Biochips beyond DNA: Technologies and applications

Biotechnology Annual Review

Volumn 9, Issue , 2003, Pages 1-149

  Ng, Jocelyn H ^a   Ilag, Leodevico L ^b  

^a IMI Consulting GmbH   (Germany)

^b NONE

Author keywords

Arrays; Chips; Diagnostics; Drug discovery; Drug screening; Electrophoresis; Expression profiling; Immunoassays; Lab on a chip; Micro total analysis systems; Microfluidics; Patterning; Photolithography; Protein; Proteomics; Soft lithography; Tissue array

Indexed keywords

APTAMER; DYE; MONOCLONAL ANTIBODY; QUANTUM DOT;

BIOASSAY; BIOSENSOR; CAPILLARY ELECTROPHORESIS; CAPILLARY PRESSURE; CELL FUNCTION; CELL MANIPULATION; CELL MIGRATION; CELL SELECTION; CELL SHAPE; DNA MICROARRAY; DRUG MONITORING; DRUG SCREENING; ELECTROCHEMISTRY; ELECTRON BEAM; ELECTRONICS; ELECTROOSMOSIS; ELECTROPHORESIS; ELECTROPLATING INDUSTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUID FLOW; GENE EXPRESSION PROFILING; HYDRODYNAMICS; IMMUNOASSAY; LAMINAR FLOW; LIGAND BINDING; MASS SPECTROMETRY; MICROFLUIDICS; NANOTECHNOLOGY; PHOTOCHEMISTRY; PROTEIN ANALYSIS; PROTEIN IMMOBILIZATION; PROTEIN MICROARRAY; PROTEIN PROCESSING; PROTEOMICS; REVIEW; SIMULATION; TISSUE ENGINEERING; TISSUE MICROARRAY; TOXICITY TESTING; BIOMEDICAL TECHNOLOGY ASSESSMENT; BIOTECHNOLOGY; EQUIPMENT DESIGN; GENETIC PROCEDURES; INSTRUMENTATION; METHODOLOGY;

BIOSENSING TECHNIQUES; BIOTECHNOLOGY; EQUIPMENT DESIGN; MICROFLUIDICS; MOLECULAR PROBE TECHNIQUES; NANOTECHNOLOGY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN ARRAY ANALYSIS; TECHNOLOGY ASSESSMENT, BIOMEDICAL;

EID: 1542650086     PISSN: 13872656     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1387-2656(03)09001-X     Document Type: Review

References (582)

1. Walter G, Büssow K, Cahill D, Lueking A and Lehrach H. Protein arrays for gene expression and molecular interaction screening. Current Opinion in Microbiology 2000;3:298-302.
2. Emili AQ and Cagney G. Large-scale functional analysis using peptide or protein arrays. Nat Biotechnol 2000;18:393-397.
3. Kodadek T. Protein microarrays: prospects and problems. Chem Biol 2001;8:105-115.
4. Ekins RP. Ligand assays: from electrophoresis to miniaturized microarrays. Clin Chem 1998;44:2015-2030.
5. Ekins R and Chu FW. Microarrays: their origins and applications. TIBTECH 1999;17(6):217-218, Jun.
6. Ekins RP. UK Patent Application 8 803 000, 1987.
7. Ekins RP. Measurement of analyte concentration, British patent, 8224600, 1983.
8. Silzel JW, Cercek B, Dodson C, Tsay T and Obremski RJ. Mass-sensing, multianalyte microarray immunoassay with imaging detection. Clin Chem 1998;44:2036-2043.
9. Wilson DS and Nock S. Functional protein microarrays. Current Opinion in Chemical Biology 2001;6:81-85.
10. McDonald JC, Duffy DC, Anderson JR, Chiu DT, Wu HK, Schueller OJA and Whitesides GM. Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 2000;21(1):27-40, Jan.
11. Owen T. Microfluidic-based Lab-on-a-Chip. LabPlus International 2002;16(3):12-14, June.
12. Freemantle M. Downsizing chemistry. Chem Eng News 1999;22:27-36, Feb.
13. Sanders GHW and Manz A. Chip-based microsystems for genomic and proteomic analysis. Trends Anal Chem 2000;19(6):364-378.
14. Terry SC, Jerman JH and Angell JB. A gas chromatographic air analyzer fabricated on a silicon wafer. IEEE Transactions on Electron Devices 1979;ED-26(12):1880-1886.
15. Manz A, Graber N and Widmer HM. Miniaturized total chemistry analysis systems: a novel concept for chemical sensing. Sensors Actuators B 1990;1:244-248.
16. Fu AY, Chou H-P, Spence C, Arnold FH and Quake SR. An integrated microfabricated cell sorter. Anal Chem 2002;74:2451-2457.
17. Manz A, Harrison DJ, Verpoorte E and Widmer HM. Advances in Chromatography. Brown PR, Grushka E (eds), New York, Marcel Dekker, 1993. pp. 1-65.
18. Seiler K, Harrison DJ and Manz A. Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency. Anal Chem 1993;65:1481-1488.
19. Manz A, Becker H. International Conference on Solid-State Sensors and Actuators, Chicago, IL, June 1997, pp. 915-918.
20. Kopp MU, de Mello AJ and Manz A. Chemical amplification: continuous-flow PCR on a chip. Science 1998;280:1046-1048.
21. Fluri K, Fitzpatrick G, Chiem N and Harrison DJ. Integrated capillary electrophoresis devices with an efficient postcolumn reactor in planar quartz and glass chips. Anal Chem 1996;68:4285-4290.
22. Salimi-Moosavi H, Tang T and Harrison DJ. Electroosmotic pumping of organic solvents and reagents in microfabricated reactor chips. J Am Chem Soc 1997;119:8716-8717.
23. Harrison DJ, Fluri K, Seiler K, Fan Z, Effenhauser CS and Manz A. Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip. Science 1993;261:895-897.
24. Liang Z, Chiem N, Ocvirk G, Tang T, Fluri K and Harrison DJ. Microfabrication of a planar absorbance and fluorescence cell for integrated capillary electrophoresis devices. Anal Chem 1996;68:1040-1946.
25. Chiem N and Harrison DJ. Microchip-based capillary electrophoresis for immunoassays: analysis of monoclonal antibodies and theophylline. Anal Chem 1997;69(3):373-378.
26. Li PCH and Harrison DJ. Transport, manipulation and reaction of biological cells on-chip using electrokinetic effects. Anal Chem 1997;69:1564-1568.
27. Khandurina J, Jacobson SC, Waters LC, Foote RS and Ramsey JM. Microfabricated porous membrane structure for sample concentration and electrophoretic analysis. Anal Chem 1999;71:1815-1819.
28. Waters LC, Jacobson SC, Kroutchinina N, Khandurina J, Foote RS and Ramsey JM. Multiple sample PCR amplification and electrophoretic analysis on a microchip. Anal Chem 1998;70:5172-5176.
29. Kutter JP, Jacobson SC, Matsubara N and Ramsey JM. Solvent-programmed microchip open-channel electrochromatography. Anal Chem 1998;70:3291-3297.
30. Jacobson SC, Culbertson CT, Daler JE and Ramsey JM. Microchip structures for submillisecond electrophoresis. Anal Chem 1998;70:3476-3480.
31. Ermakov SV, Jacobson SC and Ramsey JM. Computer simulations of electrokinetic transport in microfabricated channel structures. Anal Chem 1998;70:4494-4504.
32. Hadd AG, Raymond DE, Haliwell JW, Jacobson SC and Ramsey JM. Microchip device for performing enzyme assays. Anal Chem 1997;69:3407-3412.
33. Simpson PC, Roach D, Woolley AT, Thorsen T, Johnston R, Sensabaugh GF and Mathies RA. High-throughput genetic analysis using microfabricated 96-sample capillary array electrophoresis microplates. Proc Natl Acad Sci USA 1998;95:2256-2261.
34. Woolley AT and Mathies RA. Ultra-high-speed DNA sequencing using capillary electrophoresis chips. Anal Chem 1995;67:3676-3680.
35. Woolley AT, Lao K, Glazer AN and Mathies RA. Capillary electrophoresis chips with integrated electrochemical detection. Anal Chem 1998;70:684-688.
36. Liu S, Shi Y, Ja WW and Mathies RA. Optimization of high-speed DNA sequencing on microfabricated capillary electrophoresis channels. Anal Chem 1999;71:566-573.
37. Manz A, Fettinger JC, Verpoorte E, Lüdi H, Widmer HM and Harrison DJ. Micromachining of monocrystalline silicon and glass for chemical analysis systems - a look into next century's technology or just a fashionable craze?. Trends Anal Chem 1991;10:144-149.
38. Mitchell P. Microfluidics - downsizing large-scale biology. Nature Biotechnology 2001;19:717-721.
39. Tortora GJ and Grabowski SR. Principles of Anatomy and Physiology, New York, Harper Collins, 1996.
40. Takayama S, McDonald JC, Ostuni E, Liang MN, Kenis PJA, Ismagnilov RF and Whitesides GM. Patterning cells and their environments using multiple laminar fluid flows in capillary networks. Proc Natl Acad Sci USA 1999;96:5545-5548.
41. Chovàn T and Guttman A. Microfabricated devices in biotechnology and biochemical processing. Trends in Biotechnology 2002;20(3):116-122, March.
42. Kovacs GTA. Micromachined Transducer Sourcebook, Boston, WCB McGraw-Hill, 1998.
43. Whitesides GM and Stroock AD. Flexible methods for microfluidics. Phys Today 2001;54:42-48.
44. Nelson RW, Nedelkov D and Tubbs KA. Biosensor chip mass spectrometry: a chip-based proteomics approach. Electrophoresis 2000;21:1155-1163.
45. Sönksen CP, Nordhoff E, Jansson O, Malmqvist M and Roepstorff P. Combining MALDI mass spectrometry and biomolecular interaction analysis using a biomolecular interaction analysis instrument. Anal Chem 1998;70:2731-2736.
46. Abrantes M, Magone MT, Boyd LF and Schuck P. Adaptation of a surface plasmon resonance biosensor with microfluidics for use with small sample volumes and long contact times. Anal Chem 2001;73:2828-2835.
47. Ehret R, Baumann W, Brischwein M, Lehmann M, Henning T, Freund I, Drechsler S, Friedrich U, Hubert M-L, Motrescu E, Kob A, Palzer H, Grothe H, Wolf B. Multiparametric microsensor chips for screening applications. Fresenius J Anal Chem 2001;369:30-35.
48. Wolf B, Brischwein M, Baumann W, Ehret R and Kraus M. Monitoring of cellular signalling and metabolism with modular sensor-technique: the PhysioControl-Microsystem (PCM). Biosensors and Bioelectronics 1998;13:501-509.
49. Wolf B, Brischwein M, Baumann W, Ehret R, Henning T, Lehmann M and Schwinde A. Microsensor-aided measurements of cellular signaling and metabolism on tumor cells: the cell monitoring system (cms®). Tumor Biology 1998;19:374-383.
50. Mrksich M, Chen CS, Xia Y, Dike LE, Ingber DE and Whitesides GM. Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold. Proc Natl Acad Sci USA 1996;93(20):10775-10778, Dec 1.
51. Kane RS, Takayama S, Ostuni E, Ingber DE and Whitesides GM. Patterning proteins and cells using soft lithography. Biomaterials 1999;20(23-24):2363- 2376, Dec.
52. Chen CS, Mrksich M, Huang S, Whitesides GM and Ingber DE. Micropatterned surfaces for control of cell shape, position, and function. Biotechnol Prog 1998;14(3):356-363, May-Jun.
53. Chiu DT, Jeon NL, Huang S, Kane RS, Wargo CJ, Choi IS, Ingber DE and Whitesides GM. Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems. Proc Natl Acad Sci USA 2000;97:2408-2413.
54. Merchant M and Weinberger SR. Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry. Electrophoresis 2000;21:1164-1177.
55. Weinberger SR, Morris TS and Pawlak M. Recent trends in protein biochip technology. Pharmacogenomics 2000;1(4):395-416, Nov.
56. von Eggeling F, Davies H, Lomas L, Fiedler W, Junker K, Claussen U and Ernst G. Tissue-specific microdissection coupled with ProteinChip array technologies: applications in cancer research. Biotechniques 2000;29(5):1066-1070, Nov.
57. Mere L, Bennett T, Coassin P, England P, Hamman B, Rink T, Zimmermann S and Negulescu P. Miniaturized FRET assays and microfluidics: key components for ultra-high-throughput screening. Drug Discovery Today 1999;4(8):363-369, Aug.
58. Shumate C, Beckey S, Coassin P and Stylli H. Ultra-High throughput screening. Lab Autom News 1998;2(4):24-29.
59. Wagner P and Kim R. Protein biochips: an emerging tool for proteomics research. Current Drug Discovery 2002:23-28, May.
60. Burns MA, Mastrangelo CH, Sammarco TS, Man FP, Webster JR, Johnson BN, Foerster B, Jones D, Fields Y, Kaiser AR, Burke DT. Microfabricated structures for integrated DNA analysis. Proc Natl Acad Sci USA 1996;93:5556-5561.
61. Becker H and Gärtner C. Polymer microfabrication methods for microfluidic analytical applications. Electrophoresis 2000;21:12-26.
62. Quake SR and Scherer A. From micro- to nanofabrication with soft materials. Science 2000;290:1536-1540, Nov 24.
63. Jackman RJ. Development of methods for on-line chemical detection with liquid-phase microchemical reactors using conventional and unconventional techniques: Micro Total Analysis Systems 2000. van den Berg A. Dordrecht, The Netherlands, Kluwer Academic Publishers, 2000. pp. 155-158.
