Molecular Interactions of Cyclam and Bicyclam Non-peptide Antagonists with the CXCR4 Chemokine Receptor

Journal of Biological Chemistry

Volumn 276, Issue 17, 2001, Pages 14153-14160

  Gerlach, Lars Ole ^a   Skerlj, Renato T ^b   Bridger, Gary J ^b   Schwartz, Thue W ^a,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b GENZYME CORPORATION   (United States)

^c 7TM Pharma A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; BIOLOGICAL MEMBRANES; CELLS; VIRUSES;

CHEMICAL LINKERS;

PROTEINS;

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); BICYCLAM DERIVATIVE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; COMPLEMENTARY DNA; CYCLAM DERIVATIVE; IODINE 125; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; ALPHA CHEMOKINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIVIRUS AGENT; ASPARAGINE; ASPARTIC ACID; CYCLAM; HETEROCYCLIC COMPOUND; LIGAND; STROMAL CELL DERIVED FACTOR 1;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG POTENCY; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; CELL STRAIN COS1; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC TRANSFECTION; GENETICS; HUMAN; IC 50; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; STATISTICAL MODEL;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; ANIMALS; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; ASPARAGINE; ASPARTIC ACID; BINDING, COMPETITIVE; CHEMOKINES, CXC; COS CELLS; DNA, COMPLEMENTARY; HETEROCYCLIC COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; LINEAR MODELS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CXCR4; TRANSFECTION;

EID: 0035957911     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010429200     Document Type: Article

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