 324
    • 0034022706 scopus 로고    scopus 로고
    • Purification and characterization of a trypsin-like serine proteinase from rat brain slices that degrades laminin and type IV collagen and stimulates protease-activated receptor-2
    • Sawada K, Nishibori M, Nakaya N, Wang Z and Saeki K (2000) Purification and characterization of a trypsin-like serine proteinase from rat brain slices that degrades laminin and type IV collagen and stimulates protease-activated receptor-2. J Neurochem 74:1731-1738.
    • (2000) J Neurochem , vol.74 , pp. 1731-1738
    • Sawada, K.1    Nishibori, M.2    Nakaya, N.3    Wang, Z.4    Saeki, K.5
  • 325
    • 0026629249 scopus 로고
    • Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function
    • Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW and Coughlin SR (1992a) Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. J Biol Chem 267:13146-13149.
    • (1992) J Biol Chem , vol.267 , pp. 13146-13149
    • Scarborough, R.M.1    Naughton, M.A.2    Teng, W.3    Hung, D.T.4    Rose, J.5    Vu, T.K.6    Wheaton, V.I.7    Turck, C.W.8    Coughlin, S.R.9
  • 327
    • 0031850771 scopus 로고    scopus 로고
    • Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts
    • Schechter NM, Brass LF, Lavker RM and Jensen PJ (1998) Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts. J Cell Physiol 176:365-373.
    • (1998) J Cell Physiol , vol.176 , pp. 365-373
    • Schechter, N.M.1    Brass, L.F.2    Lavker, R.M.3    Jensen, P.J.4
  • 328
    • 0032510949 scopus 로고    scopus 로고
    • The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets
    • Schmidt VA, Nierman WC, Maglott DR, Cupit LD, Moskowitz KA, Wainer JA and Bahou WF (1998) The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets. J Biol Chem 273:15061-15068.
    • (1998) J Biol Chem , vol.273 , pp. 15061-15068
    • Schmidt, V.A.1    Nierman, W.C.2    Maglott, D.R.3    Cupit, L.D.4    Moskowitz, K.A.5    Wainer, J.A.6    Bahou, W.F.7
  • 329
    • 9844231500 scopus 로고    scopus 로고
    • Endogenous trypsin receptors in Xenopus oocytes: Linkage to internal calcium stores
    • Schultheiss M, Neumcke B and Richter HP (1997) Endogenous trypsin receptors in Xenopus oocytes: linkage to internal calcium stores. Cell Mol Life Sci 53:842-849.
    • (1997) Cell Mol Life Sci , vol.53 , pp. 842-849
    • Schultheiss, M.1    Neumcke, B.2    Richter, H.P.3
  • 330
    • 0028674019 scopus 로고
    • Tryptase: A mast cell serine protease
    • Schwartz LB (1994) Tryptase: a mast cell serine protease. Methods Enzymol 244: 88-100.
    • (1994) Methods Enzymol , vol.244 , pp. 88-100
    • Schwartz, L.B.1
  • 331
    • 0033612371 scopus 로고    scopus 로고
    • Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration
    • Seasholtz TM, Majumdar M, Kaplan DD and Brown JH (1999) Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res 84:1186-1193.
    • (1999) Circ Res , vol.84 , pp. 1186-1193
    • Seasholtz, T.M.1    Majumdar, M.2    Kaplan, D.D.3    Brown, J.H.4
  • 334
    • 0030774997 scopus 로고    scopus 로고
    • The effects of trypsin on apoptosis, utriculi size, and skin elasticity in the Rhino mouse
    • Seiberg M, Siock P, Wisniewski S, Cauwenbergh G and Shapiro SS (1997a) The effects of trypsin on apoptosis, utriculi size, and skin elasticity in the Rhino mouse. J Invest Dermatol 109:370-376.
    • (1997) J Invest Dermatol , vol.109 , pp. 370-376
    • Seiberg, M.1    Siock, P.2    Wisniewski, S.3    Cauwenbergh, G.4    Shapiro, S.S.5
  • 335
    • 0030971926 scopus 로고    scopus 로고
    • Trypsin-induced follicular papilla apoptosis results in delayed hair growth and pigmentation
    • Seiberg M, Wisniewski S, Cauwenbergh G and Shapiro SS (1997b) Trypsin-induced follicular papilla apoptosis results in delayed hair growth and pigmentation. Dev Dyn 208:553-564.