64. Deng T, Wu H, Brittain ST and Whitesides GM. Prototyping of masks, masters, and stamps/molds for soft lithography using an office printer and photographic reduction. Anal Chem 2000;72(14):3176-3180, Jul 15.
65. Duffy DC, McDonald JC, Schueller OJA and Whitesides GM. Rapid prototyping of microfluidic systems in poly(dimethylsiloxane). Anal Chem 1998;70:4974-4984.
66. Clarson SJ and Semlylen JA. Siloxane Polymers, Englewood Cliffs, NJ, Prentice Hall, 1993.
67. Whelan J. Microscale valves drive progress in microfluidics. Drug Discovery Today 2001;6(22):1134-1135, Nov.
68. Ferguson GS, Chaudhury MK, Biebuyck HA and Whitesides GM. Monolayers on disordered substrates: self-assembly of alkyltrichlorosilanes on surface-modified polyethylene and poly(dimethylsiloxane). Macromolecules 1993;26:5870-5875.
69. Jones VW, Kenseth JR, Porter MD, Mosher CL and Henderson E. Microminiaturized immunoassays using atomic force microscopy and compositionally patterned antigen arrays. Anal Chem 1998;70:1233-1241.
70. Kristensen BW, Noraberg J, Thiébaud P, Koudelka-Hep M and Zimmer J. Biocompatibility of silicon-based arrays of electrodes coupled to organotypic hippocampal brain slice cultures. Brain Research 2001;896:1-17.
71. Schneider BH, Dickinson EL, Vach MD, Hoijer JV and Howard LV. Highly sensitive optical chip immunoassays in human serum. Biosens Bioelectron 2000;15:13-22.
72. Schneider BH, Dickinson EL, Vach MD, Hoijer JV and Howard LV. Optical chip immunoassay for hCG in human whole blood. Biosensors and Bioelectronics 2000;15:597-604.
73. Kutter JP. Current developments in electrophoretic and chromatographic separation methods on microfabricated devices. Trends in Analytical Chemistry 2000;19(6):352-363.
74. Mendoza LG, McQuary P, Mongan A, Gangadharan R, Brignac S and Eggers M. High-throughput microarray-based enzyme-linked immunosorbent assay (ELISA). Biotechniques 1999;27(4):778-780, 782-786, 788.
75. Dolnik V, Liu SR and Jovanovich S. Capillary electrophoresis on microchip. Electrophoresis 2000;21:41-54.
76. Sara M and Sleytr UB. S-layer proteins. Journal of Bacteriology 2000;182(4):859-868.
77. Sleytr UB and Beveridge TJ. Bacterial S-layers. Trends in Microbiology 1999;7(6):253-260.
78. Sleytr UB, Pum D and Sara M. Advances in S-layer nanotechnology and biomimetics. Adv Biophys 1997;34:71-79.
79. Mitchell P. A perspective on protein microarrays. Nature Biotechnology 2002;20:225-229, Mar.
80. Dodge A, Fluri K, Verpoorte E and de Rooij NF. Electrokinetically driven microfluidic chips with surface-modified chambers for heterogeneous immunoassays. Anal Chem 2001;73:3400-3409.
81. Mooney JF, Hunt AJ, McIntosh JR, Liberko CA, Walba DM and Rogers CT. Patterning of functional antibodies and other proteins by photolithography of silane monolayers. Proc Natl Acad Sci USA 1996;93:12287-12291.
82. Schwarz A, Rossier JS, Roulet E, Mermod N, Roberts MA and Girault HH. Micropatterning of biomolecules on polymer substrates. Langmuir 1998;14:5526-5531.
83. Ford SM, Davies J, Kar B, Qi SD, McWhorter S, Soper SA and Malek CK. Mircomachining in plastics using X-ray lithography for the fabrication of microelectrophoresis devices. J Biomech Eng 1999;121(1):13-21, Feb.
84. Flounders AW, Brandon DL and Bates AH. Patterning of immobilized antibody layers via photolithography and oxygen plasma exposure. Biosens Bioelectron 1997;12:447-456.
85. Sundberg SA, Barrett RW, Pirrung M, Lu AL, Kiangsoontra B and Holmes CP. Spatially-addressable immobilization of macromolecules on solid supports. J Am Chem Soc 1995;117:12050-12057.
86. Sundarababu G, Gao H and Sigrist H. Photochemical linkage of antibodies to silicon chips. Photochem Photobiol Photochem Photobiol 1995;61:540-544.
87. Schena M, Shalon D, Heller R, Chai A, Brown PO and Davis RW. Parallel human genome analysis: microarray-based expression monitoring of 1000 genes. Proc Natl Acad Sci USA 1996;93(20):10614-10619, Oct 1.
88. Nicolau DV, Tauguchi T, Taniguchi H and Yoshikawa S. Micron-sized protein patterning on diazonaphthoquinone/novolak thin polymeric films. Langmuir 1998;14:1927-1936.
89. Jansen HV, Gardeniers JGE, de Boer MJ, Elwenspoek MC and Fluitman JHJ. A survey on the reactive ion etching of silicon in microtechnology. J Micromech Microeng 1996;6:14-28.
90. Ehrfeld W, Hessel V, Löwe H, Schulz C and Weber L. Materials of LIGA technology. Microsystem Technol 1999;5:105-112.
91. Ehrfeld W and Münchmeyer D. Nucl Instrum Methods 1991;A303:523-532.
92. Arnold J, Dasbach U, Ehrfeld W, Hesch K and Löse H. Combination of excimer-laser micromachining and replication processes suited for large-scale production. Appl Surf Sci 1995;86:251-258.
93. McCormick RM, Nelson RJ, Alonso-Amigo MG, Benvegnu DJ and Hooper HH. Microchannel electrophoretic separations of DNA in injection-molded plastic substrates. Anal Chem 1997;69:2626-2630.
94. Martynova L, Locascio LE, Gaitan M, Kramer GW, Christensen RG and MacCrehan WA. Fabrication of plastic microfluid channels by imprinting methods. Anal Chem 1997;69:4783-4789.
95. Locascio LE, Gaitan M, Hong J and Eldefrawi M. Proc. Micro-TAS '98, Banff, Canada 1998, pp. 367-370.
96. Becker H and Heim U. Proc. MEMS '99, Orlando, FL 1999, pp. 228-231.
97. Niggermann M, Ehrfeld W and Weber L. Proc. SPIE Micromachining and Microfabrication Process Technology IV, Vol. 3511, Santa Clara, CA 1998, pp. 204-213.
98. Becker H, Dietz W and Dannberg P. Proceedings Micro-TAS '98, Banff, Canada 1998, pp. 253-256.
99. Becker H and Dietz W. Proc. SPIE Microfluidic Devices and Systems, Santa Clara, CA 1998, pp. 177-182.
100. Konrad R, Ehrfeld W, Hartmann HJ, Jacob P, Pommersheim R and Sommer I. Proc. 3rd Int. Conference on Microreaction Technologies, Frankfurt, April 18-21, 1999.
101. Becker H, Dietz W and Dannberg P. Micro Total Analysis Systems. Harrison DJ, Van den Berg A (eds), Boston, MA, Kluwer Academic Publishers, 1998. pp. 253-356.
102. Ekström B, Jacobsen G, Öhman O and Sjödin H. US patent 5, 376, 252, 1994.
103. Paulus A, Williams SJ, Sassi AP, Kao PK, Tan H and Hooper HH. Integrated Capillary Electrophoresis using glass and plastic chips for multiplexed DNA analysis. Proc. SPIE Microfluidic Devices and Systems, Vol. 3515, Santa Clara, CA 1998, pp 94-103.
104. Qin D, Xia Y, Rogers JA, Jackman RJ, Zhao XM and Whitesides GM. Microfabrication, microstructures, and microsystems: Microsystem Technology in Chemistry and Life Sciences. Manz A, Becker H (eds), Heidelberg, Springer-Verlag, 1998. pp. 1-20.
105. Effenhauser CS, Bruin GJM, Paulus A and Ehrat M. Integrated capillary electrophoresis on flexible silicone microdevices: analysis of DNA restriction fragments and detection of single DNA molecules on microchips. Anal Chem 1997;69:3451-3457.
106. Ekström B, Jacobsen G, Öhman O and Sjödin H. International patent WO 91/16966, 1990.
107. Pethig R, Burt JPH, Parton A, Rizvi N, Talary MS and Tame JA. Development of biofactory-on-a-chip technology using excimer laser micromachining. J Micromech Microeng 1998;8:57-63.
108. Roberts MA, Rossier JS, Bercier P and Girault H. UV laser machined polymer substrates for the development of microdiagnostic systems. Anal Chem 1997;69:2035-2042.
109. Reyna LG and Sobehart JR. Laser-ablation of multilayer polymer-films. J Appl Phys 1994;76:4367-4371.
110. Niino H and Yabe A. Excimer-laser polymer ablation - formation of positively charged surfaces and its application into the metallization of polymer-films. Appl Surf Sci 1993;69:1-6.
111. Schwarz A, Rossier JS, Bianchi F, Reymond F, Ferrigno R and Girault HH. Proc. Micro-TAS '98, Banff, Canada 1998, pp. 241-244.
112. Becker H and Klotzbücher T. Proc. 3rd Int. Conference on Microreaction Technologies, Frankfurt, April 18-21, 1999.
113. Srinivasan R and Braren B. Ultraviolet-laser ablation of organic polymers. Chem Rev 1989;89:1303-1316.
114. Kleinfeld D, Kahler KH and Hockberger PE. Controlled outgrowth of dissociated neurons on patterned substrates. Neuroscience 1988;8(11):4098-4120.
115. Plueddemann E. Silane Coupling Agents, 2nd ed., New York, Plenum Press, 1991. pp. 1-250.
116. Blawas AS and Reichert WM. Protein patterning. Biomaterials 1998;19(7-9):595-609.
117. Renaud P, van Lintel H, Heuschkel M and Guerin L. Proc. Micro-TAS '98, Banff, Canada 1998, pp. 17-22.
118. MacBeath G and Schreiber SL. Printing Proteins as microarrays for high-throughput function determination. Science 2000;289:1760-1763.
119. Rowe CA, Scruggs SB, Feldstein MJ, Golden JP and Ligler FS. An array immunosensor for simultaneous detection of clinical analytes. Anal Chem 1999;71(2):433-439, Sep.
120. Paweletz CP, Charboneau L, Bichsel VE, Simone NL, Chen T, Gillespie JW, Emmert-Buck MR, Roth MJ, Petricoin EF III, Liotta LA. Reverse-phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene 2001;20:1981-1989.
121. Joos TO, Schrenk M, Höpfl P, Kröger K, Chowdhury U, Stoll D, Schörner D, Dürr M, Herick K, Rupp S, Sohn K, Hämmerle H. A microarray enzyme-based immunosorbent assay for autoimmune diagnostics. Electrophoresis 2000;21:2641-2650.
122. Lin JN, Andrade JD and Chang I-N. The influence of adsorption of native and modified antibodies on their activity. J Immunol Methods 1989;125:67-77.
123. Butler JE, Ni L, Nessler R, Joshi KS, Suter M, Rosenberg B, Chang J, Brown WR and Cantarero LA. The physical and functional behavior of capture antibodies adsorbed on polystyrene. J Immunol Methods 1992;150:77-90.
124. Butler JE, Brown WR, Joshi KS, Chang J, Rosenberg B and Voss EW. The immunochemistry of sandwich ELISAs. VI Greater than 90% of monoclonal and 75% of polyclonal anti-fluorescyl capture antibodies (CAbs) are denatured by passive adsorption. Mol Immunol 1993;30:1165-1175.
125. (a) Templin MF, Stoll D, Schrenk M, Traub PC, Vöhringer CF and Joos TO. Protein microarray technology. Drug Discovery Today 2002 August;7(15):815-822;
126. (b) Templin MF, Stoll D, Schrenk M, Traub PC, Vöhringer CF and Joos TO. Protein microarray technology. Trends in Biotechnology 2002 April;20(4):160-165.
127. Ruiz-Taylor LA, Martin TL, Zaugg G, Witte K, Indermuhle P, Nock S and Wagner P. Monolayers of derivatized poly(L-lysine)-grafted-poly(ethylene glycol) on metal oxides as a class of biomolecular interfaces. Proc Natl Acad Sci USA 2001;98:852-857.
128. Ruiz-Taylor LA, Martin TL and Wagner P. X-ray photoelectron spectroscopy and radiometry studies of biotin-derivatized poly(L-lysine)-grafted- poly(ethylene glycol) monolayers on metal oxides. Langmuir 2001;17:7313-7322.
129. Zhu H, Bilgin M, Bangham R, Hall D, Casamayor A, Bertone P, Lan N, Jansen R, Bidlingmaier S, Houfek T, Mitchell T, Miller P, Dean RA, Gerstein M, Snyder M. Global analysis of protein activities using proteome chips. Science 2001;293(5537):2101-2105, Sep 14.
130. Owaku K, Goto M, Ikariyama Y and Aizawa M. Optical Immunosensing for IgG. Sensors Actuators B 1993;13-14:723-724.
131. Schramm W and Paek SH. Antibody-antigen complex formation with immobilized immunoglobulins. Anal Biochem 1992;205:47-56.
132. Wilchek M and Bayer E. The avidin-biotin complex in immunology. Immunology Today 1984;5(2):39-43.
133. Wilchek M and Bayer E. Applications of avidin-biotin technology. Methods in Enzymology 1990;184:14-45.
134. Niemeyer CM. The developments of semisynthetic DNA-protein conjugates. Trends in Biotechnology 2002;20(9):395-401, Sept.
