Mechanisma and role of PDZ domains in signaling complex assembly

Journal of Cell Science

Volumn 114, Issue 18, 2001, Pages 3219-3231

  Harris, B Z ^a   Lim, W A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

PDZ; Scaffolding; Signaling

Indexed keywords

AMINO ACID; CELL PROTEIN; MEMBRANE PROTEIN; PEPTIDE; DISCS LARGE 1 PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; INSECT PROTEIN; LIGAND; NERVE PROTEIN; PHOSPHOPROTEIN; POSTSYNAPTIC DENSITY PROTEINS; TUMOR SUPPRESSOR PROTEIN; ZONULA OCCLUDENS 1 PROTEIN; ZONULA OCCLUDENS-1 PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; METAZOON; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; OLIGOMERIZATION; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SYNAPSE; ANIMAL; BINDING SITE; CAENORHABDITIS ELEGANS; CHEMICAL MODEL; CHEMISTRY; DROSOPHILA MELANOGASTER; HUMAN; MACROMOLECULE; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; REVIEW; SEQUENCE HOMOLOGY;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; INSECT PROTEINS; LIGANDS; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MODELS, CHEMICAL; NERVE TISSUE PROTEINS; PHOSPHOPROTEINS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0034740693     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (104)

1. Interaction of eye protein kinase C and INAD in Drosophila
2. The visual G protein of fly photoreceptors interacts with the PDZ domain assembled INAD signaling complex via direct binding of activated Gα(q) to phospholipase Cβ
3. Substrate recognition through a PDZ domain in tail-specific protease
4. The Protein Data Bank
5. PDZ Domains: More than just a glue
6. The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein
7. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting
8. Sorting out genes that regulate epithelial and neuronal polarity
9. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains
10. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain
11. Genome sequence of the nematode C. elegans: A platform for investigating biology
12. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor
13. Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex
14. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
15. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain
16. PDZ proteins organize synaptic signaling pathways
17. Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition
18. GRIP: A synaptic PDZ domain-containing protein that interacts with AMPA receptors
19. Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture
20. Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
21. PSD-95 involvement in maturation of excitatory synapses
22. PDZ domains and the formation of protein networks at the plasma membrane
23. Protein modules as organizers of membrane structure
24. Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions
25. Analysis of PDZ domain-ligand interactions using carboxyl-terminal phage display
26. Cyclic peptides as non-carboxyl-terminal ligands of syntrophin PDZ domain
27. Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family
28. + exchanger regulatory factor family of PDZ proteins
29. + exchange
30. Energetic determinants of internal motif recognition by PDZ domains
31. Peptide-surface association: The case of PDZ and PTB domains
32. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex
33. 2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD
34. 2+ channel assembled in a signaling complex by the PDZ domain protein INAD is phosphorylated through the interaction with protein kinase C (ePKC)
35. Initial Sequencing and Analysis of the human genome
36. Characterization of MALS/Velis-1, -2, and -3: A family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex
37. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells
38. + exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains
39. + exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator
40. Signal-processing machines at the postsynaptic density
41. + channels by interaction with a family of membrane-associated guanylate kinases
42. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins
43. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A
44. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
45. Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor
46. The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3
47. Oligomerization of nherf-1 and nherf-2 pdz domains: Differential regulation by association with receptor carboxyl-termini and by phosphorylation
48. G protein-coupled receptors III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization
49. TRP and the PDZ Protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells
50. Crystal structures of the photosystem II D1 C-terminal processing protease
51. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
52. Human homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site
53. J. Biol. Chem. Association of neuronal calcium channels with modular adaptor proteins
54. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
55. Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice
56. Crystal structure of a PDZ domain
57. Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site
58. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo
59. Improving biosensor analysis
60. Survey of the 1998 optical biosensor literature
61. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
62. Exploiting the basis of proline recognition by SH3 and WW domains: Design of N-substituted inhibitors
63. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases
64. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90
65. PDZ domains in bacterial proteins
66. Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95
67. Sequestration and recycling of β2-adrenergic receptors permit receptor resensitization
68. Evidence for PDZ domains in bacteria, yeast, and plants
69. Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction
70. PDZ domain proteins: Scaffolds for signaling complexes
71. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP
72. LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia
73. Mutagenesis and selection of PDZ domains that bind new protein targets
74. Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels
75. SMART, a simple modular architecture research tool: Identification of signaling domains
76. SMART: A web-based tool for the study of genetically mobile domains
77. Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses
78. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport
79. Molecular organization of the postsynaptic specialization
80. The Shank family of scaffold proteins
81. NHERF: Targeting and trafficking membrane proteins
82. 2+ channel by INAD in Drosophila photoreceptors
83. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction
84. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains
85. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP
86. Interaction with mLin-7 alters the targeting of endocytosed transmembrane proteins in mammalian epithelial cells
87. 2 terminus
88. PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences
89. Formation of nNOS/PSD-95 PDZ dimer requires a preformed β-finger structure from the nNOS PDZ domain
90. Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide
91. Role of endocytosis in mediating downregulation of G-protein-coupled receptors
92. The organization of INAD-signaling complexes by a multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling
93. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
94. Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors
95. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
96. Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling
97. The sequence of the human genome
98. Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity
99. + exchanger regulatory factor
100. NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3
101. Zo-1, DlgA and PSD-95/SAP90: Homologous proteins in tight, septate and synaptic cell junction
102. Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo
103. Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins
104. Sequencing and functional analysis of the yeast genome