    • (1997) Dev Dyn , vol.208 , pp. 553-564
    • Seiberg, M.1    Wisniewski, S.2    Cauwenbergh, G.3    Shapiro, S.S.4
  • 336
    • 0028850759 scopus 로고
    • Inhibition of thrombin and SFLLR-peptide stimulation of platelet-aggregation, phospholipase a(2) and Na+/H+ exchange by a thrombin receptor antagonist
    • Seiler SM, Peluso M, Michel IM, Goldenberg H, Fenton JW, Riexinger D and Natarajan S (1995) Inhibition of thrombin and SFLLR-peptide stimulation of platelet-aggregation, phospholipase a(2) and Na+/H+ exchange by a thrombin receptor antagonist. Biochem Pharmacol 49:519-528.
    • (1995) Biochem Pharmacol , vol.49 , pp. 519-528
    • Seiler, S.M.1    Peluso, M.2    Michel, I.M.3    Goldenberg, H.4    Fenton, J.W.5    Riexinger, D.6    Natarajan, S.7
  • 337
    • 0030023688 scopus 로고    scopus 로고
    • Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: Receptor-stimulated GTPase and evaluation of agonists and partial agonists
    • Seiler SM, Peluso M, Tuttle JG, Pryor K, Klimas C, Matsueda GR and Bernatowicz MS (1996) Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: receptor-stimulated GTPase and evaluation of agonists and partial agonists. Mol Pharmacol 49:190-197.
    • (1996) Mol Pharmacol , vol.49 , pp. 190-197
    • Seiler, S.M.1    Peluso, M.2    Tuttle, J.G.3    Pryor, K.4    Klimas, C.5    Matsueda, G.R.6    Bernatowicz, M.S.7
  • 338
    • 0025681555 scopus 로고
    • Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not GO to S phase progression in hamster fibroblasts - Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine-receptors
    • Seuwen K, Kahan C, Hartmann T and Pouyssegur J (1990) Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not GO to S phase progression in hamster fibroblasts - comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine-receptors. J Biol Chem 265:22292-22299.
    • (1990) J Biol Chem , vol.265 , pp. 22292-22299
    • Seuwen, K.1    Kahan, C.2    Hartmann, T.3    Pouyssegur, J.4
  • 339
    • 0032582534 scopus 로고    scopus 로고
    • Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1
    • Shapiro MJ and Coughlin SR (1998) Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1. J Biol Chem 273: 29009-29014.
    • (1998) J Biol Chem , vol.273 , pp. 29009-29014
    • Shapiro, M.J.1    Coughlin, S.R.2
  • 340
    • 0030478939 scopus 로고    scopus 로고
    • Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization
    • Shapiro MJ, Trejo J, Zeng D and Coughlin SR (1996) Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem 271:32874-32880.
    • (1996) J Biol Chem , vol.271 , pp. 32874-32880
    • Shapiro, M.J.1    Trejo, J.2    Zeng, D.3    Coughlin, S.R.4
  • 341
    • 0034682810 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin
    • Shapiro MJ, Weiss EJ, Faruqi TR and Coughlin SR (2000) Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. J Biol Chem 275:25216-25221.
    • (2000) J Biol Chem , vol.275 , pp. 25216-25221
    • Shapiro, M.J.1    Weiss, E.J.2    Faruqi, T.R.3    Coughlin, S.R.4
  • 343
    • 0028808617 scopus 로고
    • Modified thrombin receptor-agonist peptide ligands - Synthesis and conformational-analysis of analogs of the N-terminal tripeptide region
    • Shimamoto T, Tsuboi H, Kitajima Y, Miyazaki T, Oyama Y, Imajo S and Ishiguro M (1995) Modified thrombin receptor-agonist peptide ligands - synthesis and conformational-analysis of analogs of the N-terminal tripeptide region. Bioorg Med Chem Lett 5:2417-2422.
    • (1995) Bioorg Med Chem Lett , vol.5 , pp. 2417-2422
    • Shimamoto, T.1    Tsuboi, H.2    Kitajima, Y.3    Miyazaki, T.4    Oyama, Y.5    Imajo, S.6    Ishiguro, M.7
  • 344
    • 0028167682 scopus 로고
    • Differential roles of 2 consecutive phenylalanine residues in thrombin receptor-tethered ligand peptides (SFFLRNP) in thrombin receptor activation
    • Shimohigashi Y, Nose T, Okazaki M, Satoh Y, Ohno M, Costa T, Shimizu N and Ogino Y (1994) Differential roles of 2 consecutive phenylalanine residues in thrombin receptor-tethered ligand peptides (SFFLRNP) in thrombin receptor activation. Biochem Biophys Res Commun 203:366-372.