135. Klibanov AM. Enzyme stabilization by immobilization. Anal Biochem 1979;93:1-25.
136. Ligler FS, Georger JH, Bhatia SK, Calvert J, Shriver-Lake LC and Bredehorst R. US Patent 5,077,210, 31 December 1991.
137. Zhu H, Klemic JF, Chang S, Bertone P, Casamayor A, Klemic KG, Smith D, Gerstein M, Reed MA, Snyder M. Analysis of yeast protein kinases using protein chips. Nat Genet 2000;26:283-289.
138. Arenkov P, Kukhtin A, Gemmell A, Voloshchuk S, Chupeeva V and Mirzabekov A. Protein microchips: use for immunoassay and enzymatic reactions. Anal Biochem 2000;278(2):123-131.
139. Shriver-Lake LC, Donner B, Edelstein R, Breslin K, Bhatia SK and Ligler FS. Antibody immobilization using heterobifunctional crosslinkers. Biosens Bioelectron 1997;12:1101-1106.
140. Ligler F, Bhatia S, Shriver-Lake L, George J, Calvert J and Dulcey C. Surface modification to create regions resistant to adsorption of biomolecules. US Patent: 5,391,463, 1995.
141. Kumar A and Whitesides G. Formation of microstamped patterns on surfaces and derivative articles. US Patent: 5,512,131, 1996.
142. Bhatia SK, Teixeira JL, Anderson M, Shriver-Lake LC, Calvert JM, Georger JH, Hickman JJ, Dulcey CS, Schoen PE, Ligler FS. Fabrication of surfaces resistant to protein adsorption and application to 2-D protein patterning. Anal Biochem 1993;208:197-205.
143. Bhatia SK, Shriver-Lake LC, Prior KJ, Georger JH, Calvert JM, Bredehorst R and Ligler FS. Use of thiol-terminal silanes and heterobifunctional cross linkers for immobilization of antibodies on silica surfaces. Anal Biochem 1989;178:408-413.
144. Houseman BT and Mrksich M. Towards quantitative assays with peptide chips: a surface engineering approach. Trends in Biotechnology 2002;20(7):279-281, July.
145. Mrksich M. A surface chemistry approach to studying cell adhesion. Chem Soc Rev 2000;29:267-273.
146. Yousaf MN, Houseman BT and Mrksich M. Turning on cell migration with electroactive substrates. Agnew Chem Int Ed Engl 2001;40:1093-1096.
147. Boguslavsky J. Microarray technology empowers proteomics. Genomics and Proteomics 2001;1(3):44-46.
148. MacNeil JS. Researchers Want Em, but Will Protein Microarrays Ever Make it to Market? http://www.genomeweb.com, Article = 200132132430, March 2, 2001.
149. Prime KL and Whitesides GM. Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces. Science 1991;252:1164-1167.
150. Kenausis GL, Voros J, Elbert DL, Huang N, Hofer R, Ruiz-Taylor L, Textor M, Hubbell JA and Spencer ND. Poly(L-lysine)-g-poly(ethylene glycol) layers on metal oxide surfaces: attachment mechanism and effects of polymer architecture on resistance to protein adsorption. J Phys Chem B 2000;104:3298-3309.
151. Mirzabekov A and Kolchinsky A. Emerging array-based technologies in proteomics. Curr Opin Chem Biol 2002;6:70-75.
152. Guschin D, Yershove G, Zaslavsky A, Gemmell A, Shick V, Proudnikov D, Arenkov P and Mirzabekov A. Manual manufacturing of oligonucleotide, DNA, and protein microchips. Anal Biochem 1997;250:203-211.
153. Calkins K. Putting chips down. BioCentury 2001;9(10):A1-A6.
154. Fang Y, Frutos AG and Lahiri J. Membrane protein microarrays. J Am Chem Soc 2002;124:2394. Additional information (fabrication, storage, and FRAP experiments) available on http://pubs.acs.org.
155. Qin D, Xia Y and Whitesides GM. Rapid prototyping of complex structures with feature sizes larger than 20 μm. Adv Mater 1996;8:917-919.
156. Sigrist H, Collioud A, Clemence JF, Gao H, Luginbuhl R, Sanger M and Sundarababu G. Surface immobilization of biomolecules by light. Optic Eng 1995;34(8):2339-2348.
157. Pillai VNR. Photosensitive protecting groups. Synthesis 1980;92(21):1-25.
158. Das M and Fox CF. Chemical crosslinking in biology. Ann Rev Biophys Bioeng 1979;8:165-193.
159. Pritchard DJ, Morgan H and Cooper JM. Patterning and regeneration of surfaces with antibodies. Anal Chem 1995;67(19):3605-3607.
160. Savage MD, Mattson G, Desai S, Nielander G, Morgensen S and Conklin E. Avidin-Biotin: A Handbook, Rockford, IL, Pierce Chemical Company, 1992. pp. 25-86.
161. Pritchard DJ, Morgan H and Cooper JM. Micron-scale patterning of biological molecules. Angew. Chem Int Ed Engl 1995;34(1):91-92.
162. Pirrung M, Read JL, Fodor SP and Stryer L. Large scale solid phase synthesis of polypeptides and receptor binding screening thereof. US Patent: 5,142,854, 1992.
163. Barret R, Pirrung M, Stryer L, Holmes C and Sundberg S. Spatially addressable immobilization of anti-ligands on surfaces. US Patent: 5,252,743, 1993.
164. Fodor S, Stryer L, Winkler J, Holmes C and Solas D. Photolabile nucleoside and peptide protecting groups. US Patent: 5,489,678, 1996.
165. Pease AC, Solas D, Sullivan EJ, Cronin MT, Holmes CP and Fodor SPA. Light-generated oligonucleotide arrays for rapid DNA sequence analysis. Proc Natl Acad Sci USA 1994;91:5022-5026.
166. Pirrung MC and Huang C-Y. A general method for the spatially defined immobilization of biomolecules on glass surfaces using 'caged' biotin. Bioconjugate Chem 1996;7:317-321.
167. Fodor S, Read JL, Pirrung M, Stryer L, Tsai Lu A and Solas D. Light-directed spatially addressable parallel chemical synthesis. Science 1991;251:767-773.
168. Blawas AS, Huang C-Y, Pirrung MC and Reichert WM. Patterning Antibodies for Multiple Analyte Sensor via Photodeprotection Chemistry, San Jose, SPIE, 1996.
169. Vogt R, Phillips D, Henderson O, Whitfield W and Spierto F. Quantitative differences among various proteins as blocking agents for ELISA microtiter plates. J Immunol Methods 1987;101:43-50.
170. Hengsakul M and Cass AEG. Protein patterning with a photoactivatable derivative of biotin. Bioconj Chem 1996;7:249-254.
171. Morgan H, Pritchard DJ and Cooper JM. Photo-patterning of sensor surfaces with biomolecular structures: characterisation using AFM and fluorescence microscopy. Biosens Bioelectron 1995;10:841-846.
172. Delamarche E, Sundarababu G, Biebuyck H, Michel B, Gerber C, Sigrist H, Wolf H, Ringsdorf H, Xanthopoulos N, Matthieu HJ. Immobilization of antibodies on a photoactivatable self-assembled monolayer of gold. Langmuir 1996;12:1997-2006.
173. Liu X, Wang H, Herron JN and Prestwich GD. Patterning of antibodies on biosensors. Bioconj Chem 2000;11:755-761.
174. Brunner J. New photolabeling and cross-linking methods. Annu Rev Biochem 1993;62:483-514.
175. Ji TH. The application of chemical cross-linking for studies on cell membranes and the identification of surface reporters. Biochim Biophys Acta 1979;559:39-69.
176. Hypolite CL, McLernon TL, Adams DN, Chapman KE, Herbert CB, Huand CC, Distefano MD and Hu W-S. Formation of microscale gradients of protein using heterobifunctional photolinkers. Bioconjugate Chem 1997;8:658-663.
177. Prestwich GD, Dormán G, Elliot JT, Marecak DM and Chaudhary A. Benzophenone photoprobes for phosphoinositides, peptides, and drugs. Photochem Photobiol 1997;65:222-234.
178. Dormán G and Prestwich GD. Benzophenone photoprobes in biochemistry. Biochemistry 1994;33:5661-5673.
179. Dormán G and Prestwich GD. Using photolabile ligands in drug discovery and development. Trends Biotech 2000;18:64-77.
180. Olszweski JD, Dormán G, Elliot JT, Hong Y, Ahern DG and Prestwich GD. Tethered benzophenone reagents for the synthesis of photoactivatable ligands. Bioconjugate Chem 1995;6:395-400.
181. Roznyai L, Benson D, Fodor S and Schultz P. Photolithographic immobilization of biopolymers on solid supports. Angew Chem Int Ed Engl 1992;31:759-761.
182. Nakanishi K, Muguruma H and Karube I A. Novel method of immobilizing antibodies on a quartz crystal microbalance using plasma-polymerized films for immunosensors. Anal Chem 1996;68:1695-1700.
183. Allara DL. Critical issues in applications of self-assembled monolayers. Biosensors Bioelectron 1995;10:771-783.
184. Delamarche E, Sundarababu G, Biebuyck H, Michel B, Gerber C, Sigrist H, Wolf H, Ringsdorf H, Xanthopoulus N, Mathieu HJ. Immobilization of antibodies on a photoactive self-assembled monolayer of gold. Langmuir 1996;12:1997-2006.
185. Kumar A, Biebuyck HA and Whitesides GM. Patterning self-assembled monolayers - applications in materials science. Langmuir 1994;10:1498-1511.
186. Hickman JJ, Bhatia SK, Quong JN, Shoen P, Stenger DA, Pike CJ and Cotman CW. Rational pattern design for in vitro cellular networks using surface photochemistry. J Vac Sci Technol A 1994;12:607-616.
187. Margel S, Vogler EA, Firment L, Watt T, Haynie S and Sogah DY. Peptide, protein, and cellular interactions with self-assembled monolayer model surfaces. J Biomed Mater Res 1993;27:1463-1476.
188. Singhvi R, Kumar A, Lopez GP, Stephanopoulos GN, Wang DIC, Whitesides GM and Ingber DE. Engineering cell shape and function. Science 1994;264:696-698.
189. Stenger DA, Georger JH, Dulcey CS, Hickman JJ, Rudolph AS, Nielsen TB, McCort SM and Calvert JM. Coplanar molecular assemblies of amino- and perfluorinated alkylsilanes: characterization and geometric definition of mammalian cell adhesion and growth. J Am Chem Soc 1992;114:8435-8442.
190. Lopez GP, Biebuyck HA, Härter R, Kumar A and Whitesides GM. Fabrication and imaging of two-dimensional patterns of proteins adsorbed on self-assembled monolayers by scanning electron microscopy. J Am Chem Soc 1993;115:10774-10781.
191. Bhatia SK, Hickman JJ and Ligler FS. New approach to producing patterned biomolecular assemblies. J Am Chem Soc 1992;114:4432-4433.
192. Fragneto G, Thomas RK, Rennie AR and Penfold J. Neutron reflection study of bovine beta-casein adsorbed on OTS self-assembled monolayers. Science 1995;267:657-660.
193. Ichinose N, Shimo N and Masuhara H. Chem Lett 1995:237-238.
194. Amador SM, Pachence JM, Fischette R, McCauley JP Jr, Smith AB III and Blasie JK. Use of self-assembled monolayers to covalently tether protein monolayers to the surface of solid substrates. Langmuir 1993;9:812-817.
195. Duan C and Meyerhoff ME. Mikrochim Acta 1995;117:195-206.
196. Sigal GB, Mrksich M and Whitesides GM. Effect of surface wettability on the adsorption of proteins and detergents. J Am Chem Soc 1998;120:3464-3473.
197. Sigal GB, Bamdad C, Barberis A, Strominger J and Whitesides GM. A self-assembled monolayer for the binding and study of histidine tagged proteins by surface plasmon resonance. Anal Chem 1996;68:490-497.
198. Kumar A, Abbott N, Kim E, Biebuyck H and Whitesides G. Patterned self-assembled monolayers and meso-scale phenomena. Acc Chem Res 1995;28:219-226.
199. Tender LM, Worley RL, Fan H and Lopez GP. Electrochemical patterning of self-assembled monolayers onto microscopic arrays of gold electrodes fabricated by laser ablation. Langmuir 1996;12:5515-5518.
200. Dulcey C, Georger J, Krauthamer V, Stenger D, Fare T, Calvert J and Deep UV. photochemistry of chemisorbed monolayers: patterned coplanar molecular assemblies. Science 1991;252:551-554.
201. Mrksich M, Dike LE, Tien J, Ingber DE and Whitesides GM. Using microcontact printing to pattern the attachment of mammalian cells to self-assembled monolayers of alkanethiolates on transparent films of gold and silver. Exp Cell Res 1997;235:305-313.
202. Prime KL and Whitesides GM. Adsorption of proteins onto surfaces containing end-attached oligo(ethylene oxide): a model system using self-assembled monolayers. J Am Chem Soc 1993;115:10714-10721.
203. Deng L, Mrksich M and Whitesides GM. Self-assembled monolayers of alkanethiolates presenting tri(propylenesulfoxide) groups resist the adsorption of protein. J Am Chem Soc 1996;118:5136-5137.
204. Laibinis PL, Whitesides GM, Allara DL, Tao YT, Parikh AN and Nuzzo RG. A comparison of the structures and wetting properties of self-assembled monolayers of n-alkanethiols on the coinage metal surfaces Cu, Ag, Au. J Am Chem Soc 1991;113:7152-7167.
205. Spargo BJ, Testoff MA, Nielsen TB, Stenger DA, Hickman JJ and Rudolph AS. Spatially controlled adhesion, spreading, and differentiation of endothelial cells on self-assembled molecular monolayers. Proc Natl Acad Sci USA 1994;91:11070-11074.
