Small molecule modulation of smoothened activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 22, 2002, Pages 14071-14076

  Chen, James K ^a   Taipale, Jussi ^a   Young, Keith E ^a   Maiti, Tapan ^a   Beachy, Philip A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; BENZOTHIOPHENE DERIVATIVE; CHLOROBENZOIC ACID DERIVATIVE; CYCLOPAMINE; G PROTEIN COUPLED RECEPTOR; PROTEIN SMO; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DRUG PROTEIN BINDING; EMBRYO DEVELOPMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; BENZAMIDES; BENZIMIDAZOLES; BINDING SITES; CELL LINE; CINNAMATES; CYCLOHEXYLAMINES; GTP-BINDING PROTEINS; HEDGEHOG PROTEINS; HUMANS; MICE; PIPERAZINES; PIPERIDINES; PYRAZOLES; PYRIDINES; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SULFIDES; THIOPHENES; TRANS-ACTIVATORS;

ANIMALIA; ERINACEIDAE; VERTEBRATA;

EID: 0037195074     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.182542899     Document Type: Article

References (38)

1. Ingham, P. W. & McMahon, A. P. (2001) Genes Dev. 15, 3059-3087.
2. Goodrich, L. V. & Scott, M. P. (1998) Neuron 21, 1243-1257.
3. Taipale, J. & Beachy, P. A. (2001) Nature 411, 349-354.
4. Wicking, C. & McGlinn, E. (2001) Cancer Lett. 173, 1-7.
5. Hooper, J. E. & Scott, M. P. (1989) Cell 59, 751-765.
6. Nakano, Y., Guerrero, I., Hidalgo, A., Taylor, A., Whittle, J. R. & Ingham, P. W. (1989) Nature 341, 508-513.
7. Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M. & Hooper, J. E. (1996) Cell 86, 221-232.
8. Stone, D. M., Hynes, M., Armanini, M., Swanson, T. A., Gu, Q., Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A., Phillips, H., et al. (1996) Nature 384, 129-134.
9. van den Heuvel, M. & Ingham, P. W. (1996) Nature 382, 547-551.
10. Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M. & Tabin, C. J. (1996) Nature 384, 176-179.
11. Fuse, N., Maiti, T., Wang, B., Porter, J. A., Hall, T. M., Leahy, D. J. & Beachy, P. A. (1999) Proc. Natl. Acad. Sci. USA 96, 10992-10999.
12. Kalderon, D. (2000) Cell 103, 371-374.
13. Aza-Blanc, P., Ramirez-Weber, F. A., Laget, M. P., Schwartz, C. & Kornberg, T. B. (1997) Cell 89, 1043-1053.
14. Chen, C. H., von Kessler, D. P., Park, W., Wang, B., Ma, Y. & Beachy, P. A. (1999) Cell 98, 305-316.
15. Nusslein-Volhard, C., Wieschaus, E. & Kluding, H. (1984) Roux's Arch. Dev. Biol. 193, 267-282.
16. Zhang, X. M., Ramalho-Santos, M. & McMahon, A. P. (2001) Cell 106, 781-792.
17. Barresi, M. J., Stickney, H. L. & Devoto, S. H. (2000) Development (Cambridge, U.K.) 127, 2189-2199.
18. Chen, W., Burgess, S. & Hopkins, N. (2001) Development (Cambridge, U.K.) 128, 2385-2396.
19. Denef, N., Neubuser, D., Perez, L. & Cohen, S. M. (2000) Cell 102, 521-531.
20. Ingham, P. W., Nystedt, S., Nakano, Y., Brown, W., Stark, D., van den Heuvel, M. & Taylor, A. M. (2000) Curr. Biol. 10, 1315-1318.
21. Taipale, J., Cooper, M. K., Maiti, T. & Beachy, P. A. (2002) Nature 418, 892-896.
22. Cooper, M. K., Porter, J. A., Young, K. E. & Beachy, P. A. (1998) Science 280, 1603-1607.
23. Incardona, J. P., Gaffield, W., Kapur, R. P. & Roelink, H. (1998) Development (Cambridge, U.K.) 125, 3553-3562.
24. Taipale, J., Chen, J. K., Cooper, M. K., Wang, B., Mann, R. K., Milenkovic, L., Scott, M. P. & Beachy, P. A. (2000) Nature 406, 1005-1009.
25. Chen, J. K., Taipale, J., Cooper, M. K. & Beachy, P. A. (2002) Genes Dev., in press.
26. Tseng, T. T., Gratwick, K. S., Kollman, J., Park, D., Nies, D. H., Goffeau, A. & Saier, M. H., Jr. (1999) J. Mol. Microbiol. Biotechnol. 1, 107-125.
27. Davies, J. P., Chen, F. W. & loannou, Y. A. (2000) Science 290, 2295-2298.
28. Baxter, A. D., Boyd, E. A., Guicherit, O. M., Porter, J., Price, S. & Rubin, L. E. (2001) PCT Int. Appl., WO 2001-US10296.
29. Berman, D. M., Karhadkar, S. S., Hallahan, A. R., Pritchard, J. I., Eberhart, C. G., Watkins, N., Chen, J. K., Cooper, M. K., Taipale, J., Olson, J. M. & Beachy, P. A. (2002) Science 297, 1559-1561.
30. Goodrich, L. V., Milenkovic, L., Higgins, K. M. & Scott, M. P. (1997) Science 277, 1109-1113.
31. Christopoulos, A. & Kenakin, T. (2002) Pharmacol. Rev. 54, 323-374.
32. Incardona, J. P., Gruenberg, J. & Roelink, H. (2002) Curr. Biol. 12, 983-995.
33. Pinson, K. I., Brennan, J., Monkley, S., Avery, B. J. & Skarnes, W. C. (2000) Nature 407, 535-538.
34. Wehrli, M., Dougan, S. T., Caldwell, K., O'Keefe, L., Schwartz, S., Vaizel-Ohayon, D., Schejter, E., Tomlinson, A. & DiNardo, S. (2000) Nature 407, 527-530.
35. Bhanot, P., Brink, M., Samos, C. H., Hsieh, J. C., Wang, Y., Macke, J. P., Andrew, D., Nathans, J. & Nusse, R. (1996) Nature 382, 225-230.
36. Sprong, H., van der Sluijs, P. & van Meer, G. (2001) Nat. Rev. Mol. Cell. Biol. 2, 504-513.
37. Lam, C. W., Xie, J., To, K. F., Ng, H. K., Lee, K. C., Yuen, N. W., Lim, P. L., Chan, L. Y., Tong, S. F. & McCormick, F. (1999) Oncogene 18, 833-836.
38. Frank-Kamenetsky, M., Zhang, X. M., Bottega, S., Guicherit, O., Wichterle, H., Dudek, D., Bumcrot, D., Wang, F., Jones, S., Shulok, J., Rubin, L. & Porter, J. A. (2002) J. Biol., in press.