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 366-372
    • Shimohigashi, Y.1    Nose, T.2    Okazaki, M.3    Satoh, Y.4    Ohno, M.5    Costa, T.6    Shimizu, N.7    Ogino, Y.8
  • 345
    • 0022924087 scopus 로고
    • Thrombin-cellular interactions
    • Shuman MA (1986) Thrombin-cellular interactions. Ann N Y Acad Sci 485:228-239.
    • (1986) Ann N Y Acad Sci , vol.485 , pp. 228-239
    • Shuman, M.A.1
  • 349
    • 0029134929 scopus 로고
    • Opposing actions of thrombin and protease nexin-1 on amyloid beta-peptide toxicity and on accumulation of peroxides and calcium in hippocampal neurons
    • Smith-Swintosky VL, Zimmer S, Fenton JW and Mattson MP (1995) Opposing actions of thrombin and protease nexin-1 on amyloid beta-peptide toxicity and on accumulation of peroxides and calcium in hippocampal neurons. J Neurochem 65:1415-1418.
    • (1995) J Neurochem , vol.65 , pp. 1415-1418
    • Smith-Swintosky, V.L.1    Zimmer, S.2    Fenton, J.W.3    Mattson, M.P.4
  • 350
    • 0031807665 scopus 로고    scopus 로고
    • Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo
    • Sobey CG and Cocks TM (1998) Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo. Stroke 29: 1439-1444.
    • (1998) Stroke , vol.29 , pp. 1439-1444
    • Sobey, C.G.1    Cocks, T.M.2
  • 351
    • 0032867472 scopus 로고    scopus 로고
    • Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation
    • Sobey CG, Moffatt JD and Cocks TM (1999) Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation. Stroke 30:1933-1940.
    • (1999) Stroke , vol.30 , pp. 1933-1940
    • Sobey, C.G.1    Moffatt, J.D.2    Cocks, T.M.3
  • 352
    • 0025903807 scopus 로고
    • Thrombin modulates phosphoinositide metabolism, cytosolic calcium, and impulse initiation in the heart
    • Steinberg SF, Robinson RB, Lieberman HB, Stern DM and Rosen MR (1991) Thrombin modulates phosphoinositide metabolism, cytosolic calcium, and impulse initiation in the heart. Circ Res 68:1216-1229.
    • (1991) Circ Res , vol.68 , pp. 1216-1229
    • Steinberg, S.F.1    Robinson, R.B.2    Lieberman, H.B.3    Stern, D.M.4    Rosen, M.R.5
  • 353
    • 0032814121 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 in human skin: Tissue distribution and activation of keratinocytes by mast cell tryptase
    • Steinhoff M, Corvera CU, Thoma MS, Kong W, Caughey GH, Ansel JC and Bunnett NW (1999) Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Exp Dermatol 8:282-294.
    • (1999) Exp Dermatol , vol.8 , pp. 282-294
    • Steinhoff, M.1    Corvera, C.U.2    Thoma, M.S.3    Kong, W.4    Caughey, G.H.5    Ansel, J.C.6    Bunnett, N.W.7
  • 355
    • 0022221113 scopus 로고
    • A platelet alpha-granule membrane-protein (Gmp-140) is expressed on the plasma-membrane after activation
    • Stenberg PE, McEver RP, Shuman MA, Jacques YV and Bainton DF (1985) A platelet alpha-granule membrane-protein (Gmp-140) is expressed on the plasma-membrane after activation. J Cell Biol 101:880-886.
    • (1985) J Cell Biol , vol.101 , pp. 880-886
    • Stenberg, P.E.1    McEver, R.P.2    Shuman, M.A.3    Jacques, Y.V.4    Bainton, D.F.5
  • 356
    • 0030589624 scopus 로고    scopus 로고
    • Trypsin induced von Willebrand factor release from human endothelial cells is mediated by PAR-2 activation
    • Storck J, Kusters B, Vahland M, MorysWortmann C and Zimmermann ER (1996) Trypsin induced von Willebrand factor release from human endothelial cells is mediated by PAR-2 activation. Thromb Res 84:463-473.
    • (1996) Thromb Res , vol.84 , pp. 463-473
    • Storck, J.1    Kusters, B.2    Vahland, M.3    Moryswortmann, C.4    Zimmermann, E.R.5
  • 357
    • 0030663183 scopus 로고    scopus 로고
    • Brefeldin A inhibits thrombin receptor regeneration in human endothelial cells
    • Storck J, Vahland M, Breer T and Zimmermann ER (1997) Brefeldin A inhibits thrombin receptor regeneration in human endothelial cells. Br J Haematol 99: 555-561.