206. Matsuzawa M, Potember RS, Stenger DA and Krauthamer V. Containment and growth of neuroblastoma cells on chemically patterned substrates. J Neurosci Methods 1993;50:253-260.
207. DiMilla P. Wetting and protein adsorption of self-assembled monolayers of alkanethiolates supported on transparent films of gold. J Am Chem Soc 1994;116:2225-2226.
208. Dubois LH and Nuzzo RG. Ann Rev Phys Chem 1992;43:437-463.
209. Self-Assembled Monolayers: Models For Organic Surface Chemistry, Handbook of Surface Imaging and Visualization. Whitesides GM, Gorman CB (eds), Boca Raton, CRC Press, 1995. pp. 713-733.
210. Wadu-Mesthrige K, Amro NA, Garno JC, Xu S and Liu G. Fabrication of nanometer-sized protein patterns using atomic force microscopy and selective immobilization. Biophys J 2001;80(4):1891-1899, Apr.
211. Wadu-Mesthrige K, Xu S, Amro NA and Liu G. Fabrication and imaging of nanometer-sized protein patterns. Langmuir 1999;15:8580-8583.
212. Haswell SJ and Skelton V. Chemical and biochemical microreactors. Trends Anal Chem 2000;19:389-395.
213. Martin BD, Gaber BP, Patterson CH and Turner DC. Direct protein microarray fabrication using a hydrogel "stamper". Langmuir 1998;14:3971-3975.
214. Whitesides GM, Ostuni E, Takayama S, Jiang X and Ingber DE. Soft lithography in biology and biochemistry. Annu Rev Biomed Eng 2001;3:335-373.
215. Deng T, Tien J, Xu B and Whitesides GM. Using patterns in microfiche as photomasks in 10 μm scale microfabrication. Langmuir 1999;15:6575-6581.
216. Grzybowski BA, Haag R, Bowden N and Whitesides GM. Generation of micrometer-sized patterns for microanalytical applications using a laser direct-write method and microcontact printing. Anal Chem 1998;70:4645-4652.
217. Xia YN and Whitesides GM. Soft lithography. Angew Chem Int Ed Engl 1998;37:550-575.
218. Zhao XM, Xia YN and Whitesides GM. Soft lithographic methods for nano-fabrication. J Mat Chem 1997;7:1069-1074.
219. Bernard A, Delamarche E, Schmid H, Michel B, Bosshard HR and Biebuyck H. Printing patterns of proteins. Langmuir 1998;14:2225-2229.
220. Delamarche E, Geissler M, Wolf H and Michel B. Positive microcontact printing. J Am Chem Soc 2002;124:3834-3835.
221. Biebuyck HA and Whitesides GM. Self-organization of organic liquids on patterned self-assembled monolayers of alkanethiolates on gold. Langmuir 1994;10:2790-2793.
222. Drelich J, Wilbur JL, Miller JD and Whitesides GM. Contact angles for liquid drops at a model heterogeneous surface consisting of alternating and parallel hydrophobic hydrophilic strips. Langmuir 1996;12:1913-1922.
223. Palacin S, Hidber PC, Bourgoin J-P, Miramond C, Fermon C and Whitesides GM. Patterning with magnetic materials at the micron scale. Chem Mater 1996;8:1316-1325.
224. Aizenberg J, Black AJ and Whitesides GM. Oriented growth of calcite controlled by self-assembled monolayer of functionalized alkanethiols supported on gold and silver. J Am Chem Soc 1999;121:4500-4509.
225. Crane EL, Girolami GS and Nuzzo RG. Additive fabrication and the mechanisms of nucleation and growth in chemical vapor deposition processes. Acc Chem Res 2000;33:869-877.
226. Gupta VK and Abbott NL. Design of surfaces for patterned alignment of liquid crystals on planar and curved substrates. Science 1997;276:1533-1536.
227. Clark SL, Handy ES, Rubner MF and Hammond PT. Creating microstructures of luminescent organic thin films using layer-by-layer assembly. Adv Mater 1999;11:1031-1035.
228. Ghosh P, Lackowski WM and Crooks RM. Two new approaches for patterning polymer films using templates prepared by microcontact printing. Macromolecules 2001;34:1230-1236.
229. Kumar A and Whitesides GM. Features of gold having micrometer to centimeter dimensions can be formed through a combination of stamping with an elastomeric stamp and an alkanethiol ink followed by chemical etching. Appl Phys Lett 1993;63:2002-2004.
230. Xia Y, Kim E and Whitesides GM. Microcontact printing of alkanethiols on silver and its application in microfabrication. J Electrochem Soc 1996;143:1070-1079.
231. Jackman RJ, Brittain ST, Adams A, Prentiss M and Whitesides GM. Design and fabrication of topologically complex, three-dimensional microstructures. Science 1998;280:2089-2091.
232. Geissler M, Schmid H, Bietsch A, Michel B and Delamarche E. Defect-tolerant and directional wet-etch systems for using monolayers as resists. Langmuir 2002;18:2374-2377.
233. Carvalho A, Geissler M, Schmid H, Michel B and Delamarche E. Self-assembled monolayers of eicosanethiol on palladium and their use in microcontact printing. Langmuir 2002;18:2406-2412.
234. Xia Y, Mrksich M, Kim E and Whitesides GM. Microcontact printing of octadecylsiloxane on the surface of silicon dioxide and its application in microfabrication. J Am Chem Soc 1995;117:9576-9577.
235. Jeon NL, Clem PG, Nuzzo RG and Payne DA. Patterning of dielectric oxide thin layers by microcontact printing of self-assembled monolayers. J Mater Res 1995;10:2996-2999.
236. St. John PM and Craighead HG. Microcontact printing and pattern transfer using trichlorosilanes on oxide substrates. Appl Phys Lett 1996;68:1022-1024.
237. Jeon NL, Finnie K, Branshaw K and Nuzzo RG. Langmuir 1997;13:3382-3391.
238. Kim E, Xia Y and Whitesides GM. Polymer microstructures formed by moulding in capillaries. Nature 1995;376:581-584.
239. Folch A and Toner M. Cellular micropatterns on biocompatible materials. Biotechnol Prog 1998;14:388-392.
240. Folch A, Ayon A, Hurtado O, Schmidt MA and Toner M. Molding of deep polydimethylsiloxane microstructures for microfluidics and biological applications. J Biomech Eng 1999;121:28-34.
241. Jeon NL, Baskaran H, Dertunger SKW, Whitesides GM, Van De Water L and Toner M. Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nature Biotechnology 2002;20:826-830.
242. Schueller OJA, Brittain ST and Whitesides GM. Fabrication of glassy carbon microstructures by pyrolysis of microfabricated polymeric precursors. Adv Mater 1997;9:477-480.
243. Schueller OJA, Brittain ST, Marzolin C and Whitesides GM. Fabrication and characterization of glassy MEMS. Chem Mater 1997;9:1399-1406.
244. Trau M, Yao N, Kim E, Whitesides GM and Aksay IA. Microscopic patterning of oriented mesoscopic silica through guided growth. Nature 1997;390:674-676.
245. Xia Y, Kim E and Whitesides GM. Micromolding of polymers in capillaries: applications in microfabrication. Chem Mater 1996;8:1558-1567.
246. Kim E, Xia Y and Whitesides GM. Two- and three-dimensional crystallization of polymeric microspheres by micromoulding in capillaries. Adv Mater 1996;8:245-247.
247. Kim Y-D, Park CB and Clark DS. Stable sol-gel microstructured and microfluidic networks for protein patterning. Biotechnology and Bioengineering 2001;73(5):331-337.
248. Delamarche E, Bernard A, Schmid H, Michel B and Biebuyck H. Patterned delivery of immunoglobulins to surfaces using microfluidic networks. Science 1997;276:779-781.
249. Delamarche E, Bernard A, Schmid H, Bietsch A, Michel B and Biebuyck H. Microfluidic networks for chemical patterning of substrates: design and application to bioassays. J Am Chem Soc 1998;120:500-508.
250. Bernard A, Michel B and Delamarche E. Micromosaic immunoassays. Anal Chem 2001;73:8-12.
251. Patel N, Padera R, Sanders GH, Cannizzaro SM, Davies MC, Langer R, Roberts CJ, Tendler SJ, Williams PM, Shakesheff KM. Spatially controlled cell engineering on biodegradable polymer surfaces. FASEB J 1998;12:1447-1454.
252. Anderson JR, Chiu DT, Jackman RJ, Cherniavskaya O, McDonald JC, Wu H and Whitesides GM. Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping. Anal Chem 2000;72(14):3158-3164, Jul 15.
253. Jo BH, VanLerberghe LM, Motsegood KM and Beebe DJ. Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer. J Microelectromech Syst 2002;9:76-81.
254. Sommer M, Cavallo R, Lisoukov H, Wang C, Corden F and Burke J. Packard's Hydrogel™ Coated Slides as a Substrate for Multiplexed Immunoassays in a Microarray Format. Packard BioScience Application Note BCT-008, © 2001 Packard BioScience Company, http://www.packardbioscience.com.
255. Liu G-Y, Xu S and Qian Y. Nanofabrication of self-assembled monolayers using scanning probe lithography. Acc Chem Res 2000;33:457-466.
256. Mrksich M and Whitesides GM. Patterning self-assembled monolayers using microcontact printing: a new technology for biosensors?. Trends Biotechnol 1995;13:228-236.
257. Chen CS, Mrksich M, Huang S, Whitesides GM and Ingber DE. Geometric control of cell life and death. Science 1997;276:1425-1428.
258. Michel B, Bernard A, Bietsch A, Delamarche E, Geissler M, Juncker D, Kind H, Renault JP, Rothuizen H, Schmid H, Schmidt-Winkel P, Stutz R, Wolf H. Printing meets lithography: soft approaches to high-resolution patterning. IBM J Res Dev 2001;45:697-791.
259. James CD, Davis RC, Kam L, Craighead HG, Isaacson M, Turner JN and Shain W. Patterned protein layers on solid substrates by thin stamp microcontact printing. Langmuir 1998;14:741-744.
260. Roda A, Guardigli M, Russo C, Pasini P and Baraldini M. Protein microdeposition using a conventional ink-jet printer. BioTechniques 2000;28:492-496.
261. Van Brunt J Protein Chip Challenges. http://www.SignalsMag.com 11/08/2000.
262. Lee K-B, Park S-J, Mirkin CA, Smith JC and Mrksich M. Protein nanoarrays generated by dip-pen nanolithography. Science 2002;295:1702-1705.
263. Hong S, Zhu J and Mirkin CA. Multiple ink nanolithography: toward a multiple-pen nanoplotter. Science 1999;286:523-525.
264. Hong S and Mirkin CA. A nanoplotter with both parallel and serial writing capabilities. Science 2000;288:1808-1811, Jun 9.
265. Piner RD, Zhu J, Xu F, Hong S and Mirkin CA. "Dip-pen" nanolithography. Science 1999;283:661-663.
266. Morozov VN and Morozova TY. Electrospray deposition as a method for mass fabrication of mono- and multicomponent microarrays of biological and biologically active substances. Anal Chem 1999;71:3110-3117.
267. Moermann R, Frank J, Marijnissen JC, Schalkhammer TG and van Dedem GW. Miniaturized electrospraying as a technique for the production of microarrays of reproducible micrometer sized protein spots. Anal Chem 2001;73:2183-2189.
268. Guesdon JL, Ternynck T and Avrameas S. The use of avidin-biotin interaction in immunoenzymatic techniques. J Histochem Cytochem 1979;27:1131.
269. Miralles F, Takeda Y and Escribano MJ. Comparison of carbohydrate and peptide biotinylation on the immunological activity of IgG1 murine monoclonal antibodies. J Immunol Methods 1991;140:191-196.
270. O'Shannessy DJ and Quareles RH. Labeling of the oligosaccharide moieties on immunoglobulins. J Immunol Methods 1987;19:153.
271. Gaertner HF and Offorf RE. Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins. Bioconj Chem 1996;7:38-44.
272. Vijayendran RA and Leckband DE. A quantitative assessment of heterogeneity for surface-immobilized proteins. Anal Chem 2001;73:471-480.
273. Lu B, Smyth MJ and O'Kennedy R. Oriented immobilization of antibodies and its applications to immunoassays and immunosensors. Analyst 1996;121:29R-32R.
274. Effenhauser CS, Bruin GJM, Paulus A and Ehrat M. Integrated capillary electrophoresis on flexible silicone microdevices: analysis of DNA restriction fragments and detection of single DNA molecules on microchips. Anal Chem 1997;69:3451-3457.
275. Chou HP, Spence A, Scherer A and Quake SR. A microfabricated device for sizing and sorting DNA molecules. Proc Natl Sci Acad USA 1999;96:11-13.
276. Fu AF, Spence C, Scherer A, Arnold FH and Quake SR. An microfabricated fluorescence-activated cell sorter. Nat Biotechnol 1999;17:1109-1111.
277. Bowden N, Brittain S, Evans AG, Hutchinson JW and Whitesides GM. Spontaneous formation of ordered structures in thin films of metals supported on an elastomeric polymer. Nature 1998;393:146-149.
278. Chaudhury MK and Whitesides GM. Direct measurement of interfacial interactions between semispherical lenses and flat sheets of poly(dimethylsiloxane) and their chemical derivatives. Langmuir 1991;7:1013-1025.
279. Chaudhury MK and Whitesides GM. Correlation between surface free energy and surface constitution. Science 1991;255:1230-1232.
280. Ikuta K, Maruo S, Fukaya Y and Fujisawa T. Proc. MEMS '98, Heidelberg 1998, pp. 131-136.
281. Webster JR, Burke DT and Mastrangelo CH. Proc. 1997 IEEE Int. Conf. Solid-State Sens. Actuators, Chicago, IL 1997, pp. 503-506.
