The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells

Journal of Leukocyte Biology

Volumn 71, Issue 5, 2002, Pages 854-862

  Kwakkenbos, Mark J ^a,b,c   Chang, Gin Wen ^b,c   Lin, Hsi Hsien ^b,c   Pouwels, Walter ^a,b,c   De Jong, Esther C ^b,c   Van Lier, René A W ^a,b,c   Gordon, Siamon ^b,c   Hamannz, Jörg ^a,b,c  

^a CLB   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CD97; Myeloid lineage; Proteolytic processing

Indexed keywords

DECAY ACCELERATING FACTOR; EPIDERMAL GROWTH FACTOR; MEMBRANE RECEPTOR; MONOCLONAL ANTIBODY; PROTEIN EMR2; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW CELL; CELLULAR DISTRIBUTION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; LEUKOCYTE; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR BINDING;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; DENDRITIC CELLS; DIMERIZATION; EPIDERMAL GROWTH FACTOR; GRANULOCYTES; HUMANS; LECTINS; LYMPHOCYTES; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MONOCYTES; MYELOID CELLS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; TISSUE DISTRIBUTION;

EID: 0036587674     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Bockaert, J., Pin, J-P. (1999) Molecular tinkering of G protein-coupled receptors: an evolutionary sucess. EMBO J. 18, 1723-1729.
2. Kehrl, J. H. (1998) Heterotrimeric G protein signaling: roles in immune function and fine-tuning by RGS proteins. Immunity 8, 1-10.
3. Segre, G. V., Goldring, S. R. (1993) Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family. Trends Endocrinol. Metab. 4, 309-314.
4. Stacey, M., Lin, H-H., Gordon, S., McKnight, A. J. (2000) LNB-TM7, a group of seven-transmembrane proteins related to family-B G-proten-coupled receptors. Trends Biochem. Sci. 25, 284-289.
5. McKnight, A. J., Gordon, S. (1998) The EGF-TM7 family: unusual structures at the leukocyte surface. J. Leukoc. Biol. 63, 271-280.
6. Hamann, J., Eichler, W., Hamann, D., Kerstens, H. M. J., Poddighe, P. J., Hoovers, J. M. N., Hartmann, E., Strauss, M., Van Lier, R. A. W. (1995) Expression cloning and chromosomal mapping of the leucocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretin receptor superfamily with an unusual extracellular domain. J. Immunol. 155, 1942-1950.
7. Gray, J. X., Haino, M., Roth, M. J., Maguire, J. E., Jensen, P. N., Yarme, A., Stetler-Stevenson, M-A., Siebenlist, U., Kelly, K. (1996) CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. J. Immunol. 157, 5438-5447.
8. Qian, Y-M., Haino, M., Kelly, K., Song, W-C. (1999) Structural characterization of mouse CD97 and study of its specific interaction with murine decay-accelerating factor (DAF, CD55). Immunology 98, 303-311.
9. Hamann, J., van Zeventer, C., Bijl, A., Molenaar, C., Tesselaar, K., Van Lier, R. A. W. (2000) Molecular cloning and characterization of mouse CD97. Int. Immunol. 12, 439-448.
10. Baud, V., Chissoe, S. L., Viegas-Pequignot, E., Diriong, S., N'Guyen, V. C., Roe, B. A., Lipinski, M. (1995) EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. Genomics 26, 334-344.
11. McKnight, A. J., Macfarlane, A. J., Dri, P., Turley, L., Willis, A. C., Gordon, S. (1996) Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family. J. Biol. Chem. 271, 486-489.
12. Lin, H-H., Stubbs, L. J., Mucenski, M. L. (1997) Identification and characterization of a seven transmembrane hormone receptor using differential display. Genomics 41, 301-308.