    • (1997) Br J Haematol , vol.99 , pp. 555-561
    • Storck, J.1    Vahland, M.2    Breer, T.3    Zimmermann, E.R.4
  • 358
    • 0030068979 scopus 로고    scopus 로고
    • Regulation of the thrombin receptor response in human endothelial cells
    • Storck J and Zimmermann ER (1996) Regulation of the thrombin receptor response in human endothelial cells. Thromb Res 81:121-131.
    • (1996) Thromb Res , vol.81 , pp. 121-131
    • Storck, J.1    Zimmermann, E.R.2
  • 359
    • 0034053127 scopus 로고    scopus 로고
    • The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations
    • Striggow F, Riek M, Breder J, Henrich-Noack P, Reymann KG and Reiser G (2000) The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations. Proc Natl Acad Sci USA 97:2264-2269.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2264-2269
    • Striggow, F.1    Riek, M.2    Breder, J.3    Henrich-Noack, P.4    Reymann, K.G.5    Reiser, G.6
  • 360
    • 0027409404 scopus 로고
    • A player of many parts-the spotlight falls on thrombins structure
    • Stubbs MT and Bode W (1993) A player of many parts-the spotlight falls on thrombins structure. Thromb Res 69:1-58.
    • (1993) Thromb Res , vol.69 , pp. 1-58
    • Stubbs, M.T.1    Bode, W.2
  • 361
    • 0026795027 scopus 로고
    • Thrombin receptor-14 amino-acid peptide mediates Endothelial hyperadhesivity and neutrophil adhesion by P-selectin dependent mechanism
    • Sugama Y and Malik AB (1992) Thrombin receptor-14 amino-acid peptide mediates Endothelial hyperadhesivity and neutrophil adhesion by P-selectin dependent mechanism. Circ Res 71:1015-1019.
    • (1992) Circ Res , vol.71 , pp. 1015-1019
    • Sugama, Y.1    Malik, A.B.2
  • 363
    • 0030055624 scopus 로고    scopus 로고
    • Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis
    • Suzuki A, Kozawa O, Shinoda J, Watanabe Y, Saito H and Oiso Y (1996) Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis. J Cell Physiol 168:209-216
    • (1996) J Cell Physiol , vol.168 , pp. 209-216
    • Suzuki, A.1    Kozawa, O.2    Shinoda, J.3    Watanabe, Y.4    Saito, H.5    Oiso, Y.6
  • 364
    • 0034723344 scopus 로고    scopus 로고
    • Pari thrombin receptor-G protein interactions - Separation of binding and coupling determinants in the G alpha subunit
    • Swift S, Sheridan PJ, Covic L and Kuliopulos A (2000) Pari thrombin receptor-G protein interactions - separation of binding and coupling determinants in the G alpha subunit. J Biol Chem 275:2627-2635.
    • (2000) J Biol Chem , vol.275 , pp. 2627-2635
    • Swift, S.1    Sheridan, P.J.2    Covic, L.3    Kuliopulos, A.4
  • 366
    • 0034714379 scopus 로고    scopus 로고
    • Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates
    • Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR and Craik CS (2000) Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem 275:26333-26342.
    • (2000) J Biol Chem , vol.275 , pp. 26333-26342
    • Takeuchi, T.1    Harris, J.L.2    Huang, W.3    Yan, K.W.4    Coughlin, S.R.5    Craik, C.S.6
  • 367
    • 0019310629 scopus 로고
    • Platelet thrombin receptors-binding of alpha-thrombin is coupled to signal generation by a chymotrypsin-sensitive mechanism
    • Tam SW, Fenton JW II and Detwiler TC (1980) Platelet thrombin receptors-binding of alpha-thrombin is coupled to signal generation by a chymotrypsin-sensitive mechanism. J Biol Chem 255:6626-6632.
    • (1980) J Biol Chem , vol.255 , pp. 6626-6632
    • Tam, S.W.1    Fenton J.W. II2    Detwiler, T.C.3
  • 368
    • 25944479864 scopus 로고
    • Cloning of the mouse thrombin receptor from osteoblastic cells and regulation of its expression by 1,25-dihydroxyvitamin-D(3) and parathyroid-hormone
    • Tanaka H, Suva LJ, Duong LT and Rodan GA (1993) Cloning of the mouse thrombin receptor from osteoblastic cells and regulation of its expression by 1,25-dihydroxyvitamin-D(3) and parathyroid-hormone. J Bone Miner Res 8:S143.
