Similar structures and shared switch mechanisms of the β2- adrenoceptor and the parathyroid hormone receptor. Zn(II) Bridges between helices III and VI block activation

Journal of Biological Chemistry

Volumn 274, Issue 24, 1999, Pages 17033-17041

  Sheikh, Søren P ^a,b   Vilardarga, Jean Pierre ^a   Baranski, Thomas J ^a   Lichtarge, Olivier ^c   Iiri, Taroh ^d   Meng, Elaine C ^a   Nissenson, Robert A ^a   Bourne, Henry R ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Dept of Cardiology B   (Denmark)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e Univ of Tokyo School of Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; AMINO ACID; BETA 2 ADRENERGIC RECEPTOR; CYANOPINDOLOL I 125; GUANINE NUCLEOTIDE BINDING PROTEIN; HISTIDINE; ISOPRENALINE; PARATHYROID HORMONE RECEPTOR; RHODOPSIN; SERPENTINE; ZINC;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; METAL BINDING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BINDING, COMPETITIVE; EVOLUTION, MOLECULAR; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HISTIDINE; HUMANS; ISOPROTERENOL; MODELS, MOLECULAR; MUTATION; OPSIN; PINDOLOL; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, PARATHYROID HORMONE; SECRETIN; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; ZINC;

EID: 0033546197     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.24.17033     Document Type: Article

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