282. Webster JR, Burns MA, Burke DT and Mastrangelo CH. Proc. Micro-TAS '98, Banff, Canada 1998, pp. 249-252.
283. Man PF, Jones DK and Mastrangelo CH. Proc. 1997 IEEE MEMS '97, Nagoya, Japan 1997, pp. 311-316.
284. Bousse L, Cohen C, Nikiforov T, Chow A, Kopf-Sill AR, Dubrow R and Parce JW. Electrokinetically controlled microfluidic analysis systems. Annu Rev Biophys Biomol Struct 2000;29:155-181.
285. McKnight TE, Culbertson CT, Jacobson SC and Ramsey JM. Electroosmotically induced hydraulic pumping with integrated electrodes on microfluidic devices. Anal Chem 2001;73(16):4045-4049, Aug 15.
286. Schasfoort RB, Schlautmann S, Hendrikse J and van den Berg A. Field-effect flow control for microfabricated fluidic networks. Science 1999;286:942-945, Oct 29.
287. Lemoff AV and Lee AP. Sens Actuators, B 2000;63:178-185.
288. Prins MWJ, Welters WJJ and Weekamp JW. Fluid control in multichannel structures by electrocapillary pressure. Science 2001;291:277-279.
289. Gallardo BS, Gupta VK, Eagerton FD, Jong Li, Craig VS, Shah RR and Abbott NL. Electrochemical principles for active control of liquids on submillimeter scales. Science 1999 Jan 1;283(5398):57-60.
290. Kataoka DE and Troian SM. Patterning liquid flow in the microscopic scale. Nature 1999;402:794-797.
291. Burns MA, Mastrangelo CH, Sammarco TS, Man FP, Webster JR, Johnsons BN, Foerster B, Jones D, Fields Y, Kaiser AR, Burke DT. Microfabricated structures for integrated DNA analysis. Proc Natl Acad Sci USA 1996;93:5556-5561.
292. Zhao B, Moore JS and Beebe DJ. Surface-directed liquid flow inside microchannels. Science 2001;291:1023-1026.
293. Unger MA, Chou H-P, Thorsen T, Scherer A and Quake SR. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 2000;288:113-116.
294. Ichimura K, Oh S-K and Nakagawa M. Light-driven motion of liquids on a photoresponsive surface. Science 2000;288:1624-1626, June 2.
295. Reyes DR, Iossifidis D, Auroux P-A and Manz A. Micro total analysis systems. 1. Introduction, theory, and technology. Anal Chem 2002;74:2623-2636.
296. Ahn CH. Structurally programmable microfluidic systems: Micro Total Analysis Systems 2000. van den Berg A Dordrecht, The Netherlands, Kluwer Academic Publishers, 2000. pp. 205-208.
297. Hughes MP. Strategies for dielectrophoretic separation in laboratory-on-a chip systems. Electrophoresis 2002;23(16):2569-2582, Aug.
298. Morgan H, Green NG, Hughes MP, Monaghan W and Tan TC. Large-area travelling-wave dielectrophoresis particle separator. J Micromech Microeng 1997;7:65-70.
299. Green NG, Morgan H and Milner JJ. Manipulation and trapping of sub-micron bioparticles using dielectrophoresis. J Biochem Biophys Methods 1997;35(2):89-192, Sep 25.
300. Fiedler S, Shirley SG, Schnelle T and Fuhr G. Dielectrophoretic sorting of particles and cells in a microsystem. Anal Chem 1998;70(9):1909-1915, May 1.
301. Brody JP and Yager P. Proceedings of Solid-State Sensor and Actuator Workshop, Hilton Head, SC, June 1996, pp. 105-108.
302. Chien RL and Parce JW. Multiport flow-control system for lab-on-a chip microfluidic devices. Fresenius J Anal Chem 2001;371(2):106-111, Sep.
303. Beebe DJ, Moore JS, Bauer JM, Qing Y, Liu RH, Devadoss C and Jo B-H. Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature 2000;404:588-590, April 6.
304. Rich DH and Gurwara SK. Preparation of a New o-nitrobenzyl resin for solid-phase synthesis of tert-butoxycarbonyl protected peptide acids. J Am Chem Soc 1975;97:1575.
305. Ulman A. An Introduction to Ultrathin Organic Films, Boston, Academic Press, 1991.
306. Ulman A. Formation and structure of self-assembled monolayers. Chem Rev 1996;96:1533-1554.
307. Zhao B, Mulkey D, Brittain WJ, Chen Z and Foster MD. Synthesis and characterization of phenol- and o-chlorophenol-terminated monolayers. Langmuir 1999;15:6856-6861.
308. Auroux P-A, Iossifidis D, Reyes DR and Manz A. Micro total analysis systems. 2. Standard operations and applications. Anal Chem 2002;74:2637-2652.
309. Hoole ACF, Weiland ME and Broers AN. Negative PMMA as a high-resolution resist-the limits and possibilities. Semicond Sci Technol 1997;12:1166-1170, Sept.
310. Welland ME, Durkan C and Saifullah MSM. E-Beam Lithography, © Nanoscale Science Laboratory, University of Cambrigde, http://www-g.eng.cam.ac. uk/nano/emlitho.htm.
311. Bergman AA, Buijs J, Herbig J, Mathes DT, Demarest JJ, Wilson CD, Reimann CT, Baragiola RA, Hull R, Oscarsson SO. Nanometer-scale arrangement of human serum albumin by adsorption on defect arrays created with a finely focused ion beam. Langmuir 1998;14:6785-6788.
312. Guo LJ, Krauss PR and Chou SY. Nanoscale silicon field effect transistors fabricated using imprint lithography. Appl Phys Lett 1997;71:1881-1883.
313. Li MT, Wang JA, Zhuang L and Chou SY. Fabrication of circular optical structures with a 20 nm minimum feature size using nanoimprint lithography. Appl Phys Lett 2000;76:673-675.
314. Chou SY, Krauss PR and Renstrom PJ. Imprint lithography with 25 nanometer resolution. Science 1996;272:85-87.
315. Khang DY, Yoon H and Lee HH. Room-temperature imprint lithography. Adv Mater 2001;13:749-752.
316. Sleytr UB and Sara M. Ultrafiltration membranes with uniform pores from crystalline bacterial cell envelope layers. Appl Microbiol Biotechnol 1986;25:83-90.
317. Douglas K, Clark N and Rothschild K. Nanometer molecular lithography. Appl Phys Lett 1986;48(10):676-678.
318. Xia YN, Kim E, Zhao XM, Rogers JA, Prentiss M and Whitesides GM. Complex optical surfaces formed by replica molding against elastomeric masters. Science 1996;273:347-349.
319. Mackie S and Beaumont SP. Materials and processes for nanometer lithography. Solid State Technol 1985;28:117-122.
320. Mait JN, Scherer A, Dial O, Prather DW and Gao X. Diffractive lens fabricated with binary features less than 60 nm title. Opt Lett 2000;25:381-383.
321. Broers AN. Resolution limits for electron-beam lithography. IBM J Res Dev 1988;3:502-513.
322. Van der Gaag BP and Scherer A. Microfabrication below 10 nm. Appl Phys Lett 1990;56:481-483.
323. Bensimon A, Simon A, Chiffaudel A, Croquette V, Heslot F and Bensimon D. Alignment and sensitive detection of DNA by a moving interface. Science 1994;265:2096-2098.
324. Tuttle E, Quake SR and Scherer A. Unpublished data. See also Quake and Scherer [62].
325. Irving RA and Hudson PJ. Proteins emerge from disarray. Nature Biotechnology 2000;18:932-933.
326. Chee M, Yang R, Hubbell E, Berno A, Huang XC, Stern D, Winkler J, Lockhart DJ, Morris MS, Fodor SP. Accessing genetic information with high-density DNA arrays. Science 1996;274:610-614.
327. Ekins RP. Multi-analyte immunoassay. J Pharm Biomed Anal 1989;7:155-168.
328. Ekins R, Chu F and Biggart E. Multispot, multianalyte immunoassay. Ann Biol Clin (Paris) 1990;48:655-666.
329. Ekins R and Chu F. Multianalyte microspot immunoassay. The microanalytical "compact disk" of the future. Ann Biol Clin (Paris) 1992;50:337-353.
330. Finckh P, Berger H, Karl J, Eichenlabu U, Weindel K, Hornauer H, Lenz H, Sluka P, Weinreich GE, Chu FW et al. Microspot - an ultrasensitive microarray-based ligand assay system. A practical application of ambient analyte asay theory. Proc. UK NEQAS Meeting 1998;3:155-165.
331. Lockhart DJ and Trulson MO. Multiplex metallica. Nature Biotechnology 2001;19:1122-1123.
332. Abbott A. Betting on tomorrow's chips. Nature 2002;415:112-114, Jan.
333. Ryu DD and Nam DH. Recent progress in biomolecular engineering. Biotechnol Prog 2000;16:2-16.
334. Lecerf JM, Shirley TL, Zhu Q, Kazantsev A, Amersdorfer P, Housman DE, Messer A and Huston JS. Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease. Proc Natl Acad Sci USA 2001;98:4764-4769.
335. Gao C, Mao S, Lo CH, Wirsching P, Lerner RA and Janda KD. Making artificial antibodies: a format for phage display of combinatorial heterodimeric arrays. Proc Natl Acad Sci USA 1999;96:6025-6030.
336. Knappik A, Ge LM, Honegger A, Pack P, Fischer M, Wellnhofer G, Hoess A, Wolle J, Pliickthun A, Virnekas B. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides. J Mol Biol 2000;296:57-86.
337. Krebs B, Rauchenberger R, Reiffert S, Rothe C, Tesar M, Thomassen E, Cao M, Dreier T, Fischer D, Hoss A, Inge L, Knappik A, Marget M, Pack P, Meng XQ, Schier R, Sohlemann P, Winter J, Wolle J and Kretzschmar T. High-throughput generation and engineering of recombinant human antibodies. J Immunol Methods 2001;254:67-84.
338. Raum T, Gruber R, Riethmuller G and Kufer P. Anti-self antibodies selected from a human IgD heavy chain repertoire: a novel approach to generate therapeutic human antibodies against tumor-associated differentiation antigens. Cancer Immunol Immunother 2001;50:141-150.
339. van den Brink EN, Turenhout EA, Bovenschen N, Heijnen BG, Mertens K, Peters M and Voorberg J. Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII. Blood 2001;97:966-972.
340. Huls G, Gestel D, van der Linden J, Moret E and Logtenberg T. Tumor cell killing by in vitro affinity-matured recombinant human monoclonal antibodies. Cancer Immunol Immunother 2001;50:163-171.
341. de Wildt RMT, Mundy CR, Gorick BD and Tomlinson IM. Antibody arrays for high-throughput screening of antibody-antigen interactions. Nature Biotechnology 2000;18:989-994.
342. Clackson T, Hoogenboom HR, Griffiths AD and Winter G. Making antibody fragments using phage display libraries. Nature 1991;352:624-628.
343. Honig B. Protein folding: from the levinthal paradox to structure prediction. J Mol Biol 1999;293:283-293.
344. Moult J. Predicting protein three-dimensional structure. Curr Opin Biotechnol 1999;10:583-588.
345. Jenkins RE and Pennington SR. Arrays for protein expression profiling: towards a viable alternative to two-dimensional gel electrophoresis?. Proteomics 2001;1:13-29.
346. Marks T and Sharp R. Bacteriophages and biotechnology: a review. J Chem Technol Biotechnol 2000;75:6-17.
347. Hudson PJ. Recombinant antibody fragments. Curr Opin Biotechnol 1998;9:395-402.
348. Hoogenboom HR, de Bruine AP, Hufton SE, Hoet RM, Arends JW and Roovers RC. Antibody phage display technology and its applications. Immunotechnology 1998;4:1-20.
349. Cahill DJ. Protein and antibody arrays and their medical applications. J Immunol Methods 2001;250:81-91.
350. Williams DM and Cole PA. Kinase chips hit the proteomics era. Trends in Biochemical Sciences 2001;26(5):271-273.
351. Roberts RW. Totally in vitro protein selection using mRNA-protein fusions and ribosome display. Curr Opin Chem Biol 1999;3:268-273.
352. Nord K, Gunneriusson E, Ringdahl J, Stahl S, Uhlen M and Nygren PA. Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain. Nature Biotechnology 1997;15:772-777.
353. Gunneriusson E, Nord K, Uhlen M and Nygren P. Affinity maturation of a Taq DMA polymerase specific affibody by helix shuffling. Protein Eng 1999;12:873-878.
354. Gunneriusson E, Samuelson P, Ringdahl J, Gronlund H, Nygren PA and Stahl S. Staphylococcal surface display of immunoglobulin A (IgA)- and IgE-specific in vitro-selected binding proteins (affibodies) based on Staphylococcus aureus protein A. Appl Environ Microbiol 1999;65:4134-4140.
355. Karlsröm A and Nygren P-A. Dual labeling of a binding protein allows for specific fluorescence detection of native protein. Anal Biochem 2001;295:22-30.
356. Pollok BA and Heim R. Using GFP in FRET-based applications. Trends Cell Biol 1999;9:57-60.
357. Brody EN, Willis MC, Smith JD, Jayasena S, Zichi D and Gold L. Use of aptamers in large arrays for molecular diagnostics. Molecular Diagnosis 1999;4(4):381-388.
