Agonist-induced, G protein-dependent and -independent down-regulation of the μ opioid receptor. The receptor is a direct substrate for protein- tyrosine kinase

Journal of Biological Chemistry

Volumn 274, Issue 39, 1999, Pages 27610-27616

  Pak, Youngshil ^d   O'Dowd, Brian F ^a   Wang, Jia Bei ^b   George, Susan R ^a,c  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN; MU OPIATE RECEPTOR; PERTUSSIS TOXIN;

AGONIST; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; DRUG RECEPTOR BINDING; INTERNALIZATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENZYME INHIBITORS; GTP-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NALOXONE; PERTUSSIS TOXIN; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-TYROSINE KINASES; RATS; RECEPTORS, OPIOID, MU; RECOMBINANT PROTEINS; THREONINE; TRANSFECTION; VIRULENCE FACTORS, BORDETELLA;

EID: 0033600736     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.39.27610     Document Type: Article

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