13. Lin, H-H., Stacey, M., Hamann, J., Gordon, S., McKnight, A. J. (2000) Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. Genomics 67, 188-200.
14. Stacey, M., Lin, H-H., Hilyard, K. L., Gordon, S., McKnight, A. J. (2001) Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J. Biol. Chem. 276, 18863-18870.
15. Nechiporuk, T., Urness, L. D., Keating, M. T. (2001) ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. J. Biol. Chem. 276, 4150-4157.
16. Krasnoperov, V. G., Bittner, M. A., Beavis, R., Kuang, Y., Salnikow, K. V., Chepurny, O. G., Little, A. R., Plotnikov, A. N., Wu, D., Holz, R. W., Petrenko, A. G. (1997) Alpha-latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron 18, 925-937.
17. Ponting, C. P., Hofmann, K., Bork, P. (1999) A latrophilin/CL-1-like GPS domain in polycystin-1. Curr. Biol. 9, R585-R588.
18. Eichler, W., Aust, G., Hamann, D. (1994) Characterization of an early activation-dependent antigen on lymphocytes defined by the monoclonal antibody BL-Ac(F2). Scand. J. Immunol. 39, 111-115.
19. Eichler, W., Hamann, J., Aust, G. (1997) Expression characteristics of the human CD97 antigen. Tissue Antigens 50, 429-438.
20. Jaspars, L. H., Vos, W., Aust, G., Van Lier, R. A. W., Hamann, J. (2001) Tissue distribution of the human CD97 EGF-TM7 receptor. Tissue Antigens 57, 325-331.
21. Aust, G., Eichler, W., Laue, S., Lehmann, I., Heldin, N. E., Lotz, O., Scherbaum, W. A., Dralle, H., Hoang-Vu, C. (1997) CD97: a dedifferentiation marker in human thyroid carcinomas. Cancer Res. 57, 1798-1806.
22. Hamann, J., Vogel, B., Van Schijndel, G. M. W., Van Lier, R. A. W. (1996) The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). J. Exp. Med. 184, 1185-1189.
23. Liszewski, M. K., Farries, T. C., Lublin, D. M., Rooney, I. A., Atkinson, J. P. (1996) Control of the complement system. Adv. Immunol. 61, 201-283.
24. Hamann, J., Eichler, W., Vogel, B., Stortelers, C., Hamann, D., Horejsi, V., Van Lier, R. A. W. (1997) CD97 workshop panel report. In Leucocyte Typing VI (T. Kishimoto, S. Goyert, H. Kikutani, D. Mason, M. Miyasaka, L. Moretta, T. Ohno, K. Okumura, S. Shaw, T. A. Springer, K. Sugumura, A. E. G. K. Von dem Borne, H. Zola, eds.), London, Garland, 527-529.
25. Lin, H-H., Stacey, M., Saxby, C., Knott, V., Chaudhry, Y., Evans, D., Gordon, S., McKnight, A. J., Handford, P., Lea, S. (2001) Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. J. Biol. Chem. 276, 24160-24169.
26. Kwakkenbos, M. J., Van Lier, R. A. W., Hamann, J. (2001) Characterization of EGF-TM7 family members by novel monoclonal antibodies. In Leucocyte Typing VII (D. Mason, ed.), Oxford, Oxford University Press.
27. Kuipers, T. W., Tool, A. T. J., van der Schoot, C. E., Ginsel, L. A., Onderwater, J. J. M., Roos, D., Verhoeven, A. J. (1991) Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation. Blood 78, 1105-1111.
28. Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenyi, S., Buck, D. W., Schmitz, J. (2000) BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 165, 6037-6046.
29. + subpopulation. Immunol. Today 17, 424-428.
30. ++ cells derived in vitro from peripheral blood monocytes exhibit phenotypic and functional dendritic cell-like characteristics. Eur. J. Immunol. 30, 1872-1883.
31. Ji, T. H., Grossmann, M., Ji, I. (1998) G protein-coupled receptors. I. Diversity of receptor-ligand interactions. J. Biol. Chem. 273, 17299-17302.