358. Soomets U, Hallbrink M and Langel U. Antisense properties of peptide nucleic acids. Front Biosci 1999;4:782-786.
359. Braasch DA and Corey DR. Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA. Chem Biol 2001;8:1-7.
360. Green LS, Bell C and Janjic N. Aptamers as reagents for high-throughput screening. Biotechniques 2001;30:1094-1111.
361. Brody E and Gold L. Aptamers as therapeutic and diagnostic agents. Rev Mol Biotechnol 2000;74:5-13.
362. Hoppe-Seyler F and Butz K. Peptide aptamers: powerful new tools for molecular medicine. J Mol Med 2000;78:426-430.
363. Wilson DS, Keefe AD and Szostak JW. The use of mRNA display to select high-affinity protein-binding peptides. Proc Natl Acad Sci USA 2001;98:3750-3755.
364. Wilson DS and Szostak JW. In vitro selection of functional nucleic acids. Annu Rev Biochem 1999;68:611-647.
365. Golden MC, Collins BD, Willis MC and Koch TH. Diagnostic potential of PhotoSELEX-evolved ssDNA aptamers. J Biotechnol 2000;81:167-178.
366. MacBeath G, Koehler AN and Schreiber SL. Printing small molecules as microarrays and detecting protein-ligand interactions en masse. J Am Chem Soc 1999;121:7967-7968.
367. Baba Y. Development of novel biomedicine based on genome science. Eur J Pharmacol Sci 2001;13:3-4.
368. Blagoev B and Pandey A. Microarrays go live - new prospects for proteomics. Trends in Biochemical Sciences 2001;26(11):639-641.
369. Klarreich E. Biologists join the dots. Nature 2001;413:450-452.
370. Alivisatos AP. Semiconductor clusters, nanocrystals, and quantum dots. Science 1996;271:933-937.
371. Chan W and Nie S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 1998;281:2016-2018.
372. Bruchez M Jr, Moronne M, Gin P, Weiss S and Alivisatos AP. Semiconductor nanocrystals as fluorescent biological labels. Science 1998;281:2013-2016.
373. Han M, Gao X, Su J Z and Nie S. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nature Biotechnol 2001;19:631-635.
374. Nicewarner-Pena SR, Freeman RG, Reiss BD, He L, Pena DJ, Walton ID, Keating CD and Natan MJ. Submicrometer metallic barcodes. Science 2001;294:137-141.
375. Needles MC, Jones DG, Tate EH, Heinkel GL, Kochersperger LM, Dower WJ, Barrett RW and Gallop MA. Generation and screening of an oligonucleotide-encoded synthetic peptide library. Proc Natl Acad Sci USA 1993;90:10700-10704.
376. Haab BB, Dunham MJ and Brown PO. Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions. Genome Biology 2001;2(2):1-13.
377. Reineke U, Sabat R, Misselwitz R, Welfle H, Volk HD and Schneider-Mergener J. A synthetic mimic of a discontinuous binding site on interleukin-10. Nature Biotechnology 1999;17:271-275.
378. Gausepohl H, Boulin C, Kraft M and Frank RW. Automated multiples peptide synthesis. Pept Res 1992;5:315-320.
379. Kramer A and Schneider-Mergener J. Synthesis and screening of peptide libraries on continuous cellulose membrane supports. Methods Mol Biol 1998;87:25-39.
380. Holliger P, Prospero T and Winter G. "Diabodies": small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 1993;90:6444-6448.
381. Lliades P, Kortt AA and Hudson PJ. Triabodies: single chain Fv fragments without a linker form trivalent trimers. FEBS Lett 1997;409:437-441.
382. Bobrow MN, Harris TD, Shaughnessy KJ and Litt GJ. Catalyzed reporter deposition, a novel method of signal amplification. Application to immunoassays. J Immunol Methods 1989;125:279-285.
383. Osbourn JK, Derbyshire EJ, Vaughan TJ, Field AW and Johnson KS. Pathfinder selection: in situ isolation of novel antibodies. Immunotechnology 1998;3:293-302.
384. Zimmermann J. Biochips: miniature labs, maximum potential. Genetic Engineering News 2000 October 15;20(18):8,10,56, and 72.
385. Gonzales JE and Negulescu PA. Intracellular detection assays for high-throughput screening. Curr Opin Biol 1998;9:624-631.
386. Joos TO, Stoll D and Templin MF. Miniaturized multiplexed immunoassays. Curr Opin Chem Biol 2001;6:76-80.
387. Duveneck GL, Pawlak M and Neuschaefer D. Novel Bioaffinity sensors for trace analysis based on luminescence excitation by planar waveguides. Sensors Actuators B 1997;B38:88-95.
388. Schweitzer B, Wiltshire S, Lambert J, O'Malley S, Kukanskis K, Zhu Z, Kingsmore SF, Lizardi PM and Ward DC. Immunoassays with rolling circle DNA amplification: a versatile platform for ultrasensitive antigen detection. Proc Natl Acad Sci USA 2000;97:10113-10119.
389. Schweitzer B, Roberts S, Grimwade B, Shao W, Wag M, Fu Q, Shu Q, Laroche I, Zhou Z, Tchernev VT, Christiansem J, Velleca M, Kingsmore SF. Multiplexed protein profiling on microarrays by rolling-circle amplification. Nat Biotechnol 2002;20(4):359-365, Apr.
390. Schweitzer B and Kingsmore SF. Measuring proteins on microarrays. Curr Opin Biotechnol 2002;13(1):14-19, Feb.
391. Büssow K, Nordhoff E, Lubbert C, Lehrach H and Walter G. A human cDNA library for high-throughput protein expression screening. Genomics 2000;65(1):1-8.
392. Mazzola LT and Fodor SP. Imaging biomolecule arrays by atomic force microscopy. Biophys J 1995;68:1653-1660.
393. Baselt DR, Lee GU, Natesan M, Metzger SW, Sheehan PE and Colton RJ. A biosensor based on magnetoresistance technology. Biosens Bioelectron 1998;13:731-739.
394. Gizelli E and Lowe CR. Immunosensors. Curr Opin Biotechnol 1996;7:66-71.
395. Su XD, Chew FT and Li SFY. Design and application of piezoelectric quartz crystal-based immunoassay. Anal Sci 2000;16:107-114.
396. Lin SM, Lu CC, Chien HF and Hsu SM. J Immunol Methods 2000;239:121-124.
397. Woodhouse G, King L, Wieczorek L, Osman P and Cornell B. The ion channel switch biosensor. J Mol Recognit 1999;12:328-334.
398. Cornell BA, Braach-Maksvytis VLB, King LG, Osman PDJ, Raguse B, Wieczorek L and Pace RJ. A biosensor that uses ion-channel switches. Nature 1997;387:580-583.
399. Ziegler C and Göpel W. Biosensor development. Curr Opin Chem Biol 1998;2:585-591.
400. Nice EC and Catimel B. Instrumental biosensors: new perspectives for the analysis of biomolecular interactions. Bioessays 1999;21:339-352.
401. Stefan RI, vanStaden JKF and Aboul-Enein HY. Analysis of chiral drugs with enantioselective biosensors. An overview Electroanalysis 1999;11:1233-1235.
402. Gyurcsanyi RE, Vagfoldi Z, Toth K and Nagy G. Fast response potentiometric acetylcholine biosensor. Electroanalysis 1999;11:712-718.
403. Jacobson SC, Hergenröder R, Koutny LB and Ramsey JM. High-speed separations on a microchip. Anal Chem 1994;66:1114-1118.
404. Jacobson SC, Hergenröder R, Koutny LB and Ramsey JM. Open channel electrochromatography on a microchip. Anal Chem 1994;66:2369-2373.
405. Liu YM and Sweedler JV. Channel electrophoresis for kinetic assays. Anal Chem 1996;68:2471-2476.
406. Mangru SD and Harrison DJ. Chemiluminescence detection in intergrated post-separation reactors for microchip-based capillary electrophoresis and affinity electrophoresis. Electrophoresis 1998;19:2301-2307.
407. Culbertson CT, Jacobson SC and Ramsey JM. Dispersion sources for compact geometries on microchips. Anal Chem 1998;70:3781-3789.
408. Burggraf N, Manz A, Effenhauser CS, Verpoorte E, de Rooij NF and Widmer HM. Synchronized cyclic capillary electrophoresis - a novel approach to ion separations in solution. J High Resolut Chromatogr 1993;16:594-596.
409. Burggraf N, Manz A, Effenhauser CS, Verpoorte E and de Rooij NF. A novel approach to ion separations in solution: synchronized cyclic capillary electrophoresis (SCCE). Sensors Actuators B 1994;20:103-110.
410. Effenhauser CS. Integrated chip based microcolumn separation systems: Microsystem Technology in Chemistry and Life Sciences. Manz A, Becker H (eds), Springer-Verlag, 1998. pp. 51-82.
411. Ying F, Mastrangelo CH, Burke DT and Burns MA. Electrophoretic separations using sweeping fields. Electrophoresis 1998;19:1388-1393.
412. Effenhauser CS, Bruin GJ and Paulus A. Integrated chip-based CE - a review. Electrophoresis 1997;18:2203-2213.
413. Jacobson SC and Ramsey JM. Microchip electrophoresis with sample stacking. Electrophoresis 1995;16:481-486.
414. Carbeck JD, Colton IJ, Gao J and Whitesides GM. Protein charge ladders, capillary electrophoresis, and the role of electrostatics in biomolecular recognition. Acc Chem Res 1998;31:343-350.
415. Colton IJ, Anderson JR, Gao J, Chapman RG, Isaacs L and Whitesides GM. Formation of protein charge ladders by acylation of amino groups on proteins. J Am Chem Soc 1997;119:12701-12709.
416. Mammen M, Gomez F and Whitesides GM. Determination of the binding of ligands containing the N-2,4-dinitrophenyl group to bivalent monoclonal rat anti-DNP antibody using affinity capillary electrophoresis. Anal Chem 1995;67:3526-3535.
417. Kutter JP, Jacobson SC and Ramsey JM. Integrated microchip device with electrokinetically controlled solvent mixing for isocratic and gradient elution in micellar electrokinetic chromatography. Anal Chem 1997;69:5165-5171.
418. Moore AW Jr, Jacobson SC and Ramsey JM. Microchip separations of neutral species via micellar electrokinetic capillary chromatography. Anal Chem 1995;67:4184-4189.
419. von Heeren F, Verpoorte E, Manz A and Thormann W. Micellar electrokinetic chromatography separations and analyses of biological samples on a cyclic planar microstructure. Anal Chem 1996;68:2044-2053.
420. Wallenborg SR, Arnold DW and Bailey CG. Proceedings of the 21th International Symposium on Capillary Chromatography and Electrophoresis. Park City, UT 1999, p. 271.
421. Manz A, Miyahara J, Miura Y, Watanabe H, Miyagi K and Sato K. Design of an open-tubular column liquid chromatograph using silicon chip technology. Sens Actual B 1990;1:249-255.
422. Cowen S and Craston DH. Proceedings of Micro Total Analysis Systems, Enschede, 1994, p. 295.
423. Schweitz L, Andersson LI and Nilsson S. Molecular imprint-based stationary phases for capillary electrochromatography. J Chromatogr A 1998;817:5-13.
424. Ericson C, Holm J, Ericson T and Hjerten S. Electroosmosis- and pressure-driven chromatography in chips using continuous beds. Anal Chem 2000;72(1):81-87, Jan 1.
425. Oleschuk RD. Utilization of bead based reagents in microfluidic systems: Micro Total Analysis Systems 2000. van den Berg A Dordrecht, The Netherlands, Kluwer Academic Publishers, 2000. pp. 11-14.
426. Oleschuk RD and Harrison DJ. Analytical microdevices for mass spectrometry. Trends in Analytical Chemistry 2000;19(6):379-388.
427. Raymond DE, Manz A and Widmer HM. Continuous sample pretreatment using a free-flow electrophoresis device integrated onto a silicon chip. Anal Chem 1994;66:2858-2865.
428. Jacobson SC, Hergenröder R, Moore AW Jr and Ramsey JM. Precolumn reactions with electrophoretic analysis integrated on a microchip. Anal Chem 1994;66:4127-4132.
429. Cheng J, Kricka LJ, Sheldon EL and Wilding P. Microsystem Technology in Chemistry and Life Sciences. Becker H, Manz A (eds), Heidelberg, Springer, 1998. pp. 216.
430. Kutter JP, Jacobson SC and Ramsey JM. Solid phase extraction on microfluidic devices. Microcolumn Sep 2000;12:93-97.
431. Xu N, Lin Y, Hofstadler SA, Matson D, Call CJ and Smith RD. A microfabricated dialysis device for sample cleanup in electrospray ionization mass spectrometry. Anal Chem 1998;70:3553-3556.
432. Bullard KM, Hietpas PB and Ewing AG. Multiple separations in microfabricated channels: from biological microenvironments to DNA. Biomed Microdev 1998;1:27-37.
433. Jacobson SC, Koutny LB, Hergenröder R, Moore AW Jr and Ramsey JM. Microchip capillary electrophoresis with an integrated postcolumn reactor. Anal Chem 1994;66:3472-3476.
434. Burggraf N, Krattiger B, de Mello AJ, de Rooij NF and Manz A. Holographic refractive index detector for application in microchip-based separation systems. Analyst 1998;123:1443-1447.
435. Leitiko O and Jensen PF. Integrated bio/chemical microsystems employing optical detection: the clip-on. J Micromech Microeng 1998;8:148-150.
436. Roulet J-C, Fluri K, Verpoorte R, Völkel R, Herzig H-P, de Rooij NF and Dändliker R. Proceedings of Transducers 99, Sendai, 1999.
437. Schueller OJA, Duffy DC, Rogers JA, Brittain ST and Whitesides GM. Reconfigurable diffraction gratings based on elastomeric microfluidic devices. Sensors Actuators A 1999;78:149-159.