    • (1993) J Bone Miner Res , vol.8
    • Tanaka, H.1    Suva, L.J.2    Duong, L.T.3    Rodan, G.A.4
  • 369
    • 0029047721 scopus 로고
    • Contractile actions of thrombin receptor-derived polypeptides in human umbilical and placental vasculature: Evidence for distinct receptor systems
    • Tay-Uyboco J, Poon MC, Ahmad S and Hollenberg MD (1995) Contractile actions of thrombin receptor-derived polypeptides in human umbilical and placental vasculature: evidence for distinct receptor systems. Br J Pharmacol 115:569-578.
    • (1995) Br J Pharmacol , vol.115 , pp. 569-578
    • Tay-Uyboco, J.1    Poon, M.C.2    Ahmad, S.3    Hollenberg, M.D.4
  • 370
    • 0028214577 scopus 로고
    • Distinct receptors and signaling pathways in alpha-thrombin-receptor and thrombin-receptor peptide-induced vascular contractions
    • Tesfamariam B (1994a) Distinct receptors and signaling pathways in alpha-thrombin-receptor and thrombin-receptor peptide-induced vascular contractions. Circ Res 74:930-936.
    • (1994) Circ Res , vol.74 , pp. 930-936
    • Tesfamariam, B.1
  • 371
    • 0028061845 scopus 로고
    • Thrombin receptor-mediated vascular relaxation differentiated by a receptor antagonist and desensitization
    • Tesfamariam B (1994b) Thrombin receptor-mediated vascular relaxation differentiated by a receptor antagonist and desensitization. Am J Physiol-Heart Circ Physiol 36:H1962-H1967.
    • (1994) Am J Physiol-Heart Circ Physiol , vol.36
    • Tesfamariam, B.1
  • 374
    • 0023822343 scopus 로고
    • Mast-cells in the initial-stages of psoriasis
    • Toruniowa B and Jablonska S (1988) Mast-cells in the initial-stages of psoriasis. Arch Dermatol Res 280:189-193.
    • (1988) Arch Dermatol Res , vol.280 , pp. 189-193
    • Toruniowa, B.1    Jablonska, S.2
  • 375
    • 0029028786 scopus 로고
    • G-protein beta-gamma-subunits stimulate phosphorylation of SHC adapter protein
    • Touhara K, Hawes BE, Vanbiesen T and Lefkowitz RJ (1995) G-protein beta-gamma-subunits stimulate phosphorylation of SHC adapter protein. Proc Natl Acad Sci USA 92:9284-9287.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9284-9287
    • Touhara, K.1    Hawes, B.E.2    Vanbiesen, T.3    Lefkowitz, R.J.4
  • 376
    • 0033593210 scopus 로고    scopus 로고
    • The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling
    • Trejo J and Coughlin SR (1999) The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem 274:2216-2224.
    • (1999) J Biol Chem , vol.274 , pp. 2216-2224
    • Trejo, J.1    Coughlin, S.R.2
  • 377
    • 0032506111 scopus 로고    scopus 로고
    • Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting
    • Trejo J, Hammes SR and Coughlin SR (1998) Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci USA 95:13698-13702.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13698-13702
    • Trejo, J.1    Hammes, S.R.2    Coughlin, S.R.3
  • 378
    • 0027159503 scopus 로고
    • Thrombin promotes angiogenesis by a mechanism independent of fibrin formation
    • Tsopanoglou NE, Pipilisynetos E and Maragoudakis ME (1993) Thrombin promotes angiogenesis by a mechanism independent of fibrin formation. Am J Physiol 264:C1302-C1307.
    • (1993) Am J Physiol , vol.264
    • Tsopanoglou, N.E.1    Pipilisynetos, E.2    Maragoudakis, M.E.3
  • 379
    • 0032100686 scopus 로고    scopus 로고
    • 2+](i)-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells
    • 2+](i)-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells. Neuroscience 86:597-609.
    • (1998) Neuroscience , vol.86 , pp. 597-609
    • Ubl, J.J.1    Vohringer, C.2    Reiser, G.3
  • 381
    • 0027411213 scopus 로고
    • Pertussis toxin-sensitive activation of P21(Ras) by G-protein-coupled receptor agonists in fibroblasts
    • Van Corven EJ, Hordijk PL, Medema RH, Bos JL and Moolenaar WH (1993) Pertussis toxin-sensitive activation of P21(Ras) by G-protein-coupled receptor agonists in fibroblasts. Proc Natl Acad Sci USA 90:1257-1261.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1257-1261
    • Van Corven, E.J.1    Hordijk, P.L.2    Medema, R.H.3    Bos, J.L.4    Moolenaar, W.H.5
  • 384
    • 0026775223 scopus 로고
    • Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides
    • Vassallo RR Jr, Kieber-Emmons T, Cichowski K and Brass LF (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem 267:6081-6085.
