Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. Binding to a common chemokine receptor motif within the helical bundle

Journal of Biological Chemistry

Volumn 275, Issue 33, 2000, Pages 25562-25571

  Mirzadegan, T ^a   Diehl, F ^a   Ebi, B ^a   Bhakta, S ^a   Polsky, I ^a   McCarley, D ^a   Mulkins, M ^a   Weatherhead, G S ^a   Lapierre, J M ^a   Dankwardt, J ^a   Morgans D , Jr ^a   Wilhelm, R ^a   Jarnagin, K ^a  

^a Entelos Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR3; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; PIPERIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ARTICLE; ASTHMA; ATHEROSCLEROSIS; BINDING AFFINITY; HUMAN; HUMAN CELL; MUTATION; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; RECEPTOR BINDING; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM; CELL LINE; CHEMOTAXIS; CHO CELLS; CRICETINAE; CYCLIC AMP; CYTOKINES; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; LUCIFERASES; MOLECULAR SEQUENCE DATA; MONOCYTE CHEMOATTRACTANT PROTEINS; MUTAGENESIS, SITE-DIRECTED; NITROGEN; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; RANTES; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034682767     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M000692200     Document Type: Article

References (52)