438. Schueller OJA, Zhao X-M, Whitesides GM, Smith SP and Prentiss M. Fabrication of liquid-core waveguides by soft lithography. Adv Mater 1999;11:37-41.
439. Li J, Thibault P, Bings NH, Skinner CD, Wang C, Colyer CL and Harrison DJ. Integration of microfabricated devices to capillary electrophoresis- electrospray mass spectrometry using a low dead volume connection: application to rapid analyses of proteolytic digests. Anal Chem 1999;71:3036-3045.
440. Zhang B, Liu H, Karger BL and Foret F. Microfabricated devices for capillary electrophoresis-electrospray mass spectrometry. Anal Chem 1999;71:3258-3264.
441. Jensen KF. Microreaction engineering - is small better?. Chem Eng Sci 2000;56:293-303.
442. Hsing IM. Simulation of micromachined chemical reactors for heterogeneous partial oxidation reactions. Chem Eng Sci 2000;55:3-13.
443. Despande M. Novel design for electrokinetic injection in. TAS: Micro Total Analysis Systems 2000. van den Berg A Kluwer Academic Publishers, 2000. pp. 339-342.
444. Roussel T et al. Computer simulation of separation and flow within microfabricated capillaries. In PITTCON 2001: The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (Abstr.).
445. Mosher LA. The dynamics of electrophoresis: Electrophoresis Library. Radola BJ Weinheim, Germany Wiley-VCH, Verlag GmbH and Co. KGaA, 1992. pp. 11-70.
446. Ermakov SV. Computer simulations for microchip electrophoresis: Micro Total Analysis Systems '98. Harrison DJ, van den Berg A (eds) Dordrecht, The Netherlands, Kluwer Academic Publishers, 1998. pp. 149-152.
447. Ermakov SV. Computer simulations of electrokinetic sample manipulations in microfluidic devices: Micro Total Analysis Systems 2000. Harrison DJ, van den Berg A (eds) Dordrecht, The Netherlands, Kluwer Academic Publishers, 2000. pp. 291-294.
448. Ermakov SV, Jacobson SC and Ramsey JM. Computer simulations of electrokinetic injection techniques in microfluidic devices. Anal Chem 2000;72(15):3512-3517, Aug 1.
449. Ermakov SV. Computer simulations of electrokinetic transport techniques in microfabricated channel structures. Anal Chem 1998;70:4494-4504.
450. Holmes D. Dielectrophoretic separation/isolation of rare particles/cell types from a heterogeneous suspension within a microfluidic system: Micro Total Analysis Systems 2000. van den Berg A Dordrecht, The Netherlands, Kluwer Academic Publishers, 2000. pp. 115-118.
451. Rector DR and Palmer BJ. Simulation of chemical separation processes using the lattice-Boltzmann method. In IMRET 3, 1999 (Abstract).
452. Mathies RA and Huang XC. Capillary array electrophoresis - an approach to high-speed, high-throughput DNA sequencing. Nature 1992;359:167-169.
453. Fister JC III, Jacobson SC, Davis LM and Ramsey JM. Counting single chromophore molecules for ultrasensitive analysis and separations on microchip devices. Anal Chem 1998;70:431-437.
454. Haab BB and Mathies RA. Single-molecule detection of DNA separations in microfabricated capillary electrophoresis chips employing focused molecular streams. Anal Chem 1999;71:5137-5145.
455. Koutny LB, Schmalzing D and Taylor TA. Fuchs M microchip electrophoretic immunoassay for serum cortisol. Anal Chem 1996;68:18-22.
456. Taylor LC and Walt DR. Application of high-density optical microwell arrays in a live-cell biosensing system. Anal Biochem 2000;278:132-142.
457. Rockett JC. Macroresults through microarrays. Drug Discovery Today 2002;7(15):804-805, August.
458. Zlauddin J and Sabatini DM. Microarrays of cells expressing defined cDNAs, Nature 2001 May 3;411:107-110. For detailed protocols and alternative methods, see: http://staffa.wi.-mit.edu/sabatini_public/reverse_transfection/ frame.htm.
459. Sabatini DM, personal communication.
460. Fuhr G. Examples of three-dimensional microstructures for handling and investigation of adherently growing cells and submicron particles. In Analytical methods and Instrumentation, Special issue of '96 mTAS, 1996, pp. 39-54.
461. Chou HP, Unger MA, Scherer A and Quake SR. Proceedings of Solid State Sensor and Actuator Workshop, Hilton Head, SC, June 2000.
462. Chou HP, Unger MA and Quake SR. A microfabricated rotary pump. Biomed Microdevices 2001;2:323-330.
463. Bakajin O, Carlson R, Chou CF, Chan SS, Gabel C, Knight J, Cox T and Austin RH. Solid-State Sensor and Actuator Workshop, Hilton Head, SC June, 1998, pp. 116-119.
464. Waters LC, Jacobson SC, Kroutchinina N, Khandurina J, Foote RS and Ramsey JM. Microchip Device for cell lysis, multiplex per amplification, and electrophoretic sizing. Anal Chem 1998;70:158-162.
465. Kallioniemi OP, Wagner U, Kononen J and Sauter G. Tissue microarray technology for high-throughput molecular profiling of cancer. Human Molecular Genetics 2001;10(7):657-662.
466. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP. Tissue microarrays for high throughput molecular profiling of tumour specimens. Nat Med 1998;4:844-847.
467. Torhorst J, Bucher C, Kononen J, Haas P, Zuber M, Kochli OR, Mross F, Dietrerich H, Moch H, Mihatsch M, Kallioniemi OP, Sauter G. Tissue microarrays for rapid linking of molecular changes to clinical endpoints. Am J Pathol 2001;159(6):2249-2256, Dec.
468. Nocito A, Kononen J, Kallioniemi OP and Sauter G. Tissue microarrays (TMAs) for high-throughput molecular pathology research. Int J Cancer 2001;94(1):1-5, Oct 1.
469. Englert CR, Baibakov GV and Emmert BM. Layered expression scanning: rapid molecular profiling of tumor samples. Cancer Res 2000;60:1526-1530.
470. Blackstock WP and Weir MP. Proteomics: quantitative and physical mapping of cellular proteins. Trends Biotechnol 1999;17:121-127.
471. Ng JH and Hag LL. Functional proteomics: separating the substance from the hype. Drug Discovery Today 2002;7(9):504-505.
472. Ensing K and Paulus A. Immobilization of antibodies as a versatile tool in hybridized capillary electrophoresis. J Pharm Biomed Anal 1996;14:305-315.
473. Phillips TM and Chmielinska JJ. Immunoaffinity capillary electrophoretic analysis of cyclosporin in tears. Biomed Chromatogr 1994;8:242-246.
474. Kuschel M Lab-on-a-Chip Technology - Applications for Life Sciences. Agitent technologies, Lab-on-a-chip Technology Application Literature, May 2001 at http://www.chem.agi-lent.com/scripts/LiteraturePDFasp?iWHID = 22699. Reprinted from Pharmaceutical Technology Europe, May 2001. PDF Reprint No.: 0468. Agilent Technologies Publication Number: 5988-3035EN.
475. Gao J, Xu J, Locascio LE and Lee CS. Integrated microfluidic system enabling protein digestion, peptide separation, and protein identification. Anal Chem 2001;73:2648-2655.
476. Cohen CB, Chin-Dixon E, Jeong S and Nikiforov TT. A microchip-based enzyme assay for protein kinase A. Anal Biochem 1999;273(1):89-97.
477. Throckmorton DJ, Shepodd TJ and Singh AK. Electrochromatography in microchips: reverse-phase separation of peptides and amino acids using photopatterned rigid polymer monoliths. Anal Chem 2002;74(4):784-789, Feb 15.
478. McClain MA, Culbertson CT, Jacobson SC and Ramsey JM. Flow cytometry of Escherichia coli on microfluidic devices. Anal Chem 2001;73(821):5334-5338, Nov 1.
479. Rüdiger AH, Rüdiger M, Carl UD, Chakraborty T, Roepstorff P and Wehland J. Affinity mass spectrometry-based approaches for the analysis of protein-protein interaction and complex mixtures of peptide-ligands. Anal Biochem 1999;275:162-170.
480. Zhao YM, Muir TW, Kent SBH, Tischer E, Scardina JM and Chait BT. Mapping protein-protein interaction by affinity-directed mass spectrometry. Proc Natl Acad Sci USA 1996;93:4020-4024.
481. Zhang B, Foret F and Karger BL. High-throughput microfabricated CE/ESI-MS: automated sampling from a microwell plate. Anal Chem 2001;73(11):2675-2681, Jun 1.
482. Prosser SJ, Corso TN and Schultz GA. Automated Microchip-Based Nano-Electrospray. American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics. Chicago, IL May 27-31, 2001. TPA 007.
483. Schultz GA, Corso TN, Prosser SJ and Zhang S. A fully integrated monolithic microchip electrospray device for mass spectrometry. Anal Chem 2000;72(17):4058-4063, Sep 1.
484. Liu H, Felten C, Xue Q, Zhang B, Jedrzejewski P, Karger BL and Foret F. Development of multichannel devices with an array of electrospray tips for high-throughput mass spectrometry. Anal Chem 2000;72(14):3303-3310, Jul 15.
485. Knezevic K, Leethanakul C, Bichsel VE, Worth JM, Prabhu VV, Gutkind JS, Liotta LA, Munson PJ, Petricoin EF III, Krizman DB. Proteomic profiling of the cancer microenvironment by antibody arrays. Proteomics 2001;1:1271-1278.
486. Lueking A, Horn M, Eickhoff H, Büssow K, Lehrach H and Walter G. Protein microarrays for gene expression and antibody screening. Anal Biochem 1999;270(1):103-111.
487. Büssow K, Cahill D, Nietfeld W, Bancroft D, Scherzinger E, Lehrach H and Walter G. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Nucleic Acid Res 1998;26:5007-5008.
488. Lehnert S. Prediction of tumor response to therapy: molecular markers and the microenvironment apoptosis and chips: an overview of the proceedings. Radiation Research 2000;154:121-124.
489. Cahill DJ. Protein arrays: a high-throughput solution for proteomics research?. Proteomics: A Trends Guide 2000:47-51.
490. Schmidt F, Lueking A, Nordhoff E, Gobom J, Klose J, Seitz H, Egelhofer V, Eickhoff H, Lehrach H, Cahill DJ. Generation of minimal protein identifiers of proteins from two-dimensional gels and recombinant proteins. Electrophoresis 2002;23(4):621-625, Feb.
491. Huang RP. Simultaneous detection of multiple proteins with an array-based enzyme-linked immunosorbent assay (ELISA) and enhanced chemiluminescence (ECL). Clin Chem Lab Med 2001;39:209-214.
492. Holt LJ, Büssow K, Walter G and Tomlinson IM. Bypassing selection: direct screening for antibody-antigen interactions using protein arrays. Nucleic Acids Res 2000;28:e-72 (i-v).
493. de Haard HJ, van Neer N, Reurs A, Hufton SE, Roovers RC, Henderikx P, de Bruine AP, Arends JW and Hoogenboom HR. A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies. J Biol Chem 1999;274(26):18218-18230, Jun 25.
494. Vaughan TJ, Williams AJ, Pritchard K, Osbourn JK, Pope AR, Earnshaw JC, McCafferty J, Hodits RA, Wilton J, Johnson KS. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library. Nature Biotechnol 1996;14:309-314.
495. x from a phage display library. J Immunol 1996;157:732-738.
496. x. Proc Natl Acad Sci USA 1999;96:6953-6958.
497. Zhu H and Snyder M. Protein arrays and microarrays. Curr Opin Chem Biol 2001;5(1):40-45, Feb.
498. Martzen MR, McCraith SM, Spinelli SL, Torres FM, Fields S, Grayhack EJ and Phizicky EM. A biochemical genomics approach for identifying genes by the activity of their products. Science 1999;286:1153-1155.
499. Kipriyanov SM and Little M. Generation of recombinant antibodies. Molecular Biotechnology 1999;12:173-201.
500. Dunbar BS and Skinner SM. Preparation of monoclonal antibodies. Methods in Enzymology 1990;182:670-679.
501. Harlow E and Lane D. Antibodies, A Laboratory Manual, Cold Spring Harbour Laboratory, Cold Spring Harbor, New York, 1988.
502. Huls GA, Heijnen IAFM, Cuomo ME, Koningsberger JC, Wiegman L, Boel E, van der Vuurst de Vries A-R, Loyson SAJ, Helfrich W, van Berge Henegouwen GP, van Meijer M, de Kruif J, Logtenberg T. A recombinant, fully human monoclonal antibody with antitumor activity constructed from phage-displayed antibody fragments. Nature Biotechnology 1999;17:276-281.
503. Griffiths AD, Williams SC, Hartley O, Tomlinson IM, Waterhouse P, Crosby WL, Kontermann RE, Jones PT, Low NM, Allison TJ, Prospero TD, Hoogenboom HR, Nissin A, Cox JPL, Harrison JL, Zaccolo M, Gherardi E, Winter G. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J 1994;13:3245-3260.
504. Griffiths AD and Duncan AR. Strategies for selection of antibodies by phage display. Current Opinion in Biotechnology 1998;9:102-108.
505. De Bruin R, Spelt K, Mol J, Koes R and Quattrocchio F. Selection of high-affinity phage antibodies from phage display libraries. Nature Biotechnol 1999;17:397-399.
506. Vaughan TJ, Osbourn JK and Tempest PR. Human antibodies by design. Nature Biotechnol 1998;16:535-539.
507. Winter G, Griffiths AD, Hawkins RE and Hoogenboom HR. Making antibodies by phage display technology. Annu Rev Immunol 1994;12:433-455.