    • (1992) J Biol Chem , vol.267 , pp. 6081-6085
    • Vassallo R.R., Jr.1    Kieber-Emmons, T.2    Cichowski, K.3    Brass, L.F.4
  • 385
    • 0029012029 scopus 로고
    • Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults
    • Vaughan PJ, Pike CJ, Cotman CW and Cunningham DD (1995) Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J Neurosci 15:5389-5401.
    • (1995) J Neurosci , vol.15 , pp. 5389-5401
    • Vaughan, P.J.1    Pike, C.J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 386
    • 0028566867 scopus 로고
    • Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimers disease
    • Vaughan PJ, Su J, Cotman CW and Cunningham DD (1994) Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimers disease. Brain Res 668:160-170.
    • (1994) Brain Res , vol.668 , pp. 160-170
    • Vaughan, P.J.1    Su, J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 387
    • 0029869192 scopus 로고    scopus 로고
    • Thrombin stimulates wortmannin-inhibitable phosphoinositide 3-kinase and membrane blebbing in CHRF-288 cells
    • Vemuri GS, Zhang J, Huang R, Keen JH and Rittenhouse SE (1996) Thrombin stimulates wortmannin-inhibitable phosphoinositide 3-kinase and membrane blebbing in CHRF-288 cells. Biochem J 314:805-810.
    • (1996) Biochem J , vol.314 , pp. 805-810
    • Vemuri, G.S.1    Zhang, J.2    Huang, R.3    Keen, J.H.4    Rittenhouse, S.E.5
  • 388
    • 0032708759 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo
    • Vergnolle N (1999) Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. J Immunol 163:5064-5069.
    • (1999) J Immunol , vol.163 , pp. 5064-5069
    • Vergnolle, N.1
  • 389
    • 0034055571 scopus 로고    scopus 로고
    • Review article: Proteinase-activated receptors - Novel signals for gastrointestinal pathophysiology
    • Vergnolle N (2000) Review article: proteinase-activated receptors - novel signals for gastrointestinal pathophysiology. Aliment Pharmacol Ther 14:257-266.
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 257-266
    • Vergnolle, N.1
  • 390
    • 0005972440 scopus 로고    scopus 로고
    • Injection of proteinase-activated receptor-2-activating peptides (PAR2-APs) in the rat hindpaw induces hyperalgesia
    • Vergnolle N, Hollenberg MD and Wallace JL (2000) Injection of proteinase-activated receptor-2-activating peptides (PAR2-APs) in the rat hindpaw induces hyperalgesia. FASEB J 14:A386.
    • (2000) FASEB J , vol.14
    • Vergnolle, N.1    Hollenberg, M.D.2    Wallace, J.L.3
  • 391
    • 0032560576 scopus 로고    scopus 로고
    • Proteinase-activated receptor 2 (PAR2)-activating peptides: Identification of a receptor distinct from PAR2 that regulates intestinal transport
    • Vergnolle N, MacNaughton WK, Al-Ani B, Saifeddine M, Wallace JL and Hollenberg MD (1998) Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc Natl Acad Sci USA 95:7766-7771.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7766-7771
    • Vergnolle, N.1    MacNaughton, W.K.2    Al-Ani, B.3    Saifeddine, M.4    Wallace, J.L.5    Hollenberg, M.D.6
  • 393
    • 25944438591 scopus 로고    scopus 로고
    • Activation of proteinase-activated receptor-2 (PAR-2) induces leukocyte adhesion
    • Vergnolle N, Wallace JL and Hollenberg MD (1999) Activation of proteinase-activated receptor-2 (PAR-2) induces leukocyte adhesion. FASEB J 13:A668.
    • (1999) FASEB J , vol.13
    • Vergnolle, N.1    Wallace, J.L.2    Hollenberg, M.D.3
  • 394
    • 0026594963 scopus 로고
    • Thrombin inhibits proliferation of the human megakaryoblastic MEG-01 cell line: A possible involvement of a cyclic-AMP dependent mechanism
    • Vittet D, Mathieu MN, Launay JM and Chevillard C (1992) Thrombin inhibits proliferation of the human megakaryoblastic MEG-01 cell line: a possible involvement of a cyclic-AMP dependent mechanism. J Cell Physiol 150:65-75.
    • (1992) J Cell Physiol , vol.150 , pp. 65-75
    • Vittet, D.1    Mathieu, M.N.2    Launay, J.M.3    Chevillard, C.4
  • 396
    • 0031717365 scopus 로고    scopus 로고
    • Regulation of the actin cytoskeleton by thrombin in human endothelial cells: Role of Rho proteins in endothelial barrier function
    • Vouret-Craviari V, Boquet P, Pouyssegur J and Van Obberghen-Schilling E (1998) Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. Mol Biol Cell 9:2639-2653.