508. Lueking A, Holz C, Gotthold C, Lehrach H and Cahill DJ. A novel system for dual protein expression in Pichia pastoris and Escherichia coli. Protein Expression and Purification 2000;20:372-378.
509. Albala JS and Humphrey-Smith I. Array-based proteomics: high-throughput expression and purification of IMAGE consortium cDNA clones. Curr Opin Mol Ther 1999;1:680-684.
510. Strausberg RL, Feingold EA, Klausner RD and Collins FS. The mammailian gene collection. Science 1999;286:455-457.
511. Kawai J. Functional annotation of a full-length mouse cDNA collection. Nature 2001;409:685-690.
512. Yudate HT. HUNT: launch of a full-length cDNA database from the Helix Research Institute. Nucleic Acids Res 2001;29:185-188.
513. Wiemann S. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res 2001;11:422-435.
514. Frank R. The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports-principles and applications. J Immunol Methods 2002;1:13-26, Sep 1.
515. Ge H. UPA, a universal protein array system for quantitative detection of protein-protein, protein-DNA, protein-RNA and protein-ligand interactions. Nucleic Acids Res 2000;28(2):e3(i-vii), Jan 15.
516. Geysen HM, Meloen RH and Barteling SJ. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc Natl Acad Sci USA 1984;81:3998-4002.
517. Caveman A. I'll have a genome with chips, please. J Cell Sci 2000;113:3543-3544.
518. Santini JT, Cima MJ and Langer R. A controlled-release microchip. Nature 1999;397:335-338.
519. Santini JT Jr, Richards AC, Scheldt RA, Cima MJ and Langer RS. Microchip technology in drug delivery. Ann Med 2000;32(6):377-379, Sep.
520. Borrebaeck CAK. Antibodies in diagnostics - from immunoassays to protein chips. Immunology Today 2000;21(8):379-382.
521. Sapsford KE, Charles PT, Patterson CH Jr and Ligler FS. Demonstration of four immunoassay formats using the array biosensor. Anal Chem 2002;74:1061-1068.
522. Rowe-Taitt CA, Hazzard JW, Hoffmann KE, Cras JJ, Golden JP and Ligler FS. Simultaneous detection of six biohazardous agents using a planar waveguide array biosensor. Biosens Bioelectron 2000;15:579-589.
523. Jain KK. Post-genomic applications of lab-on-a-chip and microarrays. Trends in Biotechnology 2002;20(5):184-185.
524. Yorde DE, Sasse EA, Wang TY, Hussa OO and Garancis JC. Competitive enzyme-linked immunoassay with the use of soluble enzyme antibody immune complexes for labeling. I Measurement of human choriogonadotropin. Clin Chem 1976;22:1372-1377.
525. Ekins R and Chu F. Immunoassay and other ligand assays: present status and future trends. J Int Fed Clin Chem 1997;9(3):100-109.
526. Chiem N and Harrison DJ. Microchip systems for immunoassay: an integrated immunoreactor with electrophoretic separation for serum theophylline determination. Clin Chem 1998;44(3):591-598, Mar.
527. Huang RP, Huang R, Fan Y and Lin Y. Simultaneous detection of multiple cytokines from conditioned media and patient's sera by antibody-based protein array system. Anal Biochem 2001;294:55-62.
528. Moody MD, Van Ardel SW, Orencole SF and Burns C. Array-based ELISAs for high-throughput analysis of human cytokines. BioTechniques 2001;31:186-194.
529. Wiese R, Belosludtsev Y, Powdrill T, Thompson P and Hogan M. Simultaneous multianalyte ELISA performed on a microarray platform. Clin Chem 2001;47:1451-1457.
530. Wang J. On-chip enzymatic assays. Electrophoresis 2002;23:713-718.
531. Hansen EH. Flow-injection enzymatic assays. Anal Chim Acta 1989;216:257-273.
532. He B, Ji J and Re FE. Capillary electrochromatography of peptides in a neurofabricated system. J Chromatogr. A 1998;853:257-262.
533. Regnier F, He B, Lin S and Busse J. Chromatography and electrophoresis on chips: critical elements of future integrated, microfluidic analytical systems for life science. Trends Biotechnol 1999;17:101-106.
534. Waterval JC, Lingerman H, Bult A and Underberg WJ. Derivatization trends in capillary electrophoresis. Electrophoresis 2000;21:4029-4045.
535. Belov L, de la Vega O, dos Remedios CG, Mulligan SP and Christopherson RI. Immunophenotyping of leukemias using a cluster of differentiation antibody microarray. Cancer Res 2001;61:4483-4489.
536. Wiltshire S, O'Malley S, Lambert J, Kukanskis K, Edgar D, Kingsmore SF and Schweitzer B. Detection of multiple allergen-specific IgEs on microarrays by immunoassay with rolling circle amplification. Clin Chem 2000;46(12):1990-1993, Dec.
537. Molina R, Jo J, Filella X, Zanon G, Pahisa J, Munoz M, Farrus B, Latre ML, Escriche C, Estape J, Ballesta AM. c-erbB-2 oncoprotein, CEA, and CA 15.3 in patients with breast cancer: prognostic value. Breast Cancer Res Treat 1998;51(2):109-119, Sep.
538. Bucher C, Torhorst J, Bubendorf L, Schraml P, Kononen J Moch H, Mihatsch M, Kallioniemi OP and Sauter G. Tissue microarrays ("tissue chips") for high-throughput cancer genetics: linking molecular changes to clinical endpoints. Am J Hum Genet 1999;65(suppl.):43. See also Torhorst et al. [466].
539. Gillett CE, Springall RJ, Barnes DM and Hanby AM. Multiple tissue core arrays in histopathology research: a validation study. J Pathol 2000;192:549-553.
540. Camp RL, Charette LA and Rimm DL. Validation of tissue microarray technology in breast carcinoma. Lab Invest 2000;80:1943-1949.
541. Chiu DT. A microfluidics platform for cell fusion. Commentary. Current Opinion in Chemical Biology 2001;5:609-612.
542. Cheng SB, Skinner CD, Taylor T, Attiya S, Lee WE, Picelli G and Harrison DJ. Development of a multichannel microfluidic analysis system employing affinity capillary electrophoresis for immunoassay. Anal Chem 2001;73:1472-1479.
543. Schilling EA, Kamholz AE and Yager P. Cell lysis and protein extraction in a microfluidic device with detection by a fluorogenic enzyme assay. Anal Chem 2002;74(8):1798-1804, Apr 15.
544. DeBusschere BD, Borkholder DA and Kovacs GTA. Solid-State Sensor and Actuator Workshop, Hilton Head Island, SC, June 1998, pp. 358-362.
545. Chou HP, Spence C and Scherer A. Quake SR. Proc SPIE 1998;3258:181-187.
546. Jaroszeski MJ, Gilbert R and Heller R. Detection and quantitation of cell-cell electrofusion products by flow cytometry. Anal Biochem 1994;216:271-275.
547. Hammarback JA, Palm SL, Furcht LT and Letourneau PC. Guidance of neurite outgrowth by pathways of substratum-adsorbed laminin. J Neurosci Res 1985;13:213-220.
548. Yeo W-S, Hodneland CD and Mrksich M. Electroactive monolayer substrates that selectively release adherent cells. Chembiochem 2001;2(7/8):590-593.
549. Mooney D, Hansen L, Vacanti I, Langer R, Farmer S and Ingber D. Switching from differentiation to growth in hepatocytes: control by extracellular matrix. J Cell Phys 1992;151:497-505.
550. Wight TN, Kinsella MG and Qwarnstrom EE. The role of proteoglycans in cell adhesion, migration and proliferation. Curr Opin Cell Biol 1992;4:793-801.
551. Stetler-Stevenson WG, Aznavoorian S and Liotta LA. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 1993;9:541-573.
552. Yang XD, Corvalan JR, Wang P, Roy CM and Davis CG. Fully human anti-interleukin-8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states. J Leukoc Biol 1999;66:401-410.
553. Clemons MJ. A randomized phase-II study of BB-10010 (macrophage inflammatory protein-1a) in patients with advanced breast cancer receiving 5-fluorouracil, adriamycin, and cyclophosphamide chemotherapy. Blood 1998;92:1532-1540.
554. Kolber DL, Knisely TL and Maione TE. Inhibition of development of murine melanoma lung metastases by systemic administration of recombinant platelet factor 4. J Natl Cancer Inst 1995;87:304-309.
555. Strigini M and Cohen SM. Wingless gradient formation in the Drosophila wing. Curr Biol 2000;10:293-300.
556. McDowell N, Gurdon JB and Grainger DJ. Formation of a functional morphogen gradient by a passive process in tissue from the early Xenopus embryo. Int J Dev Biol 2001;45:199-207.
557. Grunstein J, Masbad JJ, Hickey R, Giordano F and Johnson RS. Isoforms of vascular endothelial growth factor act in the coordinate fashion to recruit and expand tumor vasculature. Mol Cell Biol 2000;20:7282-7291.
558. Weigl BH and Yager P. Microfluidics - microfluidic diffusion-based separation and detection. Science 1999;283:346-347.
559. Macounova K, Cabrera CR, Holl MR and Yager P. Generation of natural pH gradients in microfluidic channels for use in isoelectric focusing. Anal Chem 2000;72:3745-3751.
560. Jeon NL, Dertinger SKW, Chiu DT, Choi IS, Stroock AD and Whitesides GM. Generation of solution and surface gradients using microfluidic systems. Langmuir 2000;16:8311-8316.
561. Dertinger SKW, Chiu DT, Jeon NL and Whitesides GM. Generation of gradients having complex shapes using microfluidic networks. Anal Chem 2001;73:1240-1246.
562. Healy KE, Lom B and Hockberger PE. Spatial distribution of mammalian cells dictated by material surface chemistry. Biotechnol Bioeng 1994;43:792-800.
563. Thiébaud P, Beuret C, Koudelka-Hep M, Bove M, Martinoia S, Grattarola M, Jahnsen H, Rebaudo R, Balestrino M, Zimmer J and Dupont Y. An array of Pt-tip microelectrodes for extracellular monitoring of activity of brain slices. Biosensors and Bioelectronics 1999;14:61-51.
564. Microsystem Technology in Chemistry and Life Sciences. Manz A, Becker H (eds), Heidelberg, Springer-Verlag, 1998.
565. Micro Total Analysis Systems 2000. Berg A van den, Olthuis W, Bergveld P (eds) Dordrecht, Kluwer Academic Publishers, 2000. pp. 623. ISBN: 0-7923-6387-6.
566. Stoll D, Templin MF, Schrenk M, Traub PC, Vöhringer CF and Joos TO. Protein microarray technology. Front. Biosci. 2002;7:c13-c32, Jan 1.
567. Bhadriraju K and Chen CS. Engineering cellular microenvironments to improve cell-based drug testing. Drug Discovery Today 2002;7(11):612-620.
568. Talary MS, Burt JPH and Pethig R. Future trends in diagnosis using laboratory-on-a-chip technologies. Parasitology 1998;117:S191-S203.
569. Figeys D and Pinto D. Proteomics on a chip: promising developments. Electrophoresis 2001;22(2):208-216, Jan.
570. Mousses S, Kallioniemi A, Kauraniemi P, Elkahloun A and Kallioniemi OP. Clinical and functional target validation using tissue and cell microarrays. Curr Opin Chem Biol 2002;6(1):97-101, Feb.
571. Gottschlich N, Culbertson CT, McKnight TE, Jacobson SC and Ramsey JM. Integrated microchip-device for the digestion, separation, and postcolumn labeling of proteins and peptides. J Chromatogr B Biomed Sci Appl 2000;745(1):243-249, Aug 4.
572. Gottschlich N, Jacobson SC, Culbertson CT and Ramsey JM. Two-dimensional electrochromatography/capillary electrophoresis on a microchip. Anal Chem 2001;73(11):2669-2674, Jun 1.
573. Huang RP. Detection of multiple proteins in an antibody-based protein microarray system. J Immunol Methods 2001;255(1-2):1-13, Sep 1.
574. Sapsford KE, Liron Z, Shubin YS and Ligler FS. Kinetics of antigen binding to arrays of antibodies in different sized spots. Anal Chem 2001;73(22):5518-5524, Nov 15.
575. Plowman TE, Durstchi JD, Wang HK, Christensen DA, Herron JN and Reichert WM. Multiple-analyte fluoroimmunoassay using an integrated optical waveguide sensor. Anal Chem 1999;71(19):4344-4352, Oct 1.
576. Schult K, Katerkamp A, Trau D, Grawe F, Cammann K and Meusel M. Disposable optical sensor chip for medical diagnostics: new ways in bioanalysis. Anal Chem 1999;71(23):5430-5435, Dec 1.
577. Rowe CA, Tender LM, Feldstein MJ, Golden JP, Scruggs SB, MacCraith BD, Cras JJ and Ligler FS. Array biosensor for simultaneous identification of bacterial, viral, and protein analytes. Anal Chem 1999;71(17):3846-3852, Sep 1.
578. Martin BD, Ampofo SA, Linhardt RJ and Dordick JS. Macromolecules 1992;25:7081.
579. Chen X, Martin BD, Neubauer TK, Linhardt RJ, Dordick JS and Rethwisch DG. Carbohydr Polym 1995;28:15.
580. Jackman R, Wilbur J and Whitesides GM. Fabrication of submicron features on curved substrates by microcontact printing. Science 1995;269:664-666.
581. Rockett JC. Chip, Chip, array! Three chips for post-genomic research. Drug Discovery Today 2002;8(8):458-459, April 7.
582. Niemeyer CM. Bioorganic applications of semisynthetic DNA-protein conjugates. Chem Eur J 2001;7:3188-3195.