    • (1998) Mol Biol Cell , vol.9 , pp. 2639-2653
    • Vouret-Craviari, V.1    Boquet, P.2    Pouyssegur, J.3    Van Obberghen-Schilling, E.4
  • 398
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu TK, Hung DT, Wheaton VI and Coughlin SR (1991a) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 400
    • 0030893530 scopus 로고    scopus 로고
    • Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes
    • Wakita H, Furukawa F and Takigawa M (1997) Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes. Proc Assoc Am Phys 109:190-207.
    • (1997) Proc Assoc Am Phys , vol.109 , pp. 190-207
    • Wakita, H.1    Furukawa, F.2    Takigawa, M.3
  • 401
    • 0032407674 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB and thrombin activate phosphoinositide 3-kinase and protein kinase B: Role in mediating airway smooth muscle proliferation
    • Walker TR, Moore SM, Lawson MF, Panettieri RA Jr and Chilvers ER (1998) Platelet-derived growth factor-BB and thrombin activate phosphoinositide 3-kinase and protein kinase B: role in mediating airway smooth muscle proliferation. Mol Pharmacol 54:1007-1015.
    • (1998) Mol Pharmacol , vol.54 , pp. 1007-1015
    • Walker, T.R.1    Moore, S.M.2    Lawson, M.F.3    Panettieri R.A., Jr.4    Chilvers, E.R.5
  • 403
    • 0031951510 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia ij wild-type and tPA deficient mice
    • Wang YF, Tsirka SE, Strickland S, Steig PE, Soriano SG and Lipton SA (1998) Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia ij wild-type and tPA deficient mice. Nature Med 4:228-231.
    • (1998) Nature Med , vol.4 , pp. 228-231
    • Wang, Y.F.1    Tsirka, S.E.2    Strickland, S.3    Steig, P.E.4    Soriano, S.G.5    Lipton, S.A.6
  • 404
    • 0024388182 scopus 로고
    • Differential ability of agonists to express distinct pools of fibrinogen (Gpiib/Iiia) receptors which can mediate the aggregation of human platelets
    • Watts IS, Keery RJ and Lumley P (1989) Differential ability of agonists to express distinct pools of fibrinogen (Gpiib/Iiia) receptors which can mediate the aggregation of human platelets. Thromb Haemostasis 62:955-961.
    • (1989) Thromb Haemostasis , vol.62 , pp. 955-961
    • Watts, I.S.1    Keery, R.J.2    Lumley, P.3
  • 405
    • 0028914068 scopus 로고
    • Cellular-localization of thrombin receptor messenger-RNA in rat-brain - Expression by mesencephalic dopaminergic-neurons and codistribution with prothrombin messenger-RNA
    • Weinstein JR, Gold SJ, Cunningham DD and Gall CM (1995) Cellular-localization of thrombin receptor messenger-RNA in rat-brain - expression by mesencephalic dopaminergic-neurons and codistribution with prothrombin messenger-RNA. J Neurosci 15:2906-2919.
    • (1995) J Neurosci , vol.15 , pp. 2906-2919
    • Weinstein, J.R.1    Gold, S.J.2    Cunningham, D.D.3    Gall, C.M.4
  • 406
    • 0031869126 scopus 로고    scopus 로고
    • Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line
    • Weinstein JR, Lau AL, Brass LF and Cunningham DD (1998) Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line. J Neurochem 71:1034-1050.
    • (1998) J Neurochem , vol.71 , pp. 1034-1050
    • Weinstein, J.R.1    Lau, A.L.2    Brass, L.F.3    Cunningham, D.D.4
  • 407
    • 0027412695 scopus 로고
    • The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor
    • Weiss RH and Maduri M (1993) The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor. J Biol Chem 268:5724-5727.
    • (1993) J Biol Chem , vol.268 , pp. 5724-5727
    • Weiss, R.H.1    Maduri, M.2
  • 409
    • 0025615602 scopus 로고
    • Post-traumatic epilepsy: Cellular mechanisms and implications for treatment
    • Willmore LJ (1990) Post-traumatic epilepsy: cellular mechanisms and implications for treatment. Epilepsia 31:S67-S73.
    • (1990) Epilepsia , vol.31
    • Willmore, L.J.1
  • 418
    • 0032496275 scopus 로고
    • Cloning and characterization of the cDNA for human airway trypsin-like protease
    • Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N and Yasuoka S (1901) (1998) Cloning and characterization of the cDNA for human airway trypsin-like protease. J Biol Chem 273:11895-11901.
    • (1901) J Biol Chem , vol.273 , pp. 11895-11901
    • Yamaoka, K.1    Masuda, K.2    Ogawa, H.3    Takagi, K.4    Umemoto, N.5    Yasuoka, S.6
  • 420
    • 0031952215 scopus 로고    scopus 로고
    • Protein kinase C beta regulates heterologous desensitization of thrombin receptor (PAR-1) in endothelial cells
    • Yan W, Tiruppathi C, Lum H, Qiao R and Malik AB (1998) Protein kinase C beta regulates heterologous desensitization of thrombin receptor (PAR-1) in endothelial cells. Am J Physiol 274:0387-396.
    • (1998) Am J Physiol , vol.274 , pp. 387-396
    • Yan, W.1    Tiruppathi, C.2    Lum, H.3    Qiao, R.4    Malik, A.B.5
  • 422
    • 0026656071 scopus 로고
    • Actions of thrombin and thrombin receptor peptide analogs in gastric and aortic smooth-muscle development of bioassays for structure-activity studies
    • Yang SG, Laniyonu A, Saifeddine M, Moore GJ and Hollenberg MD (1992) Actions of thrombin and thrombin receptor peptide analogs in gastric and aortic smooth-muscle development of bioassays for structure-activity studies. Life Sci 51:1325-1332.
    • (1992) Life Sci , vol.51 , pp. 1325-1332
    • Yang, S.G.1    Laniyonu, A.2    Saifeddine, M.3    Moore, G.J.4    Hollenberg, M.D.5
  • 423
    • 0030936370 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway
    • Yu Z, Ahmad S, Schwartz JL, Banville D and Shen SH (1997) Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway. J Biol Chem 272:7519-7524.
    • (1997) J Biol Chem , vol.272 , pp. 7519-7524
    • Yu, Z.1    Ahmad, S.2    Schwartz, J.L.3    Banville, D.4    Shen, S.H.5
  • 424
  • 425
    • 25944450681 scopus 로고
    • Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs
    • Zaleski JK and Ku DD (1993) Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs. FASEB Jl 7:A118.
    • (1993) FASEB Jl , vol.7
    • Zaleski, J.K.1    Ku, D.D.2
  • 426
    • 0033801789 scopus 로고    scopus 로고
    • Molecular aspects of muscarinic receptor dimerization
    • Zeng FY and Wess J (2000) Molecular aspects of muscarinic receptor dimerization. Neuropsychopharmacology 23:S19-S31.
    • (2000) Neuropsychopharmacology , vol.23
    • Zeng, F.Y.1    Wess, J.2
  • 427
    • 0028951061 scopus 로고
    • Sequestration of a G-protein beta gamma subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases
    • Zhang J, Benovic JL, Sugai M, Wetzker R, Gout I and Rittenhouse SE (1995) Sequestration of a G-protein beta gamma subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases. J Biol Chem 270:6589-6594.
    • (1995) J Biol Chem , vol.270 , pp. 6589-6594
    • Zhang, J.1    Benovic, J.L.2    Sugai, M.3    Wetzker, R.4    Gout, I.5    Rittenhouse, S.E.6
  • 429
    • 0028130016 scopus 로고
    • Thrombin receptor peptide-mediated leukocyte rolling in rat mesenteric venules -roles of P-selectin and sialyl-Lewis. X
    • Zimmerman BJ, Paulson JC, Arrhenius TS, Gaeta FCA and Granger DN (1994) Thrombin receptor peptide-mediated leukocyte rolling in rat mesenteric venules -roles of P-selectin and sialyl-Lewis. X. Am J Physiol 267:H1049-H1053.
    • (1994) Am J Physiol , vol.267
    • Zimmerman, B.J.1    Paulson, J.C.2    Arrhenius, T.S.3    Gaeta, F.C.A.4    Granger, D.N.5
  • 430
    • 0028804964 scopus 로고
    • Thrombin induces the activation of progelatinase a in vascular endothelial cells. Physiologic regulation of angiogenesis
    • Zucker S, Conner C, DiMassmo BI, Ende H, Drews M, Seiki M and Bahou WF (1995) Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis. J Biol Chem 270:23730-23738.
    • (1995) J Biol Chem , vol.270 , pp. 23730-23738
    • Zucker, S.1    Conner, C.2    Dimassmo, B.I.3    Ende, H.4    Drews, M.5    Seiki, M.6    Bahou, W.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.